WO2011039735A3 - Composés ayant une activité inhibitrice et utilisations de ceux-ci - Google Patents
Composés ayant une activité inhibitrice et utilisations de ceux-ci Download PDFInfo
- Publication number
- WO2011039735A3 WO2011039735A3 PCT/IB2010/054475 IB2010054475W WO2011039735A3 WO 2011039735 A3 WO2011039735 A3 WO 2011039735A3 IB 2010054475 W IB2010054475 W IB 2010054475W WO 2011039735 A3 WO2011039735 A3 WO 2011039735A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- inhibitory activity
- ddx3
- ddx3 inhibitory
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La présente invention concerne l'utilisation médicale du composé de formule 1, 2, 3 ou 4 :
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/499,547 US20120202814A1 (en) | 2009-10-02 | 2010-10-04 | Compounds with ddx3 inhibitory activity and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24803009P | 2009-10-02 | 2009-10-02 | |
US61/248,030 | 2009-10-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011039735A2 WO2011039735A2 (fr) | 2011-04-07 |
WO2011039735A3 true WO2011039735A3 (fr) | 2011-06-16 |
Family
ID=43402166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2010/054475 WO2011039735A2 (fr) | 2009-10-02 | 2010-10-04 | Composés ayant une activité inhibitrice et utilisations de ceux-ci |
Country Status (2)
Country | Link |
---|---|
US (1) | US20120202814A1 (fr) |
WO (1) | WO2011039735A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2595965B1 (fr) * | 2010-07-20 | 2016-06-22 | Vestaron Corporation | Triazines et pyrimidines insecticides |
US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
AU2013313974A1 (en) | 2012-09-04 | 2015-03-12 | Niigata University | Cancer diagnostic and therapeutic method targeting molecules expressed in cancer stem cells |
GB201300435D0 (en) | 2013-01-10 | 2013-02-27 | Medical Res Council | Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases |
JP6120311B2 (ja) * | 2013-02-12 | 2017-04-26 | 学校法人銀杏学園 | ポリフェノール化合物 |
GB201404372D0 (en) * | 2014-03-12 | 2014-04-23 | Univ Warwick | Assay and treatment |
CN104739838B (zh) * | 2014-09-30 | 2017-07-14 | 三峡大学 | 小分子抑制剂及在抑制鸟氨酸脱羧酶(odc)上的应用 |
EP3256461B1 (fr) | 2015-02-13 | 2023-09-13 | Azienda Ospedaliera Universitaria Senese | Dérivés d'urée et de sulfonamide utilisés en tant qu'inhibiteurs d'hélicase ddx3 humaine utiles dans le traitement de maladies virales |
CN104974142A (zh) * | 2015-06-12 | 2015-10-14 | 中国人民解放军第二军医大学 | 取代三氨基三嗪类分泌型天冬氨酸蛋白酶抑制剂及其制备方法 |
WO2017066428A1 (fr) | 2015-10-13 | 2017-04-20 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Inhibiteurs de brd4-kinase à utiliser en tant qu'agents thérapeutiques anticancéreux |
ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
CN111466338B (zh) * | 2019-01-23 | 2022-03-22 | 中国科学院广州生物医药与健康研究院 | Ddx5基因缺失的生精障碍小鼠模型及其构建方法 |
BR112022000325A2 (pt) | 2019-07-11 | 2022-03-15 | Escape Bio Inc | Indazois e azaindazois como inibidores de lrrk2 |
TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
CN113893254B (zh) * | 2021-09-07 | 2023-03-21 | 南开大学 | 一种去乙酰化酶sirt1变构激动剂及其应用 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6335339B1 (en) * | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
US20050101518A1 (en) * | 2002-01-18 | 2005-05-12 | David Solow-Cordero | Methods of treating conditions associated with an EDG-2 receptor |
US20060199804A1 (en) * | 2005-02-25 | 2006-09-07 | Kudos Pharmaceuticals Ltd | Compounds |
WO2007071199A1 (fr) * | 2005-12-22 | 2007-06-28 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Composes de 2,4-disubstituee amido-6-substituee-[1,3,5]triazine ou de 1,3-pyrimidine, leurs procedes d'elaboration, et preparations pharmaceutiques les contenant et leurs utilisations |
CN101058573A (zh) * | 2006-04-18 | 2007-10-24 | 上海医药工业研究院 | 2-腙代三嗪类化合物,其制备方法和以该化合物为活性成分的药物组合物及其用途 |
WO2008094319A2 (fr) * | 2007-02-01 | 2008-08-07 | The Board Of Regents Of The University Of Texas Sytem | Procédés et compositions d'agonistes/activateurs du récepteur de mort trail |
WO2009023558A1 (fr) * | 2007-08-10 | 2009-02-19 | Vm Discovery Inc. | Compositions et procédés pour modulateurs d'apoptose |
US20090088420A1 (en) * | 2007-04-12 | 2009-04-02 | University Of Southern California | Compounds with hiv-1 integrase inhibitory activity and use thereof as anti-hiv/aids therapeutics |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
US7052676B2 (en) * | 2000-09-26 | 2006-05-30 | The Regents Of The University Of Michigan | Methods for inhibition of HIV replication using a small molecule inhibitor |
KR100960909B1 (ko) * | 2002-04-22 | 2010-06-04 | 유니버시티 오브 메릴랜드, 볼티모어 카운티 | 캡시드 단백질의 항바이러스 억제 |
-
2010
- 2010-10-04 US US13/499,547 patent/US20120202814A1/en not_active Abandoned
- 2010-10-04 WO PCT/IB2010/054475 patent/WO2011039735A2/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6335339B1 (en) * | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
US20050101518A1 (en) * | 2002-01-18 | 2005-05-12 | David Solow-Cordero | Methods of treating conditions associated with an EDG-2 receptor |
US20060199804A1 (en) * | 2005-02-25 | 2006-09-07 | Kudos Pharmaceuticals Ltd | Compounds |
WO2007071199A1 (fr) * | 2005-12-22 | 2007-06-28 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Composes de 2,4-disubstituee amido-6-substituee-[1,3,5]triazine ou de 1,3-pyrimidine, leurs procedes d'elaboration, et preparations pharmaceutiques les contenant et leurs utilisations |
CN101058573A (zh) * | 2006-04-18 | 2007-10-24 | 上海医药工业研究院 | 2-腙代三嗪类化合物,其制备方法和以该化合物为活性成分的药物组合物及其用途 |
WO2008094319A2 (fr) * | 2007-02-01 | 2008-08-07 | The Board Of Regents Of The University Of Texas Sytem | Procédés et compositions d'agonistes/activateurs du récepteur de mort trail |
US20090088420A1 (en) * | 2007-04-12 | 2009-04-02 | University Of Southern California | Compounds with hiv-1 integrase inhibitory activity and use thereof as anti-hiv/aids therapeutics |
WO2009023558A1 (fr) * | 2007-08-10 | 2009-02-19 | Vm Discovery Inc. | Compositions et procédés pour modulateurs d'apoptose |
Non-Patent Citations (5)
Title |
---|
CHAO CHI-HONG ET AL: "DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21(waf1/cip1) promoter, is a candidate tumor suppressor", CANCER RESEARCH, vol. 66, no. 13, July 2006 (2006-07-01), pages 6579 - 6588, XP002616181, ISSN: 0008-5472 * |
DENG J ET AL: "Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 15, no. 14, 15 July 2007 (2007-07-15), pages 4985 - 5002, XP026265763, ISSN: 0968-0896, [retrieved on 20070715], DOI: DOI:10.1016/J.BMC.2007.04.041 * |
MAGA GIOVANNI ET AL: "Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid-Glutamic Acid-Alanine-Aspartic Acid Box Polypeptide 3", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 21, November 2008 (2008-11-01), pages 6635 - 6638, XP002616029, ISSN: 0022-2623 * |
WANG HAIFENG ET AL: "DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids", JOURNAL OF VIROLOGY, vol. 83, no. 11, June 2009 (2009-06-01), pages 5815 - 5824, XP002616182, ISSN: 0022-538X * |
YEDAVALLI VENKAT S R K ET AL: "Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 16, August 2008 (2008-08-01), pages 5043 - 5051, XP002616030, ISSN: 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011039735A2 (fr) | 2011-04-07 |
US20120202814A1 (en) | 2012-08-09 |
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