WO2010119311A1 - Sac pour contenir et congeler des cellules souches - Google Patents

Sac pour contenir et congeler des cellules souches Download PDF

Info

Publication number
WO2010119311A1
WO2010119311A1 PCT/IB2010/000545 IB2010000545W WO2010119311A1 WO 2010119311 A1 WO2010119311 A1 WO 2010119311A1 IB 2010000545 W IB2010000545 W IB 2010000545W WO 2010119311 A1 WO2010119311 A1 WO 2010119311A1
Authority
WO
WIPO (PCT)
Prior art keywords
bag
stem cells
envelope
fact
containment chamber
Prior art date
Application number
PCT/IB2010/000545
Other languages
English (en)
Inventor
Marco Bertoni
Original Assignee
Biomed Device S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomed Device S.R.L. filed Critical Biomed Device S.R.L.
Publication of WO2010119311A1 publication Critical patent/WO2010119311A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0236—Multiple bag systems for separating or storing blood components with sampling means, e.g. sample bag or sampling port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A61J1/12—Bag-type containers with means for holding samples of contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/10—Bar codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/30—Printed labels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems

Definitions

  • the present invention relates to a bag for containing and freezing stem cells.
  • stem cells are primitive, non-specialised cells having the singular capacity of transforming themselves into any other type of body cell.
  • Stem cells can be of various kinds and are generally classified as cord stem cells, meaning the cells taken from the umbilical cord of a baby, or peripheral cells, meaning the cells taken by selective apheresis from the peripheral venous system or from bone marrow.
  • the stem cells after being taken from the umbilical cord or from the donor, undergo a number of treatments and/or additions of adequate additives and solutions (plasma, salt solution, DMSO, etc.) and are then collected in special bags to be cryopreserved, i.e., preserved in liquid nitrogen at a temperature approximately between - 130 0 C and - 190 C.
  • adequate additives and solutions plasma, salt solution, DMSO, etc.
  • the bags used comprise an envelope that defines a containment chamber for holding the stem cells and which is associable with introduction and removal means.
  • a label On each bag containing stem cells, a label must then be affixed showing a series of indications according to the provisions of the guidelines and applicable laws (identification details of donor and of the cells themselves, bag production lots, sampling date, expiry date, cell production date, etc, etc .). Because it is crucial to preserve the integrity of the stem cells contained in the bags and prevent them from coming into contact with "contaminating” or mutagenous agents that could in some way cause damage, pollution or mutations of the stem cells themselves, all the elements which are used for labelling must be properly selected and certified. To date, some types of paper and ink for certified labels exist on the market, the use of which is safe and in no way affects the "quality" of the cells contained in the bags. In the same way however, no type of certified glue exists that can be safely used for labelling the bags containing stem cells.
  • the glues marketed to date contain solvents capable of crossing the wall of the envelope making up the bag and on which the labels are affixed, thereby contaminating the cells contained inside it.
  • a number of solutions can be adopted to prevent the risk of damage or mutations or contamination.
  • the solution most often adopted consists in inserting the bags containing the cells in special removable bag covers, before positioning them in the liquid nitrogen, and in affixing the identification labels on the outside of these bag covers after suitably closing them by means of sealing. Because, before making a transplant of stem cells, it is best to make sure the recipient or receiver is compatible with the cells contained inside a bag, it is crucial to carry out some compatibility tests.
  • the labels affixed outside the bag covers can tear, become unthreaded or detach during the handling of the bags and above all during their storage soaked in liquid nitrogen. This can therefore result in the relative bag being without an identification label or in the latter being damaged and therefore not legible.
  • a bag without the relative identification label or with the label illegible cannot be used because it is not possible to identify the donor and the properties of the cells contained in it, and it must therefore be destroyed.
  • Another drawback of the bags of known type consists in the fact that the samples held freely inside such metal containers can accidentally come out of these during their handling. This consequently means that the samples are no longer traceable or in any case that they are no longer reliably traceable to the corresponding bag.
  • the main aim of the present invention is to provide a bag for containing and freezing stem cells that allows easily and reliably affixing the identification label to the bag itself, as provided by applicable laws, without this in any way contaminating or damaging the cells contained inside the bag.
  • One object of the present invention is to provide a bag for containing and freezing stem cells that allows reliably affixing the identification label directly to the bag and avoiding this becoming accidentally detached or being damaged during handling of the bag itself or during its preservation in liquid nitrogen.
  • Yet another object of the present invention is to provide a bag that allows using a plurality of samples to perform tests or compatibility tests and which at the same time permits preventing these samples from coming out of the relative container, so that they can be reliably retraced to the relative bag.
  • Yet another object of the present invention is to provide a bag for containing and freezing stem cells which allows affixing the identification label in a reliable way and which at the same time substantially maintains the external overall dimensions of the bags used to date, in such a way as to be able to be cryopreserved inside the same containers in use to date for such purpose.
  • Another object of the present invention is to provide a bag for containing and freezing stem cells, which allows overcoming the mentioned drawbacks of the state of the art within the ambit of a simple, rational, easy, effective to use and low cost solution.
  • the last object of the present invention is to provide a bag for containing and freezing stem cells which, the containment chamber volume being equal, has reduced external overall dimensions with respect to bags of known type, while at the same time satisfying all the requirements of applicable standards and allowing the easy management of the bags themselves.
  • the present bag for containing and freezing stem cells comprising an envelope defining a containment chamber for holding the stem cells and associable with introduction/removal means, characterised by the fact that it comprises protection means associated integral with said envelope and suitable for supporting at least an identification label for identifying the characteristics of the stem cells contained in said containment chamber.
  • figure 1 is a front view of a bag with the relative bag cover according to the invention
  • figure 2 is a perspective view of a bag according to the invention according to a first embodiment
  • figure 3 is a perspective view of a bag according to the invention according to a second embodiment.
  • a bag for containing and freezing stem cells globally indicated by 1 is a bag for containing and freezing stem cells.
  • the bag 1 comprises an envelope 2 defining a containment chamber 3 of the stem cells and associable with introduction/removal means not shown in the illustrations. More in particular, the containment chamber 3 has an inlet gap 4 communicating with a filling tube 20 associable with introduction means not shown in the illustrations and closable, e.g. by sealing, to isolate the containment chamber itself from the outside and not allow the stem cells to come out. Furthermore, the bag 1 has one or more openable connectors 5, e.g., by tearing off, and associable with relative removal or reintroduction means. According to the invention, the bag 1 comprises protection means associated integral with the envelope 2 and suitable for supporting at least a label 6 identifying the characteristics of the stem cells contained in the containment chamber 3. More in particular, the information shown on the label 6 comprises all the details required by applicable regulations, such as, e.g., the name and the surname of the donor, his/her date of birth, the cell collection date and a bar code indicating a management system.
  • applicable regulations such as
  • the protection means comprise at least a protection element 7, substantially plate-shaped, associated integrally with the envelope 2, outside this.
  • the protection element 7 can be superimposed on the envelope 2 in correspondence to the containment chamber 3.
  • the protection element 7 is made of transparent material, so as to also allow reading the label 6 from outside. Possibly, but not necessarily, the material making up the protection element 7 is the same as that making up the envelope 2.
  • An example of material suitable for making the envelope 2 and/or the protection element 7 is ethylene-vinyl acetate (EVA).
  • EVA ethylene-vinyl acetate
  • the protection means are made up of a single protection element 7 associated with the envelope 2.
  • the protection element 7 is associated with the envelope 2 by at least one of its sides 7a.
  • the opposite side 7b can also be associated with the envelope 2 or, in an alternative embodiment, released with respect to the envelope 2 and therefore free to turn, by a restricted angle, around the side 7a sealed on the envelope itself.
  • the protection element 7 defines two opposite faces 8, one of which is turned outwards and on which is affixed the label 6, and the other turned towards the envelope 2.
  • the protection element 7 is associated with the envelope 2 in correspondence to the surrounding edge 9 of the latter.
  • the protection means comprise two protection elements 7 associated the one with the other in correspondence to two connection areas 1 Oa and 10b, of which a first connection area 1 Oa and a second connection area 10b, distinct from one another to define a housing pocket 11 for the label 6.
  • the protection elements 7 are associated with the envelope 2, by sealing or similar techniques, with at least a connection area 10a and 10b. More in particular, in the embodiment shown in figure 3, the connection elements 7 are associated with the envelope 2 with a connection area 10a, 10b while the other connection area 10b, 10a is free and released with respect to the envelope 2.
  • connection areas 10a and 10b are defined in correspondence to two opposite sides of the protection elements 7. More in particular, the protection elements 7 are associated with the envelope 2 in correspondence to the surrounding edge 9 of the latter. An alternative embodiment cannot however be ruled out envisaging the fixing of both the connection areas 10a and 10b to the envelope 2.
  • the protection elements 7 can also be associated the one with the other in correspondence to at least a third connection area, not shown in the illustrations and arranged substantially crossways with respect to the connection areas 10a and 10b. More in particular, the third connection area can be defined in correspondence to one of the sides of the protection elements 7 adjacent to the sides in correspondence to which are defined the connection areas 10a and 10b.
  • the bag 1 comprises at least an auxiliary container 12 for carrying out compatibility tests or analyses, associated integral with the envelope 2 and separable from it.
  • the auxiliary container 12 is separate from the filling tube 20.
  • the bag 1 comprises a plurality of auxiliary containers 12, as shown in the illustrations.
  • the auxiliary containers 12 each define a collection tank 21 communicating with the containment chamber 3 and suitable for being closed, by means of sealing or the like, to isolate a predefined quantity of stem cells contained in the containment chamber itself.
  • the auxiliary containers 12 comprise suction means 13 suitable for varying the volume of the relative collection tank 21 to recall a predefined quantity of stem cells contained in the containment chamber 3. More in particular, the suction means 13 are made up of a compressible wall which delimits at least partially the relative collection tank 21.
  • the object of the present invention is therefore also a bag 1 containing stem cells and comprising one or more of the above-described characteristics and at least an auxiliary container 12, distinct from the filling tube 20, which branches from the containment chamber 3 and which has a fastening 22 in correspondence to its connection with the containment chamber itself so as to isolate a predefined quantity of the stem cells collected in the containment chamber 3.
  • Such quantity of stem cells isolated from the auxiliary container 12 is to be used to carry out tests or analyses, and therefore as a sample quantity.
  • the fastening 22 is therefore to be opened to access the contents of the auxiliary container 12.
  • the auxiliary containers 12 are independent from the presence of other above-mentioned characteristics, such as, e.g., the protection means 7.
  • the auxiliary containers 12 can in fact also be present in bags 1 without the protection means 7 and their presence is particularly advantageous for carrying out tests or analyses without this involving the need to open the containment chamber 3.
  • the operation of the present invention is as follows.
  • the filling tube 20 is closed, e.g., by sealing, so as to isolate the containment chamber itself from the outside.
  • the auxiliary containers themselves are isolated from the containment chamber 3 realising the fastening 22, e.g., by sealing.
  • the auxiliary containers 12 are isolated from the containment chamber 3 and contain a predefined quantity of stem cells usable to carry out tests or analyses.
  • the label 6 can be affixed to the bag 1, exploiting the protection means according to the invention, before or after filling the bag with cellular suspension. Generally speaking, the label 6 is affixed to the bag 1 before introducing the stem cells inside the containment chamber 3. More in particular, in the first embodiment shown in figure 2, the label 6 can be affixed, using any type of glue or adhesive means on the market, on the outer face 8 defined by the protection element 7.
  • the glue applied to the label 6 is not at direct contact with the envelope 2 but with the protection element 7, which acts as a barrier between the glue and the envelope 2.
  • the protection element 7 is made to adhere to the envelope 2 so the bag 1 can be placed inside a bag cover 14, subsequently hermetically sealed and suitable for being placed inside a metal container not shown in the illustrations for preservation in liquid nitrogen.
  • the label 6 can be affixed on one of the outer faces defined by the protection elements 7 or, preferably, positioned inside the housing pocket 1 1, with or without glue or adhesive means.
  • the label 6 is withheld by the protection elements 7, both in the variation which envisages the connection areas 10a and 10b only and in that which also has the third connection area, and which does not therefore require the use of glue or adhesive means to secure the label 6 to the bag 1.
  • the opening/s of the pocket 1 1 is/are sealed so as to avoid the label itself accidentally coming out.
  • auxiliary containers 12 will have to be detached by, e.g., cutting it in correspondence to its fastening 22.
  • the separation of the auxiliary containers 12 in any case maintains the integrity of the envelope 2 and therefore keeps the containment chamber 3 hermetically closed.
  • the bag according to the invention is therefore considerably safer than the bags currently used to preserve and freeze stem cells inasmuch as it defines a sort of protection barrier between the label and the envelope inside which the stem cells are contained. Furthermore, in the embodiment which envisages the identification label being introduced inside the housing pocket separate from the envelope containing the stem cells, it is even possible to avoid applying glue or adhesive means to the label.
  • the bags for containing and freezing the stem cells according to the invention ensure the traceability and the linking of the bags to the relevant samples for compatibility tests. Such samples in fact, because they are associated integral with the envelope defining the cell containment chamber, cannot accidentally come out of the metal container during the extraction, the handling and the opening of the container itself. Furthermore, the bags according to the invention ensure that the sample content is the same as that of the bag housed in the same container.
  • the bag according to the invention also permits complying with the requirements of the blood law, according to which the samples used for compatibility tests must be linked in an integral way with the envelope containing the stem cells.
  • the bag according to the invention while complying with all the requirements of the blood law as regards the use and affixing of the identification labels, is also of reduced overall dimensions with respect to the bags of known type, thereby ensuring easier handling and storage in the relative containers.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Selon l'invention, le sac (1) pour contenir et congeler des cellules souches comprend une enveloppe (2) définissant une chambre de confinement (3) pour contenir les cellules-souches et qui peut être associée à des moyens d'introduction/de retrait et des moyens de protection (7) associés d'un seul tenant à l'enveloppe (2) et est approprié pour supporter au moins une étiquette d'identification (6) pour identifier les caractéristiques des cellules-souches contenues dans la chambre de confinement (3).
PCT/IB2010/000545 2009-04-16 2010-03-15 Sac pour contenir et congeler des cellules souches WO2010119311A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000093A ITMO20090093A1 (it) 2009-04-16 2009-04-16 Sacca per il contenimento ed il congelamento di cellule staminali
ITMO2009A000093 2009-04-16

Publications (1)

Publication Number Publication Date
WO2010119311A1 true WO2010119311A1 (fr) 2010-10-21

Family

ID=41328406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/000545 WO2010119311A1 (fr) 2009-04-16 2010-03-15 Sac pour contenir et congeler des cellules souches

Country Status (2)

Country Link
IT (1) ITMO20090093A1 (fr)
WO (1) WO2010119311A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMO20110057A1 (it) * 2011-03-16 2012-09-17 Biomed Device S R L Dispositivo per il riempimento di unita' di contenimento di liquidi biologici
WO2013007921A1 (fr) 2011-07-08 2013-01-17 Maco Pharma Kit pour la conservation d'un produit biologique comprenant une poche tridimensionnelle et une enveloppe tridimensionnelle adaptée
US9879217B2 (en) 2014-08-14 2018-01-30 Merial, Inc. Cryopreservation bags and method of use thereof for closed system, high capacity cell-banking
WO2018150730A1 (fr) * 2017-02-16 2018-08-23 リンテック株式会社 Étiquette adhésive
CN110382014A (zh) * 2017-01-08 2019-10-25 赛斯卡医疗有限公司 用于生物加工细胞样品的装置和方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654725A1 (de) * 1975-12-02 1977-06-08 Bioveta N P Universeller separations-blutbeutel zur sterilen zubereitung von blutserum fuer einmalige benuetzung
FR2591101A1 (fr) * 1985-12-10 1987-06-12 Assistance Publique Conteneur aplatissable et souple pour prelevement et/ou administration de liquides biologiques comportant des moyens d'identification de la provenance et/ou de la destination des susdits liquides.
US6183460B1 (en) * 1998-01-22 2001-02-06 Baxter International Inc. Multi-use solution container having flaps
WO2003026724A1 (fr) * 2001-09-27 2003-04-03 Gambro, Inc. Systeme r.f. ou electromagnetique d'information, et procedes associes de traitement du sang extracorporel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654725A1 (de) * 1975-12-02 1977-06-08 Bioveta N P Universeller separations-blutbeutel zur sterilen zubereitung von blutserum fuer einmalige benuetzung
FR2591101A1 (fr) * 1985-12-10 1987-06-12 Assistance Publique Conteneur aplatissable et souple pour prelevement et/ou administration de liquides biologiques comportant des moyens d'identification de la provenance et/ou de la destination des susdits liquides.
US6183460B1 (en) * 1998-01-22 2001-02-06 Baxter International Inc. Multi-use solution container having flaps
WO2003026724A1 (fr) * 2001-09-27 2003-04-03 Gambro, Inc. Systeme r.f. ou electromagnetique d'information, et procedes associes de traitement du sang extracorporel

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMO20110057A1 (it) * 2011-03-16 2012-09-17 Biomed Device S R L Dispositivo per il riempimento di unita' di contenimento di liquidi biologici
WO2013007921A1 (fr) 2011-07-08 2013-01-17 Maco Pharma Kit pour la conservation d'un produit biologique comprenant une poche tridimensionnelle et une enveloppe tridimensionnelle adaptée
US9879217B2 (en) 2014-08-14 2018-01-30 Merial, Inc. Cryopreservation bags and method of use thereof for closed system, high capacity cell-banking
US10689611B2 (en) 2014-08-14 2020-06-23 Boehringer Ingelheim Animal Health USA Inc. Cryopreservation bags and method of use thereof for closed system, high capacity cell-banking
CN110382014A (zh) * 2017-01-08 2019-10-25 赛斯卡医疗有限公司 用于生物加工细胞样品的装置和方法
WO2018150730A1 (fr) * 2017-02-16 2018-08-23 リンテック株式会社 Étiquette adhésive

Also Published As

Publication number Publication date
ITMO20090093A1 (it) 2010-10-17

Similar Documents

Publication Publication Date Title
US4917867A (en) Apparatus for the collection and transportation of dual biological samples
WO2010119311A1 (fr) Sac pour contenir et congeler des cellules souches
US9364288B2 (en) Sterile battery containment
EP1072030B1 (fr) Dispositif permettant d'associer un conteneur et un dispositif de suivi informatique de son contenu
US5415282A (en) Thermal storage and/or shipping container with leak-resistant bag
US5388699A (en) Dual pocket specimen collection package
AU2011293832B2 (en) Biological fluid sampling and storage apparatus for remote use
CA2641777C (fr) Recipient d'echantillonnage servant a contenir de petites quantites de liquide pour analyses
ES2236430T3 (es) Embalaje para la venta o el almacenamiento para pilas de zinc-aire.
US5135313A (en) Chain-of-custody bag
US8858568B2 (en) System for marking a non-human biological object and for taking a sample of the biological object
US10285906B2 (en) RFID tag and blood container/system with integrated RFID tag
EP3328286B1 (fr) Recipient de 30 ou 90ml pour stockage ou transport de tissus ou organes humains en vue d'un examination histologique
US8999260B2 (en) Sterilization box seal device
EP1627566B1 (fr) Poche de sécurité pour cryoconservation des cellules souches et des composants sanguins similaires
EP2041322A1 (fr) Cartouche echantillon destinee a un echantillonneur d'air
US20170350797A1 (en) Sample collection and DNA preservation device
GB2482036A (en) Flexible sample retainer opens to provide access to sample
CN217171568U (zh) 一种样品取样用样品袋
CN209797964U (zh) 一种便于口腔脱落细胞直接扩增检验的采集盒
CN111249508B (zh) 指示标签、灭菌验证装置组件、判断灭菌效果的方法
US20230165494A1 (en) Processing of dried blood samples on lateral flow paper
US8669070B2 (en) Procurement extraction bag
CN215246931U (zh) 一种用于生物试剂存储装置
CN211418216U (zh) 一种细胞生物技术用试剂盒

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10713508

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10713508

Country of ref document: EP

Kind code of ref document: A1