WO2010074915A3 - Evaporation mitigation for slide staining apparatus - Google Patents

Evaporation mitigation for slide staining apparatus Download PDF

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Publication number
WO2010074915A3
WO2010074915A3 PCT/US2009/066568 US2009066568W WO2010074915A3 WO 2010074915 A3 WO2010074915 A3 WO 2010074915A3 US 2009066568 W US2009066568 W US 2009066568W WO 2010074915 A3 WO2010074915 A3 WO 2010074915A3
Authority
WO
WIPO (PCT)
Prior art keywords
slide
conduit
fluid
reservoir
capillary gap
Prior art date
Application number
PCT/US2009/066568
Other languages
French (fr)
Other versions
WO2010074915A2 (en
Inventor
Brian H. Kram
Original Assignee
Ventana Medical Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems, Inc. filed Critical Ventana Medical Systems, Inc.
Publication of WO2010074915A2 publication Critical patent/WO2010074915A2/en
Publication of WO2010074915A3 publication Critical patent/WO2010074915A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

A device for mitigating evaporation of treatment liquids from a sample on a substrate can include a solvent reservoir and a conduit. A slide with a sample on a surface thereof can be placed into a device, creating a capillary gap between the slide surface and a surface of the device. Treatment fluids can be dispensed and drawn into the capillary gap, such as by capillary action. The slide and/or the reservoir can be moved towards the conduit, such that the fluid in the capillary gap contacts a fluid meniscus formed in the conduit. In this manner, fluid lost to evaporation from the capillary gap can be replenished by fluid in the conduit and reservoir, via capillary action. The slide and/or reservoir can then be moved again to break contact with the conduit, and the fluid within the capillary gap can then be mixed, such as by rocking the slide.
PCT/US2009/066568 2008-12-23 2009-12-03 Evaporation mitigation for slide staining apparatus WO2010074915A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14025908P 2008-12-23 2008-12-23
US61/140,259 2008-12-23

Publications (2)

Publication Number Publication Date
WO2010074915A2 WO2010074915A2 (en) 2010-07-01
WO2010074915A3 true WO2010074915A3 (en) 2010-09-16

Family

ID=42288359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/066568 WO2010074915A2 (en) 2008-12-23 2009-12-03 Evaporation mitigation for slide staining apparatus

Country Status (1)

Country Link
WO (1) WO2010074915A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10509216B2 (en) 2012-12-26 2019-12-17 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
CA2851101C (en) 2010-10-06 2017-02-14 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
US8454908B2 (en) * 2010-11-10 2013-06-04 Constitution Medical, Inc. Automated systems and methods for preparing biological specimens for examination
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US20130137136A1 (en) * 2011-11-30 2013-05-30 Dako Denmark A/S Method and system for automated deparaffinization and non-immunohistochemical special staining of tissue samples
KR101816372B1 (en) * 2012-12-26 2018-01-08 벤타나 메디컬 시스템즈, 인코포레이티드 Specimen processing systems and methods for preparing reagents
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
KR101813344B1 (en) * 2012-12-26 2017-12-28 벤타나 메디컬 시스템즈, 인코포레이티드 Specimen processing systems and methods for moderating evaporation
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
US10209166B2 (en) 2014-11-18 2019-02-19 Alfonso Heras System and method for processing biological specimens
CN108051270B (en) * 2017-12-29 2023-12-15 杭州依美洛克医学科技有限公司 Discharge device for slide reaction liquid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425918A (en) * 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
US5654199A (en) * 1990-03-02 1997-08-05 Ventana Medical Systems, Inc. Method for rinsing a tissue sample mounted on a slide
WO2006012498A1 (en) * 2004-07-23 2006-02-02 Ventana Medical Systems, Inc. Method and apparatus for applying fluids to a biological sample

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654199A (en) * 1990-03-02 1997-08-05 Ventana Medical Systems, Inc. Method for rinsing a tissue sample mounted on a slide
US5425918A (en) * 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
WO2006012498A1 (en) * 2004-07-23 2006-02-02 Ventana Medical Systems, Inc. Method and apparatus for applying fluids to a biological sample

Also Published As

Publication number Publication date
WO2010074915A2 (en) 2010-07-01

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