WO2010080414A3 - Substituted fno (2-[furan-2-yl] naphthalen-1-ol) derivatives as anti-cancer agents - Google Patents

Substituted fno (2-[furan-2-yl] naphthalen-1-ol) derivatives as anti-cancer agents Download PDF

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Publication number
WO2010080414A3
WO2010080414A3 PCT/US2009/068163 US2009068163W WO2010080414A3 WO 2010080414 A3 WO2010080414 A3 WO 2010080414A3 US 2009068163 W US2009068163 W US 2009068163W WO 2010080414 A3 WO2010080414 A3 WO 2010080414A3
Authority
WO
WIPO (PCT)
Prior art keywords
fno
naphthalen
furan
derivatives
substituted
Prior art date
Application number
PCT/US2009/068163
Other languages
French (fr)
Other versions
WO2010080414A2 (en
Inventor
Kuo-Hsiung Lee
Yizhou Dong
Qian Shi
Kenneth F. Bastow
Original Assignee
The University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of North Carolina At Chapel Hill filed Critical The University Of North Carolina At Chapel Hill
Publication of WO2010080414A2 publication Critical patent/WO2010080414A2/en
Publication of WO2010080414A3 publication Critical patent/WO2010080414A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of Formulas I are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
PCT/US2009/068163 2008-12-19 2009-12-16 Substituted fno (2-[furan-2-yl] naphthalen-1-ol) derivatives as anti-cancer agents WO2010080414A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13920808P 2008-12-19 2008-12-19
US61/139,208 2008-12-19

Publications (2)

Publication Number Publication Date
WO2010080414A2 WO2010080414A2 (en) 2010-07-15
WO2010080414A3 true WO2010080414A3 (en) 2010-11-04

Family

ID=42317059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/068163 WO2010080414A2 (en) 2008-12-19 2009-12-16 Substituted fno (2-[furan-2-yl] naphthalen-1-ol) derivatives as anti-cancer agents

Country Status (1)

Country Link
WO (1) WO2010080414A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013014681A2 (en) 2010-12-16 2016-10-04 N30 Pharmaceuticals Inc new substituted bicyclic aromatic compounds as s-nitrosoglutathione reductase inhibitors
CN103588739A (en) * 2011-03-25 2014-02-19 上海长恒生物医药科技有限公司 Nitrofurans compounds, preparation method and application of nitrofurans compounds
WO2014138357A1 (en) * 2013-03-06 2014-09-12 The University Of Akron Novel tashinone drugs for alzheimer disease
CN103992332B (en) * 2014-06-06 2016-01-13 广西师范大学 Prepare the method for furans [3,2-C] coumarin compound
CN106243071A (en) * 2016-07-15 2016-12-21 中国人民解放军第四军医大学 New derivatives of tanshinone IIA and its preparation method and application
CN112573999B (en) * 2019-09-29 2022-09-02 中国海洋大学 Preparation method of 3-chlorogentitol

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250751A1 (en) * 2004-03-10 2005-11-10 Kuo-Hsiung Lee Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250751A1 (en) * 2004-03-10 2005-11-10 Kuo-Hsiung Lee Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases

Also Published As

Publication number Publication date
WO2010080414A2 (en) 2010-07-15

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