WO2010086698A1 - Dispositif de mélange et procédé associé pour mélanger ou émulsifier au moins deux substances - Google Patents

Dispositif de mélange et procédé associé pour mélanger ou émulsifier au moins deux substances Download PDF

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Publication number
WO2010086698A1
WO2010086698A1 PCT/IB2009/055330 IB2009055330W WO2010086698A1 WO 2010086698 A1 WO2010086698 A1 WO 2010086698A1 IB 2009055330 W IB2009055330 W IB 2009055330W WO 2010086698 A1 WO2010086698 A1 WO 2010086698A1
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WO
WIPO (PCT)
Prior art keywords
mixing chamber
material flow
mixture
mixer
elongating
Prior art date
Application number
PCT/IB2009/055330
Other languages
English (en)
Inventor
Marina Scremin
Original Assignee
Marina Scremin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marina Scremin filed Critical Marina Scremin
Publication of WO2010086698A1 publication Critical patent/WO2010086698A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements

Definitions

  • the present invention relates to a mixing device to be used (although not in a limiting sense) for mixing or emulsifying or, more generally, forming a colloidal solution (or still more generally forming any aggregation, solution, composition or mixture) between two or more components in a homogeneous or heterogeneous aggregation phase.
  • mixers the function of which is to cause mutual and physical and/or chemical penetration of the two substances into each other; at the end of the operating cycle of a mixer, the obtained mixture is sent into a suitable container.
  • suitable machines exactly referred to as mixers, the function of which is to cause mutual and physical and/or chemical penetration of the two substances into each other; at the end of the operating cycle of a mixer, the obtained mixture is sent into a suitable container.
  • mixers the function of which is to cause mutual and physical and/or chemical penetration of the two substances into each other; at the end of the operating cycle of a mixer, the obtained mixture is sent into a suitable container.
  • a mixing chamber is positioned horizontally to the ground and is fed from opposite sides through inlet ports mutually facing in the mixing chamber; by co-ordinated and cyclical thrust actions of the two substances through such inlet ports mixing in the chamber occurs.
  • This first type of structure however has some serious operating drawbacks; in fact, the particular positioning of the mixing chamber does not allow the air remaining in the chamber at the beginning of the operating cycle to efficiently escape; this air therefore will tend to take up room also inside the mixture being formed, thus altering homogeneity and reducing density of same.
  • the air left in the mixing chamber (or at all events introduced thereinto at the moment of admission of particular substances, because it is entrapped in the hollow spaces between the powder grains, for example) is then incorporated into the mixture M, constituting an element worsening the overall quality and purity of said mixture.
  • this residual air creates discontinuity in the movement of the substances to be mixed, through expansion and/or contraction in an unforeseeable manner; this creates an inconstant flow and brings to decay of the finished product, when the compound (gel or other) being prepared is to be forced to a high speed, for example.
  • the problems connected with the presence of residual air therefore involve oversizing of the mixer, while at the same time making it necessary to provide various sealing means counteracting and controlling an uncontrolled air diffusion.
  • mixers contemplates a "continuously working" operation, or in other words is not based on a movement cycle of the substances to be mixed within a closed volume; these mixers practically consist of an extruder, in the end portion of which a particular device is present which imparts a high turbulence to the outgoing fluid and/or divides it into threads which are then mixed again being oriented on "collision trajectories".
  • mixers of known type are usually designed for treating a very limited number of substances, or in any case are not able to operate with a satisfactory flexibility in terms of variety of the substances to be used and/or of overall volumes of the obtainable mixture.
  • the hitherto highlighted drawbacks have a further worsening factor if the substances to be treated are designed for very advanced or delicate applications or at all events substances having a very high cost (to be mentioned is for example the hyaluronic acid with a high purity degree, to be used in tissue reconstruction or also the polysaccharides or hydratable powers, maybe those of gelatine, compounds of the hyaluronic acid, alginates and polymers of various kinds, thermoplastic or not) ; these materials are to be prepared in the form of mixtures, typically turned into gel, having precise features, and the machines that must govern this preparation have to ensure a high product yield with an important elimination of waste products or of products remaining inside the machines (that are therefore to be ejected by "washing” ) .
  • the present invention aims at conceiving a mixer that can offer high operating capabilities in terms of homogeneity and density of the obtainable mixture, eliminating all operating problems connected with the presence of residual air (or other undesirable substance) within the mixing chamber.
  • the present invention aims at conceiving a mixer that can operate on a wide variety of substances and is able to generate a wide range of volumes of obtainable mixture in each operating cycle, while at the same time minimising possible waste or residues of unworked material or material that cannot be extracted from the machine at the end of the production cycle.
  • the present invention aims at providing a mixer having a high reliability and reduced costs for planning, installation and servicing.
  • - Fig. 1 is a scheme in section of a mixer according to the invention.
  • Figs. 2 to 9 show different steps of a first operating cycle to be carried out with the mixer seen in Fig. 1;
  • - Figs. 10 to 17 show different steps of a second operating cycle to be carried out with the mixer seen in Fig. 1; and - Fig. 18 is a scheme in section of an alternative embodiment of the mixer according to the invention.
  • the mixer of the invention is generally identified with reference numeral 1 and substantially comprises at least one mixing chamber 2 which in turn has an operating volume adapted to contain at least two substances Sl and S2 to be mixed.
  • the mixing chamber 2 can be provided with additional particular operating functions, for instance it can be interlocked with thermoregulation means for determining a given temperature and/or inner thermal energy condition; the mixing chamber 2 may also have at least one transparent portion to enable an operator/controller to visually evaluate the progress of the production cycle.
  • this operating volume in the course of the operating cycle of mixer 1, will also contain at least one mixture M exactly derived from the above mentioned substances to be mixed.
  • the mixing chamber 2 extends along an operating axis 2a and comprises an elongating portion 2b adapted to impart a deforming stretching in the operating or axial direction 2a to a material flow F inside the mixing chamber (or at least in the running direction of the flow within the elongating portion 2b itself during the operating cycle of mixer 1) , and in succession also comprises at least one stratifying portion 2c which on the contrary is connected without a break to the elongating portion 2b and is adapted to internally define a multi-layer accumulation of the material flow F coming out of the elongating portion 2b.
  • material flow F means a mass of material moving inside the mixer and more specifically inside the mixing chamber 2; conveniently, this mass at any "intermediate” moment of the operating cycle of mixer 1, will comprise the mixture M that has been already partly obtained and/or the substances to be mixed.
  • the material flow F is cyclically and reversibly movable through the elongating portion and the stratifying portion; as a result of this, the present mixer differs from the "single passage" extruders described in connection with the known art, since the mixture M is obtained through several passages in a closed volume (the mixing chamber 2) which is then discharged, when appropriate.
  • Division of the mixing chamber into the two portions 2b and 2c mentioned above is designed to obtain a well precise state of efforts and deformation internal to the material flow F; actually, the elongating portion gives the material flow F a change in shape involving reduction of the passage section (and consequently, due to the constant volume, a longitudinal expansion and arising of forces of mutual penetration transverse to the flow direction) , the volume remaining constant, by virtue of which the substances will be forced to penetrate into each other thus carrying out a first mechanism promoting mixing.
  • the material flow F (that internally has generated the mentioned forces of mutual penetration) will be in a condition at which the viscous efforts generated inside it during its forcing through portion 2b will tend to have an effect from a kinematic point of view, giving rise to curves and bending in the flow itself; in addition, by its impacting against the walls confining the stratifying portion 2c, the material flow F will tend to gather upon itself, thus creating a three-dimensional accumulation of loops resting on each other (which can then collapse one after the other due to the intrinsic weight of the material itself) ; thus a further mixing mechanism is promoted that is amplified due to all possible ways in which the loops of the flow (that is continuous and substantially oriented in a single direction) coming out of portion 2b can approach or overlap each other in the space of the portion 2c itself.
  • the mixing chamber 2 first of all comprises an elongating portion adapted to impose isochoric deformations (i.e.
  • the mixing chamber 2 can advantageously comprise a collecting portion adapted to receive the material flow F by effect of the force of gravity, as well as a vent portion connected to the collecting portion and adapted to receive at least one foreign substance X relative to the substances to be mixed and/or to mixture M and/or relative to the material flow F.
  • this vent portion is connected without a break to the collecting portion and can take a position overlying the collecting portion.
  • division of the mixing chamber 2 into a "collecting portion” and a “vent portion” as herein described (and claimed in the following) can also be independent of the division into an "elongating portion” and a “stratifying portion”; the choice of combining these pairs of functional features or not can be done based on current requirements, such as for instance the determination of a more or less high mixing/homogeneity degree and so on.
  • the present invention can also introduce (in a manner also independent of the above description) a particular division of the mixing chamber which is conveniently shaped for exploiting the effect of spontaneous separation between mixture M that will be obtained and one or more "foreign substances" (such as the residual air remaining within the mixing chamber at the beginning of the production cycle) that are characterised by having a smaller weight and/or density than the product-mixture M to be obtained: actually, due to the difference in the density and/or weight (or also in the specific weight) the present invention can advantageously provide a chamber in which the product-mixture M can be separated in ah autonomous and "automatic" manner from the undesirable substances at the end of the mixing process.
  • collecting portion is coincident with the stratifying portion in which the material flow F and/or the foreign substance X have a potential energy of a minimum value
  • vent portion is coincident with the stratifying portion 2c (or also, depending on the spatial arrangement of the mixing chamber 2, with the elongating portion 2b or even with only part of the latter) in which the material flow F and/or the foreign substance X have a potential energy of a maximum value.
  • the elongating portion 2b can be disposed in a vertical direction relative to the ground, while two stratifying portions 2c also disposed in a vertical direction are present and they are connected to opposite ends of the elongating portion
  • the operating axis 2a is ideally defined by a continuous vertical straight segment passing through the stratifying portions 2c and the elongating portion 2b.
  • the elongating portion 2b can be disposed in a horizontal direction relative to the ground, while the two stratifying portions 2c are disposed in a vertical direction (and can protrude in the half-space above or under the lying plane containing the elongating portion 2b) , although they are always connected through suitable curved or angled connecting portions, to opposite ends of the elongating portion 2b; in this case, the operating axis 2a is defined by a broken line having two vertical end stretches passing through the stratifying portions 2c and a median horizontal stretch passing through the elongating portion 2b.
  • the elongating portion may also have developments different from the straight one; in fact provision can be made for a C- or V- or U-shaped development or a development in the form of a siphon with one or more curves, and so on.
  • the latter can be defined as a portion of the mixing chamber 2 placed to a minimum height from the ground, while the “vent portion” is made up of a portion of the mixing chamber 2 placed to a maximum height from the ground.
  • charging and discharging means 5 can be present which is adapted to selectively determine entry and/or exit of the substances to be mixed and/or mixture M and/or the material flow F and/or the foreign substance X relative to the mixing chamber 2.
  • the charging and discharging means 5 comprises a predetermined number of injectors 5a preferably placed at the opposite ends of the elongating portion 2b (but also, if necessary, in one or more of the stratifying portions 2c or even in the propulsion means 4) and a predetermined and corresponding number of closure members 5b that can be operatively activated on the respective injectors 5a so as to reversibly configure them between an access condition and an isolation condition relative to the mixing chamber 2.
  • the elongating portion 2b has a constant section extending along the operating axis 2a, while a typical conformation of the stratifying portion 2c is characterised by a varying development of its section along the operating axis 2a; in particular, in order to impart the torsional/curving effect to the material flow F coming out of the elongating portion 2b, at least one stratifying portion 2c has an increasing section on moving away from the elongating portion 2b (thus defining a conical or pyramidal three-dimensional shape the inner space of which allows formation and subsequent overlapping/accumulation of the above mentioned "loops”) .
  • the presence of at least one turbulence- inducing element 6 can be advantageously provided, which element is inserted in the mixing chamber 2 and acts at least on the material flow F.
  • the turbulence- inducing element 6 can be connected in an irremovable manner to the mixing chamber 2 or it can be provided with a rotational and/or translational movement relative to said mixing chamber 2; at all events, irrespective of the structure or type of the turbulence-inducing element 6, it is useful to the aims of the present invention the fact that this device is adapted to impart a predetermined deforming state that is obtained by applying shearing stresses and/or speed and/or direction and/or acceleration variations to the material flow F.
  • the turbulence-inducing element 6 can be positioned anywhere; for instance, at least one turbulence- inducing element 6 can be placed between the elongating portion 2b and at least one stratifying portion 2c, so as to amplify the stirring-up effects on the material flow F.
  • said means comprises a predetermined number of pushers 4a (and in particular one pusher 4a for each portion of the mixing chamber that can be defined as a "stratifying portion") acting by their movements in at least one stratifying portion 2c.
  • the propulsion means can also act in the elongating portion 2b or in both portions 2b and 2c of chamber 2; at all events, pushers 4a can be moved in the different portions of chamber 2 with a reciprocating motion.
  • the propulsion means 4 comprises at least one pair of pushers 4a acting on the mixing chamber 2 in order to impose movement directions that can be alternately inverted to the flow material F and/or the foreign substance X; advantageously, these pushers 4a can be movable in mutual synchronism (and more particularly, they can be synchronised in such a manner that while one of them approaches the elongating portion 2c, the other moves away therefrom and vice versa) .
  • the mutual synchronism between pushers 4c can also be eliminated, and they can move in a substantially autonomous and mutually independent manner; typically, the above described mutual synchronism can be implemented in the "central" steps of the production cycle when the material flow F is required to carry out different "passages" through the elongating portion 2b, while during a discharging step of chamber 2 it may be useful that both pushers 4a would simultaneously approach the elongating portion 2b; likewise, during a charging step of chamber 2, both pushers 4a could usefully carry out a simultaneous moving-apart movement.
  • the separation efficiency already achieved between mixture M (under preparation) and the foreign substance X (be it residual air or any other substance the presence of which is undesirable in the final product) can be further increased by means of a purification assembly 7 adapted to eliminate the foreign substance X from the mixing chamber 2 and/or the material flow F; it is to be pointed out that the purification or suction unit 7 is not only able to eliminate the foreign substance X that has carried out a spontaneous separation from the mixture M being formed, but is also capable of promoting egress and separation of the foreign substance X that remains entrapped into the material flow F; this removal mechanism can be conveniently based on different chemical or physical principles, depending on the nature and/or the aggregation state of the foreign substance X.
  • this purification assembly 7 is advantageously adapted to create a predetermined (partial or full) vacuum degree in the mixing chamber; in this manner, not only the foreign substance X already accumulated in the "vent portion" is eliminated due to a pneumatic effect, but all possible micro-bubbles of air and/or gas entrapped in the material flow F are forced to expand and burst due to the difference in the static pressure that is formed around each "entrapped" micro-bubble, which will give rise to release of the foreign substance X that is sucked by the purification assembly 7.
  • the purification assembly 7 is preferably connected to at least one access port 3 and can be typically connected to the vent portion of the mixing chamber 2 in such a manner that it will act in that part of chamber 2 where accumulation of the foreign substance X already spontaneously separated from the material flow F during the operating cycle of mixer 1 is more likely to occur.
  • the purification assembly 7 utilising different principles; for instance, for eliminating magnetically permeable metal slags the purification assembly can comprise a series of magnetically active elements attracting these slags towards the outside of chamber 2, or for eliminating electrostatic charges the purification assembly can apply suitable electric fields and provide appropriate "earthing" circuits.
  • the mixing chamber 2 comprises different portions that in turn are defined by volumes fixed over time; however, always within the scope of the present invention, a mixer can be also defined in which the mixing chamber 2 comprises at least one portion (that could be an elongating portion and/or a stratifying portion, or yet the collecting portion and/or the vent portion) having a shape and/or volume varying over time.
  • a turbulence-inducing element 6 can be present which is slidable relative to the operating axis 2a; this turbulence-inducing element 6 therefore divides the overall volume of chamber 2 into at least one, and preferably two, stratifying portions 2c corresponding to the chamber parts disposed upstream or downstream of said element 6, while the elongating portion 2b is represented by, or at all events comprises, the inner passage section formed in the turbulence-inducing element 6 itself.
  • actuating means 6a for instance, electromagnetic actuating means like those shown in Fig. 18, where a solenoid is placed externally around the mixing chamber 2 and by creation of a variable magnetic field moves the turbulence-inducing element 6 made of a magnetically permeable material
  • actuating means 6a for instance, electromagnetic actuating means like those shown in Fig. 18, where a solenoid is placed externally around the mixing chamber 2 and by creation of a variable magnetic field moves the turbulence-inducing element 6 made of a magnetically permeable material
  • the step of defining the material flow F comprises a sub-step of inducing an elongating deformation in the material flow F, and a subsequent sub-step of determining a multi-layer accumulation of the material flow F itself.
  • mixture M obtained by the method of the invention be a gel or similar colloidal solution or dispersion containing hyaluronic acid for medical use, or more generally at least one polysaccharide to be used in the branch of the so- called "tissue engineering" or at all events in the pharmaceutical/medical field.
  • the latter further comprises a step of spontaneously separating the material flow F and/or mixture M from a foreign substance X; this separating step in turn comprises a sub-step of spontaneously separating mixture M and/or the material flow F from the foreign substance X by effect of the force of gravity or more generally by effect of the different densities of mixture M and/or of the substances to be mixed, as compared with the density of the foreign substance X.
  • the foreign substance X can be confined in a vent portion of the mixing chamber, and said foreign substance X can be subsequently discharged from the vent portion itself.
  • the operating steps illustrated above can be carried out by alternate, synchronised or autonomous, movements of at least one pusher and preferably with synchronised or autonomous alternate movements of two or more pushers exerting pumping and/or suction actions in the mixing chamber.
  • a step of separating a foreign substance X entrapped in mixture M or in the material flow F can be carried out; this step of releasing the entrapped foreign substance X is put into practice by the above described purification assembly.
  • the present method can give rise to an operating cycle essentially consisting of the following steps:
  • this discharging step may take place simultaneously with the step of compressing the first substance Sl, as shown in Fig. 5 or in Fig. 13.
  • the method and the production cycle in accordance with the invention can be put into practice by a mixer 1 having one or more of the features included in those hereinbefore described and/or hereinafter claimed.
  • the invention enables important advantages to be achieved.
  • the present mixer has the advantage, strictly correlated with the above listed one, of enabling highly homogeneous mixtures to be obtained that are also characterised by a high density.
  • the present mixer allows a greatly efficient discharge of the mixing chamber to be achieved, thanks to which the obtained mixture M can be collected with the greatest accuracy, and when mixture M is drawn off the mixing chamber the occurrence of contaminations is avoided.
  • the present mixer is able to implement particularly efficient production cycles, due to its structural and functional features allowing quick charging of the substances to be mixed, a mixing action as quick as the charging operation and a quick and practical step of preliminary preparation before starting a new production cycle.
  • the present invention allows accomplishment of the machine being the subject matter of the invention itself with a high degree of reliability and repeatability and high operating flexibility, both in terms of substances that can be treated and of volumes of mixture M that can be produced, all that combined with low costs for production, validation of the process, cleaning/servicing and sale.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Confectionery (AREA)

Abstract

L'invention concerne un mélangeur comportant une chambre (2) de mélange, des orifices (3) d'accès prévu pour donner accès à la chambre de mélange et un moyen (4) de propulsion agissant sur la chambre de mélange pour déplacer un mélange M ou au moins deux substances appelées à y être mélangées ; la chambre de mélange s'étend le long d'un axe (2a) de fonctionnement et comporte une partie (2b) d'allongement prévue pour appliquer une déformation d'étirement, dans la direction de l'axe de fonctionnement le long duquel s'étend la chambre de mélange proprement dite, à un écoulement F de matière disposé à l'intérieur de la chambre de mélange, et au moins une partie (2c) de stratification reliée sans rupture à la partie d'allongement et prévue pour définir intérieurement une accumulation multicouches de l'écoulement F de matière sortant de la partie d'allongement.
PCT/IB2009/055330 2009-01-29 2009-11-25 Dispositif de mélange et procédé associé pour mélanger ou émulsifier au moins deux substances WO2010086698A1 (fr)

Applications Claiming Priority (2)

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IT000102A ITMI20090102A1 (it) 2009-01-29 2009-01-29 Miscelatore
ITMI2009A000102 2009-01-29

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WO2010086698A1 true WO2010086698A1 (fr) 2010-08-05

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046359A1 (fr) * 2016-01-05 2017-07-07 Ac&B Procede et dispositif pour la fabrication d'un produit personnalise par melange avec capsules
FR3046358A1 (fr) * 2016-01-05 2017-07-07 Ac&B Procede et dispositif pour le melange de composants pour la fabrication d'un produit personnalise

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EP0266058A2 (fr) * 1986-09-29 1988-05-04 Collagen Corporation Dispositif et méthode pour effectuer le mélange collagène/minéral
JPH06170198A (ja) * 1992-12-02 1994-06-21 Sumitomo Metal Mining Co Ltd ペースト混合装置
EP1338332A1 (fr) * 2002-02-20 2003-08-27 Mitsubishi Materials Corporation Appareil de pétrissage et procédé pour le pétrissage
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US20070269355A1 (en) * 2004-04-30 2007-11-22 Mats Malmqvist Closed Reaction Vessel System
US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
US20080212399A1 (en) * 2005-05-24 2008-09-04 Mihra Pharmaceuticals Double-Chamber Mixing Device For Viscous Pharmaceutical Substances
WO2008142234A1 (fr) * 2007-04-05 2008-11-27 Universite Louis Pasteur, U.L.P. Dispositif melangeur modulaire et instrumente pour le melange d'au moins deux matieres visqueuses

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Publication number Priority date Publication date Assignee Title
EP0266058A2 (fr) * 1986-09-29 1988-05-04 Collagen Corporation Dispositif et méthode pour effectuer le mélange collagène/minéral
JPH06170198A (ja) * 1992-12-02 1994-06-21 Sumitomo Metal Mining Co Ltd ペースト混合装置
EP1338332A1 (fr) * 2002-02-20 2003-08-27 Mitsubishi Materials Corporation Appareil de pétrissage et procédé pour le pétrissage
US20070269355A1 (en) * 2004-04-30 2007-11-22 Mats Malmqvist Closed Reaction Vessel System
US20050270897A1 (en) * 2004-06-02 2005-12-08 Mccoy William Method and apparatus for compounding medications
US20080212399A1 (en) * 2005-05-24 2008-09-04 Mihra Pharmaceuticals Double-Chamber Mixing Device For Viscous Pharmaceutical Substances
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
WO2008142234A1 (fr) * 2007-04-05 2008-11-27 Universite Louis Pasteur, U.L.P. Dispositif melangeur modulaire et instrumente pour le melange d'au moins deux matieres visqueuses

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046359A1 (fr) * 2016-01-05 2017-07-07 Ac&B Procede et dispositif pour la fabrication d'un produit personnalise par melange avec capsules
FR3046358A1 (fr) * 2016-01-05 2017-07-07 Ac&B Procede et dispositif pour le melange de composants pour la fabrication d'un produit personnalise
WO2017118802A1 (fr) * 2016-01-05 2017-07-13 Ac&B Sas Procede et dispositif pour la fabrication d'un produit personnalise par melange avec capsules
WO2017118799A1 (fr) * 2016-01-05 2017-07-13 Ac&B Sas Procédé et dispositif pour le mélange de composants pour la fabrication d'un produit personnalisé
CN108472607A (zh) * 2016-01-05 2018-08-31 Ac&B联合股份公司 混合用于制造定制产品的组分的方法和装置
JP2019503862A (ja) * 2016-01-05 2019-02-14 エーシー＆ビー エスエーエス カスタマイズされた製品を製造するための成分を混合するための方法および装置
JP2022050393A (ja) * 2016-01-05 2022-03-30 エーシー＆ビー エスエーエス カスタマイズされた製品を製造するための成分を混合するための方法および装置
US11318428B2 (en) 2016-01-05 2022-05-03 L'oreal (Sas) Method and device for mixing components for manufacturing a customised product
JP7316696B2 (ja) 2016-01-05 2023-07-28 エーシー＆ビー エスエーエス カスタマイズされた製品を製造するための成分を混合するための方法および装置

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