WO2010032899A3 - Eno1-specific human antibody - Google Patents

Eno1-specific human antibody Download PDF

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Publication number
WO2010032899A3
WO2010032899A3 PCT/KR2008/006116 KR2008006116W WO2010032899A3 WO 2010032899 A3 WO2010032899 A3 WO 2010032899A3 KR 2008006116 W KR2008006116 W KR 2008006116W WO 2010032899 A3 WO2010032899 A3 WO 2010032899A3
Authority
WO
WIPO (PCT)
Prior art keywords
human antibody
eno1
specific human
present
cancer
Prior art date
Application number
PCT/KR2008/006116
Other languages
French (fr)
Other versions
WO2010032899A2 (en
Inventor
Young Woo Park
Kwang-Lae Hoe
So-Young Choi
Ji Hyun Park
Eun-Jung Song
Jung Yu
Myung-Ho Sohn
Sungsub Kim
Myeoung Hee Jang
Dong-Jin Kim
Original Assignee
Korea Research Institute Of Bioscience And Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute Of Bioscience And Biotechnology filed Critical Korea Research Institute Of Bioscience And Biotechnology
Publication of WO2010032899A2 publication Critical patent/WO2010032899A2/en
Publication of WO2010032899A3 publication Critical patent/WO2010032899A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to an alpha-endolase (ENO1) -specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to ENO1. The ENO1-specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.
PCT/KR2008/006116 2008-09-22 2008-10-16 Eno1-specific human antibody WO2010032899A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0092736 2008-09-22
KR1020080092736A KR100910962B1 (en) 2008-09-22 2008-09-22 Eno1-specific human antibody

Publications (2)

Publication Number Publication Date
WO2010032899A2 WO2010032899A2 (en) 2010-03-25
WO2010032899A3 true WO2010032899A3 (en) 2010-07-15

Family

ID=41209526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/006116 WO2010032899A2 (en) 2008-09-22 2008-10-16 Eno1-specific human antibody

Country Status (2)

Country Link
KR (1) KR100910962B1 (en)
WO (1) WO2010032899A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI468176B (en) * 2010-01-28 2015-01-11 Univ Taipei Medical Anti-α-enolase i antibodies for diagnosis and treatment of α-enolase i-associated diseases
US8449881B2 (en) * 2010-01-28 2013-05-28 Taipei Medical University Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases
KR102438838B1 (en) * 2013-01-18 2022-09-02 서울대학교산학협력단 A Biomarker for Diagnosing Rheumatoid Arthritis
CN106488932B (en) * 2013-12-20 2020-07-14 财团法人生物技术开发中心 α -enolase-specific antibodies and methods of use thereof in the treatment of cancer
TWI572358B (en) * 2013-12-20 2017-03-01 財團法人生物技術開發中心 Alpha-enolase specific antibodies and methods of use in immune diseases
US9527922B2 (en) * 2014-12-31 2016-12-27 Development Center For Biotechnology Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy
AU2014415566A1 (en) * 2014-12-31 2017-07-20 Develpment Center For Biotechnology Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy
BR112019002258A2 (en) 2016-08-05 2019-05-14 Y-Biologics Inc. pd-1 binding antibody or antigen binding fragment of the antibody, method for producing the same and composition for preventing or treating cancer
CA3171288A1 (en) * 2020-05-11 2021-11-18 Ta-Tung Yuan Drug conjugates containing alpha-enolase antibodies and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58198758A (en) * 1982-05-15 1983-11-18 Amano Pharmaceut Co Ltd Method for determining enolase and diagnosing cancer using it
US20070077583A1 (en) * 2005-09-21 2007-04-05 Aurelium Biopharma, Inc. Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance
US20070172487A1 (en) * 2005-12-30 2007-07-26 Neng-Yao Shih Alpha-enolase specific antibody and method of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58198758A (en) * 1982-05-15 1983-11-18 Amano Pharmaceut Co Ltd Method for determining enolase and diagnosing cancer using it
US20070077583A1 (en) * 2005-09-21 2007-04-05 Aurelium Biopharma, Inc. Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance
US20070172487A1 (en) * 2005-12-30 2007-07-26 Neng-Yao Shih Alpha-enolase specific antibody and method of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDRONICOS, N. M. ET AL.: "The human ENO1 gene product(recombinant human alpha-enolase) displays characteristics required for a plasminogen binding protein", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1337, no. 1, 4 January 1997 (1997-01-04), pages 27 - 39 *

Also Published As

Publication number Publication date
WO2010032899A2 (en) 2010-03-25
KR100910962B1 (en) 2009-08-05

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