WO2010083404A3 - Linked myc-max small molecule inhibitors - Google Patents

Linked myc-max small molecule inhibitors Download PDF

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Publication number
WO2010083404A3
WO2010083404A3 PCT/US2010/021183 US2010021183W WO2010083404A3 WO 2010083404 A3 WO2010083404 A3 WO 2010083404A3 US 2010021183 W US2010021183 W US 2010021183W WO 2010083404 A3 WO2010083404 A3 WO 2010083404A3
Authority
WO
WIPO (PCT)
Prior art keywords
myc
small molecule
molecule inhibitors
max
cell
Prior art date
Application number
PCT/US2010/021183
Other languages
French (fr)
Other versions
WO2010083404A2 (en
Inventor
Steven Metallo
Edward Prochownik
Ariele Viacava Follis
Original Assignee
University Of Pittsburgh-Of The Commonwealth System Of Higher Education
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Pittsburgh-Of The Commonwealth System Of Higher Education, Georgetown University filed Critical University Of Pittsburgh-Of The Commonwealth System Of Higher Education
Priority to US13/144,674 priority Critical patent/US8637556B2/en
Publication of WO2010083404A2 publication Critical patent/WO2010083404A2/en
Publication of WO2010083404A3 publication Critical patent/WO2010083404A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
PCT/US2010/021183 2009-01-16 2010-01-15 Linked myc-max small molecule inhibitors WO2010083404A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/144,674 US8637556B2 (en) 2009-01-16 2010-01-15 Linked Myc-max small molecule inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20520809P 2009-01-16 2009-01-16
US61/205,208 2009-01-16

Publications (2)

Publication Number Publication Date
WO2010083404A2 WO2010083404A2 (en) 2010-07-22
WO2010083404A3 true WO2010083404A3 (en) 2010-11-04

Family

ID=42340303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/021183 WO2010083404A2 (en) 2009-01-16 2010-01-15 Linked myc-max small molecule inhibitors

Country Status (2)

Country Link
US (1) US8637556B2 (en)
WO (1) WO2010083404A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396764B1 (en) 2011-11-02 2013-12-19 Universidad Autónoma de Madrid P38 INHIBITING DRUGS AND APPLICATIONS.
US9242944B2 (en) 2013-03-27 2016-01-26 University Of Maryland, Baltimore Potent analogues of the C-Myc inhibitor 10074-G5 with improved cell permeability
CN113149930B (en) * 2021-04-16 2022-09-02 天津大学 Cell sugar transport channel inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026343B2 (en) * 2002-06-12 2006-04-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Pharmacologic inhibition of Myc function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7872027B2 (en) 2006-02-17 2011-01-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Low molecular weight Myc-max inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026343B2 (en) * 2002-06-12 2006-04-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Pharmacologic inhibition of Myc function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIAOYING YIN ET AL.: "Low molecular weight inhibitors of Myc-Max interaction and function", ONCOGENE, vol. 22, no. 40, 2003, pages 6151 - 6159, XP002995346, DOI: doi:10.1038/sj.onc.1206641 *

Also Published As

Publication number Publication date
US8637556B2 (en) 2014-01-28
US20120015989A1 (en) 2012-01-19
WO2010083404A2 (en) 2010-07-22

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