WO2010123838A3 - Nouveaux dérivés amide et amidine et leurs utilisations - Google Patents

Nouveaux dérivés amide et amidine et leurs utilisations Download PDF

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Publication number
WO2010123838A3
WO2010123838A3 PCT/US2010/031660 US2010031660W WO2010123838A3 WO 2010123838 A3 WO2010123838 A3 WO 2010123838A3 US 2010031660 W US2010031660 W US 2010031660W WO 2010123838 A3 WO2010123838 A3 WO 2010123838A3
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Prior art keywords
amidine derivatives
novel amide
type
disorders
obesity
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PCT/US2010/031660
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English (en)
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WO2010123838A2 (fr
Inventor
Sridhar Peddi
Meena V. Patel
Jeffrey J. Rohde
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Abbott Laboratories
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Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to JP2012507294A priority Critical patent/JP5848698B2/ja
Priority to CA2757866A priority patent/CA2757866A1/fr
Priority to CN201080026472.4A priority patent/CN102459158B/zh
Priority to MX2011011082A priority patent/MX2011011082A/es
Publication of WO2010123838A2 publication Critical patent/WO2010123838A2/fr
Publication of WO2010123838A3 publication Critical patent/WO2010123838A3/fr

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Abstract

La présente invention concerne des inhibiteurs de l'enzyme 11-β-hydroxystéroïde déshydrogénase de type 1 et leur utilisation dans le traitement du diabète non-insulinodépendant de type 2, de la résistance à l'insuline, de l'obésité, des troubles lipidiques, du syndrome métabolique, de troubles du système nerveux central et de maladies et états qui sont liés à un excès de glucocorticoïdes.
PCT/US2010/031660 2009-04-20 2010-04-20 Nouveaux dérivés amide et amidine et leurs utilisations WO2010123838A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2012507294A JP5848698B2 (ja) 2009-04-20 2010-04-20 新規アミドおよびアミジン誘導体ならびにこれらの使用
CA2757866A CA2757866A1 (fr) 2009-04-20 2010-04-20 Nouveaux derives amide et amidine et leurs utilisations
CN201080026472.4A CN102459158B (zh) 2009-04-20 2010-04-20 新的酰胺和脒衍生物和其用途
MX2011011082A MX2011011082A (es) 2009-04-20 2010-04-20 Derivados de amida y amidina novedosos y usos de los mismos.

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US17094309P 2009-04-20 2009-04-20
US61/170,943 2009-04-20

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WO2010123838A2 WO2010123838A2 (fr) 2010-10-28
WO2010123838A3 true WO2010123838A3 (fr) 2011-03-03

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5848698B2 (ja) * 2009-04-20 2016-01-27 アッヴィ・インコーポレイテッド 新規アミドおよびアミジン誘導体ならびにこれらの使用
BR112015009567A2 (pt) * 2012-11-06 2017-07-04 Lilly Co Eli compostos de benzil sulfonamida novos úteis como inibidores de mogat-2
CN104592148A (zh) * 2015-02-10 2015-05-06 佛山市赛维斯医药科技有限公司 一类含环丙基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途
CN104592152A (zh) * 2015-02-10 2015-05-06 佛山市赛维斯医药科技有限公司 一种含脒结构的硝基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途
CN104557766A (zh) * 2015-02-10 2015-04-29 佛山市赛维斯医药科技有限公司 一类含叔丁基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途
CN104672164A (zh) * 2015-02-10 2015-06-03 佛山市赛维斯医药科技有限公司 一类含苯基脒结构的sglt2/sglt1双靶点抑制剂、其制备方法及用途
CN104710382A (zh) * 2015-02-10 2015-06-17 佛山市赛维斯医药科技有限公司 一类含叔丁基脒结构的卤代苯基噻唑羧酸酰胺类化合物及用途
CN104672165B (zh) * 2015-02-10 2016-06-01 佛山市赛维斯医药科技有限公司 一类含环丙基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途
CN104910097A (zh) * 2015-02-10 2015-09-16 佛山市赛维斯医药科技有限公司 一类含苯基脒结构的卤代苯基噻唑羧酸酰胺类化合物、其制备方法及用途
CN104628673A (zh) * 2015-02-10 2015-05-20 佛山市赛维斯医药科技有限公司 一类含叔丁基脒结构的腈基苯噻唑羧酸酰胺类化合物及用途
CN104672166A (zh) * 2015-02-10 2015-06-03 佛山市赛维斯医药科技有限公司 一种含脒结构的腈基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途
CN104628672A (zh) * 2015-02-10 2015-05-20 佛山市赛维斯医药科技有限公司 一类含苯基脒结构的烷氧苯基噻唑羧酸酰胺类化合物及用途
CN104592150A (zh) * 2015-02-10 2015-05-06 佛山市赛维斯医药科技有限公司 一类含环丙基脒结构的腈基苯噻唑羧酸酰胺类化合物及用途
CN110850012B (zh) * 2018-08-21 2022-07-08 四川弘远药业有限公司 一种1-(2,3-二氯苯基)哌嗪盐酸盐及其有关物质的检测方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333522A2 (fr) * 1988-03-18 1989-09-20 MITSUI TOATSU CHEMICALS, Inc. Dérivés du catéchol et préparations pharmaceutiques les contenant
EP0418065A2 (fr) * 1989-09-12 1991-03-20 MITSUI TOATSU CHEMICALS, Inc. Dérivés de l'acide dihydrocaféique, leur usage pour des traitements médicaux et compositions pharmaceutiques les contenant
US5338745A (en) * 1990-08-10 1994-08-16 Mitsui Toatsu Chemicals, Incorporation Amide derivatives of dihydrocaffeic acid and their application to pharmaceuticals
WO2006024628A1 (fr) * 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Derives de lactame tricyclique utilises en tant qu'inhibiteurs de 11-beta-hydroxysteroide deshydrogenase
US20060149070A1 (en) * 2005-01-05 2006-07-06 Rohde Jeffrey J Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2450386A (en) * 1945-09-04 1948-09-28 Boots Pure Drug Co Ltd Manufacture of compounds containing amidine groups
GB1306139A (fr) * 1970-08-06 1973-02-07
US4156014A (en) * 1977-03-21 1979-05-22 The Upjohn Company N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression
FR2387977A1 (fr) * 1977-04-19 1978-11-17 Hoechst France Procede de fabrication de l'acide thienyl-2 acetique
JPS562957A (en) * 1979-06-18 1981-01-13 Otsuka Pharmaceut Factory Inc N-adamantylthioamide derivative
CA1157774A (fr) * 1980-07-30 1983-11-29 Anthony Cerami Methode pour diminuer la viscosite de la mucine
AU671071B2 (en) * 1990-08-30 1996-08-15 State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, Substituted amidines having high binding to the sigma receptor and the use thereof
DE19921886A1 (de) * 1999-05-12 2000-11-16 Bayer Ag Substituierte N-Cyano-amidine
CA2430951A1 (fr) * 2000-12-07 2002-06-13 Cv Therapeutics, Inc. Composes d'augmentation d'abca-1
WO2004056744A1 (fr) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
CN1227010C (zh) * 2003-04-22 2005-11-16 中国药科大学 取代的四氢异喹啉衍生物的用途
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
JP5208505B2 (ja) * 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体
CN101137616A (zh) * 2005-01-05 2008-03-05 艾博特公司 11-β-羟甾类脱氢酶1型酶的抑制剂
ZA200800142B (en) * 2005-06-08 2009-05-27 Japan Tobacco Inc Heterocyclic compound
EP1801098A1 (fr) * 2005-12-16 2007-06-27 Merck Sante Dérivés de 2-Adamantylurea comme inhibiteurs de 11B-HSD1
EP1935420A1 (fr) * 2006-12-21 2008-06-25 Merck Sante Dérivés du 2-adamantyl-butyramide en tant qu'inhibiteurs selectifs de la 11beta-HSD1
JP2010526777A (ja) * 2007-04-24 2010-08-05 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 置換アミドの医薬用途
JP5736098B2 (ja) * 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
JP5848698B2 (ja) * 2009-04-20 2016-01-27 アッヴィ・インコーポレイテッド 新規アミドおよびアミジン誘導体ならびにこれらの使用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333522A2 (fr) * 1988-03-18 1989-09-20 MITSUI TOATSU CHEMICALS, Inc. Dérivés du catéchol et préparations pharmaceutiques les contenant
EP0418065A2 (fr) * 1989-09-12 1991-03-20 MITSUI TOATSU CHEMICALS, Inc. Dérivés de l'acide dihydrocaféique, leur usage pour des traitements médicaux et compositions pharmaceutiques les contenant
US5338745A (en) * 1990-08-10 1994-08-16 Mitsui Toatsu Chemicals, Incorporation Amide derivatives of dihydrocaffeic acid and their application to pharmaceuticals
WO2006024628A1 (fr) * 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Derives de lactame tricyclique utilises en tant qu'inhibiteurs de 11-beta-hydroxysteroide deshydrogenase
US20060149070A1 (en) * 2005-01-05 2006-07-06 Rohde Jeffrey J Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

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JP2012524121A (ja) 2012-10-11
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