WO2010031238A1 - 一种解烟毒的过滤物及其制备方法 - Google Patents

一种解烟毒的过滤物及其制备方法 Download PDF

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Publication number
WO2010031238A1
WO2010031238A1 PCT/CN2009/000763 CN2009000763W WO2010031238A1 WO 2010031238 A1 WO2010031238 A1 WO 2010031238A1 CN 2009000763 W CN2009000763 W CN 2009000763W WO 2010031238 A1 WO2010031238 A1 WO 2010031238A1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
tea
mouthpiece
core
nicotine
Prior art date
Application number
PCT/CN2009/000763
Other languages
English (en)
French (fr)
Inventor
梁永林
赵保路
陶然
梁兴一
Original Assignee
Liang Yonglin
Zhao Baolu
Tao Ran
Liang Xingyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNA2008101402336A external-priority patent/CN101361596A/zh
Priority claimed from CNA2008101601151A external-priority patent/CN101444336A/zh
Priority claimed from CNA2009100136231A external-priority patent/CN101455444A/zh
Priority claimed from CN200910019990A external-priority patent/CN101843365A/zh
Priority to CA2740530A priority Critical patent/CA2740530C/en
Priority to JP2011527180A priority patent/JP2012502637A/ja
Application filed by Liang Yonglin, Zhao Baolu, Tao Ran, Liang Xingyi filed Critical Liang Yonglin
Priority to ES09813959.5T priority patent/ES2676540T3/es
Priority to BRPI0918660-3A priority patent/BRPI0918660B1/pt
Priority to US13/119,237 priority patent/US9861124B2/en
Priority to UAA201104624A priority patent/UA100919C2/ru
Priority to RU2011115135A priority patent/RU2613018C2/ru
Priority to EP09813959.5A priority patent/EP2338360B1/en
Publication of WO2010031238A1 publication Critical patent/WO2010031238A1/zh
Priority to LTEP19151824.0T priority patent/LT3511330T/lt

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
    • A24D3/06—Use of materials for tobacco smoke filters
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
    • A24D3/02—Manufacture of tobacco smoke filters
    • A24D3/0204—Preliminary operations before the filter rod forming process, e.g. crimping, blooming
    • A24D3/0212—Applying additives to filter materials
    • A24D3/0225—Applying additives to filter materials with solid additives, e.g. incorporation of a granular product
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
    • A24D3/02—Manufacture of tobacco smoke filters
    • A24D3/0229—Filter rod forming processes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
    • A24D3/02—Manufacture of tobacco smoke filters
    • A24D3/0275—Manufacture of tobacco smoke filters for filters with special features
    • A24D3/0287—Manufacture of tobacco smoke filters for filters with special features for composite filters
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
    • A24D3/06—Use of materials for tobacco smoke filters
    • A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to a filter rod and a cigarette holder without dependence, smoldering and harm reduction and a preparation method thereof. Background technique
  • Smoking can play a role in regulating mood in some people, but smoking is harmful to health has become a social consensus.
  • the World Health Organization lists tobacco hazard as one of the most important hazards to human health. Because of the addictive nature of cigarettes, some consumers who want to regulate their physiology through smoking are unfortunately infected with cigarettes, and it is difficult to completely quit by their own efforts. Long-term smoking has increased the risk of cancer, cardiovascular diseases, respiratory diseases, etc.
  • the social health care system resources have been squeezed by smoking for a long time, which puts an extra burden on society and families. Many families suffering from cancer and other diseases are in economic difficulties. Smoking is more harmful to health than any other disease. It has become a major public health problem facing humanity. Smoking has become an unavoidable part of the international community and the rest of the world. Social development process.
  • Filter rods and cigarette holders are important tools for reducing harmful substances in cigarette smoke.
  • the so-called filter rods are usually made of a filter material and a plasticizer, which is rolled from a paper.
  • a filter rod can be cut into two, four or six filters.
  • the filter attached to the cigarette is called a filter.
  • the filter material is a substance that is filled in the filter rod to play a main filtering role, such as traditional vinegar fiber. Tow.
  • the so-called cigarette holder is generally used in the art as a tool that can insert one end of a cigarette while smoking and a cigarette at the other end.
  • the mouthpieces that people are in contact with are generally filter cigarette holders, that is, using physical and chemical principles, to filter the smoke tar so that The smoke in the mouth is more mellow, and the harm to the human body is greatly reduced.
  • cigarette holders that is, using physical and chemical principles, to filter the smoke tar so that The smoke in the mouth is more mellow, and the harm to the human body is greatly reduced.
  • people's health awareness has gradually strengthened, and traditional cigarette holders have been unable to meet the development of the times.
  • Tobacco consumers must increase the amount and depth of smoking to compensate for the physiological dependence on cigarettes, which poses a major hidden danger to the health and safety of tobacco consumers.
  • the increase in diseases caused by smoking caused by tobacco consumers is attracting the attention of international organizations and governments.
  • the situation in the tobacco industry is becoming more and more serious.
  • the economic security of tobacco is turning to political security.
  • the legal risks of tobacco are increasing year by year, changing the current filter only.
  • the historical situation of palliative treatment is imminent.
  • activated carbon and vinegar filament bundles are used as a filter rod filter material to reduce damage and filter additives, and some health-conscious tobacco consumers seek to use multiple independent filter rods and mouthpiece applications. In this way, the quality of cigarettes is reduced and the damage is reduced.
  • the use of independent cigarette holders has been flashy, and the price is high and the effect is low, which still cannot meet the development needs of society and the market.
  • the composite filter rod and the mouthpiece can improve the filtration effect, the accuracy of the filter additive is uncontrollable and does not achieve the desired effect.
  • the invention discloses a filter rod and a cigarette holder which are non-dependent, smoldering and harmless, and a preparation method thereof, so that the smoker does not produce any psychological and physiological discomfort, and gradually achieves smog addiction and no dependence on tobacco. , liberated from the dangers of tobacco. Summary of the invention
  • the invention aims to provide a non-dependent, smoldering and harmless filter (including a filter for a filter rod and a cigarette holder) which is novel in method, remarkable in effect, economical and safe, and is beneficial to social civilization and human health, and a preparation method thereof. And the filter is used to regulate physiological smoking use.
  • the filter and the preparation method thereof are scientific and easy to apply. Compared with cigarettes and nicotine substitutes, the filter has a good taste, a unique style, an anxiolytic effect, and has the dual effects of calming and regulating, and does not produce a spirit and a smoker. Physiological dependence.
  • the invention also provides a non-dependent, smoldering-reducing filter for regulating physiological smoking use, and can include any combination or any one of the active ingredients and/or additives according to different needs, and cater for diversification. The market needs.
  • the filter of the present invention is for example included in a mouthpiece or filter rod, for example as a filler in place of a conventional vinegar filament bundle for use in a filter rod, or as part of a mouthpiece or as a whole mouthpiece.
  • the filler used in the filter rod of the present invention refers to a functional material used to fill the filter paper of the filter rod to form a filter rod and to function as a filter.
  • the active ingredient refers to any compound used, for example, in a filter of a mouthpiece or filter rod to aid in the harm reduction of cockroaches, particularly including, for example, Y-aminobutyric acid, tea Amino acid, tryptophan, glutamic acid or tea alkaloids.
  • the active ingredient is one or more selected from the group consisting of Y-aminobutyric acid, theanine, tryptophan, glutamic acid, and tea alkaloid.
  • the active ingredient itself may be used as it is, for example, using an active ingredient such as pure theanine or glutamic acid; or an extract containing the active ingredient, such as a tea extract; or Natural or synthetic materials containing the ingredients are used directly.
  • an active material comprising one or more of the active ingredients is used in a filter such as a mouthpiece or filter plug to introduce the one or more active ingredients.
  • the active material can be natural or synthetic.
  • the active material is any natural or commercial product used in a filter such as a mouthpiece or filter rod to aid in the mitigation of smog, particularly including, for example, tea powder, tea granules. Or a tea leaf sheet, the active material containing one or more of the active ingredients of the present invention.
  • the active material is a tea powder, tea granules or tea leaf flakes.
  • the filter of the present invention may further contain additives other than the active ingredient to further contribute to the harm reduction of smog.
  • the additive of the present invention is selected from the group consisting of bupropion, varenicline, varenicline, rimonabant, dihydrotricin, dopamine, mecamylamine, cytisine, 3-nonylaminoisoindole One or a combination of any of alkane, baclofen, clonidine, and butyrate.
  • the active material such as tea powder, tea leaf flakes and tea granules
  • the active material is heated by aeration or soaked with an appropriate amount of water to cause the organic matter of the tea to ooze out, especially the dissolution rate of the active ingredient from the cell wall is increased, thereby improving the smoky addiction effect.
  • a part of the fiber is added by the adhesion and water resistance of the exuded organic substance, and the tea powder, the tea leaf and the tea granule are produced according to the following process conditions, respectively.
  • the tea leaf flake generally refers to a tea form having a specific gravity of 25-55 g/m 2 and a width of 180-380 mm, and preferably has a water content of 5-8 wt%, a wrinkle pitch of 0.8-1.8 mm, and more preferably a specific gravity of about 40 g/m 2 . , width is about 205 mm.
  • the tea granules are in the form of tea leaves having a particle size of from 0.01 to 0,08 mm or, in certain cases, even greater than 0.08 mm, and preferably have a moisture content of from 5 to 8% by weight.
  • Tea powder generally refers to the form of tea leaves having a particle size of less than about 0.01 mm. Within this range, the filter rod can be made to not shrink and not collapse.
  • the active material is directly contained in the filtrate.
  • the present invention provides a core, characterized in that the core included in the core refers to a filter comprising the package and the package comprising the active ingredient itself and/or the active material. Assembly.
  • the non-dependent, smoky addiction to the smoke filter One or more of the additives may also be contained in the core.
  • the core of the non-dependent, smoky addiction toxic filter contains tea powder, tea granules or tea leaf flakes.
  • the tea used to prepare the tea powder, tea granules or tea leaf flakes may be tea containing any one or more of the active ingredients of the present invention.
  • the core can be used in both the mouthpiece and the filter rod.
  • a cartridge in a mouthpiece is that it is easy to install and replace.
  • the use of a spring core in a mouthpiece or filter rod may provide additional technical benefits with the particular construction of the core.
  • a particular core internal structure can be designed to allow the gas to pass through the core more fully with the active material.
  • Electronic components may also be incorporated in the core to facilitate the functioning of the active material, such as by heating; and/or to monitor the consumption of the active material to indicate exhaustion or replacement.
  • the present invention also provides a process for the preparation of the non-dependent, smoky addiction toxic filter, characterized in that the active ingredient and/or the active material of the invention are added to the filter.
  • a method of continuously feeding a filler such as a vinegar tow and a wrapping paper to wrap the filler to form a filter rod
  • the present invention particularly adopts a vertical type.
  • a method of filling a pre-formed wrapper in the form of a cylinder with a filler to form a filter plug may include, for example, inserting a filler into the tip end in a cylinder that is pre-formed and placed upright or in a plurality of cylinders arranged side by side.
  • a section of active material may be inserted first in the production process, a length of tow and corrugated paper may be injected, then a section of active material may be inserted, a length of tow and corrugated paper may be injected, and finally the active material may be inserted.
  • the active material may be inserted in the last paragraph, and in accordance with the foregoing process, produce all the second, all four or all six non-dependent, smoky addiction smoke filters.
  • the present invention also provides the active ingredient, active material and/or additive, such as the active ingredient contained in the filtrate of the present invention, using the non-dependent, smoky addiction toxic filter of the present invention, Use of an active material and/or an additive for regulating an physiology, an additive for inhibiting nicotine receptors to reduce smoking, characterized in that the active ingredient, active material and/or additive are used in the present invention to pass through the respiratory tract together with cigarette smoke absorb.
  • the active ingredient, active material and/or additive according to the invention can also be added directly to the cut tobacco so that the active ingredient and/or the additive ingredient are taken together with the cigarette smoke. It can also be added in the production of tobacco sheets, as well as in the application of chewing tobacco and snuff. In addition, it can also be added to alternatives to non-traditional cigarettes, mixed with non-cut tobacco materials.
  • Figure 1 shows a schematic diagram of the structure of a filter plug containing a filter. Among them: 1 full active ingredient and / or active material (I) filter rod; 2 active ingredient / or composite filter rod of active material and conventional vinegar fibril bundle ( II ).
  • Figure 2 shows a schematic view of the structure of the mouthpiece of the filter. Among them, 15 times use the cigarette holder; 2 1 use the cigarette holder.
  • Figure 3 shows a schematic view of the structure of the core in the form of a mouthpiece containing the filter.
  • 1 plastic core 2 vortex core, 6 vortex openings at the bottom of the core, vortex forward in the core when the airflow passes, increasing the contact chance of active substances in the airflow zone.
  • Active ingredient and / or active material (I) conventional vinegar fiber tow (11).
  • Figure 4 shows a schematic diagram of a vertical filter rod production unit for the filtrate.
  • Figure 5 shows the effect of glutamate and theanine on nicotine dependence in mice. 1, control; 2, nicotine; 3, nicotine + tea polyphenols; 4, nicotine + caffeine; 5: nicotine + low concentration of glutamic acid, theanine; 6, nicotine + high concentration of glutamic acid, theanine . #P ⁇ 0.01 compared with the control, *P ⁇ 0.05 compared with nicotine.
  • Figures 6A and B show the effects of daily average smoking (support) on volunteers who do not rely on smog addiction to reduce tea filter sticks and cigarette holders.
  • A The average number of cigarettes in the tea filter group;
  • B The tea filter group The proportion of smoking decreased; 1. Before using the tea filter cigarette; 2-9, 1-8 weeks after taking the tea filter cigarette.
  • Figure 7A-E shows the effect of glutamate, theanine (No. 1) on mouse nicotine dependence (A) and nicotine-induced nicotine receptor expression in the brain.
  • B ⁇ ventral cover area
  • C C1: forebrain cortex
  • D D1: marginal nucleus
  • E El: SY5Y. 1, control; 2, nicotine; 3, nicotine + tea polyphenols; 4, nicotine + caffeine
  • 5 nicotine + low concentration of glutamic acid, theanine
  • 7 Nicotine receptor inhibitors.
  • Figures 8A-D show the effect of glutamate, theanine (No. 1) on mouse nicotine-induced brain c-fos expression.
  • Figure 9 Effect of theanine on the release of tyrosine hydroxylase receptor-expressing dopamine in the ventral tegmental area of mice induced by nicotine.
  • Figure 10 shows the effects of glutamate and theanine on the glucose metabolism activities of mouse nicotine-induced brain regions (A) and SY5Y cells (B). * Compared with the control PO.01, # compared with nicotine P ⁇ 0,05.
  • Figure 11 shows the effect of tea filter plugs on the pathological changes of lung tissue in rats caused by smoking.
  • the active ingredients of tea leaves have the functions of 'strong heart, diuretic, excitatory central nervous system, and have anti-fatigue and detoxification effects. It has a calming nerve, an anxiolytic effect, and has the function of dilating blood vessels and improving memory. It has the effects of inhibiting nerve excitability and improving sleep, and promotes brain function and nerve growth, thereby increasing memory and learning function.
  • Tea powder, tea flakes, and tea granules have the function of adsorbing smoke odor and adding aroma.
  • the active ingredients in tea have the effect of inhibiting the invasion of nicotine on the human brain, suppressing the dependence of brain receptors on nicotine, anticonvulsant and anti-anxiety, preventing unpleasant information from being transmitted to the brain, inhibiting the habitual desire of smoking, and Supplementing the low nicotine content of cigarettes due to harm reduction can not meet the physiological strength deficiency, and achieve the effect of replacing nicotine; It has the functions of scavenging free radicals, nitrosamines, benzopyrene, phenols and other harmful substances, and can Nicotine combines to form a non-toxic complex.
  • the filter of the present invention for example, a filter contained in a cigarette holder or a filter rod, when the cigarette is smoked, heat and steam in the cigarette smoke are added to the suction force to volatilize the effective substance in the core. Sublimation, part of which is consuming with smoke and gas shields, and some of them are absorbed as the smoke enters the human lungs, enabling tobacco consumers to effectively get rid of cigarette addiction and smoking, so that tobacco consumers have different choices according to different physiological changes. Smoking has become a possibility, in line with the theoretical principles of Chinese medicine, and embodies the humanized consumption civilization. A cigarette detoxification cigarette holder that can be used to quit smoking has great social significance.
  • the technical process of the cigarette filter rod and the cigarette holder of the invention is scientific and reasonable, and the harm reduction effect is further improved on the basis of the raw material, and the application is strong.
  • the filter rod and the cigarette holder are safe, energy-saving and hygienic, and the cigarette holder is more acceptable, and can increase the high added value of the cigarette.
  • the complexity of the secondary process of the composite filter rod and the high waste and high cost are solved.
  • This cigarette filter stick and cigarette holder cater to the progress of civilization in today's society, and is very suitable for the development direction of modern tobacco.
  • the application of cigarette filter stick and cigarette holder, whether it is a disposable cigarette holder or a multi-purpose cigarette holder, reflects low cost. The advantage of high added value.
  • the filter is made into a filter plug in the form of a bundle of vinegar filaments used in a conventional filter plug.
  • the filter rod can be filled with a separate active material, that is, the active ingredient and/or active material filter I of the present invention is completely replaced by the conventional vinegar filament bundle, as shown in FIG. 1;
  • the filter I of the present invention is used in combination with a filler such as a conventional vinegar tow, for example, the filter of the present invention is alternately filled in sections in the axial direction with the conventional filler 12, as shown in FIG.
  • the filter may be formed as a whole or part of the mouthpiece.
  • the filter of the present invention may be shaped to be suitable for smoking, such as in the form of a truncated pusher I, as shown in Figure 1, such that one end is inserted into the cigarette and the other end is used for smoking, thereby forming the entire filter from a single filter.
  • the mouthpiece can be disposable or it can be used repeatedly.
  • active materials can be used in place of portions and/or components of conventional mouthpieces.
  • the active material may be formed into a cigarette insertion portion I, an intermediate portion II, and/or a suction portion III of a conventional mouthpiece, as shown in Figs.
  • the active material of the present invention can be attached to the mouthpiece as part of the mouthpiece so that it can be attached to the mouthpiece as a detachable part as the mouthpiece is replaced as a whole, thereby periodically or irregularly replacing the active material from the mouthpiece.
  • a reminder member may be mounted on the mouthpiece to prompt replacement of the active material.
  • a filter comprising any combination of the active ingredients and additives of the present invention or any single one may be filled in an aluminum foil or a metal and other packaging material identifiable by the sensor to form a core.
  • the core can be provided as a separate product or as a kit with one of the components or a conventional or inventive mouthpiece or filter rod.
  • the core of the present invention can be provided to the consumer as a mouthpiece kit along with a conventional mouthpiece (only the mouthpiece is specifically designed to fit into the core of the present invention).
  • the core of the present invention can be provided to a cigarette manufacturer as a mouthpiece kit along with a conventional filter rod (only the filter rod is specifically designed to fit into the core of the present invention).
  • the packaging material is electrostatically perforated to control the air permeability to a certain applicable range.
  • the circuit, the processor, and the sensing device assembled by the sensing heater are such that when the device is pumped, the pressure causes the sensor to generate a signal and transmits the signal to the microprocessor, thereby transferring the electrical energy from the electron to the heater.
  • the heater then heats the active ingredients and additives in the material that the sensor can identify to a temperature that can be volatilized and sublimed.
  • the use of the sensor and/or heater provides further targeted heating based on the aforementioned heating of the cigarette smoke, promoting volatilization and sublimation of the active ingredient and/or additive.
  • the active substance is inhaled into the respiratory tract with the rhythm of the suction.
  • the substances entering the respiratory tract are absorbed by the respiratory tract and the alveolar capillaries, enter the blood, and function through the blood-brain barrier.
  • the product of the present invention the user can obtain a refreshing refreshing scent and have a full physiological strength.
  • an essential oil (Essential oil) of about 5% of the effective shield can be added to increase the physiological strength.
  • This method can also be used to wrap additives to achieve equal or synergistic effects.
  • a pure fiber, plastic, and plastic material is packaged into a cigarette holder core to form a single one and a plurality of series combinations, enriching diverse market demands.
  • the core is a capsule having one or more holes, for example, eight at both ends of the capsule, so that the cigarette smoke enters the capsule and is in contact with the active ingredient and/or the active material, and Drain from the hole at the other end.
  • the capsule may be in the form of a capsule in a conventional form, such as a commercially available capsule for a drug.
  • the size, outer diameter of the core is as shown in FIG. 2, and the vortex core is opened at the bottom of the core, for example, six vortex openings, which are in the air when the airflow passes.
  • the core is vortexed to increase the contact potential of the active material in the gas flow zone, wherein (I) is the active ingredient and/or the active material, and (II) the conventional vinegar filament bundle.
  • the active ingredients contained in tea powder, tea flakes and tea granules have the functions of acting alone and synergistically. According to different consumer groups, they are divided into a single substance and a mixture of two or more substances. It has become a product portfolio.
  • the various active materials and/or active ingredients are packaged into a cigarette holder core by pure fiber, plastic, and plastic materials, and the ends of the core material are electrostatically punched.
  • the filter of the present invention is used as a cigarette holder, the cigarette holder is twisted to divide the mouthpiece into two sections, and the cartridge containing the effective substance is taken out and placed in a magazine reserved for the mouthpiece, the cigarette holder is twisted, and the cigarette is placed. .
  • the production technology of the cigarette filter rod and the cigarette holder of the present invention firstly changes the production method of the conventional cigarette holder.
  • the conventional composite cigarette holder molding machine is produced by continuously feeding a filler such as a vinegar filament bundle horizontally, and wrapping the filler with a wrapping paper to form a filter plug, wherein the filler One line runs along the pipe line of the production equipment from the hole at one end. In the middle of the equipment, two kinds of materials are combined and combined to form a composite filter, and the material of the filter rod runs along the pipe. Leveling, limiting production capacity.
  • the production of the filter rod and the mouthpiece of the present invention is an erected production process, which greatly improves the production capacity.
  • a vertical filter rod producing apparatus which fills a pre-formed packaging paper in the form of a cylinder with a filler to form a filter rod.
  • the method may include, for example, inserting a filler into the tip end in a cylinder prepared in advance and placed upright or in a plurality of cylinders arranged side by side.
  • the apparatus 100 primarily includes a receiver 110 and a distributor 120.
  • Receiver 110 includes one or more cylindrical recesses 111 having an inner diameter that matches the outer diameter of the filter rod to be produced.
  • the dispenser 120 includes a hopper 121 for charging and a feed head 122 for feeding material into the recess 111 of the receiver 110.
  • the feed head is frustoconical, and the diameter of the lower cone 123 is slightly smaller than the diameter of the cone 124, for example 5-8 mm, preferably about 6 mm. At the same time, the outer diameter of the cone 123 is 1-2 mm smaller than the inner diameter of the recess 11 1 so that the feed head 122 is inserted into the recess 11 1 .
  • the receiver and dispenser may be of various shapes commonly used in the art and/or generally understood, such as circular, square, etc., and preferably the receiver and dispenser shape are identical.
  • One or more recesses may be disposed on the receiver, and the respective recesses may be arranged in various conventional manners.
  • the depressions may be arranged in a row, in a row, or in a circular shape, as shown in Fig. 4; or, the depressions may be arranged in a similarly radioactive manner.
  • the arrangement can be optimized to place as many recesses as possible on the receiver per unit area.
  • the arrangement of the feed heads on the dispenser corresponds to the dispenser.
  • materials such as fillers, such as active materials, are fed into the hopper 121 and enter the respective feed heads 122 under gravity.
  • a cylindrical wrapping paper 112 for wrapping the filter rod has been previously placed in the recess 111 of the receiver 110.
  • the dispenser is operated downward so that the cone 123 of each feed head 122 enters its corresponding recess 1 11 to cause the filler to fill the wrapper 112 under the influence of gravity and additional pressure.
  • a filled filter plug is obtained after discharge.
  • the active material of the present invention is alternately filled with conventional fillers such as vinegar tow segments.
  • a plurality of dispensers 120 may be associated by one or more receivers 110. The specific number of dispensers is determined by the number of types of fillers. Generally, a filler uses a dispenser.
  • a dispenser can be used to dispense a variety of fillers.
  • a plurality of feed channels preferably in the same number of filler types, can be connected to one of the dispensers, when it is necessary to switch between different fillers for distribution to the receiver, With the It is only necessary to switch between different channels in which the distributor performs the connection.
  • the active material of the present invention and a vinegar tow are used, and correspondingly, a receiver 110 and two dispensers, 120 and 120a (not shown), respectively, are used to contain the active material and Vinegar filaments.
  • the dispenser 120 containing the active material is injected into the first round of the wrapper 112 to form a filling of the active material; then the dispenser 120 leaves the receiver 110, and the dispenser 120a repeats similar
  • a second round of implantation process injects a portion of the wrapper 112 into a fill of vinegar fibrils.
  • a filter rod structure in which the active material and the vinegar filament bundle are alternately distributed once is obtained by two rounds of injection.
  • the filter rods of the aforementioned distributors 120 and 120a which are alternately arranged in sections in the cross-axis direction may be repeated a plurality of times. , , , , :
  • dispensers 120 can be used for a receiver 110.
  • one dispenser contains a filler.
  • the active material of the present invention and vinegar tow are used, but two receivers 110, 110a (not shown) and two dispensers 120, 120a are used.
  • the receivers 110 and 110a are each provided with the same wrapper
  • the dispenser 120 is filled with the active material of the present invention
  • the dispenser 120a is filled with a bundle of vinegar.
  • the active material is first injected into the first wheel of the receiver 110 by the dispenser 120, at which time the receiver 110a and the distributor 120a are empty.
  • the dispenser 120 is then transferred to the receiver 110a to inject the active material into the second of the 110a; at the same time, the dispenser 120a is transferred to the receiver 1 10 to inject the vinegar tow into the second of the 110.
  • the dispenser 1 10a is only filled with the active material, which is referred to herein as 0.5 for convenience of description. Secondary distribution.
  • the dispenser 120 is then transferred again to the receiver 110, the third round of which injects the active material, thereby completing 1.5 distributions in the receiver 110; at the same time, the dispenser 120a is transferred to the receiver 1 10a, and the third round is injected into the vinegar tow, Thus, the distribution is completed once in the receiver 110a. It can be seen that a total of 2.5 distributions are achieved by a total of three rounds of injection. After obtaining the filter rod product having the desired number of distributions, the product is discharged. For example, if it is only necessary to obtain an alternately distributed structure of the active material and the vinegar tow as the desired product, that is, the obtained product contains only one distribution alternately, the receiver 1 10 is obtained after the second round of injection.
  • the filter rod is unloaded and loaded with new wrapping paper.
  • the filter rod obtained in the receiver 110a is discharged after the third round of injection.
  • the unloading and loading of the new wrapping paper is achieved during the transfer of the dispenser, from And to achieve continuous production between each injection.
  • a receiver or a distributor is referred to as a 0.5 unit
  • a receiver plus a distributor is referred to as a unit.
  • one receiver and a plurality of dispensers may be employed as described in the scheme, and the number of dispensers is preferably equal to the species of the filler.
  • a plurality of receivers and a plurality of distributors may be employed as described in Scheme B, and the number of receivers and distributors is equal, preferably the number is equal to the number of fillers.
  • the efficiency of the scheme B is significantly higher than that of the scheme A, and the cost is that for the filler in n, the scheme B is more than the scheme A.
  • (n-1) receivers For example, when one of the active material, an additive of the present invention and a vinegar tow is used, one receiver and three dispensers can be used as described in Scheme A; The ground uses 3 receivers and 3 distributors.
  • the wood pulp is generally selected to be a cylinder conforming to the circumference of the mouthpiece and the hardness standard
  • the cardboard roll can also be selected to be a cylinder conforming to the mouthpiece standard.
  • the invention is not limited to wood pulp and active materials and additives.
  • the ratio of the tow. First fill one end with a tow and corrugated paper, erect the cylinder from top to bottom with an additive, per 2 cm length of additive, insert 1 cm tow and corrugated paper, then pour a period of additive, then insert a length of tow and corrugated paper .
  • This method can accurately grasp the accuracy of the infusion additive and the stability of the filter's resistance, which will not cause gaps in the filter additive section and reduce the filtering effect, and can produce all the two, all four, all six filter rods according to the needs. .
  • the method of the present invention is advantageous in that it increases productivity, reduces waste, and enhances the function of the filter.
  • the scope of the present invention is not intended to be limited to a particular material, and thus the materials used in the methods are illustrative and not limiting; rather, those skilled in the art can The method of the invention is carried out by one or more of these materials.
  • the wood pulp can be used with the old tea leaves (crushing) to enhance the adhesion of the material. After the pulping and stirring are hooked, the pressure is filled into a cigarette cigarette holder mold to form, dry and polish. Aluminum foil and tin foil decorate the exterior.
  • a filter comprising the active ingredient and/or active material of the present invention for example, in the form of being loaded in a core, can be introduced into a mouthpiece similar to the conventional form.
  • the mouthpiece structure is designed to be unscrewed, and a core is placed in the middle. After each sucking or a certain number of cigarettes, the original filter element is taken out and replaced with a new core, and the mouthpiece can be used multiple times.
  • the number of times the core is used may depend on a predetermined number of times and/or a predetermined condition.
  • the core can be designed to be replaced every time a cigarette is smoked, or by changing the amount of active ingredient and/or active material in the core to take a predetermined amount, for example 2, 3, 4, 5 or more. Replace after multiple.
  • the core can be designed to be replaced after certain conditions have been met.
  • a sensor containing one or more active ingredients in the core the sensor issues an alarm when the active ingredient in the core is depleted or below its threshold of active ingredient.
  • the alarm includes, but is not limited to, an audible and/or optical signal.
  • the spraying of the active material and the additive of the filter material is not limited.
  • the vinegar fiber tow is used to spray the active ingredient in the opening process of the filter forming machine, and the active ingredient is added to the activated carbon and the filter paper and the tow.
  • the amount of the additive is not particularly limited, and the active material which is sprayed with the active ingredient and the additive adds a new effect.
  • the cigarette filter of the present invention particularly a filter containing an active ingredient and an additive, is more suitable for the development of today's society and modern tobacco.
  • the present invention provides filter plug and mouthpiece active ingredients and additives for inhibiting nicotine receptors and thereby reducing smoking desire.
  • the cigarette active ingredient and the additive for inhibiting the nicotine receptor to reduce smoking desire fundamentally reduce the smoking amount of the smoker, avoid the opportunity of the tobacco carcinogen to contact with the human body, and avoid the dependence of tobacco addiction on human beings.
  • the filter rod and the mouthpiece active ingredient or additive which inhibits the nicotine receptor's desire to reduce smoking can be compatible with each other according to the type of consumption, and can be added to the disposable and multi-purpose cigarette holders in a single type or in a mixture of plural kinds. in.
  • the active ingredient and the additive may be added to the filter rod and the cigarette holder for disposable and multiple use, and may also be added to the cut tobacco. in.
  • the active ingredient or additive of the present invention can also be added to non-traditional cut tobacco, as well as chewing tobacco and snuff, and can also be added to tobacco substitutes to achieve the purpose of smoking.
  • the active ingredient, active material and/or additive can be used in combination with prior art fillers.
  • the invention provides the inclusion of nicotine receptor for reducing smoking desire
  • the filter of the active ingredient or additive has great social and economic prospects.
  • the invention may be attained, for example, by the following exemplary, non-limiting embodiments of the invention:
  • Example 1 Production of tea flakes
  • tea 1 ton of tea (Yushan Maofeng, Qingdao Zhongpin Tea Co., Ltd.) is pulverized into powder, and the tea is added with 5% of the weight of the clean water to be stirred. The temperature is controlled at 80 ° C for 5 minutes in the steamer. Slurry for 15 minutes. The organic matter of the tea is fully exuded to enhance the adhesion and water resistance.
  • the tea leaves were added with 40% by weight of cellulose, and 40 g/m 2 of tea leaves were produced by the existing thick pulp papermaking process. When rewinding, the cut was 205 mm wide and the moisture content was 5-8%.
  • tea (Yushan Maofeng, Qingdao Zhongpin Tea Co., Ltd.) was pulverized into powder, and the 5% of the tea was added with 5% clean water to stir it. It was heated in a steaming cylinder at a temperature of 80 ° C for 5 minutes and stirred for 30 minutes. The organic matter of the tea can be fully exuded from the cell wall to increase the degree of adhesion.
  • the tea powder after heating or stirring forms tea granules by the vibration of the scorpion.
  • the size of the granules is determined by the mesh number of the sieve.
  • the particles of the first sieve are 1.8 mm, and the particles of the second sieve are 1.2 mm.
  • the granules from the third layer of sieve are dried by natural air drying or indoor heating at 0.8 mm tea granules.
  • the tea granules can satisfy the addition amount of the filter rod and the mouthpiece, and have no effect on the stability of the suction resistance.
  • the filter rod is prepared, the opening roller of the filter rod forming machine is removed, and the crushed tea leaf sheet is installed.
  • the two hobbing teeth are symmetrical up and down, and the pitch of the tooth edges is controlled at 1.8mm.
  • the tea flakes are hobbed, they are crushed into a semi-Zou-like shape, and then the semi-Zou-like tea leaf flakes enter the filter rod synthesizer to synthesize the filter rod.
  • the hardness and the suction resistance of the filter rod are adjusted by the increase and decrease of the hobbing pressure to adjust the bulkiness of the tea leaf sheet to achieve the fullness of the filter rod filling.
  • Example 2 One ton of tea granules obtained according to Example 1 was weighed, and a calcium hardened hard enamel having a diameter of 0.75 cm and a length of 2.5 cm was used as a packaging material of an active ingredient and an additive. There are 8 regular micropores at the two ends of the core material which make the material not easy to leak out.
  • the core is placed in the magazine that is reserved in the unscrewable cigarette holder. When smoking, the smoke passes through the micropores at both ends of the core. The heat of the smoke and The water vapor and the suction force volatilize and sublimate the effective substances in the core, and enter the oral cavity and the lungs to exert effective substances.
  • the aluminum foil sensor can identify the active component and the additive into a core.
  • the electrostatic punching allows the air permeability of the two ends of the packaging material to be controlled within a certain range.
  • the elastic core is placed on the replaceable electronic and microcircuit.
  • the sensor In the device of the sensor heater combination, the sensor generates a signal by pumping and pressurizing, and the electric energy in the electron is transmitted to the heater, so that the effective substance in the package is heated to a temperature of 1 15 ° C which can be volatilized and sublimated, inhaled. The respiratory tract works.
  • 1 ton of wood pulp (Shandong Asia-Pacific Senbo Pulp and Paper Co., Ltd.) was selected as the base material of the filter rod to produce a 0.8 cm diameter forming cylinder with a length of 6 cm. Insert the end of the tow with a tow 0.5 cm, first insert the end of the tow into the bottom. , erect the cylinder side by side, inject the additive 3cm from top to bottom, then insert a length of tow 1cm with the track, then inject the additive 3cm, then insert a length of tow 0.5cm, produce all four filter rods, the tow at both ends The length is 0.5 cm, the middle section is 1 cm, and the length of the additive injection is 1.5 cm.
  • mice were injected with various nicotine-dependent addictions in nicotine and tea, and it was found that mice injected with nicotine alone had significant nicotine-dependent behavior for 2 weeks, while simultaneously injecting glutamate and tea ammonia. Acidic mice can be significantly addictive to nicotine (see Figure 1 for details).
  • Smoking dependence is primarily the result of nicotine in tobacco acting on nicotine receptors in the brain of smokers.
  • mice we experimented with mice as a model and found that mice injected with nicotine and glutamate and theanine significantly reduced the dependence on nicotine and similar effects to nicotine receptor inhibitors (Fig. 3). .
  • glutamate and theanine we studied glutamate and theanine.
  • Nicotine-injected mice were exposed to nicotine-dependent mice for 2 weeks, mainly in three subtypes of the nicotine receptor (nAChR) in three brain regions (ventral cover, forebrain cortex and marginal nucleus). 2 and 7) showed a significant increase in expression, while the increase in expression of these three subtypes of nicotine receptors in the three brain regions injected with glutamate and theanine (No. 1) was significantly inhibited (Fig. 3). No other nicotine receptors in other brain regions were found to be significantly affected.
  • nAChR nicotine receptor
  • C-fos is the upstream gene of nicotine-activated nicotine receptor.
  • Tyrosine hydroxylase is the rate-limiting enzyme in dopamine synthesis, so we tested this enzyme change. It was found that mice injected with nicotine had significantly increased expression of Tyrosine Hydroxylase in the ventral tegmental area of mice, and glutamate and theanine were injected simultaneously. (No. 1) Increased expression of tyrosine hydroxylase in the ventral tegmental area of the mouse was significantly inhibited (Fig. 5B).
  • Tea filter sticks and cigarette holders can significantly reduce the effects of acute and chronic toxic tea filter sticks and cigarette holders on the pathological changes of lung tissue in rats caused by smoking.
  • 80% of the mice had obvious lung tissue damage, alveolar rupture and pulmonary hemorrhage, renal interstitial small blood vessels dilated and congested, liver lobular central vein or interlobular vein slightly dilated bleeding, no abnormalities in heart and spleen.
  • Inhalation of tea leaf filter plug and cigarette holder cigarette group 20% of mice lung tissue also appeared interstitial small blood vessels and renal interstitial small blood vessels dilated blood, liver lobular central vein or interlobular vein mild dilated bleeding, heart, spleen No abnormalities were observed (Fig. 7).
  • Table 1 The effect of two cigarette smoke on the survival time of mice. Only the weight survival time of the group increased by ten, according to 8 28.5 1.9 1 1.5 ⁇ 1.8
  • Control smoke group 10 8 ⁇ 55 ⁇ 1 ⁇ 06

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Description

一种解烟毒的过滤物及其制备方法 技术领域
本发明涉及无依赖、 祛烟瘾、 减害的滤棒和烟嘴及其制备方法。 背景技术
吸烟可在部分人群中起到调节情緒的作用， 但吸烟有害健康已成 为社会的共识， 世界卫生组织将烟草危害列为对人类健康的最主要的 危害之一。 由于卷烟的成瘾性是一些想通过吸烟来调节生理的消费者 不幸染上烟瘾， 而且很难通过自身努力完全戒断。 长期吸烟增加了癌 症、 心血管***疾病、 呼吸***疾病等的隐患， 社会医疗保障体系资 源被吸烟导致的疾病长期挤占， 使社会和家庭背上了格外的负担。 许 多因吸烟患上癌症等疾病的家庭落于经济困境， 吸烟对健康的危害大 于任何其他一种疾病， 已成为人类面临的重大公共卫生问题， 祛烟瘾 已成为国际社会和世界各国不可回避的一个社会发展过程。
目前， 市场上的尼古丁替代品尚不够完备， 争议较大， 并且有可 能形成新的依赖的风险。 使用不方便， 也没有考虑到吸烟'者的感受， 戒烟效果不明显。 控烟举措的法制化不断完备， 烟瘾的折磨就变的越 来越突出， 新的社会问题也将随之暴露出来。 同时， 对于部分短时间 仍然可能难以摆脱吸烟需求的人群， 又没有无危害和无依赖的新产品 迎合这一群体的需要， 因此亟需一种无依赖用于调节生理的吸食方法。 目前， 美国引用遗传变异祛除烟草成瘾的技术存在成本高、 普及性难 度大等不足， 而市场上出售的戒烟药等由于烟草的成瘾顽性很难达到 成功的祛烟瘾目的。 因此， 亟需一种有效的祛烟瘾可用于戒烟的卷烟 解毒产品。
滤棒和烟嘴是减少卷烟烟气中有害物质的重要工具， 其中， 所谓 滤棒在本领域中通常是由滤材加增塑剂， 用盘纸卷制而成。 一支滤棒 可分切为二、 四、 六支滤嘴， 对接在卷烟上的叫滤嘴， 滤材是指填充 在滤棒中以起到主要的过滤作用的物质， 例如传统的醋纤丝束。 而所 谓烟嘴 （cigarette holder )在本领域中通常是指一种在吸烟时能够把香 烟一端***， 另一端用嘴可以吸食烟的一种工具。 现在人们所接触的 烟嘴一般是过滤烟嘴， 即采用物理化学原理'， 对烟焦油实施过滤， 使 吸到嘴里的烟气更为醇和， 对人体的危害也大为减轻。 由于社会的进 步曰益加快， 人们的健康意识逐步加强， 传统烟嘴已经难以满足时代 的发展了， 在没能解决真正戒烟的前提下， 通过手段袪除烟瘾来减少 其危害就具有了其历史意义， 这就是烟嘴新的使命， 这才是当下人们 普遍认识的烟嘴。
滤棒（特别是滤材） 的材料和形状不同对卷烟减害和风格有不同 的影响， 因此有必要对滤棒进行改革。 当今科学研究发现， 传统的醋 纤烟嘴只对焦油减少有一定作用， 对卷烟烟气中的气相物质作用并不 大， 使卷烟烟气存在辛辣、 刺激的不足与缺陷， 对口腔粘膜和呼吸道 粘膜产生不良的影响， 造成粘膜细胞的伤害引发病变。 醋纤滤嘴添加 活性炭和一些添加剂成为改善和弥补醋纤滤嘴不足的有效手段， 但由 于生产方法的限制， 效果并不大。 烟草消费者须加大吸烟的量和深度 来补偿生理上对卷烟的依赖， 对烟草消费者健康安全产生较大的隐患。 由吸烟导致烟草消费者疾病的增加引发社会问题正引起国际社会组织 和各国政府的重视， 烟草业形势日益严峻， 烟草经济安全转向政治安 全， 烟草的法律风险正在逐年加大， 改变当前滤嘴只治标不治本的历 史局面已迫在眉睫。
由于传统滤棒生产方法的限制， 活性炭和醋纤丝束作为滤棒滤材 的减害和滤材添加剂被束縛， 一些有健康认识的烟草消费者寻求多次 性用独立滤棒和烟嘴应用， 以此提高卷烟质量减少伤害， 但是现有市 场上多次性用独立烟嘴存在着华而不实的现象， 价格高、 作用低， 仍 然无法满足社会和市场的发展需要。 虽然复合滤棒和烟嘴可以提高过 滤效果， 但是在滤材添加剂的量度上准确性无法控制， 达不到应有的 效果。 因此， 无论是一次性用滤棒和烟嘴和多次性用滤棒和烟嘴亟待 在技术和方法上突破， 满足政治、 经济、 社会、 市场的发展需要， 因 而， 亟需一种全新方法生产的一种卷烟滤棒和烟嘴。
吸烟者难以自拔的习惯性吸烟是由烟草尼古丁成瘾导致的。 世界 上有 70%的吸烟者有戒烟的欲望， 但因尼古丁的特性而无法实现， 祛 烟瘾已经成为世界性难题。 目前市场虽然有尼古丁替代品销售， 但效 果并不理想， 并出现一定不良反应。 对于口服戒烟药通过消化道吸收 的方法， 事实证明也无法达到理想效果， 且复吸率高。 滤嘴打孔、 滤 棒和烟嘴添加活性炭等一些技术， 虽然对焦油、 尼古丁有一定下降作 用， 但单支吸入量下降并不等于人接受量就下降， 吸烟者可能通过支 数来补偿单支的不足。 吸烟的危害已成为人类面临的重大公共卫生问 题， 全球每年用于此的医疗费用净消耗达 2000亿美元之巨。 因此， 亟 需一种抑制尼古丁受体减少吸烟欲的滤棒和烟嘴添加剂。
尽管世界卫生组织和各国政府都采取了一系列严格的控烟措施， 市场也出现各种戒烟产品， 但是效果都不太明显和理想。 其中一个重 要原因就是这些措施和方法没有考虑吸烟人的感受， 以及人性化的科 学自然规律， 使吸烟者无法接受甚至抵触。 因此亟需一种使吸烟者可 以接受的无依赖、 祛烟瘾减害的滤棒和烟嘴。 本发明就是根据这种情 况， 发明了一种无依赖、 祛烟瘾减害的滤棒和烟嘴及其制备方法， 使 吸烟者不产生任何心理和生理的不适， 逐步达到祛烟瘾和对烟草无依 赖， 从烟草危害中解放出来。 发明内容
本发明在于提供方法新颖、 效果显著、 经济安全、 有利于社会文 明和人类健康的一种无依赖、 祛烟瘾减害的过滤物 （包括用于滤棒和 烟嘴的过滤物）及其制备方法， 和该过滤物用于调节生理的吸食用途。 所述过滤物及其制备方法科学而易于应用， 与卷烟、 尼古丁替代品比 较， 具有口感好， 风格独特， 抗焦虑， 同时还具有镇静与调节的双重 功效， 且不会对吸食者产生精神和生理上的依赖。 本发明还提供了无 依赖、 祛烟瘾减害的过滤物用于调节生理的吸食用途， 并可以根据不 同的需求包含所述活性成分和 /或添加剂的任意组合或者任意的一种， 迎合多样化的市场需要。
在一个实施方案中， 本发明所述过滤物例如为包含在烟嘴或滤棒 中， 例如作为填充物替代传统的醋纤丝束而用在滤棒中， 或者作为烟 嘴的一部分或整个烟嘴。 本发明所述的滤棒所用的填充物是指用来填 充滤棒的包装纸以形成滤棒、 起到过滤作用的功能性物质。 在本发明 的实施方案中， 所述活性成分是指用于例如包含在烟嘴或滤棒的过滤 物中以有助于祛烟瘾减害的任何化合物，特别是例如包括 Y-氨基丁酸、 茶氨酸、 色氨酸、 谷氨酸或茶生物碱。 在一个具体实施方案中， 所述 活性成分为选自 Y-氨基丁酸、 茶氨酸、 色氨酸、 谷氨酸和茶生物碱中 的一种或多种。 在本发明中， 可以直接使用所述活性成分本身， 例如使用纯的茶 氨酸、 谷氨酸等活性成分； 或者可以使用包含所述活性成分的提取物， 例如茶叶提取物； 或者， 还可以直接使用包含所述成分的天然或合成 材料。 因而， 在本发明的一个实施方案中， 在例如烟嘴或滤棒的过滤 物中使用包含所述活性成分中的一种或多种的活性材料， 从而引入所 述一种或多种活性成分。 所述活性材料可以是天然的或合成的。 例如， 在本发明的实施方案中， 所述活性材料是用于例如烟嘴或滤棒的过滤 物中以有助于祛烟瘾减害的任何天然或商业产品， 特别是例如包括茶 粉末、 茶颗粒或茶叶薄片， 所述活性材料含有本发明所述活性成分中 的一种或多种。 例如， 在一个具体实施方案中， 所述活性材料为茶粉 末、 茶颗粒或茶叶薄片。
此外， 本发明所述过滤物还可以含有所述活性成分之外的添加剂， 以进一步有助于祛烟瘾减害。 本发明所述的添加剂为选自安非他酮、 瓦伦尼克林、 伐尼克兰、 利莫那班、 二氢刺桐定、 多巴胺、 美加明、 金雀花碱、 3-曱氨基异莰烷、 巴氯芬 (badofen)、 氯压定和丁普酮中的 一种或其中任意多种的任意组合。
所述活性材料， 例如茶粉末、 茶叶薄片和茶颗粒， 经过加气加热 或者用适量的水浸泡搅拌使茶的有机物质渗出， 特别是活性成分从细 胞壁中溶出率增加， 提高了袪烟瘾作用， 利用渗出的有机物质的黏合 度和抗水性效果添加部分纤维， 分别按以下工艺条件生产茶粉末、 茶 叶薄片和茶颗粒。 茶叶薄片一般是指比重在 25-55 克 /m2， 幅宽 180-380mm 的茶叶形式， 并优选含水率 5-8 重量％, 皱丝间距 0.8-1.8mm, 更优选比重约 40g/m2， 幅宽约 205 mm。 茶颗粒是粒度在 0.01-0,08mm或在特定情况下根据需要甚至大于 0.08mm的茶叶形式， 并优选含水率 5-8重量％。 茶粉末一般是指粒度小于约 0.01mm的茶叶 形式。 在这个范围内， 可以使滤棒达到不萎缩、 不塌陷。
在本发明的一个实施方案中， 所述活性材料直接包含在所述过滤 物中。
在另一实施方案中， 本发明提供了弹芯， 其特征在于该弹芯内包 述弹芯是指包含包装和包裹在包装^的包括所述活 ^成分本身和、 /或活 性材料的过滤物的装配件。 所述的无依赖、 祛烟瘾解烟毒过滤物的弹 芯内还可以含有添加剂中的一种或多种。 在一个实施方案中， 所述的 无依赖、 祛烟瘾解烟毒过滤物的弹芯内含有茶粉末、 茶颗粒或茶叶薄 片。 用于制备所述茶粉末、 茶颗粒或茶叶薄片的茶可以为含有本发明 所述活性成分中的任何一种或多种的茶。 在烟嘴和滤棒中均可使用所 述弹芯。 在烟嘴中使用弹芯的情况下， 其优点之一是方便安装和更换。 此外， 利用弹芯的特定构造， 在烟嘴或滤棒中使用弹芯可能带来额外 的技术效果。 例如， 可以设计特定的弹芯内部结构， 以使气体通过弹 芯时与活性材料的相互接触更加充分。 弹芯中还可装有电子部件， 以 促进活性材料功能的发挥， 例如通过加热； 和 /或用于监测活性材料的 消耗情况， 以提示用尽或更换。
本发明还提供了所述的无依赖、 祛烟瘾解烟毒过滤物的制备方法， 其特征在于向所述过滤物中加入本发明所述的活性成分和 /或所述活性 材料。 此外， 在本发明一个实施方案中， 有别于常规水平地连续进料 填充物例如醋纤丝束， 并用包装纸包裹该填充物以形成滤棒的方法， 本发明特别地采用了立式进料， 以填充物填充预先制成的圆筒形式的 包装纸， 从而形成滤棒的方法。 具体来说， 该方法例如可以包括: 在 预先制成并竖立放置的一个圆筒或并列排布的多个圆筒内于顶端*** 填充物。 为了引入本发明的活性成分或材料， 可以例如在生产过程中 先***一段活性材料， 再注入一段丝束和瓦楞纸， 之后再***一段活 性材料， 再注入一段丝束和瓦楞纸， 最后用活性材料***最末一段， 并按照前述过程生产一切二、 一切四或一切六的无依赖、 祛烟瘾解烟 毒过滤物。
利用本发明所述的无依赖、 祛烟瘾解烟毒过滤物， 本发明还提供 了所述活性成分、 活性材料和 /或添加剂， 例如包含在本发明所述过滤 物中的所述活性成分、 活性材料和 /或添加剂用于调节生理、 抑制尼古 丁受体减少吸烟欲的添加剂的用途， 其特征在于将活性成分、 活性材 料和 /或添加剂本发明所述用于通过与卷烟烟气一起通过呼吸道吸收。
此外， 还可以将本发明所述的活性成分、 活性材料和 /或添加剂直 接添加到烟丝中， 从而使得所述活性成分和 /或添加剂成分与卷烟烟气 一起吸食。 还可以在生产烟草薄片中添加， 以及添加到嚼烟、 鼻烟中 应用。 另外， 还可以添加到非传统卷烟的替代品中， 与非烟丝物质混 合吸食。 附图说明：
图 1 显示了包含过滤物的滤棒形式结构示意图。 其中： ①全活性 成分和 /或活性材料（ I )滤棒； ②活性成分 /或活性材料与常规醋纤丝束 ( II ) 的复合滤棒。
图 2显示了过滤物的烟嘴形式的结构示意图。 其中， ① 5 次使用 烟嘴； ② 1 次使用烟嘴。 活性成分和 /或活性材料（I ) ， 常规醋纤丝束 ( II ) , 截头推体形式， 以便一端***卷烟 （III ) 而另一端用于吸食。
图 3 显示了包含过滤物的烟嘴形式的弹芯结构示意图。 ①塑料弹 芯； ②旋涡式弹芯， 在弹芯底部开有 6 个旋涡式开口， 当气流通过时 在弹芯内以旋涡式前进， 提高气流域活性物质的接触机会。 活性成分 和 /或活性材料（I ) , 常规醋纤丝束（11 ) 。
图 4显示了过滤物的立式的滤棒生产装置示意图。
图 5显示了谷氨酸、 茶氨酸对小鼠尼古丁依赖的影响。 1、 对照； 2、 尼古丁； 3、 尼古丁 +茶多酚； 4、 尼古丁 +咖啡因； 5: 尼古丁 +低浓 度谷氨酸、 茶氨酸； 6、 尼古丁 +高浓度谷氨酸、 茶氨酸。 #与对照相比 P<0.01 , *与尼古丁相比 P<0.05。
图 6A和 B分别显示无依赖祛烟瘾减害茶滤棒和烟嘴志愿者每天平 均吸烟量 （支） 的影响。 A 茶制滤嘴组平均吸烟数量； B 茶制滤嘴组 吸烟数量减少比例； 1、 吸食带茶制滤嘴香烟前； 2-9、 吸食带茶制滤 嘴香烟后第 1-8 周。 *与对照相比 PO.01 , **与尼古丁相比 P<0.01。
图 7A-E显示谷氨酸、 茶氨酸（ 1号）对小鼠尼古丁依赖 （ A ) 和 尼古丁诱导脑区尼古丁受体表达的影响。 B, Β\· 腹侧盖区； C, C1 : 前脑皮层； D, D1 : 缘核区； E， El : SY5Y。 1、 对照； 2、 尼古丁； 3、 尼古丁 +茶多酚； 4、 尼古丁 +咖啡因； 5: 尼古丁 +低浓度谷氨酸、 茶氨 酸； 6、 尼古丁 +高浓度谷氨酸、 茶氨酸， 7: 尼古丁受体抑制剂。 *与 对照相比 PO.01 , #与尼古丁相比 P<0.05。
图 8A-D显示谷氨酸、 茶氨酸（ 1号）对小鼠尼古丁诱导脑区 c-fos 表达的影响。 A: 前脑皮层； B: 缘核区； C: 腹侧盖区。 ； D: SY5Y。 1、 对照； 2、 尼古丁； 3、 尼古丁 +茶多酚； 4、 尼古丁 +咖啡因； 5: 尼 古丁 +低浓度谷氨酸、 茶氨酸； 6、 尼古丁 +高浓度谷氨酸、 茶氨酸， 7: 尼古丁受体抑制剂； *与对照相比 PO.01 , #与尼古丁相比 P<0.05。 图 9茶氨酸对小鼠尼古丁诱导脑腹侧盖区酪氨酸羟化酶受体表达 多巴胺释放的影响。 A茶氨酸对小鼠尼古丁诱导脑腹侧盖区和 B: SY5Y 细胞酪氨酸羟化酶受体表达的影响。 1、 对照； 2、 尼古丁； 3、 尼古丁 +茶多酚； 4、 尼古丁 +咖啡因； 5: 尼古丁 +低浓度谷氨酸、 茶氨酸； 6、 尼古丁 +高浓度谷氨酸、 茶氨酸， 7: 尼古丁受体抑制剂。
图 10显示了谷氨酸、茶氨酸对小鼠尼古丁诱导脑区 (A)和 SY5Y细 胞 (B)糖代谢活性的影响。 *与对照相比 PO.01 , #与尼古丁相比 P<0,05。
图 11显示了茶滤棒对吸烟引起大鼠肺组织病理变化的影响。
其中， 应注意各附图仅为说明性目的， 并非每一附图均按照严格 尺寸比例绘制， 而可能出于清楚和 /或解释的目的有所放大和 /或缩小。 具体实施方式
茶叶犮其活性成分具有'强心、 利尿、 兴奋中枢神经的作用， 并有 抗疲劳、 解毒的功效。 具有镇静神经、 抗焦虑的作用， 并有扩张血管 '和改善记忆力的功能。 具有抑制神经兴奋和改善睡眠的作用， 并可促 进大脑功能和神经的生长， 从而增加记忆力和学习功能。
茶粉末、 茶叶薄片、 茶颗粒具有吸附烟气异味和增添香气质的作 用。 茶叶中的活性成分具有抑制烟碱对人体大脑的侵袭， 遏制大脑受 体对烟碱的依赖， 抗惊厥和抗焦虑的作用， 阻止不愉快的信息传递到 大脑中枢， 抑制吸烟习惯***求， 以及可以补充因减害而使卷烟的烟 碱含量低无法满足生理强度的不足， 达到替代烟碱的作用； 具有清除 自由基、 亚硝胺、 苯并芘、 酚类等有害物质的作用， 并可以与烟碱结 合形成无毒复合物。
通过使用本发明的过滤物， 例如包含在烟嘴或滤棒中的过滤物， 在燃吸卷烟时， 卷烟烟气中的热量和水蒸气加上抽吸力， 使弹芯内的 有效物质挥发、 升华， 一部分与烟气物盾拮抗而消耗， 一部分随烟气 进入人体肺部被吸收而发挥功效， 使烟草消费者有效的摆脱烟瘾束缚 和吸烟侵害， 使烟草消费者根据不同的生理变化有选择的吸烟成为一 种可能， 符合中医药理论原理， 体现了人性化的消费文明， 一种祛烟 瘾可用于戒烟的卷烟解毒烟嘴有着巨大的社会意义。
本发明所述卷烟滤棒和烟嘴的技术工艺的可操作性科学合理， 在 原材料的基础上进一步提高了减害效果， 应用性强。 与传统的一次性 滤棒和烟嘴和多次性用烟嘴的生产工艺相比较， 具有安全、 节能、 卫 生， 烟嘴更容易被接受， 并可以提升卷烟的高附加值。 特别是解决了 复合滤棒二次工艺的复杂性和高浪费、 高成本。 这种卷烟滤棒和烟嘴 迎合了当今社会的文明进步， 非常适应现代烟草的发展方向， 卷烟滤 棒和烟嘴无论是一次性烟嘴的应用还是多次性用烟嘴的应用， 都体现 了低成本、 高附加值的优点。
例如， 对于滤棒， 过滤物被制成类似于常规滤棒中所用醋纤丝束 的形式而填充在滤棒中。 在用于生产滤棒时， 可以使用单独的活性材 料填充滤棒， 即完全由本发明所述活性成分和 /或活性材料过滤物 I代 替常规醋纤丝束，如图 1中所示； 也可将本发明所述过滤物 I与常规醋 纤丝束等填充物结合使用， 例如， 本发明所述过滤物与常规填充物 12 在轴向上分段地交替填充， 如图 4中所示。
再例如， 对于烟嘴， 过滤物可以被形成为该烟嘴的整体或部分。 例如， 可以将本发明所述过滤物成型为适合吸食的， 例如截头推体 I 的形式， 如图 1 所示， 以便一端***卷烟而另一端用于吸食， 从而由 单独的过滤物构成整个烟嘴。 该烟嘴可以是一次性使用的， 也可制成 可反复多次使用的。 或者， 可以使用活性材料替代常规烟嘴的部分和 / 或构件。 例如， 可以将活性材料成型为常规烟嘴的卷烟***部分 I、 中 间部分 II和 /或吸食部分 III, 如图 1-2所示。 本发明所述活性材料可以 作为烟嘴的一部分固定在烟嘴上， 从而随着烟嘴整体更换， 也可作为 可拆卸的部分安装在烟嘴上， 从而定期或不定期地从烟嘴上更换该活 性材料。 特别地， 在烟嘴上可安装有提醒部件， 以提示更换所述活性 材料。
在一个实施方案中， 包含本发明所述活性成分和添加剂任意的组 合或任意的单独一种的过滤物可以被灌装在铝箔或者传感器可以识别 的金属和其他包装材料中以制成弹芯， 而该弹芯可以作为单独的产品 提供， 或者作为部件之一与常规的或本发明所述的烟嘴或滤棒一起作 为套件提供。 例如， 可将本发明所述弹芯与常规烟嘴 （只是该烟嘴特 别设计为可装入本发明所述弹芯） 一起作为烟嘴套件提供给消费者。 再如， 可将本发明所述弹芯与常规滤棒（只是该滤棒特别设计为可装 入本发明所述弹芯） 一起作为烟嘴套件提供给卷烟生产商。 将包装材 料用静电打孔， 使透气度控制在一定的可应用范围内。 通过电子、 微 电路、 处理器、 传感加热器组装的吸食装置， 使得当抽吸装置时， 压 力使传感器产生信号， 并把信号传给微处理器， 进而把电子中的电能 传到加热器。 加热器随后把传感器可以识别的材料中的活性成分和添 加剂加热到可以挥发、 升华的温度。 该传感器和 /或加热器的使用在前 述卷烟烟气加热的基础上提供了进一步的针对性的加热， 促进了活性 成分和 /或添加剂的挥发、 升华。 有效物质随着抽吸力有节奏的吸入呼 吸道， 进入呼吸道的物质被呼吸道和肺泡毛细血管吸收， 进入血液， 穿过血脑屏障发挥功效。 通过使用本发明所述产品， 使用者可以获得 清新的茶爽气息， 具有饱满的生理强度。 此外， 可以添加占有效物盾 约 5%的精油 （Essential oil ) 来增加生理强度。 此方法还可以用来包 裹添加剂达到同等或协同效果。
在本发明的一个实施方案中， 用纯纤维、 塑料、 胶嚢材料包装成 烟嘴用弹芯， 形成单独的一种和多种系列组合， 丰富多样化市场需求。
在图 2中， 描述了本发明所述弹芯的几个实施方案。 在图 2中， 所述弹芯为胶嚢， 在该胶嚢的两端具有一个或多个孔例如 8 个， 以便 卷烟烟气进入该胶嚢， 与活性成分和 /或活性材料接触， 并从另一端的 孔排出。 在另一个实施方案中， 所述胶嚢可采用常用形式的胶嚢， 例 如可商购的用于药物的胶嚢。 在另一实施方案中， 使得所述弹芯的尺 寸， 外径如图 2所示的旋涡式弹芯， 在弹芯底部开有多个， 例如 6个 旋涡式开口， 当气流通过时在弹芯内以旋涡式前进， 提高气流域活性 物质的接触机会， 其中 （I ) 为活性成分和 /或活性材料， （II ) 常规醋 纤丝束。
茶粉末、 茶叶薄片和茶颗粒中所含的活性成分既有单独作用的功 效又有相互协同的作用， 根据不同的消费群体， 分为单独的一种物质 和二种以上的物质混合搭配， 使其成为系列产品组合。 用纯纤维、 塑 料、 胶嚢材料将各种活性材料和 /或活性成分包装成烟嘴弹芯， 弹芯材 料两端用静电打孔。 特别地， 当本发明所述过滤物作为烟嘴使用时， 扭开烟嘴使烟嘴分为两段， 取出内含有有效物质的弹芯按放在烟嘴预 留的弹仓内， 扭上烟嘴， 放置卷烟。
本发明所述卷烟滤棒和烟嘴的生产技术工艺首先改变了传统烟嘴 的生产方法。 传统复合烟嘴成型机的生产方法是水平地连续进料填充 物例如醋纤丝束， 并用包装纸包裹该填充物以形成滤棒， 其中填充物 一条线地顺着生产设备的管道线自一端的洞孔而入， 在设备中间两种 材料合成组合一支复合滤嘴， 自另一端洞孔而出， 整个生产过程滤棒 的材料顺着管道水平进行， 限制了生产能力。 而本发明所述滤棒和烟 嘴的生产是竖立着的生产过程， 它极大的提高了生产能力。
在本发明的生产方法中， 特别地采用了立式的滤棒生产装置， 其 以填充物填充预先制成的圆筒形式的包装纸， 从而形成滤棒。 具体来 说， 该方法例如可以包括： 在预先制成并竖立放置的一个圆筒或并列 排布的多个圆筒内于顶端***填充物。 例如， 参考图 4， 该装置 100主 要包括接收器 1 10和分配器 120。接收器 110中包括一个或多个圆柱形 凹陷 111 , 其内径与将要生产的滤棒外径相匹配。 分配器 120包含用于 装料的料斗 121 以及用于将物料进料到接收器 110的凹陷 111 中的进 料头 122。 进料头是截头锥形的， 其下部的锥头 123的直径稍微小于锥 底 124的直径， 例如小 5-8 mm, 优选小大约 6 mm。 同时， 锥头 123 的外径比凹陷 11 1的内径小 1-2 mm,以便进料头 122***凹陷 11 1中。
所述接收器和分配器可以为本领域常用的和 /或普遍理解的各种形 状， 例如为圆形、 方形等等， 且优选接收器和分配器形状一致。 接收 器上可以布置有一个或多个凹陷， 且各个凹陷之间可以以常规的各种 方案布置。 例如， 各凹陷可以类似矩形地成行、 成排布置， 或在圆形 范围内布置， 如图 4 所示； 或者， 各凹陷可以以类似放射性地布置。 优选地， 可以优化其布置以在单位面积的接收器上安置尽可能多的凹 陷。 优选， 分配器上的进料头的布置与分配器相对应。
在生产中， 物料， 例如填充物， 如活性材料被进料到料斗 121中， 并在重力下进入各进料头 122。接收器 110的凹陷 111中已经预先放置 了用于包裹滤棒的呈圆筒状的包装纸 112。 分配器往下运行， 使得每一 进料头 122的锥头 123进入与其对应的凹陷 1 11 中， 在重力及附加压 力的作用下使得填充物填充包装纸 112。 卸料后即得到填充的滤棒。 在 本发明活性材料与常规填充物如醋纤丝束分段交替填充的实施方案 中。 可以由一个或多个接收器 110对应多个分配器 120, 分配器的具体 数目由填充物的种类数确定， 一般来说， 一种填充物使用一个分配器。
或者， 也可以一个分配器用于分配多种填充物。 在这种情况下， 可以在所述的一个分配器上连接多个， 优选与填充物种类数一致的进 料通道， 在需要切换不同的填充物用于分配至接收器时， 只需在与该 分配器进行连接的不同通道之间切换即可。
在一个实施方案 A中， 使用本发明活性材料和醋纤丝束， 且相应 地， 使用一个接收器 110和两个分配器， 120和 120a (图中未示出） ， 分别装有活性材料和醋纤丝束。 在如前所述的生产过程中， 装有活性 材料的分配器 120在包装纸 112中第一轮注入一段由活性材料构成填 充物； 然后分配器 120离开接收器 110， 分配器 120a再重复类似的第 二轮注入过程， 以在包装纸 112中注入一段由醋纤丝束构成的填充物。 由此， 通过两轮注入获得了活性材料和醋纤丝束在其中交替分布一次 的滤棒结构。 如果需要， 还可多次重复前述的分配器 120和 120a的交 轴向上分段地多次交替排列的滤棒。、 、 、 ：
显而易见地， 对于一个接收器 110， 还可使用更多个分配器 120, 一般来说， 一个分配器包含一种填充物。
在一个实施方案 B 中， 使用本发明活性材料和醋纤丝束， 但使用 两个接收器 110, 110a (图中未示出）和两个分配器 120， 120a。 在生 产过程中， 接收器 110和 110a均装有相同的包装纸， 分配器 120装有 本发明活性材料， 而分配器 120a装有醋纤丝束。 首先由分配器 120向 接收器 110 中第一轮注入活性材料， 此时接收器 110a和分配器 120a 轮空。然后，分配器 120转移至接收器 110a以向 110a中第二轮注入活 性材料； 与此同时， 分配器 120a转移至接收器 1 10以向 110中第二轮 注入醋纤丝束。 上述二轮注入后， 分配器 110 中已经得到了活性材料 和醋纤丝束的交替一次的分布； 而分配器 1 10a中仅注入了活性材料， 为了叙述方便， 本文中相应地称之为 0.5次分布。
分配器 120然后再次转移到接收器 110, 第三轮注入活性材料， 从 而在接收器 110中完成 1.5次分布； 同时， 分配器 120a转移到接收器 1 10a, 第三轮注入醋纤丝束， 从而在接收器 110a中完成 1次分布。 由 此可见， 通过总计三轮注入， 实现了总计 2.5次分布。 在得到具有所需 分布次数的滤棒产品后， 将产品卸料。 例如， 若仅需获得活性材料和 醋纤丝束的交替一次分布的结构作为所需产品， 即所获产品中仅包含 交替一次的分布， 则在第二轮注入后将接收器 1 10中获得的滤棒卸料， 装入新的包装纸。 类似地， 在第三轮注入后将接收器 110a中获得的滤 棒卸料。 优选地， 在分配器转移期间实现卸料和新包装纸的装料， 从 而实现各次注入之间的连续生产。
以上实施方案采用一种本发明的活性材料和一种现有填充物 （醋 纤丝束） 进行了例示性说明， 但根据其中的详细讨论， 本领域技术人 员可以非常轻易地理解， 这些技术方案可以类似地用于实施多种本发 明的活性成分、 活性材料和 /或添加剂， 并结合或不结合现有技术所述 填充物如醋紆丝束。
为本发明目的， 将一个接收器或一个分配器称为 0.5套装置， 则一 个接收器加上一个分配器称为 1 套装置。 通过前述讨论可知， 在使用 本发明活性材料和醋纤丝束这总计两种填充物的情况下， 实施方案 A 中由 1.5套装置经过两轮注入得到一次分布， 即每轮注入均得到 0.5次 分布，则可通过 3轮注入得到 1.5次分布，由 n次注入得到 n/2次分布； 而采用方案 B, 由 2套装置经过 3轮注入得到了 2.5次分布。 并可计算 得知， 除第一轮注入得到 0.5次分布之外， 运行后的每轮注入均可获得 1次分布， 则由 n轮注入可得到 0.5+(n-l)=n-0.5次分布， 比方案 A多 完成 n/2-0.5次分布。 将通过 n轮注入由不同实施方案完成的分布次数 之比定义为效率系数 η, 则实施方案 Β相对于 Α的效率系数为：
在工业化生产中， 生产往往不停地连续进行， 则方案 B相对于 A 的效率系数 η趋向于 2。 即： lim η - 2 例如， 通过前述分析可知， 进行 1,000轮注入之后， 方案 Α将获 得 500次分布； 而方案 B将获得 999.5次分布， η已经达到 1.999。
类似地， 对于填充物超过两种， 例如 3、 4、 5或更多种的情况下， 可以如方案 Α所述地采用一个接收器和多个分配器， 分配器数目优选 等于填充物的种数； 也可如方案 B所述地采用多个接收器和多个分配 器， 且接收器和分配器数目相等， 优选该数目等于填充物的种数。 根 据以上分析， 本领域技术人员可非常容易地计算得出， 方案 B的效率 明显高于方案 A, 其代价是对于 n中填充物， 方案 B比方案 A多使用 (n-1)个接收器。 例如， 当采用一种所述活性材料、 一种本发明所述添 加剂和一种醋纤丝束时， 可以如方案 A所述地采用 1个接收器和 3个 分配器； 也可如方案 B所述地采用 3个接收器和 3个分配器。
此外， 本领域技术人员还可轻易地推断出， 对于方案 A, 当使用 X 种填充物时， 可以使用多于一个（假定 y个）接收器和相应地 xy个分 配器。 类似地， 对于方案 B, 当使用 X种填充物时， 可以使用多于一套 (假定 z套） 装置， 即 xz个接收器和相应地 xz个分配器。
因此， 本领域技术人员可以容易地根据时间效率成本和设备成本 之间的平衡关系考虑使用方案 A的完全分批生产和方案 B的批次间连 续生产。
在本发明中， 一般选用木浆制作成符合烟嘴圆周和硬度标准的圆 筒， 同样也可以选择纸板卷制成符合烟嘴标准的圆筒， 本发明并不限 定为木浆和活性材料以及添加剂与丝束的比例。 首先用丝束和瓦楞纸 填充一端， 竖立圆筒由上方往下灌注添加剂， 每灌注 2公分长度的添 加剂， 再*** 1 公分丝束和瓦楞纸， 之后再灌注一段添加剂， 随后再 ***一段丝束和瓦楞纸。 此方法可以准确的掌握灌注添加剂的准确度 和滤嘴吸阻的稳定性， 不会造成滤嘴添加剂段出现空隙而减少过滤效 果， 并可以根据需要生产一切二， 一切四、 一切六的滤棒。 本发明所 述方法的优越性在于提高产能， 减少浪费， 增强滤嘴功能的效果。
本发明的范围并不专指某种材料， 因而所描述的方法采用的材料 是例示性而非限制性的； 相反， 本领域技术人员显然可以结合其专业 技术知识合理地用其它所需材料替换其中的一种或多种材料而实现本 发明所述方法。 对于独立的多次性用烟嘴， 采用木浆可以配合老茶树 叶 （粉碎） 来增强材料的粘合度， 打浆搅拌均勾后， 填压到一种卷烟 烟嘴模具中成型， 干燥、 打磨， 用铝箔和锡纸装饰外表。
此外， 可以将包含本发明活性成分和 /或活性材料的过滤物， 例如 以装填在弹芯中的形式， 而引入类似于常规形式的烟嘴中。 例如， 烟 嘴结构设计为可以拧开， 中间安放一颗弹芯， 每吸一支或一定数目的 卷烟后取出原用的滤芯更换一颗新弹芯， 该烟嘴可继续多次应用。
其中， 弹芯的使用次数可以取决于预定次数和 /或预定条件。 例如， 可以将弹芯设计为每吸食一支卷烟即进行更换， 也可通过改变弹芯中 活性成分和 /或活性材料的量而在吸食预定支数， 例如 2、 3、 4、 5或更 多支后更换。
或者， 可以将弹芯设计为达到一定条件后更换。 例如， 在弹芯中 装有一种或多种活性成分的传感器， 当弹芯中的活性成分耗尽或低于 其发挥有效成分的阈值时， 该传感器发出报警。 该报警包括但不限于 发出声和 /或光信号。
更为重要的是， 滤嘴材料喷涂活性成分和添加剂喷涂的对象并不 限定， 一般选用醋纤丝束在滤嘴成型机开松过程喷涂活性成分， 活性 炭和过滤纸与丝束添加活性成分和添加剂的量没有特别的限制， 经过 喷涂活性成分和添加剂的活性材料增加了新的效果。 本发明所述卷烟 滤嘴， 特别是添加活性成分和添加剂的滤嘴更适益于当今社会和现代 烟草的发展需要。
本发明提供了用于抑制尼古丁受体并因而减少吸烟欲的滤棒和烟 嘴活性成分和添加剂。 与传统烟嘴比较， 本发明所述抑制尼古丁受体 减少吸烟欲的烟嘴活性成分和添加剂从根本上减少吸烟者的吸烟量， 避免烟草致癌物质与人体接触的机会， 避免烟草成瘾使人产生依赖的 习惯性吸烟行为。 这种抑制尼古丁受体减少吸烟欲的滤棒和烟嘴活性 成分或添加剂可以根据消费类型的不同相互配伍， 从而以单独一种或 者以多种的混合物形式添加到一次性用和多次性用烟嘴中。
当卷烟抽吸时， 卷烟中的水蒸气、 热气流以及抽吸力使滤棒和烟 嘴中的添加剂被挥发和带动出来， 与尼古丁抢占受***置， 排斥尼古 丁， 并使尼古丁与受体结合的机会减少, 并且还可以发挥一定的补偿 效应， 有部分替代尼古丁的效果。 这样的方法优于口服效果， 是从源 头上化解烟草成瘾问题。
对于本发明抑制尼古丁受体减少吸烟欲的滤棒和烟嘴活性成分或 添加剂， 还可以将活性成分和添加剂添加应用到一次性用和多次性用 滤棒和烟嘴中， 并且还可以添加到烟丝中。 此外， 本发明所述的活性 成分或添加剂同样可以添加到非传统烟丝， 以及嚼烟、 鼻烟， 也可以 添加到烟草的替代品中， 达到祛烟瘾目的。 因此， 居以上分析， 本 领域技术人员将能够容易地选择性地采用前述关于烟嘴和 /或滤棒的一 个或多个实施方案而用于通过烟丝和 /或烟草替代品中， 从而引入本发 明所述的活性成分、 活性材料和 /或添加剂， 并可将其与现有技术的填 充物结合使用。 本发明所提供的抑制尼古丁受体减少吸烟欲的包含所 述活性成分或添加剂的过滤物有着巨大的社会效益和经济前景。 实施例
本发明可以例如通过如下措施例示性而非限制性的实施例来达到 目的：
实施例 1 : 茶叶薄片的生产
将 1 吨茶叶 （崂山毛峰， 青岛众品茶叶有限公司）粉碎成粉末， 加茶叶重量 5%的清洁水搅拌均勾， 在蒸缸中将温度控制在 80°C加热 5 分钟时间， 搅拌磨浆 15分钟。 茶的有机物质充分渗出， 增强黏合度和 抗水性。 添加茶叶重量 40%纤维素， 用现有稠浆造纸法技术工艺生产 40g/m2的茶叶薄片， 复卷时分切为 205mm的宽幅， 含水率 5-8%。
实施例 2: 茶颗粒的生产
将 1 吨茶叶 (崂山毛峰, 青岛众品茶叶有限公司 )粉碎成粉末， 加茶叶重量 5%的清洁水搅拌均勾，在蒸缸中已 80°C温度中加热 5分钟， 搅拌 30分钟，使茶的有机物质能够从细胞壁中充分渗出，增加黏合度。 加热或者搅拌后的茶粉末， 通过歸子的震动形成茶颗粒， 颗粒的大小 是筛子的目数决定的， 第一层筛子下来的颗粒在 1.8mm, 第二层筛子 下来的颗粒在 1.2mm, 第三层筛子下来的颗粒在 0.8mm茶颗粒通过自 然晾晒干燥或者室内加热烘干， 茶颗粒能满足滤棒和烟嘴添加量， 对 吸阻的稳定性不会产生影响。
实施例 3: 茶滤棒的生产
本实施例根据烟滤嘴的标准生产技术 (南通烟滤嘴有限责任公司 二元复合机， ZL23成型机） 制备滤棒， 将滤棒成型机的开松辊拆掉， 安装压溃茶叶薄片的滚齿， 两滚齿上下对称， 齿刃间距控制在 1.8mm。 茶叶薄片经过滚齿时压溃成半邹丝状， 然后半邹丝状茶叶薄片进入滤 棒合成机合成滤棒。 滤棒的硬度和吸阻， 是通过滚齿压力的增减来调 节茶叶薄片的蓬松度实现滤棒填充的饱满度。
实施例 4: 茶颗粒弹芯的生产
称取根据实施例 1获得的茶颗粒 1吨，用直径 0.75cm,长度 2.5cm 的加钙的硬胶嚢作为活性成分和添加剂的包装材料。 弹芯材料的两端 分别有 8 个使物质不易漏出的规则微孔， 把弹芯放置在可拧开的烟嘴 中预留的弹仓内， 吸烟时， 烟气通过弹芯两端的微孔， 烟气的热量和 水蒸气以及抽吸力使弹芯内的有效物质挥发、 升华， 进入口腔和肺部 发挥有效物质的功效。
实施例 5 电子滤嘴的生产
铝箔传感器可以识别的材料把活性成分和添加剂包装成弹芯， 静 电打孔使包装材料的两端透气度控制在可应用的一定范围内， 把弹芯 按放在可更换的电子、 微电路、 传感加热器组合的装置中， 通过抽吸 加压， 使传感器产生信号， 把电子中的电能传到加热器， 使包装中的 有效物质加热到可以挥发和升华的温度 1 15°C , 吸入呼吸道发挥功效。
实施例 6: —次性滤棒的生产
选用木浆（山东亚太森博浆纸有限公司 ) 1吨，作为滤棒基础材料, 生产直径 0.8cm成型圆筒， 长度为 6cm, 用丝束***一端 0.5cm, 先插 入丝束一端的为底部， 并排竖立圆筒， 自上而下灌注添加剂 3cm, 然 后随轨道移动再***一段丝束 1cm, 再注入添加剂 3cm, 再***一段 丝束 0.5cm， 生产一切四的滤棒， 两端的丝束的长度为 0.5cm, 中间段 为 lcm, 添加剂注入的长度是在 1.5cm。
实施例 7: —次性弹芯的生产
选用木浆 (山东亚太森博浆纸有限公司 ) 1吨和老茶树叶 1吨（粉 碎）加 100公斤的清洁水搅拌打浆均勾， 然后依照一种卷烟烟嘴模具 灌注原料成型， 干燥、 打磨。 用占弹芯重量 20%的活性成分和添加剂 喷施， 干燥成为最后的弹芯。 每吸一支卷烟可更换一颗弹芯。 试验例
为了证明本发明的无依赖、 祛烟瘾减害的滤棒和烟嘴和抑制尼古 丁受体减少吸烟欲的功能， 通过以下试验例实施例加以说明：
1、 谷氨酸、 茶氨酸对尼古丁依赖的祛致瘾的动物实验结果 以小鼠为模型做了动物试验。 给动物注射尼古丁和茶叶中的各种 可能对吸烟尼古丁依赖的祛致瘾成分， 结果发现， 单独注射尼古丁的 小鼠 2周就有了明显的尼古丁依赖行为， 而同时注射谷氨酸、 茶氨酸 的小鼠可以明显对尼古丁有祛致瘾作用 （具体请参见图 1 ) 。
2、 茶滤棒和烟嘴对吸烟依赖的祛致瘾临床结果
为了进一步确定茶滤棒和烟嘴有祛烟瘾效果， 我们在北京军区医 院进行了临床观察。 经过实验前问卷调查， 募集了 200个年龄在 18-65 岁之间的健康男性志愿者， 实验分二个组， 吸对照烟组和吸带茶滤棒 和烟嘴烟组。 有专门医务工作者进行跟踪观察、 检测呼出一氧化碳量、 收集血样和尿样。 实验前、 实验中和实验后进行常规体检。 发现 100 个志愿者吸带茶滤棒和烟嘴烟 4周后的吸烟量就出现明显降低（ 54% ) , 二个月减少 85%左右， 控烟的有效率 （定义为与使用茶滤棒和烟嘴前 相比， 吸烟量明显减少） 和祛烟瘾成功率 （定义为每天吸烟量少于 5 支， 对吸烟没有依赖和吸烟欲望， 在没有香烟供应的情况下， 不出现 戒断症状）分别为 90%和 71%, 明显好于文献使用尼古丁贴剂的祛烟 瘾效果（图 2A ) 。 另外有 3个人， 试验前每天只吸 4-5支香烟， 基本 没有吸烟依赖， 2个月试验后， 都减少到 0-2支， 这说明用这种茶叶薄 片和茶颗粒滤棒吸烟不会使没有烟瘾的人上瘾。 对照组 82人吸烟量没 有出现明显降低 （一个月的祛烟瘾有效率和成功率都只有 6.8% ) (图 2B ) 。 跟踪测试呼出一氧化碳量和尿样中的尼古丁和可替宁也有明显 下降（图 2C ) , 体检没有发现异常副作用。
3、 茶滤棒和烟嘴对吸烟依赖的祛致瘾作用机理（谷氨酸、 茶氨酸 对尼古丁依赖的祛致瘾作用 )
吸烟依赖主要是烟草中的尼古丁对吸烟者脑内尼古丁受体作用的 结果。 我们以小鼠为模型做了动物试验， 结果发现， 同时注射尼古丁 和谷氨酸、 茶氨酸的小鼠可以明显减少对尼古丁的依赖， 而且与尼古 丁受体抑制剂的效果类似（图 3 )。 为此， 我们研究了谷氨酸、 茶氨酸
(表 1 )对尼古丁诱导小鼠脑区尼古丁受体表达及其上游基因 c-fos表 达增加的抑制作用， 谷氨酸、 茶氨酸对尼古丁诱导小鼠脑区酪氨酸羟 化酶表达增加和多巴胺释放的影响， 谷氨酸、 茶氨酸对尼古丁诱导小 鼠脑区糖代谢活性的影响。 结果发现茶叶薄片中的谷氨酸、 茶氨酸对 尼古丁依赖的祛致瘾作用是通过抑制吸烟尼古丁诱导脑区尼古丁受体 表达增加的途径实现的。 表 1谷氨酸、 茶氨酸重量比
Figure imgf000019_0001
4、 谷氨酸、 茶氨酸对尼古丁诱导小鼠脑区尼古丁受体表达增加的 抑制作用
注射尼古丁的小鼠 2周有了明显尼古丁依赖性的小鼠主要在 3个 脑区 （腹侧盖区、 前脑皮层和缘核区）尼古丁受体 （nAChR ) 的 3 个 亚型（ 4、 2和 7 )表达明显增加， 而同时注射谷氨酸、 茶氨酸（ 1 号）这 3个脑区尼古丁受体的这 3个亚型表达增加受到明显抑制（图 3 )。 没有发现其他脑区的其它尼古丁受体受到明显影响。
5、 谷氨酸、 茶氨酸对尼古丁诱导小鼠脑区 c-fos表达增加的抑制 作用
c-fos是尼古丁激活尼古丁受体的上游基因， 我们检测了谷氨酸、 茶氨酸（ 1号）对尼古丁诱导小鼠脑区 c-fos表达增加的抑制作用， 发 现注射尼古丁的小鼠 2周有了明显尼古丁依赖性的小鼠主要在 3个脑 区 （腹侧盖区、 前脑皮层和缘核区） c-fos表达明显增加， 而同时注射 谷氨酸、 茶氨酸这 3个脑区 c-fos表达增加受到明显抑制 （图 4 ) 。
6、 谷氨酸、 茶氨酸对尼古丁诱导小鼠脑区酪氨酸羟化酶表达和多 巴胺释放增加的抑制作用
在吸烟者脑内多巴胺释放增加是尼古丁依赖的重要结果。 利用在 体脑电极测试鼠主要在脑腹侧盖区多巴胺释放发现， 注射尼古丁的小 鼠 2 周有了明显尼古丁依赖性的小鼠主要在脑腹侧盖区酪多巴胺释放 明显增加， 而同时注射谷氨酸、 茶氨酸（ 1号）小鼠脑腹侧盖区多巴胺 释放增加受到明显抑制 （图 5A ) 。
酪氨酸羟化酶是多巴胺合成的限速酶， 因此我们检测了此酶的变 化。 结果发现， 注射尼古丁的小鼠 2 周有了明显尼古丁依赖性的小鼠 主要在脑腹侧盖区酪氨酸羟化酶（ Tyrosine Hydroxylase )表达明显增 加， 而同时注射谷氨酸、 茶氨酸（ 1号）小鼠脑腹侧盖区酪氨酸羟化酶 表达增加受到明显抑制 （图 5B ) 。
7、 谷氨酸、 茶氨酸对尼古丁诱导小鼠脑区糖代谢活性的影响 尼古丁可以诱导脑区糖代谢活性增加， 我们利用 PET检测了谷氨 酸、茶氨酸（ 1号）对尼古丁诱导小鼠脑区糖代谢活性增加的抑制作用， 结果发现， 注射尼古丁的小鼠 2周有了明显尼古丁依赖性的小鼠主要 脑区糖代谢活性明显增加， 而同时注射谷氨酸、 茶氨酸这个脑区糖代 谢活性增加有明显抑制 （图 6A ) 。
另外， 我们利用 SY5Y细胞体系研究了谷氨酸、 茶氨酸（ 1号）对 尼古丁诱导神经细胞糖代谢活性增加的抑制作用， 结果发现， 尼古丁 能明显增加细胞糖代谢活性， 而同时使用谷氨酸、 茶氨酸处理细胞糖 代谢活性增加有明显抑制 （图 6B ) 。
8、 茶滤棒和烟嘴可以明显降低吸烟产生的急性和慢性毒性 茶滤棒和烟嘴对吸烟引起大鼠肺组织病理变化的影响。 对照组 80%小鼠肺组织损伤明显，肺泡破裂并见有肺出血， 肾脏间质小血管扩 张淤血， 肝脏小叶中央静脉或小叶间静脉轻度扩张出血， 心、 脾未见 异常。 吸食带茶叶薄片滤棒和烟嘴烟嘴香烟组小鼠 20%小鼠肺组织亦 出现间质小血管和肾脏间质小血管扩张淤血， 肝脏小叶中央静脉或小 叶间静脉轻度扩张出血， 心、 脾未见异常 （图 7 ) 。 表 1两种香烟烟气对小鼠存活时间的影响 组别 只数 体重 存活时间 增加 十,照、 因 8 28.5士1.9 1 1.5±1.8
复合茶滤棒烟组 8 27.6士1.5 14.9士 2.2 32.2% 全茶滤棒烟组 8 29.5±1.5 18.0±1.9 60.0% 表 2茶颗粒烟嘴香烟烟气对大鼠骨髓细胞微核率的影响 组别 只数 微核率 降低 对照组 10 1.85+1.42
对照烟组 10 8·55±1 ·06
茶滤棒烟嘴组 10 4.56±2.10 46%

Claims

权 利 要 求
1. 祛烟瘾解烟毒过滤物， 其特征在于该过滤物含有一种或多种选 自 Y-氨基丁酸、 茶氨酸、 谷氨酸、 色氨酸和茶生物碱的活性成分。
2. 根据权利要求 1所述的过滤物， 其特征在于该过滤物包含茶粉 末、 茶颗粒或茶叶薄片， 优选茶颗粒或茶叶薄片。
3. 根据权利要求 2所述的过滤物， 其特征在于所述茶叶薄片易选 择为单位面积重量 25-55g/m2, 幅宽 180-380mm, 含水率 5-8重量％, 皱丝间 巨 0.8-1.8mm。
4. 根据权利要求 2所述的过滤物， 其特征在于所述茶颗粒粒度为 0.001-0.18mm, 含水率 5-8重量％。
5. 根据权利要求 1或 2所述的过滤物， 其特征在于该过滤物包含 茶氨酸和 /或谷氨酸。
6. 根据权利要求 1或 2所述的过滤物， 其特征在于该过滤物包含 一种或多种选自安非他酮、 瓦伦尼克林、 伐尼克兰、 利莫那班、 二氢 刺桐定、 多巴胺、 美加明、 氯压定、 金雀花碱、 3-甲氨基异莰烷、 巴 氯芬和丁普酮的添加剂。
7. 卷烟用滤棒， 其包含根据权利要求 1-4中任一项所述的过滤物。
8. 根据权利要求 7所述的滤棒， 其特征在于该滤棒包含所述过滤 物作为该滤棒的唯一填充物， 且优选所述过滤物为丝束形式。
9. 根据权利要求 7所述的滤棒， 其特征在于该滤棒包含所述过滤 物和常规填充物， 如醋纤丝束， 优选所述过滤物与常规填充物在滤棒 中分段地交替填充。
10. 卷烟用烟嘴，其包含根据权利要求 1-4中任一项所述的过滤物。
11. 根据权利要求 10所述的烟嘴， 其特征在于所述过滤物构成该 烟嘴的卷烟***部分、 中间部分和 /或吸食部分。
12. 根据权利要求 10所述的烟嘴， 其特征在于所述过滤物构成该 整个烟嘴。
13. 包含根据权利要求 1-4中任一项所述的过滤物的弹芯。
14. 根据权利要求 13所述的弹芯， 该弹芯为常规胶嚢形式， 其特 征在于该胶嚢的两端具有一个或多个孔。
15. 根据权利要求 13所述的弹芯， 特征在于其为旋涡式弹芯， 在 该弹芯底部开有多个， 例如 6个旋涡式开口。
16. 根据权利要求 13-15中任一项所述的弹芯， 其特征在于该弹芯 还包含传感器、 处理器和加热器。
17. 滤棒套件，其包含滤棒和权利要求 13-16中任一项所述的弹芯， 其中所述弹芯安装在所述滤棒内。
18. 烟嘴套件，其包含烟嘴和权利要求 13- 16中任一项所述的弹芯， 其中所述弹芯包含在所述烟嘴内。
19. 根据权利要求 18所述的烟嘴套件， 其中所述烟嘴包含与所述 弹芯相对应的弹仓， 且该烟嘴可以打开以使得所述弹芯被装填至所述 弹仓中。
20. 制造权利要求 7-9中任一项所述的滤棒的方法， 其特征在于在 预先制成并竖立放置的一个圆筒或并列排布的多个圆筒内于顶端*** 填充物。
21. 根据权利要求 20所述的方法， 其中将权利要求 1-6中所述的 过滤物作为唯一的填充物***所述圆筒。
22. 根据权利要求 20所述的方法， 其中将权利要求 1-6中所述的 过滤物与常规填充物交替***所述圆筒。
23. 卷烟， 其包含根据权利要求 1-6中任一项所述的过滤物。
24. 嚼烟， 其包含根据权利要求 1-6中任一项所述的过滤物。
25. 鼻烟， 其包含根据权利要求 1-6中任一项所述的过滤物。
26. 权利要求 1-6中任一项所述的过滤物用于祛除烟瘾的用途， 其 特征在于通过加热所述过
进入呼吸道。
PCT/CN2009/000763 2008-09-17 2009-07-06 一种解烟毒的过滤物及其制备方法 WO2010031238A1 (zh)

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EP09813959.5A EP2338360B1 (en) 2008-09-17 2009-07-06 Alexipharmic cigarette filter material and its preparation
RU2011115135A RU2613018C2 (ru) 2008-09-17 2009-07-06 Фильтр для избавления от табакозависимости и детоксикации, мундштук для сигарет и способ их изготовления
UAA201104624A UA100919C2 (ru) 2008-09-17 2009-07-06 Отдельный, устраняющий табачную зависимость и детоксифицирующий фильтровальный стержень и сигаретный мундштук, и способ их изготовления
US13/119,237 US9861124B2 (en) 2008-09-17 2009-07-06 Alexipharmic cigarette filter material and their preparation
JP2011527180A JP2012502637A (ja) 2008-09-17 2009-07-06 解毒性タバコフィルタ材料およびその準備
CA2740530A CA2740530C (en) 2008-09-17 2009-07-06 Independent, tobacco addiction-dispelling and detoxifying filter rod and cigarette holder, and process for manufacturing the same
ES09813959.5T ES2676540T3 (es) 2008-09-17 2009-07-06 Material de filtro de cigarrillo antidotal y su preparación
BRPI0918660-3A BRPI0918660B1 (pt) 2008-09-17 2009-07-06 Cigarro, filtro para eliminação do vício em tabaco, bastão filtro e suporte para cigarro, kit, núcleo bala e processo para fabricação de filtro bastão de cigarro
LTEP19151824.0T LT3511330T (lt) 2008-09-17 2010-12-30 Sintetinis tarpinis junginys, naudotinas triazolpiridino c-met inhibitorių paruošimui

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CNA2008101402336A CN101361596A (zh) 2008-09-17 2008-09-17 一种无依赖用于调节生理的吸食方法
CNA2008101601151A CN101444336A (zh) 2008-11-13 2008-11-13 一种祛烟瘾可用于戒烟的卷烟解毒烟嘴
CN200810160115.1 2008-11-13
CNA2009100136231A CN101455444A (zh) 2009-01-01 2009-01-01 一种卷烟滤嘴
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CN200910019990A CN101843365A (zh) 2009-03-29 2009-03-29 一种抑制尼古丁受体减少吸烟欲的滤嘴添加剂
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