WO2010135502A1 - Agencements d'accouplement et procédés permettant de fixer des outils à des instruments chirurgicaux à ultrasons - Google Patents
Agencements d'accouplement et procédés permettant de fixer des outils à des instruments chirurgicaux à ultrasons Download PDFInfo
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- WO2010135502A1 WO2010135502A1 PCT/US2010/035530 US2010035530W WO2010135502A1 WO 2010135502 A1 WO2010135502 A1 WO 2010135502A1 US 2010035530 W US2010035530 W US 2010035530W WO 2010135502 A1 WO2010135502 A1 WO 2010135502A1
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- waveguide
- distal end
- ultrasonic
- surgical tool
- end portion
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/0046—Surgical instruments, devices or methods, e.g. tourniquets with a releasable handle; with handle and operating part separable
- A61B2017/00473—Distal part, e.g. tip or head
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00477—Coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B2017/22014—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
- A61B2017/320069—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic for ablating tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
- A61B2017/320072—Working tips with special features, e.g. extending parts
- A61B2017/320073—Working tips with special features, e.g. extending parts probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
- A61B2017/320089—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic node location
Definitions
- the present invention generally relates to surgical instruments, and more particularly, to coupling arrangements and methods for attaching a surgical tool to an ultrasonic surgical instrument.
- Ultrasonic surgical instruments are used for the safe and effective treatment of many medical conditions. Such instruments commonly include a handpiece that is coupled to an ultrasonic signal generator. The instruments also include an end effector that receives the ultrasonic vibrations. Ultrasonic vibrations, when transmitted to organic tissue at suitable energy levels and using a suitable end effector, may be used to cut, dissect, elevate, cauterize tissue or to separate muscle tissue off bone. Ultrasonic instruments utilizing solid core technology are particularly advantageous because of the amount of ultrasonic energy that may be transmitted from the ultrasonic transducer, through a waveguide, to the surgical end effector. Such instruments may be used for open procedures or minimally invasive procedures, such as endoscopic or laparoscopic procedures, wherein the end effector is passed through a trocar to reach the surgical site.
- ultrasonic vibration is induced in the surgical end effector by electrically exciting a transducer supported in the handpiece.
- the transducer may be constructed of one or more piezoelectric or magnetostrictive elements. Vibrations generated by the transducer section are transmitted to the surgical end effector via an ultrasonic waveguide that extends from the transducer section to the surgical end effector.
- the waveguides and end effectors are designed to resonate at the same frequency as the transducer. Therefore, when an end effector is attached to a transducer, the overall system frequency is the same frequency as the transducer itself.
- Solid core ultrasonic surgical instruments may be divided into two types, single element end effector devices and multiple-element end effector.
- Single element end effector devices include instruments such as scalpels, and ball coagulators.
- the use of multiple-element end effectors such as clamping coagulators includes a mechanism to press tissue against an ultrasonic blade.
- Ultrasonic clamp coagulators provide an improved ultrasonic surgical instrument for cutting/coagulating tissue, particularly loose and unsupported tissue, wherein the ultrasonic blade is employed in conjunction with a clamp for applying a compressive or biasing force to the tissue, whereby faster coagulation and cutting of the tissue, with less attenuation of blade motion, are achieved.
- Surgical elevators are instruments used to help facilitate the elevation and removal of soft tissue during surgery. Surgical elevators are generally employed to separate muscle from bone. Cobb or curette type surgical elevators and used in spine surgery, especially to assist in posterior access in removing muscle tissue from bone.
- the end effector must be effectively coupled to the waveguide.
- the end effector is permanently coupled to the waveguide by, for example, welding.
- the end effector is removably coupled to the waveguide by a threaded arrangement.
- Such end effectors are often supplied with a torque wrench that, when properly used, is designed to ensure that the end effector is attached to the waveguide by an appropriate amount of torque, while avoiding the possibility of damage or device malfunction due to the application of excessive torque to the end effector.
- Such wrenches may be designed to interface with a distal end or portion of the end effector. In some wrench arrangements, after the wrench is placed on the distal end of the end effector, the clinician applies torque to the wrench until an audible click is heard at which time the wrench may be removed from the end effector.
- the various embodiments are directed to an ultrasonic surgical instrument that has a handpiece that operably supports at least one ultrasonic transducer.
- the surgical instrument includes a surgical tool that has a proximal end with a cavity therein.
- a waveguide protrudes distally from the handpiece and interacts with the at least one ultrasonic transducer.
- the waveguide has a distal end portion that is sized to be inserted into the cavity in the proximal end of the surgical tool and selectively expanded into retaining engagement therewith.
- an ultrasonic surgical instrument that includes a handpiece that has a housing that operably supports at least one ultrasonic transducer therein.
- the ultrasonic transducers are operably coupled to an ultrasonic signal generator.
- a waveguide protrudes distally from the housing and interacts with the ultrasonic transducers.
- the waveguide has a selectively expandable distal end portion.
- An actuator rod is movably supported within the waveguide and is movable between a first position wherein the distal end portion is expanded and a second position wherein the distal end portion is unexpanded.
- the surgical instrument further includes a surgical tool that has a proximal end portion that has a cavity therein for receiving the distal end portion of the waveguide [0010]
- a method for removably coupling a surgical tool to a waveguide of an ultrasonic surgical instrument includes providing a cavity in a proximal end portion of the surgical tool and inserting a distal end of the waveguide into the cavity.
- the method further includes expanding the distal end of the waveguide to retainingly engage at least a portion of a wall of the cavity.
- FIG. 1 illustrates an ultrasonic system of various embodiments of the present invention
- FIG. 2 illustrates a coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 2A illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 2B illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 3 illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 3 A is another view of the coupling arrangement of FIG. 3 with a portion of the waveguide in an expanded condition
- FIG. 3B illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 4 illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 5 is another view of the coupling arrangement of FIG. 4 with a portion of the surgical tool shroud shown in cross-section and the latch members in unexpanded conditions;
- FIG. 6 is another view of the coupling arrangement of FIG. 4 with the latch members thereof in an expanded condition
- FIG. 7 is a side view of another handpiece embodiment of the present invention.
- FIG. 8 is an end view of the handpiece of FIG. 7;
- FIG. 9 is an end view of another surgical tool embodiment of the present invention.
- FIG. 10 is a side view of the surgical tool of FIG. 9;
- FIG. 11 illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic instrument with the shroud portion of the surgical tool shown in cross-section;
- FIG. 12 is another cross-sectional view of the coupling arrangement of FIG. 11 taken along a different cutting line and showing the latch members thereof in an expanded condition;
- FIG. 13 illustrates another coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument
- FIG. 14 illustrates one form of a power vs. time curve for the coupling arrangement embodiment depicted in FIG. 13;
- FIG. 15 is a partial exploded assembly view of a handpiece and surgical tool embodiment of the present invention with a portion of the handpiece and a portion of the surgical tool shown in cross-section;
- FIG. 16 is another partial cross-sectional exploded assembly view of the handpiece and surgical tool of FIG. 16 in a coupling orientation
- FIG. 17 another partial cross-sectional exploded assembly view of the handpiece and surgical tool of FIGS. 15 and 16 in a coupled orientation
- FIG. 18 is a cross-sectional view of a heating and cooling unit of the coupling arrangement embodiment depicted in FIGS. 15-17;
- FIG. 19 is another cross-sectional view of the heating and cooling unit of FIG. 18 as the shroud of the surgical tool is being installed thereon;
- FIG. 20 is another cross-sectional view of the heating and cooling unit of FIGS. 18 and
- FIG. 21 illustrates an ultrasonic system of various embodiments of the present invention
- FIG. 22 illustrates a coupling arrangement embodiment of the present invention for coupling a surgical tool to a waveguide of an ultrasonic surgical instrument, wherein the distal end of the waveguide is in retaining engagement with the surgical tool;
- FIG. 23 illustrates the coupling arrangement embodiment depicted in FIG. 22 prior to expanding the distal end of the waveguide.
- the various embodiments relate, in general, to ultrasonic surgical instruments and, more particularly, to coupling arrangements for coupling a surgical tool to the source of ultrasonic energy in such instruments.
- ultrasonic surgical instruments are disclosed in U.S. Pat. Nos. 5,322,055 and 5,954,736 and in combination with ultrasonic blades and surgical instruments disclosed in U.S. Pat. Nos. 6,309,400 B2, 6,278,218Bl, 6,283,981 Bl, and 6,325,811 Bl, for example, are incorporated herein by reference in their respective entireties. Also incorporated by reference in their respective its entireties is commonly-owned, co-pending U.S. Patent Application Serial No.
- FIG. 1 illustrates an ultrasonic system 10 comprising an ultrasonic signal generator 12 with ultrasonic transducer 14, handpiece 16, and surgical tool 100 which may be employed in accordance with various embodiments of the present invention.
- the ultrasonic transducer 14 which is known as a "Langevin stack” may generally include a transduction portion 18, a first resonator or end-bell 20, and a second resonator or fore-bell 22, and ancillary components.
- the ultrasonic transducer 14 is preferably an integral number of one -half system wavelengths (n ⁇ /2).
- An acoustic assembly 24 may include the ultrasonic transducer 14, mount 26, and velocity transformer 28.
- end-bell 20 is connected to the proximal end of transduction portion 18, and the proximal end of fore -bell 22 is connected to the distal end of transduction portion 18.
- Fore -bell 22 and end-bell 20 have a length determined by a number of variables, including the thickness of the transduction portion 18, the density and modulus of elasticity of the material used to manufacture end-bell 20 and fore-bell 22, and the resonant frequency of the ultrasonic transducer 14.
- the transducer may be constructed of one or more piezoelectric or magnetostrictive elements in the instrument handpiece 16. Ultrasonic vibration is induced in the surgical tool 100 by, for example, electrically exciting a transducer which may be constructed of one or more piezoelectric or magnetostrictive elements in the instrument hand-piece. Vibrations generated by the transducer section are transmitted to the surgical tool 100 via an ultrasonic waveguide 28 extending from the transducer section to the surgical tool 100.
- the transducer is constructed with piezoelectric elements 40.
- the piezoelectric elements 40 may be fabricated from any suitable material, such as, for example, lead zirconate-titanate, lead meta-niobate, lead titanate, or other piezoelectric crystal material.
- Each of the positive electrodes 42, negative electrodes 44, and piezoelectric elements 40 has a bore extending through the center.
- the positive and negative electrodes 42 and 44 are electrically coupled to wires 46 and 48, respectively. Wires 46 and 48 are encased within cable 50 and electrically connectable to ultrasonic signal generator 12 of ultrasonic system 10.
- Ultrasonic transducer 14 of the acoustic assembly 24 converts the electrical signal from ultrasonic signal generator 12 into mechanical energy that results in primarily longitudinal vibratory motion of the ultrasonic transducer 14 and surgical tool 100 at ultrasonic frequencies.
- a suitable generator is available as model number GEN04, from Ethicon Endo-Surgery, Inc., Cincinnati, Ohio.
- GEN04 model number
- the amplitude of the vibratory motion at any point along the acoustic assembly 24 may depend upon the location along the acoustic assembly 24 at which the vibratory motion is measured.
- a minimum or zero crossing in the vibratory motion standing wave is generally referred to as a node (i.e., where motion is usually minimal), and an absolute value maximum or peak in the standing wave is generally referred to as an anti- node.
- the distance between an anti-node and its nearest node is one-quarter wavelength ( ⁇ /4).
- Wires 46 and 48 transmit the electrical signal from the ultrasonic signal generator 12 to positive electrodes 42 and negative electrodes 44.
- the piezoelectric elements 40 are energized by an electrical signal supplied from the ultrasonic signal generator 12 in response to a foot switch 60 to produce an acoustic standing wave in the acoustic assembly 24.
- the electrical signal causes disturbances in the piezoelectric elements 40 in the form of repeated small displacements resulting in large compression forces within the material.
- the repeated small displacements cause the piezoelectric elements 40 to expand and contract in a continuous manner along the axis of the voltage gradient, producing longitudinal waves of ultrasonic energy.
- the ultrasonic energy is transmitted through the acoustic assembly 24 to the surgical tool 100. [0047] In order for the acoustic assembly 24 to deliver energy to the surgical tool 100, all components of acoustic assembly 24 must be acoustically coupled to the surgical tool 100.
- the components of the acoustic assembly 24 are preferably acoustically tuned such that the length of any assembly is an integral number of one-half wavelengths (n ⁇ /2), where the wavelength ⁇ is the wavelength of a pre-selected or operating longitudinal vibration drive frequency fa of the acoustic assembly 24, and where n is any positive integer. It is also contemplated that the acoustic assembly 24 may incorporate any suitable arrangement of acoustic elements. As the present Detailed Description proceeds, those of ordinary skill in the art will readily understand that the system 10 described above is but one example of a myriad of ultrasonic surgical systems that may employ various unique and novel advantages of the embodiments of the present invention.
- FIGS. 1 and 2 illustrate a coupling arrangement 110 of an embodiment of the present invention for coupling the surgical tool 100 to the waveguide 28.
- the surgical tool 100 is illustrated as a blade that has a generally smooth exterior surface that is well-suited for coagulation and tissue reshaping applications.
- the term "surgical tool” may encompass any surgical end effector or tool or blade that may be operably coupled with an ultrasonic surgical handpiece or other source of ultrasonic energy in a surgical setting and includes, but is not limited to, straight and curved blades, sharp hooks, dissecting hooks, ball coagulators, clamp coagulators, etc. Exemplary blade configurations are described in U.S. Patent No.
- the distal end 29 of the waveguide 28 is configured to be coupled to a coupling portion 101 which, in various embodiments, comprises a complementary- shaped cavity 114 provided in the proximal end portion 112 of the surgical tool 100.
- the distal end 29 may have a frusto-conical shaped and be sized to be received within cavity 14.
- the waveguide 28, or at least the distal end portion 29 of the waveguide 28 is fabricated from a first material 15 that has a first coefficient of thermal expansion (CTEl).
- CTEl first coefficient of thermal expansion
- the surgical tool 100, or at least the proximal end portion 112 of the surgical tool 100 is fabricated from a second material 103 that has a second coefficient of thermal expansion (CTE2) that is less than the first coefficient of thermal expansion.
- CTE2 second coefficient of thermal expansion
- the distal end portion 29 of the waveguide 28 is sized and shaped relative to the cavity 114 in the proximal end portion 112 of the surgical tool 100 such that a slip fit or an amount of clearance "C" is created between the distal end portion 29 of the waveguide 28 and the cavity 114 when the waveguide 28 and the surgical tool 100 are at approximately the same temperature.
- the waveguide 28, or at least the distal end portion 29 of the waveguide 28, may be fabricated from, for example, aluminum which has a coefficient of thermal expansion of 13.7 xlO "6 in/in/degree F and the proximal end portion 112 of the surgical tool 100 may be fabricated from, for example, titanium which has a coefficient of thermal expansion of 4.34 x 10 "6 in/in/degree F.
- clearance "C" may be approximately 0.0005 inches.
- the clinician positions the distal end portion 29 of the waveguide 28 into the cavity 114 of the surgical tool 100 as illustrated in FIG. 2.
- Thermal energy i.e., heat
- CTEl > CTE2
- the outer diameter or parametrical shape of the distal end portion 29 of the waveguide 14 will expand to a greater magnitude when compared to the inside diameter or shape of the cavity 114 to establish an interference fit therebetween as illustrated in FIG. 2A.
- the heat or thermal energy may be applied to the waveguide 28 by a radio frequency (RF) induction coil 120 mounted about the waveguide 28 adjacent the distal end portion 29.
- RF radio frequency
- a resistive thermoelectric heat element 130 may be employed. See FIG. 2B. Heat is applied until a sufficient interference fit is established between the proximal end portion 112 of the surgical tool 100 and the distal end portion 29 of the waveguide 28. Thereafter, the heat applicator 120, 130 must continue to be energized to maintain the interference fit throughout use. After the surgical procedure has been completed, the heat applicator 120, 130 may be de-energized. Once the temperature of the proximal end portion 29 of the waveguide 28 returns to the approximate temperature of the proximal end 114 of the surgical tool 100, the surgical tool may be detached from the waveguide 28. [0052] In the embodiment of FIG.
- the distal end portion 29' of the waveguide 28' has a portion 140 that is fabricated from material that has a high coefficient of thermal expansion.
- the portion 140 may be fabricated from, for example, aluminum, while the remaining portion of the waveguide 28' may be fabricated from steel.
- the portion 140 may have the same diameter or other parametrical shape as the distal end portion 29' of the waveguide 28' to enable the portions 29', 140 to be inserted into the cavity 114' in the proximal end portion 112' of the surgical tool 100'.
- a predetermined amount of clearance "C" is provided between the portion 140 and the wall of the cavity 114', prior to the application of heat or thermal energy to the distal end portion 29' by the heat applicator 120 or 130 (whichever the case may be).
- the heat applicator 120 or 130 is energized to cause portion 140 to expand at a greater rate than the distal end portion 112' of the surgical tool 100' to create an interference fit therebetween. See FIG. 3A.
- FIG. 3B illustrates an alternative embodiment wherein a cavity 114" is provided in the distal end 29" of the waveguide 28" and the proximal end portion 112" of the surgical tool 100" is sized to be received within the cavity 114".
- the distal end 29" of the waveguide 28" is fabricated from a first material 15" that has first coefficient of thermal expansion (CTEl) and the proximal end portion 112" of the surgical tool 100" is fabricated from a second material 103" that has a second coefficient of thermal expansion (CTE2) that is greater than the first coefficient of thermal expansion.
- CTEl first coefficient of thermal expansion
- CTE2 second coefficient of thermal expansion
- the clinician positions the proximal end portion 112" of the surgical tool 100" in the cavity 114" in the distal end portion 29" of the waveguide 28" as illustrated in FIG. 3B.
- Thermal energy i.e., heat
- the outer diameter or parametrical shape of the proximal end portion 112" of the surgical tool 100" will expand at a greater magnitude when compared to the inside diameter or shape of the cavity 114" to establish an interference fit therebetween.
- the heat or thermal energy may be applied to the proximal end portion 112" of the surgical tool 100" by a heat applicator 120 which may comprise a radio frequency (RF) induction coil or resistive heater 120" mounted on the proximal end portion 112". Power may be supplied thereto from the handpiece through appropriate connections.
- the heating element 120" may be mounted on the surgical tool 100" and, when the proximal end portion 112" of the surgical tool 100" is inserted into the cavity 114", the heat applicator 120" may be coupled to wires (not shown) protruding from the handpiece to supply power to the heat applicator 120".
- Heat is applied until a sufficient interference fit is established between the proximal end portion 112" of the surgical tool 100" and the distal end portion 29" of the waveguide 28". Thereafter, the heat applicator 120 may be de-energized and/or removed and the system may be used. Once the temperature of the proximal end portion 112" of the surgical tool 100" returns to the approximate temperature of the distal end portion 29" of the waveguide 28", the surgical tool 100" may be detached from the waveguide 28".
- FIGS. 4-6 illustrate use of another coupling arrangement 310 of various embodiments of the present invention for removably coupling a reusable surgical tool 300 to a waveguide 228 of a handpiece 216 that is similar in construction and operation as the aforementioned handpiece 16 except for the differences noted below.
- the distal end 229 of the waveguide 228 may be tapered or frusto-conically shaped for receipt within a complementary- shaped cavity 314 provided in a proximal end portion 312 of the surgical tool 300.
- the surgical tool 300 includes a housing or shroud portion 320 that supports the distal end portion 312 therein.
- the distal end portion 312 may be supported within a mount 26 that facilitates acoustic excitement of the distal end portion 312 relative to the shroud 320.
- the shroud 320 has a cavity 330 therein for receiving the distal end portion 218 of the handpiece 216 therein.
- Shroud 320 further has an axial passage 332 to enable the waveguide 228 to extend therethrough into engagement with the proximal end portion 312 of the surgical tool 300.
- the distal end portion 218 of the handpiece 216 has a tapered portion 220 formed thereon.
- the latch member(s) 350 may be fabricated from, for example, a shape memory alloy (SMA) and be coupled to corresponding tool contact(s) 352 mounted within the shroud 320.
- SMA shape memory alloy
- a latch member 350 may be fabricated in the shape of a ring or a hoop from NiTi (Nickel -Titanium), CuZnAl, CuAlNi, etc. and be coupled to contact 352 by contact strip or strips 354. As can also be seen in FIGS.
- an activation contact 230 is mounted in the distal end portion 218 of the handpiece 216.
- the activation contact 230 may comprise an annular ring or ring segment(s) formed from electrically conductive material (e.g., berillium copper) and which is in electrical communication (e.g., wired) to a source of electrical power 240.
- the source of electrical power 240 may comprise, for example, a battery or a source of alternating current and may be integrated with the aforementioned generator arrangement.
- FIGS. 5 and 6 illustrate a method of coupling of the surgical tool 300 to the waveguide 228 of the handpiece 216.
- the distal end portion 218 of the handpiece is inserted into the cavity 330 in the housing 320 of the surgical tool 300 as shown in FIG. 5 such that activation contact 230 makes electrical contact with tool contact 352 to thereby permit electrical current (actuation signal) to energize the latch member(s) 350.
- a switch 244 may be provided in the electric line/wire 242 coupling the actuation contact 230 to the source of electrical power 240.
- the switch 244 may, for example, be located on the handpiece or the generator.
- FIGS. 7-12 illustrate another coupling arrangement 510 of various embodiments of the present invention for removably coupling a reusable surgical tool 500 to a waveguide 428 of a handpiece 416 that is similar in construction and operation as the aforementioned handpiece 216 except for the differences noted below.
- at least one, and preferably four, contact tabs 450 protrude out of the distal end 418 of the handpiece as shown in FIGS. 7 and 8.
- One or more of the contact tabs 450 are wired to a source of electrical energy 240.
- a switch 244 may be provided to control the flow of current from the source 240 to the contact tabs 450.
- the tool 500 has a tool shroud 520 that has corresponding tab slots 570 therein that are adapted to receive a corresponding one of the contact tabs 450 to enable the shroud 520 to be slid onto the handpiece 416 to the position shown in FIG. 11. Thereafter, the clinician rotates the shroud 520 relative to the handpiece 416 to cause the contact tabs 450 to each be received in a corresponding locking pocket 572 at the end of each slot 570.
- An electrical contact 574 may be positioned within or adjacent to each locking pocket 572 such that it makes electrical contact with the corresponding contact tab 450 when seated within the locking pocket 572.
- the electrical contact 574 is in electrical communication with a corresponding one or more expandable latch member segments 550 supported within the shroud 520.
- the latch member segments 550 are located such that when the tool 500 is seated onto the handpiece and the contact tabs 450 are received in their respect lock pockets 572, the latch member segments 550 are positioned to engage the tapered position 420 of
- the distal end portion 418 of the handpiece is inserted into the cavity 530 in the shroud 520 of the surgical tool 500 as shown in FIG. 11 such that the contact tabs 450 are received in their corresponding slots 570, the clinician rotates the handpiece 416 relative to the surgical tool 500 to cause the contact tabs 450 to be seated in their corresponding locking pockets 572 and are in contact with the corresponding electrical contact 574 therein. If the switch 244 is closed, electrical current is then permitted to flow through the electric contacts 574 to the expandable latch member segments 550. As current flows to the expandable latch member segments 550, the latch member segments 550 expand and pull the proximal end 512 of the tool 500 into retaining engagement with the distal end 429 of the waveguide 428.
- FIGS. 13 and 14 illustrate another coupling arrangement 110' of various embodiments of the present invention for permanently coupling a surgical tool 100 to a waveguide 28 of a handpiece 16.
- the distal end 29 of the waveguide 28 is sized to be received within a cavity 114 in proximal end portion 114 of the surgical tool 100.
- Positioned within the cavity 114 is some meltable alloy material 115.
- the meltable alloy material may comprise, for example, copper-aluminum.
- the clinician inserts the distal end 29 of the waveguide 28 into the cavity 114 such that it contacts the meltable alloy material 115.
- the clinician then operates the generator 12 to provide the waveguide 28 with a sufficient power burst that is sufficient in magnitude and duration to cause the meltable alloy material 115 to weld the waveguide 28 to the tool 100.
- the clinician reduces the power to the normal operating magnitude.
- normal power magnitude may be 5 watts.
- the clinician may have to increase the power to, for example, 50 watts, for approximately 5 seconds (time).
- the magnitude and duration of such increase may be dependent upon the type of meltable material 115 employed and the transducer arrangement. In each case, however, the magnitude and duration of the power increase should be less than a magnitude and duration that would ultimately result in damage to the transducers or other components of the system.
- FIGS. 15-20 Another coupling arrangement 710 is illustrated in FIGS. 15-20 for removably coupling a reusable surgical tool 700 to a waveguide 628 of a handpiece 616 that is similar in construction and operation as the aforementioned handpiece 16 except for the differences noted below.
- the distal end 629 of the waveguide 628 may have a frusto-conically shaped cavity 630 therein for receiving a complementary-shaped proximal end portion 712 of a surgical tool 700.
- the surgical tool 700 includes a shroud 720 that supports the proximal end portion 712 therein.
- the shroud 720 may be fabricated from, for example, Titanium 64 and proximal end portion 712 may be supported within a mount 26 that facilitates acoustically-generated movement of the proximal end portion 712 relative to the shroud 720.
- the shroud 720 has an annular cavity 730 therein for receiving the distal end portion 618 of the handpiece 616 therein.
- Shroud 720 further has an axial passage 732 to enable the waveguide 628 to extend therethrough into engagement with the proximal end portion 712 of the surgical tool 700.
- the distal end 618 of the handpiece 616 movably supports a release ring 640 that has diametrically opposing stem portions 642, 644 that extend through corresponding slots 646, 648, respectively in the distal end portion 618 of the handpiece 616.
- the purpose of the release ring 640 will be explained in further detail below.
- the distal end portion 629 of the waveguide 628 is also fitted with an annular groove 650 that is configured to receive a locking ring 652 therein.
- Locking ring 652 may be fabricated from a shape memory alloy (SMA) such as, for example, NiTi (Nickel - Titanium), CuZnAl, CuAlNi, etc. Locking ring 652 may also be supported in at least two, and preferably four, heat generating and cooling units 660 that are pivotally pinned by corresponding pins 661 or are otherwise pivotally coupled to the wall 619 of the distal end of the handpiece 616.
- SMA shape memory alloy
- NiTi Nickel - Titanium
- CuZnAl CuAlNi
- Locking ring 652 may also be supported in at least two, and preferably four, heat generating and cooling units 660 that are pivotally pinned by corresponding pins 661 or are otherwise pivotally coupled to the wall 619 of the distal end of the handpiece 616.
- FIGS. 15-18 illustrate one form of a heat generating/cooling unit 660 of an embodiment of the present invention.
- each heat generating/cooling unit 660 has a body portion 663 that may be fabricated from, for example, aluminum or engineered plastics such as polycarbonate, and be configured with an upper chamber area 664 and lower chamber area 666 therein that are separated by a wall 668 that has a fluid return passage 670 therethrough.
- the outer perimeter has a retention ledge 672 formed thereon for retaining engagement with a locking protrusion or protrusions 740 (FIGS. 19 and 20) formed in the shroud 720 of the surgical tool 700 as will be further discussed below.
- a return opening bar 676 slidably extends through a passage 675 in the body portion 663 defined by a sponge member 680 and the wall 668.
- the sponge member 680 may be supported on another wall portion 682 as shown.
- Return opening bar 676 has a hole 678 therethrough that may be coaxially aligned with the fluid return passage 670 to enable fluid/vapor to pass between the lower chamber 666 and the upper chamber 664.
- a bellows or wiper arrangement 684 may be provided in the upper chamber 664 for sliding engagement with the return opening bar 676 such that the bellows 684 serves to seal off the passage 675 when the return opening bar 676 has not been axially advanced into the upper chamber 664.
- a heating/ cooling medium 686 is provided in the lower chamber 666.
- the heating/cooling medium 686 may comprise, for example, a liquid that has a relatively low boiling point such as acetone.
- FIG. 15 illustrates the positions of various components in the handpiece 616 and the surgical tool 700 prior to insertion of the distal end 618 of the handpiece into the shroud 720 of the surgical tool 700.
- the clinician inserts the distal end 618 of the handpiece 616 into the shroud 720 of the surgical tool 700. See FIG. 16.
- the handpiece 616 and the surgical tool 720 are essentially at room temperature.
- a power activation switch 690 mounted in the distal end portion 618 of the handpiece 616 permits current to flow to the generator to cause the transducers to be energized.
- the locking ring 652 is contracted about the distal end of the waveguide 628 such that the cavity 630 therein will not fully accept the frusto-conically shaped proximal end 712 of the surgical tool 700.
- the locking protrusion 740 pivots each of the heat generating/cooling units 660 about their respective pins into tight contact with the vibrating waveguide 628 to facilitate the generation of heat around the locking ring. This pivoting action is represented by arrows "A" in FIG. 16.
- the locking protrusion 740 snaps over the retention ledge 672 on the heat generating/cooling units 660 as shown in FIGS.
- the clinician may be provided with tactile feedback and/or an audible click to indicate that the surgical tool 700 has been properly advanced to the coupled position.
- the locking protrusion 740 enables the heat generating/cooling units to pivot back to a neutral or unpivoted position wherein the locking protrusion 740 and the retention ledges still retain the surgical tool 700 in the coupled position.
- the distal end 721 of the shroud 720 activates power deactivation switch 689 which stops the flow of electrical current to the transducers.
- the coupling procedure is now complete. The clinician is now free to use the system. It will be further understood that further operation of the transducers will cause the locking ring 652 to once again expand; however, the locking protrusion 740 and retention ledges 672 serve to maintain the coupled engagement between the surgical tool 700 and the handpiece 616.
- the locking ring 652 it is desirable for the locking ring 652 to be hot during the initial coupling process to enable the proximal 712 end of the tool 700 to be inserted into the cavity 630.
- the liquid 686 resides in the sponge 680 and in the upper chamber 664.
- the heat generating cooling units 660 when in the locked position, are adjacent a heat sink ring 692 mounted within the wall of the shroud 720. Such arrangement assists in dissipating the heat from the heat generating/cooling units 660.
- the locking protrusion 740 is in the retention position (FIGS.
- the locking ring 652 it is desirable for the locking ring 652 to cool to further secure the distal end of the waveguide 629 to the proximal end 712 of the tool 700.
- Advancement of the locking protrusion 740 to the locked position biases the return opening bar 676 to cause hole 678 in the bar 676 to be aligned with the return passage 670 to enable the fluid 686 in the upper chamber 664 to flow into the lower chamber 666.
- the liquid 686 flows out of the upper chamber 684 it contacts the hot lower chamber 666 surfaces and evaporates to cool those surfaces and ultimately the locking ring 652.
- the clinician moves the release ring 640 to activate the activation switch 689 or contact which causes the transducers to start the vibration process and begin the heating cycle.
- the locking ring 652 begins to expand to enable the clinician to pull the surgical tool apart from the handpiece 616.
- the power activation switch discontinues the power to the transducers after the power actuation switch is no longer activated by the distal end 721 of the tool shroud 720.
- the power activation switches may comprise proximity sensing switches or contacts that are coupled to a microprocessor housed in or mounted adjacent to the generator.
- FIGS. 21-23 illustrate another surgical tool system 800 embodiment of the present invention that includes a generator 12 and a handpiece 816 that is substantially similar in design and construction as handpiece 16 described above, except for the differences noted below.
- the distal end 829 of the waveguide 826 is selectively radially expandable to enable the distal end 829 to be effectively coupled to the proximal end 912 of the surgical tool 900.
- the distal end 829 of the waveguide 826 has two opposed lugs 830 that are shaped to retainingly engage a cavity 930 in the proximal end 912 of the surgical tool 900.
- the cavity 930 may be provided with tapered walls 932 such that when the lugs 830 are inserted in cavity 930 and then moved radially (arrows "R"), the lugs 830 serve to pull the tool 900 into retaining engagement with the distal end 829 of the waveguide 826 as shown in FIG. 23.
- the waveguide 826 may be fabricated from, for example, aluminum 7075-T6.
- Various embodiments may include an axially movable actuator rod 850 that is movably supported within a slot 840 in the waveguide 826.
- the actuator rod 850 may be fabricated from, for example, ultem, PEI and have a distal end 852 that is sized to extend between lugs 830 and, when advanced distally between the lugs 830, causes the lugs 830 to move radially.
- the actuator rod 850 may have a radially extending portion 854 that extends through slots 842 and 817 in the waveguide 826 and handpiece 816, respectively.
- the radially extending portion 854 may terminate in a button portion 856 that facilitates actuation of the rod 850 by the clinician.
- the clinician inserts the lugs 830 into the cavity 930 while the actuator rod 850 is in an unactuated position (FIG. 22).
- the clinician may slide the button portion 856 in the distal direction "DD" to cause the distal end 852 of the actuator rod 850 to axially move between the lugs 830 to cause the to move radially and engage the tapered walls of the cavity 930 (FIG. 23).
- Various devices disclosed herein can be designed to be disposed of after a single use, or they can be designed to be used multiple times. In either case, however, the device may be reconditioned for reuse after at least one use. Reconditioning can include any combination of the steps of disassembly of the device, followed by cleaning or replacement of particular pieces, and subsequent reassembly.
- the device can be disassembled, and any number of the particular pieces or parts of the device can be selectively replaced or removed in any combination.
- the device can be reassembled for subsequent use either at a reconditioning facility, or by a surgical team immediately prior to a surgical procedure.
- reconditioning of a device can utilize a variety of techniques for disassembly, cleaning/replacement, and reassembly. Use of such techniques, and the resulting reconditioned device, are all within the scope of the present application.
- the various embodiments described herein will be processed before surgery.
- a new or used instrument is obtained and if necessary cleaned.
- the instrument can then be sterilized.
- the instrument is placed in a closed and sealed container, such as a plastic bag.
- the container and instrument are then placed in a field of radiation that can penetrate the container, such as gamma radiation, x-rays, or high-energy electrons.
- the radiation kills bacteria on the instrument and in the container.
- the sterilized instrument can then be stored in the sterile container.
- the sealed container keeps the instrument sterile until it is opened in the medical facility.
- the device is sterilized. This can be done by any number of ways known to those skilled in the art including beta or gamma radiation, ethylene oxide or steam.
- beta or gamma radiation ethylene oxide or steam.
- ethylene oxide or steam ethylene oxide or steam.
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
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- Surgical Instruments (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI1013003A BRPI1013003A2 (pt) | 2009-05-20 | 2010-05-20 | "disposições de acoplamento e métodos para fixação de ferramentas a instrumentos cirúrgicos ultra-sônicos" |
JP2012512021A JP2012527325A (ja) | 2009-05-20 | 2010-05-20 | ツールを超音波外科用器具に取り付けるための連結構成及び方法 |
CN201080032636.4A CN102458271B (zh) | 2009-05-20 | 2010-05-20 | 将工具附接到超声外科器械的连接装置和方法 |
EP10720854A EP2432403A1 (fr) | 2009-05-20 | 2010-05-20 | Agencements d'accouplement et procédés permettant de fixer des outils à des instruments chirurgicaux à ultrasons |
AU2010249539A AU2010249539A1 (en) | 2009-05-20 | 2010-05-20 | Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments |
CA2762831A CA2762831A1 (fr) | 2009-05-20 | 2010-05-20 | Agencements d'accouplement et procedes permettant de fixer des outils a des instruments chirurgicaux a ultrasons |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/469,293 US9700339B2 (en) | 2009-05-20 | 2009-05-20 | Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments |
US12/469,308 | 2009-05-20 | ||
US12/469,308 US20100298743A1 (en) | 2009-05-20 | 2009-05-20 | Thermally-activated coupling arrangements and methods for attaching tools to ultrasonic surgical instruments |
US12/469,293 | 2009-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010135502A1 true WO2010135502A1 (fr) | 2010-11-25 |
Family
ID=42473639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/035530 WO2010135502A1 (fr) | 2009-05-20 | 2010-05-20 | Agencements d'accouplement et procédés permettant de fixer des outils à des instruments chirurgicaux à ultrasons |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2432403A1 (fr) |
JP (1) | JP2012527325A (fr) |
CN (1) | CN102458271B (fr) |
AU (1) | AU2010249539A1 (fr) |
BR (1) | BRPI1013003A2 (fr) |
CA (1) | CA2762831A1 (fr) |
WO (1) | WO2010135502A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210053165A1 (en) * | 2018-07-09 | 2021-02-25 | Olympus Corporation | Medical apparatus remanufacturing method |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9278027B2 (en) * | 2012-07-09 | 2016-03-08 | Alcon Research, Ltd. | Rounded-end device, system, and method for preventing posterior capsular opacification |
CN106028989B (zh) * | 2014-09-05 | 2020-01-03 | 奥林巴斯株式会社 | 处理器具、顶端侧探头单元及基端侧探头单元 |
US10004529B2 (en) | 2014-11-25 | 2018-06-26 | Ethicon Llc | Features to drive fluid toward an ultrasonic blade of a surgical instrument |
WO2016203861A1 (fr) * | 2015-06-18 | 2016-12-22 | オリンパス株式会社 | Instrument de traitement à ultrasons |
EP3381405A1 (fr) * | 2017-03-31 | 2018-10-03 | Koninklijke Philips N.V. | Dispositif de soins personnels |
EP3698735A1 (fr) * | 2019-02-21 | 2020-08-26 | Orthofix S.R.L. | Manette pour un appareil à ultrasons |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022259A2 (fr) * | 1991-06-11 | 1992-12-23 | Advanced Osseous Technologies, Inc. | Connecteur d'instrument ultrasonique |
WO1998037815A1 (fr) * | 1997-02-28 | 1998-09-03 | Ethicon Endo-Surgery, Inc. | Composants d'amortissement d'emission d'ultrasons |
US6443969B1 (en) * | 2000-08-15 | 2002-09-03 | Misonix, Inc. | Ultrasonic cutting blade with cooling |
WO2007143665A2 (fr) * | 2006-06-05 | 2007-12-13 | Broncus Technologies, Inc. | Appareils pour créer des passages et détecter des vaisseaux sanguins |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6561983B2 (en) * | 2001-01-31 | 2003-05-13 | Ethicon Endo-Surgery, Inc. | Attachments of components of ultrasonic blades or waveguides |
US8246642B2 (en) * | 2005-12-01 | 2012-08-21 | Ethicon Endo-Surgery, Inc. | Ultrasonic medical instrument and medical instrument connection assembly |
US8377044B2 (en) * | 2007-03-30 | 2013-02-19 | Ethicon Endo-Surgery, Inc. | Detachable end effectors |
-
2010
- 2010-05-20 CA CA2762831A patent/CA2762831A1/fr not_active Abandoned
- 2010-05-20 BR BRPI1013003A patent/BRPI1013003A2/pt not_active IP Right Cessation
- 2010-05-20 JP JP2012512021A patent/JP2012527325A/ja not_active Ceased
- 2010-05-20 EP EP10720854A patent/EP2432403A1/fr not_active Withdrawn
- 2010-05-20 CN CN201080032636.4A patent/CN102458271B/zh not_active Expired - Fee Related
- 2010-05-20 AU AU2010249539A patent/AU2010249539A1/en not_active Abandoned
- 2010-05-20 WO PCT/US2010/035530 patent/WO2010135502A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022259A2 (fr) * | 1991-06-11 | 1992-12-23 | Advanced Osseous Technologies, Inc. | Connecteur d'instrument ultrasonique |
WO1998037815A1 (fr) * | 1997-02-28 | 1998-09-03 | Ethicon Endo-Surgery, Inc. | Composants d'amortissement d'emission d'ultrasons |
US6443969B1 (en) * | 2000-08-15 | 2002-09-03 | Misonix, Inc. | Ultrasonic cutting blade with cooling |
WO2007143665A2 (fr) * | 2006-06-05 | 2007-12-13 | Broncus Technologies, Inc. | Appareils pour créer des passages et détecter des vaisseaux sanguins |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210053165A1 (en) * | 2018-07-09 | 2021-02-25 | Olympus Corporation | Medical apparatus remanufacturing method |
US11858074B2 (en) * | 2018-07-09 | 2024-01-02 | Olympus Corporation | Medical apparatus remanufacturing method |
Also Published As
Publication number | Publication date |
---|---|
CA2762831A1 (fr) | 2010-11-25 |
AU2010249539A1 (en) | 2011-12-08 |
JP2012527325A (ja) | 2012-11-08 |
BRPI1013003A2 (pt) | 2018-01-16 |
EP2432403A1 (fr) | 2012-03-28 |
CN102458271A (zh) | 2012-05-16 |
CN102458271B (zh) | 2014-11-26 |
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