WO2011008312A3 - Indole and indoline derivatives and methods of use thereof - Google Patents
Indole and indoline derivatives and methods of use thereof Download PDFInfo
- Publication number
- WO2011008312A3 WO2011008312A3 PCT/US2010/027931 US2010027931W WO2011008312A3 WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3 US 2010027931 W US2010027931 W US 2010027931W WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- indole
- indoline derivatives
- compounds
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22545209P | 2009-07-14 | 2009-07-14 | |
US61/225,452 | 2009-07-14 | ||
US12/568,085 US9063126B2 (en) | 2008-09-29 | 2009-09-28 | Indole and indoline derivatives and methods of use thereof |
US12/568,085 | 2009-09-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011008312A2 WO2011008312A2 (en) | 2011-01-20 |
WO2011008312A3 true WO2011008312A3 (en) | 2011-03-17 |
Family
ID=43450045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/027931 WO2011008312A2 (en) | 2009-07-14 | 2010-03-19 | Indole and indoline derivatives and methods of use thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011008312A2 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9045482B2 (en) | 2009-09-23 | 2015-06-02 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6050238B2 (en) | 2011-10-19 | 2016-12-21 | 興和株式会社 | Novel spiroindoline compound and pharmaceutical containing the same |
CN104977383A (en) * | 2015-06-18 | 2015-10-14 | 中山鼎晟生物科技有限公司 | Method for rapidly and quantitatively detecting microcystins in spirulina food |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009370A2 (en) * | 2003-07-23 | 2005-02-03 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof and their use as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409628A (en) | 1966-05-12 | 1968-11-05 | Hoffmann La Roche | 5-(3-pyridylethyl)pyridoindole derivatives |
AU6731100A (en) | 1999-09-02 | 2001-04-10 | Shionogi & Co., Ltd. | Integrase inhibitors containing aromatic heterocycle derivatives |
JP2005023207A (en) | 2003-07-02 | 2005-01-27 | Pentel Corp | Water-based ink for ball-point pen and ball-point pen using the same |
US7309699B2 (en) | 2003-12-22 | 2007-12-18 | Abbott Laboratories | 3-Quinuclidinyl amino-substituted biaryl derivatives |
EP1887003A1 (en) | 2004-03-09 | 2008-02-13 | Boehringer Ingelheim Pharmaceuticals, Inc. | 3-[4-heterocyclyl -1,2,3-triazol-1-yl]-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases |
JP5495206B2 (en) | 2006-10-24 | 2014-05-21 | コンジエニア・ソシエタ・ア・レスポンサビリタ・リミタータ | Phenyl-substituted maleimides as agents to prevent degenerative tissue damage by inhibiting MPT |
-
2010
- 2010-03-19 WO PCT/US2010/027931 patent/WO2011008312A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009370A2 (en) * | 2003-07-23 | 2005-02-03 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof and their use as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9181240B2 (en) | 2007-10-25 | 2015-11-10 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9481676B2 (en) | 2008-10-31 | 2016-11-01 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9271971B2 (en) | 2009-09-23 | 2016-03-01 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9085580B2 (en) | 2009-09-23 | 2015-07-21 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9045482B2 (en) | 2009-09-23 | 2015-06-02 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9580425B2 (en) | 2009-09-23 | 2017-02-28 | Medivation Technologies, Inc. | Pyrido[3,4-b] indoles and methods of use |
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9199996B2 (en) | 2009-09-23 | 2015-12-01 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9433626B2 (en) | 2010-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9211287B2 (en) | 2011-02-18 | 2015-12-15 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9550782B2 (en) | 2011-02-18 | 2017-01-24 | Medivation Technologies, Inc. | Compounds and methods for treating diabetes |
Also Published As
Publication number | Publication date |
---|---|
WO2011008312A2 (en) | 2011-01-20 |
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