WO2011021551A1 - 糖衣チューインガム及び糖衣チューインガムの製造方法 - Google Patents
糖衣チューインガム及び糖衣チューインガムの製造方法 Download PDFInfo
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- WO2011021551A1 WO2011021551A1 PCT/JP2010/063626 JP2010063626W WO2011021551A1 WO 2011021551 A1 WO2011021551 A1 WO 2011021551A1 JP 2010063626 W JP2010063626 W JP 2010063626W WO 2011021551 A1 WO2011021551 A1 WO 2011021551A1
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- sugar
- coating layer
- chewing gum
- enzyme
- coated
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/062—Products for covering, coating, finishing, decorating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
- A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
Definitions
- the present invention relates to a sugar-coated chewing gum and a method for producing a sugar-coated chewing gum having a fast enzyme chewing and releasing rate, excellent elution into the mouth, and excellent long-term storage stability.
- sugar-coated chewing gum in which the main surface of chewing gum mainly composed of a gum base is coated with sugar coating
- the sugar coating material is a syrup (hereinafter abbreviated as a sugar coating solution) in which an aqueous solution of edible gum is mixed with a sweetener such as sugar or starch syrup and, in some cases, pigments, acidulants, vitamins, flavors and the like. ).
- a sweetener such as sugar or starch syrup
- the rotating pan is rotated to roll the chewing gum main body thrown into the pan, and the sugar coating liquid is sprinkled on the chewing gum.
- dextranase is known to be useful as a compounding ingredient in an oral composition because it exerts a caries preventive action by decomposing dental plaque that causes caries.
- Chewing gums containing enzymes such as dextranase are known (see Patent Documents 1 to 8).
- Patent Document 1 proposes that gelatin is effective for stably blending dextranase into an oral composition, and describes a plate chewing gum composition blended with dextranase.
- Patent Document 2 discloses a technique for stably blending chewing gum by adding dextranase to a gel-like product obtained by allowing rennin to act on a casein solution containing water-soluble calcium, and
- Patent Document 3 discloses a deactivation factor or enzyme.
- An edible composition has been proposed in which enzyme activity is maintained by microencapsulating and isolating one of them.
- Patent Documents 4 and 5 disclose a trehalose-containing composition comprising trehalose and one or more ingredients selected from raw materials and processed intermediates for foods, pharmaceuticals, cosmetics, and industrial chemicals, and a method for producing the same.
- a powder composition containing trehalose has been proposed and described as being prepared as a food product such as chewing gum, and various components such as enzymes such as glucanase, maltitol, and gelatin can be blended.
- Patent Document 6 is formulated with a non-aqueous base containing gelatin and polyol in order to stably blend an active ingredient that is unstable in the presence of water such as an enzyme into an oral composition such as a dentifrice. Oral compositions have been proposed.
- Patent Document 7 proposes a composition for preventing bad breath for the purpose of removing tongue coating and bad breath, and describes dextranase, gelatin, and maltitol as components that can be blended.
- Patent Document 8 proposes a sugar-coated product in which the release time of the enzyme is increased by blending dextranase into the sugar-coating layer. It was difficult to say that a large amount of dextranase was eluted, and there was still room for improvement.
- the enzyme is rapidly released into the mouth, and the sugar-coating chewing gum and the method for producing the sugar-coating chewing gum have a high dissolution rate in the mouth with respect to the enzyme content and excellent long-term storage stability. desired.
- the present invention has been made in view of the above circumstances.
- the sugar-coated chewing gum and sugar-coated chewing gum have a high enzyme release rate when chewed in the mouth, a high enzyme elution rate in the mouth, and excellent long-term storage stability.
- An object is to provide a manufacturing method.
- the present inventors have conducted extensive research on a technique for blending an enzyme into a sugar-coating chewing gum.
- the chewing gum main body is coated with a sugar coating layer
- the chewing gum main body is composed of at least three layers of sugar coatings.
- An inner layer covering the chewing gum main body is formed with a first sugar coating layer containing gelatin, the first sugar coating layer is coated with a second sugar coating layer containing gelatin and an enzyme, and the second sugar coating is further formed.
- the sugar coating layer contains maltitol, and it is particularly preferable that the enzyme is dextranase and / or mutanase.
- the present inventors have taken a long time to release an enzyme such as dextranase even if the chewing gum containing the enzyme is chewed in the oral cavity, or a sufficient amount of the enzyme can be obtained even after chewing.
- the fact that the enzyme does not elute is presumed to be due to the fact that the enzyme is mainly adsorbed on the chewing gum, and the technology for incorporating the enzyme into the sugar-coating chewing gum was examined in more detail.
- the first sugar coating layer is formed as an inner layer covering the chewing gum main body so that the enzyme does not come into direct contact with the chewing gum main body
- the second sugar coating layer containing the enzyme is formed, and finally the enzyme-free second layer is formed.
- the present inventors have found that the speed and long-term storage stability are excellent, and have made the present invention.
- the present invention provides the following sugar-coated chewing gum and a method for producing the sugar-coated chewing gum.
- Claim 1 The chewing gum main body is a sugar-coating chewing gum coated with at least three sugar coating layers, the inner layer covering the chewing gum main body is a first sugar coating layer containing gelatin, and the first sugar coating layer contains gelatin and an enzyme
- a sugar-coated chewing gum characterized in that it is coated with a second sugar-coating layer, and the second sugar-coating layer is further coated with a third sugar-coating layer containing no enzyme.
- Claim 2 The sugar-coated chewing gum according to claim 1, wherein the sugar-coated layer contains maltitol.
- Claim 3 Sugar-coated chewing gum according to claim 1 or 2, wherein the enzyme is dextranase and / or mutanase.
- Claim 4 The sugar-coating chewing gum according to claim 1, 2 or 3, wherein the chewing gum main body and the first sugar-coating layer do not contain an enzyme.
- the chewing gum main body is a process for producing a sugar-coated chewing gum covered with at least three sugar-coated layers, (1) forming a chewing gum main body, (2) a step of forming a first sugar coating layer covering the chewing gum main body with a sugar coating layer component containing gelatin; (3) Furthermore, a step of forming a second sugar coating layer that covers the first sugar coating layer with a sugar coating layer component containing gelatin and an enzyme, (4) A method for producing a sugar-coating chewing gum, further comprising the step of forming a third sugar-coating layer that covers the second sugar-coating layer with a sugar-coating layer component that does not contain an enzyme.
- Claim 6 The manufacturing method according to claim 5, wherein the sugar coating layer contains maltitol.
- Claim 7 The production method according to claim 5 or 6, wherein the enzyme is dextranase and / or mutanase.
- Claim 8 The production method according to claim 5, 6 or 7, wherein the chewing gum main body and the first sugar-coating layer do not contain an enzyme.
- the enzyme-containing sugar-coating chewing gum of the present invention has a fast chewing release rate into the mouth of the enzyme, excellent dissolution and excellent long-term storage stability. According to the production method of the present invention, a sugar-coated chewing gum having the above-described excellent characteristics can be obtained.
- the sugar-coated chewing gum of the present invention is a sugar-coated chewing gum in which the chewing gum main body is coated with at least three sugar-coating layers, and the inner layer covering the chewing gum main body is a first sugar-coating layer containing gelatin, The layer is coated with a second sugar coating layer containing gelatin and an enzyme, and the second sugar coating layer is further coated with a third sugar coating layer containing no enzyme.
- first sugar coating layer covering the chewing gum main body is referred to as “first sugar coating layer”
- the second sugar coating layer covering the first sugar coating layer is referred to as “second sugar coating layer”
- the second sugar coating layer is coated.
- the 3 sugar coating layers are abbreviated as “third sugar coating layer”.
- the chewing gum main body can use a well-known thing, and specifically, a sweetener, a fragrance
- the sugar-coating layer is composed of at least three sugar-coating layers of the first to third sugar-coating layers, and includes a first sugar-coating layer containing gelatin that directly covers the chewing gum main body, an enzyme and gelatin, It can be prepared by laminating a second sugar coating layer to be coated and a third sugar coating layer covering the second sugar coating layer.
- the first sugar-coating layer contains gelatin and maltitol
- the second sugar-coating layer contains gelatin and maltitol
- the third sugar-coating layer contains maltitol.
- the second sugar-coating layer is an enzyme-containing layer
- the chewing gum main body or the first sugar-coating layer may not contain an enzyme.
- the third sugar coating layer does not contain an enzyme.
- Each of these first to third sugar-coating layers can further contain a binder such as edible gum, other active ingredients, sweeteners, pigments, acidulants, flavors and the like.
- the sugar-coating layer is formed by further coating another sugar-coating layer as necessary between the chewing gum main body and the sugar-coating layer, between the first to third sugar-coating layers, and the surface of the third sugar-coating layer, There may be four or more layers.
- each sugar coating layer component for forming a sugar coating layer such as the first to third sugar coating layers includes, for example, maltitol, xylitol, sorbitol, palatinose, palatinit, lactitol, erythritol, trehalose, Carbohydrates such as reduced starch syrup, glucose, sugar and the like can be blended, but it is particularly preferable to blend maltitol from the viewpoint of enzyme elution rate and long-term storage stability.
- a commercially available saccharide can be used.
- the sugar content in the sugar coating layer of each layer such as the first to third sugar coating layers is 70 to 99.9% in the sugar coating layer components of each layer (hereinafter, unless otherwise specified,% represents mass%), A range of 80 to 99.9% is particularly desirable.
- the sugar content in the entire sugar-coating layer is desirably in the range of 70 to 99.9%, particularly 80 to 99.9%. If the content is less than 70%, the long-term storage stability of the enzyme may be hindered, and if it exceeds 99.9%, the elution rate of the enzyme may be hindered.
- the first sugar-coating layer and the second sugar-coating layer contain gelatin, whereby the elution rate of the enzyme and the storage stability of the enzyme can be enhanced. Furthermore, gelatin may be blended in the third sugar coating layer.
- the gelatin is not limited to the origin of cattle, pigs, fish, etc., nor is it limited with regard to the processing method of gelatin and its physicochemical properties such as molecular weight and isoelectric point, and commercially available products can be used.
- the thing made from the thing etc. can be used.
- the gelatin content in each sugar coating layer component of the first sugar coating layer and the second sugar coating layer is preferably 0.1 to 5%, particularly preferably 0.2 to 2%. If the content in each sugar coating layer component is less than 0.1%, the storage stability of the enzyme may be inferior. If it exceeds 5%, the release rate of the enzyme into the mouth may be inferior.
- the gelatin content of the first sugar coating layer and the second sugar coating layer may be the same or different.
- the enzyme examples include dextranase, mutanase, amylase, lysozyme, lytic enzyme, protease, cellulase, glucanase, oxidoreductase, lipase and the like, and at least one of these is used alone or in combination. be able to.
- the lactoferrin which is a multifunctional protein can also be mix
- the compounding amount of the enzyme can be an effective amount according to the type and titer of the enzyme.
- the entire sugar-coated chewing gum preparation total amount of chewing gum main component and sugar-coating layer components for preparing sugar-coated chewing gum; hereinafter abbreviated as well. 0.01 to 5% is preferable, and 0.03% to 3% is particularly preferable.
- the total content of the second sugar coating layer component is preferably 0.03 to 20%, more preferably 0.3 to 10%. If it is less than 0.01% of the whole preparation, the enzyme dissolution and release rate are inferior, and the plaque removal effect may not be obtained satisfactorily.
- 1 unit of dextranase is an amount of dextranase that produces a free reducing sugar corresponding to 1 ⁇ mol of glucose per minute when the reaction is performed at 40 ° C. using dextran as a substrate.
- the amount of mutanase is preferably 0.01 to 5%, more preferably 0.03 to 3% of the total sugar-coated chewing gum preparation, based on 6,000 unit products.
- the total content of the second sugar coating layer component is preferably 0.03 to 20%, more preferably 0.3 to 10%. If it is less than 0.01% of the whole preparation, the enzyme dissolution property and release rate are inferior, and the plaque removal effect may not be obtained satisfactorily. If it exceeds 5%, the storage stability of the enzyme may be hindered.
- One unit of mutanase is the amount of mutanase that produces free reducing sugar corresponding to 1 ⁇ mol of glucose per minute when the reaction is carried out at 40 ° C. using mutan as a substrate.
- the total content of an enzyme can be made into the compounding quantity according to the kind and titer of an enzyme. 0.01 to 5% of the entire preparation of sugar-coated chewing gum is preferable, and 0.03 to 3% is more preferable.
- the total content of the second sugar coating layer component is preferably 0.03 to 20%, more preferably 0.3 to 10%. If it is less than 0.01% of the whole preparation, the enzyme dissolution property and release rate are inferior, and the plaque removal effect may not be obtained satisfactorily. If it exceeds 5%, the storage stability of the enzyme may be hindered.
- the sugar coating layer in addition to the above-mentioned components, known components such as stabilizers, fragrances, pigments, shellac and wax can be blended as required in the usual sugar coating step.
- the mass of the sugar-coating layer in the sugar-coating chewing gum (mass after the sugar-coating liquid is dried and solidified; the same applies hereinafter) can be as follows.
- the mass of the first sugar coating layer is preferably 5 to 600 mg, particularly 10 to 500 mg, with respect to 1 g of chewing gum main body. If it is less than 5 mg, the elution rate of the enzyme may be hindered, and if it exceeds 600 mg, the storage stability of the enzyme may be hindered.
- the mass of the second sugar coating layer is preferably 5 to 600 mg, particularly 10 to 500 mg, with respect to 1 g of chewing gum main body. If it is less than 5 mg, the elution rate of the enzyme may be hindered, and if it exceeds 600 mg, the storage stability of the enzyme may be hindered.
- the mass of the third sugar-coating layer is not particularly limited as long as the sugar-coating layer can be formed to the target thickness, but a suitable mass for forming the target thickness is 100 to 1,000 mg with respect to 1 g of chewing gum main body, 150 to 900 mg is particularly desirable. If it is less than 100 mg, the storage stability of the enzyme may be hindered, and if it exceeds 1,000 mg, the release rate of the enzyme may be hindered.
- the gum base to be blended mainly in the chewing gum those usually used in chewing gum compositions can be used.
- polyvinyl acetate resins having an average degree of polymerization of 100 to 1,000, natural resins (ticles, geltons, solvers) Etc.
- resins for gum base such as polyisobutylene, polybutene, ester gum (base agent)
- fillers such as calcium carbonate, calcium phosphate, talc, lanolin, stearic acid, sodium stearate, potassium stearate, glyceryl triacetate, glycerin, etc.
- Commercially available gum bases containing plasticizers or softeners, as well as natural wax, petroleum wax, paraffin and the like can be used.
- the said gum base may contain coloring agents, such as natural pigment
- the blending amount of the gum base is preferably 10 to 50%, particularly preferably 15 to 30% of the entire sugar-coated chewing gum preparation.
- the gum base content in the chewing gum main body can be 15 to 80%, in particular 20 to 60%.
- the sugar-coated chewing gum of the present invention may contain known components blended in the chewing gum as necessary in addition to the above components.
- Each sugar coating layer can further contain a binder such as edible gum, other active ingredients and sweeteners, pigments, acidulants, fragrances, etc., and chewing gum mainly comprises sweeteners, pigments, acidulants, A fragrance
- a binder may be blended in order to further improve the coating properties.
- the chewing gum main body and the like can be coated more satisfactorily with the sugar coating layer.
- the binder for example, edible gums such as gum arabic, starch, etc. are preferably used.
- the blending amount when the binder is blended may be the same or different in each layer, and is preferably 0.1 to 20%, particularly 1 to 10%, based on the sugar such as maltitol in the sugar coating layer component. If it is less than 0.1%, sufficient sugar coating may not be achieved. If it exceeds 20%, the long-term storage stability of the enzyme may be affected.
- the sugar coating layer in which gelatin is blended is not limited thereto, and the blending of the binder can be omitted.
- a sweetener can be blended to impart sweetness to the chewing gum main body.
- the sweetener include commonly used sweeteners such as maltitol, sucrose, glucose, dextrose, invert sugar, fructose, sugar, starch syrup, xylitol, erythritol, sorbitol, mannitol, lactitol, palatinose, palatinit, trehalose, oligosaccharide.
- the chewing gum main body preferably contains at least one selected from reduced starch syrup, stevia, sucralose, saccharin and aspartame, and particularly preferably contains maltitol, sucralose, xylitol, paratinite and erythritol in terms of flavor.
- the blending amount of the sweetener in the chewing gum main body is preferably 0.001 to 85%, particularly 0.01 to 80% of the whole chewing gum main body.
- flavor can be mix
- flavor may be mix
- fragrance it is preferable to use one or more kinds of oil and fat fragrances and powder fragrances such as natural fragrances and synthetic fragrances, but there is no particular limitation.
- natural flavors include mastic oil, parsley oil, anise oil, eucalyptus oil, winter green oil, cassia oil, menthol oil, spearmint oil, peppermint oil, lemon oil, coriander oil, orange oil, mandarin oil, lime oil, Lavender oil, laurel oil, chamomile oil, cardamom oil, caraway oil, bay oil, lemongrass oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute peppermint, absolute rose, orange flower, citrus oil , Mixed fruit oil, strawberry oil, cinnamon oil, clove oil, grape oil and the like.
- Single flavors include carvone, anethole, methyl salicylate, cinnamic aldehyde, linalool, linalyl acetate, limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate Rate, allylcyclohexanepropionate, methylanthranilate, ethylmethylanthranilate, vanillin, undecalactone, hexanal, ethinone alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethyl Examples include pyrazine, ethyl lactate, and ethyl thioacetate.
- Single flavor and / or natural flavors including strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, yogurt flavor, fruit mix flavor, herbal mint Flavors and the like.
- flavor may be an essential oil, an extract, a solid substance, or the powder which spray-dried these.
- the total blending amount of the fragrance is preferably 0.001 to 20%, particularly preferably 0.001 to 5% of the entire sugar-coated chewing gum preparation. If the blending amount is less than 0.001%, a satisfactory effect may not be exhibited. Yes, if it exceeds 20%, the flavor and texture of the composition may be impaired.
- additives such as acidulants, brighteners, thickeners, emulsifiers, pH adjusters, preservatives and the like are appropriately added to the sugar-coating chewing gum as long as the effects of the present invention are not impaired. May be.
- the sugar-coated chewing gum of the present invention that is, the sugar-coated chewing gum in which the chewing gum main body is coated with at least three sugar coating layers, (1) forming a chewing gum main body, (2) a step of forming a first sugar coating layer covering the chewing gum main body with a sugar coating layer component containing gelatin; (3) Furthermore, a step of forming a second sugar coating layer that covers the first sugar coating layer with a sugar coating layer component containing gelatin and an enzyme, (4) Furthermore, it can manufacture by the method including the process of forming the 3rd sugar-coating layer which coat
- a gum base comprising a gum base resin as a main component and a wax, an emulsifier, a filler and the like, if necessary, a predetermined amount of sweeteners, fragrances and coloring agents.
- additives such as a softener and a taste-masking substance are added, and the mixture is uniformly kneaded using a kneader at around 50 ° C., and then cut into an appropriate shape such as a plate shape or a block shape to obtain a chewing gum main body.
- the mass of the chewing gum main body is preferably about 1 to 2 g.
- the chewing gum main body obtained in the first step may be pretreated with a coating agent such as shellac before being coated with the first to third sugar coating layers.
- the sugar-coating process may be performed by any of a so-called hard sugar coating method using only the edible gum and sugar coating liquid, and a so-called soft sugar coating method in which a fine powder material made of powdered sugar and the sugar coating liquid are alternately applied.
- a so-called hard sugar coating method using only the edible gum and sugar coating liquid
- a so-called soft sugar coating method in which a fine powder material made of powdered sugar and the sugar coating liquid are alternately applied.
- the second sugar coating layer can be covered with the third sugar coating layer, and the thickness of the entire sugar coating layer can be appropriately adjusted according to the purpose.
- the mass of the entire sugar-coated layer after solidification is preferably 0.1 to 2.2 g based on 1 g of the chewing gum main body, but can be appropriately adjusted according to the purpose.
- the sugar coating process can be performed, for example, by the following method.
- the sugar-coated bread or rotary hook is preferably a top-opened bottomed container that is connected to a drive motor and is attached to a rotary drive shaft that is disposed at an angle of, for example, 10 to 60 ° with respect to the vertical line.
- the chewing gum main body is put into a sugar-coated bread or a rotary kettle, and the sugar-coating bread is rotated at 5 to 30 revolutions / minute while a sugar-coating material, for example, a sugar-coating liquid containing maltitol is added to mainly chewing gum.
- powder components such as crystallized maltitol and liquid components such as oil fragrances and pigments are added and dried by blowing to form a sugar coating layer To form. Drying can be performed, for example, by supplying the powder component and spreading it over the entire coating, or by blowing after the treatment with the powder component. When air is blown, the air volume is preferably 3 to 30 m 2 / min. For example, drying is preferably performed so that the water content is 1 to 3%. It is preferable to repeat this process until the ratio of the total sugar-coating layer is 9 to 69%, particularly 10 to 55%, particularly 20 to 50% of the entire sugar-coating chewing gum preparation to form the sugar-coating layer.
- a further process such as polishing may be employed.
- a polishing wax is supplied into the rotary kettle and the rotary coater is rotated while the sugar coating is being rotated. It can also be performed by coating the surface of the sugar coating layer of the chewing gum with a wax.
- carnauba wax or candelilla wax may be used as the wax.
- shellac may be used for coating after sugar coating layer coating.
- the sugar-coating chewing gum of the present invention is prepared into sugar-coating chewing gums of various shapes such as round and square, but it is particularly preferable that the sugar-coating chewing gum is prepared in a square shape because it is resistant to scratches and is stable in appearance. .
- the present invention will be described in more detail with reference to experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples.
- the blending amount is mass%.
- surface is the pure part conversion value after dry-up except the water
- sugar-coated chewing gums (Examples and Comparative Examples) were prepared by the chewing gum main composition, sugar-coating layer composition and steps described in Tables 1 to 13 and Tables 15 to 17, and evaluated by the following methods. went. The results are shown in Tables 14-17.
- Preparation of sugar-coated chewing gum (1) Preparation of chewing gum main component: According to the composition shown in Table 1, gum base [manufactured by Natural Base Co., Ltd.], xylitol [manufactured by Mitsubishi Corporation Foodtech Co., Ltd.], maltitol [Amalti MR-100, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.], reduced starch syrup [ Nikken Kasei Co., Ltd.], sucralose (manufactured by Saneigen FFI Co., Ltd.), and a fragrance were added, and the mixture was uniformly kneaded in a kneader at around 50 ° C.
- This kneaded product was cut into blocks to obtain a chewing gum main body (chewing gum layer). At this time, the mass of the chewing gum main body was set to about 1 g.
- the composition shown in Table 1 was used as the main chewing gum of the sugar-coated chewing gums of Examples 1 to 21 and Comparative Examples 3 to 8.
- the chewing gum main bodies of Comparative Examples 1 and 2 were similarly prepared according to the compositions shown in Tables 5 and 6.
- the sugar coating liquid for forming the second sugar-coating layer is applied to the surface of the first sugar-coating layer while rotating the sugar-coating bread at 15 revolutions / minute, and dried by blowing to form the second sugar-coating layer on the surface of the first sugar-coating layer.
- the sugar coating liquid for forming the third sugar coating layer is applied to the surface of the second sugar coating layer while rotating the sugar coating bread at 15 rotations / minute, and dried by blowing to form the third sugar coating layer on the surface of the second sugar coating layer. I let you.
- a sugar-coated chewing gum covered with sugar coating layers from the first sugar coating layer to the third sugar coating layer was produced.
- the solidified sugar-coating layer obtained by drying the sugar-coating liquid was formed with a mass shown in the table with respect to 1 g of the chewing gum main body.
- the sugar-coating chewing gum of the comparative example prepared the sugar-coating chewing gum which has each composition according to said method.
- gelatin is AP100 manufactured by Nitta Gelatin Co.
- dextranase is dextranase manufactured by Mitsubishi Chemical Foods Co., Ltd. (12,000 unit product)
- mutanase is a mutanase manufactured by Amano Enzyme Co., Ltd. 6,000 unit product
- maltitol a rescission manufactured by Mitsubishi Corporation Foodtech Co., Ltd. was used.
- Experiment 1 Enzyme dissolution rate confirmation test from sugar-coated chewing gum Two sugar-coated chewing gums were transferred to a 100 mL beaker, and the sugar-coated layer was dissolved in 70 mL of 10 mM phosphate buffer (pH 7) for 30 minutes. The lysate was collected, made up to 100 mL, sonicated for 5 minutes, and dextranase activity or mutanase activity was measured by the Somogi method.
- One unit of dextranase is the amount of enzyme that produces a free reducing sugar equivalent to 1 ⁇ mol of glucose per minute in a reaction at 40 ° C.
- One unit of mutanase is the amount of enzyme that produces free reducing sugar equivalent to 1 ⁇ mol of glucose per minute in a reaction at 40 ° C.
- the enzyme elution rate was calculated by the following formula.
- Experiment 2 Mastication release test of enzyme from sugar-coated chewing gum Using 10 healthy teeth as subjects, sample saliva at rest for 1 minute, chew 2 sugar-coated chewing gums for 10 minutes, and collect saliva every minute did. After 10 minutes, the sugar-coated chewing gum was discharged, and then saliva was collected at rest for 1 minute. The collected saliva was diluted with 10 mM phosphate buffer (pH 7), the enzyme activity was quantified by the same method as in Experiment 1, and the results of 10 people were averaged.
- the saliva release rate of the enzyme after 5 minutes and 10 minutes was calculated from the following formulas (i) and (ii), and the saliva release rate was evaluated according to the following criteria.
- the enzyme release rate was evaluated from the above results. The evaluation criteria for the enzyme release rate are shown below. Release rate of enzyme into saliva (average of 10 people) Release rate in saliva Over 90% release within 5 minutes: ⁇ Over 90% released within 10 minutes over 5 minutes: Even if it exceeds 10 minutes, the enzyme release rate is less than 90%: ⁇
- Experiment 3 Enzyme stability test for long-term storage of sugar-coated chewing gum Immediately after the manufacture of sugar-coated chewing gum and after standing at room temperature for one year, the enzyme activity in long-term storage of sugar-coated chewing gum was evaluated by the same measurement method as in Experiment 1. It calculated
- Gelatin in the first sugar coating layer dextranase and gelatin in the second sugar coating layer, and gum arabic in the third sugar coating layer.
- Gelatin in the first sugar coating layer dextranase and gelatin in the second sugar coating layer, and gelatin in the third sugar coating layer.
- Gelatin in the first sugar coating layer dextranase and gelatin in the second sugar coating layer, and gum arabic in the first to third sugar coating layers.
- Dextranase is added to the sugar coating layer (inner layer) that directly covers the chewing gum.
- Gelatin is blended only in the first sugar coating layer.
- Dextranase is added to the third sugar coating layer.
- the sugar-coated chewing gum containing an enzyme mainly in a chewing gum and coated with a single sugar-coating layer is inferior in enzyme elution rate, release rate and storage stability. Although the release rate was improved, the enzyme elution rate and storage stability were poor (Comparative Examples 1 to 4). Even when the sugar coating layer contains an enzyme and a plurality of sugar coating layers are laminated, if the sugar coating layer is inappropriate, the enzyme elution rate and storage stability are poor (Comparative Examples 5 to 8).
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Abstract
Description
通常、糖衣の材料は、食用ガム質の水溶液に、砂糖、水飴等の甘味剤を、場合によっては更に色素、酸味料、ビタミン、香料等を混入してなるシロップ(以下、糖衣液と略記。)である。これを使用してチューインガム主体表面を糖衣被覆するには、例えば回転パンを回転させて、パン内に投入したチューインガム主体を転動させ、これに上記糖衣液を振りかけ、万遍なく糖衣液でチューインガム主体の表面を湿らせた後、回転中の回転パンに温風を吹き込んでチューインガム主体の表面に付着した糖衣液の水分を取り除き、チューインガム主体の表面を糖衣液固形分で被覆し、更に糖衣液を振りかける。この操作を繰り返すことによって、糖衣液固形分による皮膜を適度の厚さまで成長させ、糖衣層で被覆された糖衣チューインガムが出来上がる。
特許文献1には、デキストラナーゼを口腔用組成物に安定配合するためにゼラチンの配合が有効であることが提案され、デキストラナーゼを配合した板チューインガム組成が記載されている。特許文献2には、水溶性カルシウムを含むカゼイン液にレンニンを作用させたゲル状物にデキストラナーゼを含有させることでチューインガムに安定配合する技術、特許文献3には、失活因子又は酵素の一方をマイクロカプセル化して隔離することで、酵素活性が維持された食用組成物が提案されている。
特許文献4,5には、トレハロースと共に、食品、医薬品、化粧品、及び工業化学品の原材料並びに加工中間体から選ばれる一種又は二種以上の成分を含んでなるトレハロース含有組成物及びその製造方法や、トレハロース含有粉末組成物が提案され、チューインガム等の食品として調製されること、グルカナーゼ等の酵素、マルチトール、ゼラチン等の各種成分が配合可能であることが記載されている。また、特許文献6には、歯磨剤等の口腔用組成物への酵素等の水存在下では不安定な有効成分を安定配合するために、ゼラチン及びポリオールを含有する非水系基剤を配合した口腔用組成物が提案されている。特許文献7には、舌苔除去及び口臭除去を目的とした口臭予防用組成物が提案され、デキストラナーゼや、ゼラチン、マルチトールが配合可能成分として記載されている。
請求項1;
チューインガム主体が、少なくとも3層の糖衣層で被覆された糖衣チューインガムであって、チューインガム主体を被覆する内層が、ゼラチンを含有する第1糖衣層であり、該第1糖衣層がゼラチン及び酵素を含有する第2糖衣層で被覆され、更に該第2糖衣層が酵素を含有しない第3糖衣層で被覆されてなることを特徴とする糖衣チューインガム。
請求項2;
糖衣層が、マルチトールを含有する請求項1記載の糖衣チューインガム。
請求項3;
酵素が、デキストラナーゼ及び/又はムタナーゼである請求項1又は2記載の糖衣チューインガム。
請求項4;
チューインガム主体及び第1糖衣層が酵素を含有しない請求項1、2又は3記載の糖衣チューインガム。
請求項5;
チューインガム主体が、少なくとも3層の糖衣層で被覆された糖衣チューインガムの製造方法であって、
(1)チューインガム主体を形成する工程、
(2)ゼラチンを含有する糖衣層成分で、チューインガム主体を被覆する第1糖衣層を形成する工程、
(3)更に、ゼラチン及び酵素を含有する糖衣層成分で、前記第1糖衣層を被覆する第2糖衣層を形成する工程、
(4)更に、酵素を含有しない糖衣層成分で、前記第2糖衣層を被覆する第3糖衣層を形成する工程
を含むことを特徴とする糖衣チューインガムの製造方法。
請求項6;
糖衣層が、マルチトールを含有する請求項5記載の製造方法。
請求項7;
酵素が、デキストラナーゼ及び/又はムタナーゼである請求項5又は6記載の製造方法。
請求項8;
チューインガム主体及び第1糖衣層が酵素を含有しない請求項5,6又は7記載の製造方法。
以後、上述のチューインガム主体を被覆する第1の糖衣層を「第1糖衣層」、第1糖衣層を被覆する第2の糖衣層を「第2糖衣層」、第2糖衣層を被覆する第3の糖衣層を「第3糖衣層」と略記する。
糖衣層は、第1~3糖衣層の少なくとも3層の糖衣層により構成され、チューインガム主体を直接被覆するゼラチンを含有する第1糖衣層と、酵素及びゼラチンを含有し、前記第1糖衣層を被覆する第2糖衣層と、前記第2糖衣層を被覆する第3糖衣層が積層されたものとして調製することができる。特に、第1糖衣層はゼラチンとマルチトールを含有し、第2糖衣層はゼラチンとマルチトールを含有し、第3糖衣層はマルチトールを含有することが好ましい。第2糖衣層が酵素含有層であり、チューインガム主体や第1糖衣層には酵素を配合しなくてもよい。第3糖衣層は酵素を含有しない。これらの第1~3糖衣層には、それぞれ、更に食用ガム質等の結合剤、他の有効成分や甘味剤、色素、酸味料、香料等を配合することができる。
デキストラナーゼの配合量は、12,000単位品を基準とした場合、糖衣チューインガムの製剤全体(糖衣チューインガムを調製するためのチューインガム主体成分及び糖衣層成分の総計。以下、同様に略記。)の0.01~5%が好ましく、特に0.03~3%がより好ましい。第2糖衣層成分全体中の含有量は0.03~20%が好ましく、特に0.3~10%がより好ましい。製剤全体の0.01%未満では、酵素溶出性や放出速度に劣り、歯垢除去効果が満足に得られない場合があり、5%を超えると酵素の保存安定性に支障をきたす場合がある。なお、デキストラナーゼ1単位とは、デキストランを基質として40℃で反応を行った場合に、1分間当たりにグルコース1μmolに相当する遊離還元糖を生じるデキストラナーゼの量である。
なお、酵素の総含有量は、酵素の種類と力価に応じた配合量とすることができる。糖衣チューインガムの製剤全体の0.01~5%が好ましく、特に0.03~3%がより好ましい。第2糖衣層成分全体中の含有量は0.03~20%が好ましく、特に0.3~10%がより好ましい。製剤全体の0.01%未満では酵素溶出性や放出速度に劣り、歯垢除去効果が満足に得られない場合があり、5%を超えると酵素の保存安定性に支障をきたす場合がある。
第1糖衣層の質量は、チューインガム主体1gに対して5~600mgが望ましく、特に10~500mgが望ましい。5mg未満では酵素の溶出率に支障をきたす場合があり、600mgを超えると酵素の保存安定性に支障をきたす場合がある。
ガムベースの配合量は、糖衣チューインガムの製剤全体の10~50%、特に15~30%が好ましい。チューインガム主体中のガムベースの含有量は15~80%、特に20~60%とすることができる。
結合剤としては、例えばアラビアガム等の食用ガム質、でんぷんなどが好適に使用される。結合剤を配合する場合の配合量は、各層で同じでも異なっていてもよく、糖衣層成分中のマルチトール等の糖質に対して0.1~20%、とりわけ1~10%が好ましい。0.1%未満では十分糖衣がなされない場合があり、20%を超えると酵素の長期保存安定性などに影響をきたす場合がある。なお、ゼラチンが配合されている糖衣層は、その限りではなく、結合剤の配合を省略することもできる。
単品香料としては、カルボン、アネトール、サリチル酸メチル、シンナミックアルデヒド、リナロール、リナリールアセテート、リモネン、メントン、メンチルアセテート、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビールアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルアンスラニレート、バニリン、ウンデカラクトン、ヘキサナール、エチノンアルコール、プロピルアルコール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルフェイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、エチルチオアセテート等が挙げられる。単品香料及び/又は天然香料を含む調合香料として、ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、トロピカルフルーツフレーバー、バターフレーバー、ミルクフレーバー、ヨーグルトフレーバー、フルーツミックスフレーバー、ハーブミントフレーバー等が挙げられる。また、香料の形態は、精油、抽出物、固形物、又はこれらを噴霧乾燥した粉体でも構わない。
(1)チューインガム主体を形成する工程、
(2)ゼラチンを含有する糖衣層成分で、チューインガム主体を被覆する第1糖衣層を形成する工程、
(3)更に、ゼラチン及び酵素を含有する糖衣層成分で、前記第1糖衣層を被覆する第2糖衣層を形成する工程、
(4)更に、酵素を含有しない糖衣層成分で、前記第2糖衣層を被覆する第3糖衣層を形成する工程
を含む方法で製造することができる。
第1工程で得られたチューインガム主体は、第1~3糖衣層で被覆する前に、セラック等のコーティング剤で前処理してもよい。
なお、糖衣工程は、食用ガム質と糖衣液のみを使用するいわゆるハード糖衣方法と、粉糖等からなる微細粉末原料とかかる糖衣液とを交互にかけるいわゆるソフト糖衣方法のいずれによってもよい。どちらの方法においても、酵素とチューインガム主体とを直接接触させないように、チューインガム主体を第1糖衣層で被覆した後に、酵素を含有した第2糖衣層を形成させることが好ましい。更に、第2糖衣層を第3糖衣層で被覆し、糖衣層全体の厚みを目的に応じて適宜調整することができる。なお、固形化した後の糖衣層全体の質量は、チューインガム主体1gに対して0.1~2.2gが望ましいが、目的に応じて適宜調整することができる。
糖衣パンあるいは回転釜は、駆動モータに接続され、垂直線に対して、例えば10~60°傾斜させて配置された回転駆動軸に取り付けられた上方開口型の有底容器であるのが好ましい。具体的には、糖衣パンあるいは回転釜中にチューインガム主体を投入し、糖衣パンを5~30回転/分で回転させながら糖衣層の原料、例えばマルチトールを含有する糖衣液を添加してチューインガム主体表面にかけ、この糖衣液によりチューインガム主体の表面全体が被覆されたところで、結晶化されたマルチトールなどの粉体成分やオイル香料、色素などの液体成分を投入し、送風により乾燥させて、糖衣層を形成させる。乾燥は、例えば、粉体成分を供給して被覆物全体に行き渡らせることにより行うことができ、あるいは、粉体成分での処理後に送風することにより行うこともできる。送風を行う場合、風量は3~30m2/分とするのが好ましく、例えば水分含量が1~3%となるように乾燥を行うのが好ましい。この工程を、全糖衣層の割合が糖衣チューインガム製剤全体の9~69%、特に10~55%、とりわけ20~50%になるまで繰り返して糖衣層を形成することが好ましい。
下記の方法に準拠して、表1~13、表15~17に記載したチューインガム主体組成、糖衣層組成及び工程により、糖衣チューインガム(実施例、比較例)を調製し、下記の方法で評価を行った。結果を表14~17に示す。
(1)チューインガム主体の調製:
表1に示す組成に従い、ガムベース〔ナチュラルベース(株)製〕、キシリトール〔三菱商事フードテック(株)製〕、マルチトール〔アマルティMR-100、三菱商事フードテック(株)製〕、還元水飴〔日研化成(株)製〕、スクラロース〔三栄源エフエフアイ(株)製〕、香料を加え、50℃前後にてニーダー中で均一に混練した。この混練物をブロック状に切断し、チューインガム主体(チューインガム層)を得た。この際、チューインガム主体の質量が約1gになるようにした。実施例1~21及び比較例3~8の糖衣チューインガムのチューインガム主体には、表1に示す組成を用いた。比較例1,2のチューインガム主体は、表5,6の組成に従い同様に調製した。
チューインガム主体に対して、表2~4、表7~13、表15~17の記載に従い、各糖衣層の組成からなる糖衣液を用い、第1糖衣層、第2糖衣層、第3糖衣層の順番に糖衣層を形成、積層させて糖衣チューインガムを製造した。
具体的には、糖衣パンあるいは回転釜中に上記チューインガム主体を投入し、糖衣パンを15回転/分で回転させながら、第1糖衣層を形成するための糖衣液をチューインガム主体表面にかけ、送風により乾燥させ、チューインガム主体表面に糖衣層を形成させた。引き続き、糖衣パンを15回転/分で回転させながら、第2糖衣層を形成するための糖衣液を第1糖衣層表面にかけ、送風により乾燥させ、第1糖衣層表面に第2糖衣層を形成させた。更に、糖衣パンを15回転/分で回転させながら、第3糖衣層を形成するための糖衣液を第2糖衣層表面にかけ、送風により乾燥させ、第2糖衣層表面に第3糖衣層を形成させた。この工程により、第1糖衣層~第3糖衣層までの糖衣層で被覆された糖衣チューインガムを製造した。この時に、糖衣液を乾燥させて得られる固形化した糖衣層は、チューインガム主体1gに対して表中に示す質量で形成させた。
なお、比較例の糖衣チューインガムは、上記の方法に準じて、各組成を有する糖衣チューインガムを調製した。
糖衣チューインガム2粒を100mLビーカーに移し、10mMリン酸緩衝液(pH7)70mLに30分間糖衣層を溶解させた。溶解液を回収し、100mLにメスアップし、5分間超音波処理し、デキストラナーゼ活性又はムタナーゼ活性をソモギ法により測定した。デキストラナーゼ1単位とは、40℃における反応において、1分間当たりグルコース1μmol相当量の遊離還元糖を生成させる酵素量である。また、ムタナーゼ1単位とは、40℃における反応において、1分間当たりグルコース1μmol相当量の遊離還元糖を生成させる酵素量である。
下記の計算式により、酵素溶出率を計算した。
全て健常歯である10人を被験者として、1分間安静時の唾液を採取し、糖衣チューインガム2粒を10分間咀嚼させ、1分毎に唾液を採取した。10分後に糖衣チューインガムを吐き出し、その後1分間安静時の唾液を採取した。採取した唾液を10mMリン酸緩衝液(pH7)で希釈し、実験1と同じ方法で酵素活性を定量し、10名の結果を平均した。
唾液中への酵素の放出率(10名の平均) 唾液中放出速度
5分以内に90%以上が放出 : ○
5分を超えて10分以内に90%以上が放出: △
10分を超えても酵素放出率が90%未満 : ×
糖衣チューインガムを製造直後と室温に一年間放置した後の酵素活性を実験1と同様の測定方法で評価し、糖衣チューインガム長期保存における酵素安定性を下記の計算式により求めた。
これらに対して、チューインガム主体の表面に、ゼラチンを含む第1糖衣層を形成した後、ゼラチンと酵素を含有する第2糖衣層を形成し、更に酵素を含有しない第3糖衣層を形成し、これら第1~3糖衣層で被覆した糖衣チューインガム(実施例)は、酵素溶出性、酵素放出速度及び保存安定性に優れることがわかった。
Claims (8)
- チューインガム主体が、少なくとも3層の糖衣層で被覆された糖衣チューインガムであって、チューインガム主体を被覆する内層が、ゼラチンを含有する第1糖衣層であり、該第1糖衣層がゼラチン及び酵素を含有する第2糖衣層で被覆され、更に該第2糖衣層が酵素を含有しない第3糖衣層で被覆されてなることを特徴とする糖衣チューインガム。
- 糖衣層が、マルチトールを含有する請求項1記載の糖衣チューインガム。
- 酵素が、デキストラナーゼ及び/又はムタナーゼである請求項1又は2記載の糖衣チューインガム。
- チューインガム主体及び第1糖衣層が酵素を含有しない請求項1、2又は3記載の糖衣チューインガム。
- チューインガム主体が、少なくとも3層の糖衣層で被覆された糖衣チューインガムの製造方法であって、
(1)チューインガム主体を形成する工程、
(2)ゼラチンを含有する糖衣層成分で、チューインガム主体を被覆する第1糖衣層を形成する工程、
(3)更に、ゼラチン及び酵素を含有する糖衣層成分で、前記第1糖衣層を被覆する第2糖衣層を形成する工程、
(4)更に、酵素を含有しない糖衣層成分で、前記第2糖衣層を被覆する第3糖衣層を形成する工程
を含むことを特徴とする糖衣チューインガムの製造方法。 - 糖衣層が、マルチトールを含有する請求項5記載の製造方法。
- 酵素が、デキストラナーゼ及び/又はムタナーゼである請求項5又は6記載の製造方法。
- チューインガム主体及び第1糖衣層が酵素を含有しない請求項5,6又は7記載の製造方法。
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CN103283919A (zh) * | 2012-03-01 | 2013-09-11 | 颜甄仪 | 糖果的制备方法 |
Citations (5)
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JPS5082242A (ja) * | 1973-11-26 | 1975-07-03 | ||
JPS566249B2 (ja) * | 1974-12-27 | 1981-02-10 | ||
JP2002114656A (ja) * | 2000-10-05 | 2002-04-16 | Nippon Zettoc Co Ltd | 口腔用組成物用基剤及び口腔用組成物 |
JP2003219809A (ja) * | 2002-01-29 | 2003-08-05 | Lion Corp | 糖衣製品 |
WO2008133103A1 (ja) * | 2007-04-19 | 2008-11-06 | Lion Corporation | 糖衣チューインガム組成物及び糖衣チューインガムの製造方法 |
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EP1449525A1 (en) * | 2003-02-20 | 2004-08-25 | Cross Chem Llc | chewing gum in the form of multi-layer tablets |
US7354569B2 (en) * | 2003-07-11 | 2008-04-08 | Colgate-Palmolive Company | Chewable antiplaque confectionery dental composition |
JP2005151827A (ja) * | 2003-11-21 | 2005-06-16 | Meiji Seika Kaisha Ltd | 食用組成物 |
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Publication number | Priority date | Publication date | Assignee | Title |
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JPS5082242A (ja) * | 1973-11-26 | 1975-07-03 | ||
JPS566249B2 (ja) * | 1974-12-27 | 1981-02-10 | ||
JP2002114656A (ja) * | 2000-10-05 | 2002-04-16 | Nippon Zettoc Co Ltd | 口腔用組成物用基剤及び口腔用組成物 |
JP2003219809A (ja) * | 2002-01-29 | 2003-08-05 | Lion Corp | 糖衣製品 |
WO2008133103A1 (ja) * | 2007-04-19 | 2008-11-06 | Lion Corporation | 糖衣チューインガム組成物及び糖衣チューインガムの製造方法 |
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CN103283919A (zh) * | 2012-03-01 | 2013-09-11 | 颜甄仪 | 糖果的制备方法 |
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KR101780832B1 (ko) | 2017-09-21 |
JP2011041485A (ja) | 2011-03-03 |
CN102480990A (zh) | 2012-05-30 |
KR20120055633A (ko) | 2012-05-31 |
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