WO2010032248A8 - Multifunctional albumin conjugates - Google Patents

Multifunctional albumin conjugates Download PDF

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Publication number
WO2010032248A8
WO2010032248A8 PCT/IL2009/000911 IL2009000911W WO2010032248A8 WO 2010032248 A8 WO2010032248 A8 WO 2010032248A8 IL 2009000911 W IL2009000911 W IL 2009000911W WO 2010032248 A8 WO2010032248 A8 WO 2010032248A8
Authority
WO
WIPO (PCT)
Prior art keywords
multifunctional
albumin conjugates
conjugate
conjugates
albumin
Prior art date
Application number
PCT/IL2009/000911
Other languages
French (fr)
Other versions
WO2010032248A3 (en
WO2010032248A2 (en
Inventor
Michal Neeman
Fortune Kohen
Helena Sheikhet Migalovich
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of WO2010032248A2 publication Critical patent/WO2010032248A2/en
Publication of WO2010032248A8 publication Critical patent/WO2010032248A8/en
Publication of WO2010032248A3 publication Critical patent/WO2010032248A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to conjugates comprising at least one isoflavone derivative bound to albumin and at least one bioactive moiety including a diagnostic agent or a therapeutic agent, the conjugate being capable of delivering the bioactive moiety into a tumor cell. The invention further relates to the use of said conjugate for the diagnosis and treatment of cancer.
PCT/IL2009/000911 2008-09-17 2009-09-17 Multifunctional albumin conjugates WO2010032248A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9755308P 2008-09-17 2008-09-17
US61/097,553 2008-09-17

Publications (3)

Publication Number Publication Date
WO2010032248A2 WO2010032248A2 (en) 2010-03-25
WO2010032248A8 true WO2010032248A8 (en) 2010-06-03
WO2010032248A3 WO2010032248A3 (en) 2010-08-19

Family

ID=41786279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2009/000911 WO2010032248A2 (en) 2008-09-17 2009-09-17 Multifunctional albumin conjugates

Country Status (1)

Country Link
WO (1) WO2010032248A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2798209A1 (en) * 2010-04-23 2011-10-27 Kineta, Inc. Anti-viral compounds
EP2918273B1 (en) 2011-02-25 2016-12-21 Kineta, Inc. Methods and cells for identifying rig-i pathway regulators
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
US11285227B2 (en) 2017-04-05 2022-03-29 Cornell University Trifunctional constructs with tunablepharmacokinetics useful in imaging and anti-tumor therapies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL148825A0 (en) * 2002-03-21 2002-09-12 Yeda Res & Dev Derivatives of isoflavones

Also Published As

Publication number Publication date
WO2010032248A3 (en) 2010-08-19
WO2010032248A2 (en) 2010-03-25

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