WO2010034105A8 - Hepatitis c inhibitor compounds - Google Patents

Hepatitis c inhibitor compounds Download PDF

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Publication number
WO2010034105A8
WO2010034105A8 PCT/CA2009/001237 CA2009001237W WO2010034105A8 WO 2010034105 A8 WO2010034105 A8 WO 2010034105A8 CA 2009001237 W CA2009001237 W CA 2009001237W WO 2010034105 A8 WO2010034105 A8 WO 2010034105A8
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
inhibitor compounds
analogs
compounds
treatment
Prior art date
Application number
PCT/CA2009/001237
Other languages
French (fr)
Other versions
WO2010034105A1 (en
Inventor
Jeffrey O'meara
Josée BORDELEAU
Vida Gorys
Mélissa LEBLANC
Kirsten Lenhardt
Montse Llinas-Brunet
Mathieu Parisien
Marc-André Poupart
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Priority to CA2737958A priority Critical patent/CA2737958A1/en
Priority to EP09815517A priority patent/EP2344487A4/en
Priority to JP2011527161A priority patent/JP2012502925A/en
Publication of WO2010034105A1 publication Critical patent/WO2010034105A1/en
Publication of WO2010034105A8 publication Critical patent/WO2010034105A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds of Formula (I): wherein B, R3, L0, L1, R2, Rc and R1 are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection. In particular, the present invention provides novel peptide analogs, pharmaceutical compositions containing such analogs, and uses of these analogs in the treatment of HCV infection
PCT/CA2009/001237 2008-09-23 2009-09-14 Hepatitis c inhibitor compounds WO2010034105A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2737958A CA2737958A1 (en) 2008-09-23 2009-09-14 Hepatitis c inhibitor compounds
EP09815517A EP2344487A4 (en) 2008-09-23 2009-09-14 Hepatitis c inhibitor compounds
JP2011527161A JP2012502925A (en) 2008-09-23 2009-09-14 Hepatitis C inhibitor compound

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9929208P 2008-09-23 2008-09-23
US61/099,292 2008-09-23
US18663209P 2009-06-12 2009-06-12
US61/186,632 2009-06-12

Publications (2)

Publication Number Publication Date
WO2010034105A1 WO2010034105A1 (en) 2010-04-01
WO2010034105A8 true WO2010034105A8 (en) 2011-01-06

Family

ID=42059237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2009/001237 WO2010034105A1 (en) 2008-09-23 2009-09-14 Hepatitis c inhibitor compounds

Country Status (6)

Country Link
EP (1) EP2344487A4 (en)
JP (1) JP2012502925A (en)
AR (1) AR073659A1 (en)
CA (1) CA2737958A1 (en)
TW (1) TW201016694A (en)
WO (1) WO2010034105A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32099A (en) 2008-09-11 2010-04-30 Enanta Pharm Inc HEPATITIS C SERINA PROTEASAS MACROCYCLIC INHIBITORS
JP2012505897A (en) * 2008-10-15 2012-03-08 インターミューン・インコーポレーテッド Antiviral peptide for treatment
CN103534256B (en) 2010-12-30 2016-08-10 益安药业 Macrocyclic hepatitis c serine protease inhibitors
PE20140039A1 (en) 2010-12-30 2014-03-01 Enanta Pharm Inc HEPATITIS C SERINE PROTEASE INHIBITORS BASED ON Phenanthridine Macrocyclics
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
LT2909205T (en) 2012-10-19 2016-12-27 Bristol-Myers Squibb Company 9-methyl substituted hexadecahydrocyclopropa(e)pyrrolo(1,2-a)(1,4)diazacyclopentadecinyl carbamate derivatives as non-structural 3 (ns3) protease inhibitors for the treatment of hepatitis c virus infections
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914598B1 (en) 2012-11-02 2017-10-18 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2370396A1 (en) * 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
EA009295B1 (en) * 2003-05-21 2007-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Hepatitis c inhibitor compounds
US7514557B2 (en) * 2004-05-25 2009-04-07 Boehringer Ingelheim International Gmbh Process for preparing acyclic HCV protease inhibitors
WO2006000085A1 (en) * 2004-06-28 2006-01-05 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
KR101596524B1 (en) * 2007-06-29 2016-02-22 길리애드 사이언시즈, 인코포레이티드 Antiviral compound
EA200971074A1 (en) * 2007-06-29 2010-08-30 Джилид Сайэнс, Инк. ANTI-VIRUS CONNECTIONS
JP5529036B2 (en) * 2007-12-05 2014-06-25 エナンタ ファーマシューティカルズ インコーポレイテッド Fluorinated tripeptide HCV serine protease inhibitor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors

Also Published As

Publication number Publication date
CA2737958A1 (en) 2010-04-01
WO2010034105A1 (en) 2010-04-01
EP2344487A4 (en) 2012-03-21
JP2012502925A (en) 2012-02-02
AR073659A1 (en) 2010-11-24
EP2344487A1 (en) 2011-07-20
TW201016694A (en) 2010-05-01

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