WO2010123465A3 - Method for the treatment of biomedical polymeric implants for the improvement of antithrombogenic properties thereof - Google Patents

Method for the treatment of biomedical polymeric implants for the improvement of antithrombogenic properties thereof Download PDF

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Publication number
WO2010123465A3
WO2010123465A3 PCT/SI2010/000014 SI2010000014W WO2010123465A3 WO 2010123465 A3 WO2010123465 A3 WO 2010123465A3 SI 2010000014 W SI2010000014 W SI 2010000014W WO 2010123465 A3 WO2010123465 A3 WO 2010123465A3
Authority
WO
WIPO (PCT)
Prior art keywords
dose
treatment
implants
charged molecular
improvement
Prior art date
Application number
PCT/SI2010/000014
Other languages
French (fr)
Other versions
WO2010123465A2 (en
Inventor
Lta Junkar
Miran Mozetič
Alenka Vesel
Uroš Cvelbar
Metka KRAŠNA
Dragoslav DOMANOVIČ
Original Assignee
Institut "Jožef Stefan"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut "Jožef Stefan" filed Critical Institut "Jožef Stefan"
Priority to ATA9111/2010A priority Critical patent/AT513072B1/en
Publication of WO2010123465A2 publication Critical patent/WO2010123465A2/en
Publication of WO2010123465A3 publication Critical patent/WO2010123465A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0094—Physical treatment, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Plasma & Fusion (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The subject of the invention is a method for the treatment of biomedical implants for the improvement of antithrombogenic properties thereof. The mentioned biomedical implants are cardiovascular implants, especially artificial blood vessels and stents made from a polyethyleneterephtalate (PET) polymer. The method is based on the treatment of a surface of cardiovascular implants by an adequate combination of a dose of neutral oxygen atom and positively charged molecular and atomic oxygen ions. After having been treated by a dose of said atoms and ions, the surface of cardiovascular implants becomes less prone to binding of thrombocytes. The method is characterised in that the exposure to a mixture of neutral oxygen atoms and positively charged molecular and atomic oxygen ions in pulses is such that in an individual pulse a dose of neutral oxygen atoms is reached between 1020 m-2 and 1026 m-2, and the dose of charged molecular and atomic oxygen ions between 1016 m-2 and 1023 m-2, the interval between individual pulses is between 10 s and 300 s, and that the flow of neutral oxygen atoms and positively charged molecular and atomic oxygen ions onto the surface of an implant is approximately even.
PCT/SI2010/000014 2009-04-20 2010-03-18 Method for the treatment of biomedical polymeric implants for the improvement of antithrombogenic properties thereof WO2010123465A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ATA9111/2010A AT513072B1 (en) 2009-04-20 2010-03-18 METHOD FOR THE TREATMENT OF BIOMEDICAL IMPLANTS FOR IMPROVING THEIR ANTITHROMBOGENIC PROPERTIES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200900109A SI23021A (en) 2009-04-20 2009-04-20 Method of treatment of biomedical polymeric prostheses for improvement of their antithrombogenous properties
SIP-200900109 2009-04-20

Publications (2)

Publication Number Publication Date
WO2010123465A2 WO2010123465A2 (en) 2010-10-28
WO2010123465A3 true WO2010123465A3 (en) 2011-03-24

Family

ID=42246151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2010/000014 WO2010123465A2 (en) 2009-04-20 2010-03-18 Method for the treatment of biomedical polymeric implants for the improvement of antithrombogenic properties thereof

Country Status (3)

Country Link
AT (1) AT513072B1 (en)
SI (1) SI23021A (en)
WO (1) WO2010123465A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014112956A1 (en) * 2013-01-17 2014-07-24 Center Odličnosti Polimerni Marteriali In Tehnologije Method for treatment of a vascular graft

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113478A1 (en) * 2001-12-12 2003-06-19 Dang Mai Huong Surface coating method and coated device
WO2007022174A2 (en) * 2005-08-18 2007-02-22 Boston Scientific Scimed, Inc. Surface modification of eptfe and implants using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016735A1 (en) * 1993-12-17 1995-06-22 E.I. Du Pont De Nemours And Company Polyethylene therephthalate articles having desirable adhesion and non-blocking characteristics, and a preparative process therefor
MXPA03007747A (en) * 2001-03-02 2003-12-08 Univ Laval Plasma surface graft process for reducing thrombogenicity.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113478A1 (en) * 2001-12-12 2003-06-19 Dang Mai Huong Surface coating method and coated device
WO2007022174A2 (en) * 2005-08-18 2007-02-22 Boston Scientific Scimed, Inc. Surface modification of eptfe and implants using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VESEL ET AL: "XPS study of oxygen plasma activated PET", VACUUM, PERGAMON PRESS, GB, vol. 82, no. 2, 15 October 2007 (2007-10-15), pages 248 - 251, XP022299618, ISSN: 0042-207X, DOI: DOI:10.1016/J.VACUUM.2007.07.021 *

Also Published As

Publication number Publication date
SI23021A (en) 2010-10-29
AT513072B1 (en) 2014-02-15
WO2010123465A2 (en) 2010-10-28

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