WO2010030251A3 - Integrated optical sensors operating in the frequency domain - Google Patents

Integrated optical sensors operating in the frequency domain Download PDF

Info

Publication number
WO2010030251A3
WO2010030251A3 PCT/SG2009/000341 SG2009000341W WO2010030251A3 WO 2010030251 A3 WO2010030251 A3 WO 2010030251A3 SG 2009000341 W SG2009000341 W SG 2009000341W WO 2010030251 A3 WO2010030251 A3 WO 2010030251A3
Authority
WO
WIPO (PCT)
Prior art keywords
grating
gratings
flow cell
optical sensor
sample
Prior art date
Application number
PCT/SG2009/000341
Other languages
French (fr)
Other versions
WO2010030251A2 (en
Inventor
Carl Gang Chen
Bipin Sewakram Bhola
Seng-Thiong Ho
Original Assignee
Agency For Science, Technology And Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency For Science, Technology And Research filed Critical Agency For Science, Technology And Research
Publication of WO2010030251A2 publication Critical patent/WO2010030251A2/en
Publication of WO2010030251A3 publication Critical patent/WO2010030251A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12083—Constructional arrangements
    • G02B2006/12107—Grating
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12133—Functions
    • G02B2006/12138—Sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12133—Functions
    • G02B2006/12164—Multiplexing; Demultiplexing
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/12007—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind forming wavelength selective elements, e.g. multiplexer, demultiplexer
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/28—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
    • G02B6/293—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
    • G02B6/29304—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means operating by diffraction, e.g. grating
    • G02B6/29316—Light guides comprising a diffractive element, e.g. grating in or on the light guide such that diffracted light is confined in the light guide
    • G02B6/29317—Light guides of the optical fibre type
    • G02B6/29319—With a cascade of diffractive elements or of diffraction operations
    • G02B6/2932—With a cascade of diffractive elements or of diffraction operations comprising a directional router, e.g. directional coupler, circulator

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

An integrated optical sensor operating in the frequency domain is disclosed together with a system and method for detecting the presence of a sample to be detected with the optical sensor. The optical sensor comprises a substrate for supporting the optical sensor, at least two substantially identical gratings or grating-based resonators, a waveguide directional coupler coupled to the gratings and arranged to receive light from a light source and propagate the light through to the gratings, and a flow cell for housing each of the gratings, each flow cell having a fluidic input and a fluidic output, one flow cell for receiving a reference fluid and another flow cell for receiving a fluid with the sample to be detected; the sample to be detected alters the effective refractive index of the propagating mode inside the grating by binding or being adsorbed by the grating to alter the optical frequency of the light that propagates through the grating. In an embodiment, the grating is surface functionalized with a sensitive layer to enable sample adherence or adsorption.
PCT/SG2009/000341 2008-09-15 2009-09-15 Integrated optical sensors operating in the frequency domain WO2010030251A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13656208P 2008-09-15 2008-09-15
US61/136,562 2008-09-15

Publications (2)

Publication Number Publication Date
WO2010030251A2 WO2010030251A2 (en) 2010-03-18
WO2010030251A3 true WO2010030251A3 (en) 2010-06-24

Family

ID=42005667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2009/000341 WO2010030251A2 (en) 2008-09-15 2009-09-15 Integrated optical sensors operating in the frequency domain

Country Status (1)

Country Link
WO (1) WO2010030251A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
BR112013031666B1 (en) 2011-06-07 2022-08-23 Measurement Specialties, Inc. METHOD TO DETERMINE IN A SAMPLE A CONCENTRATION OF A FIRST FLUID IN A SECOND FLUID AND SYSTEM TO DETERMINE IN A SAMPLE A CONCENTRATION OF A FLUID PERIMETER IN A SECOND FLUID
WO2013013220A2 (en) 2011-07-20 2013-01-24 University Of Washington Through Its Center For Commercialization Photonic blood typing
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
CN103293129B (en) * 2013-05-16 2015-12-23 成都谱视科技有限公司 Based on slit optical waveguide extension type grating FP chamber optics biochemical sensitive chip
WO2014198409A1 (en) * 2013-06-12 2014-12-18 Optics Balzers Ag Integrated optical waveguide sensor system
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
CN104034694B (en) * 2014-06-09 2016-08-17 大连理工大学 Integrated waveguide optical biochemical sensor based on the demodulation of luminous power ratio
CN107003234B (en) * 2014-07-29 2020-01-21 Ldip有限责任公司 Partially packaged waveguide-based sensing chip, system and method of use
WO2016087442A1 (en) * 2014-12-01 2016-06-09 Danmarks Tekniske Universitet Compact optical sensor for measuring physical parameters
KR102356454B1 (en) 2015-02-17 2022-01-27 삼성전자주식회사 Dual coupler device, spectroscope including the dual coupler device, and non-invasive biometric sensor including the spectroscope
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
CN107532995B (en) * 2015-04-24 2021-02-05 株式会社岛津制作所 Optical analysis device and method for manufacturing the same
CN104810595A (en) * 2015-05-06 2015-07-29 储鹏 Substrate integrated waveguide cavity with several responses
CN104950393B (en) * 2015-07-02 2018-02-27 龙岩学院 A kind of mode converter based on asymmetric Bragg grating
KR102568788B1 (en) 2015-11-26 2023-08-21 삼성전자주식회사 Bragg grating and spectroscopy device including the bragg grating
CN108298497A (en) * 2018-01-30 2018-07-20 中国电子科技集团公司第三十八研究所 A kind of microfluid packaging method of silicon based photon biologic sensor chip
CN109596570A (en) * 2018-10-24 2019-04-09 昆明理工大学 A kind of biochemical sensitive system based on Si-based photodetectors
TWI687687B (en) * 2019-01-11 2020-03-11 國立中正大學 Dual grating sensor, detecting method and its manufacturing method
CN112161907B (en) * 2020-09-23 2021-06-04 武汉大学 Surface wettability variable micro-pore model and manufacturing and using method thereof
US20220214480A1 (en) * 2021-01-06 2022-07-07 GM Global Technology Operations LLC Airborne coronavirus detector and alerting system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186567B1 (en) * 2002-08-29 2007-03-06 Science Applications International Corporation Device and method for detection and identification of biological agents
US7285420B2 (en) * 2004-11-18 2007-10-23 Corning Incorporated System and method for self-referencing a sensor in a micron-sized deep flow chamber
US20080043248A1 (en) * 2006-08-18 2008-02-21 Meric Ozcan Photonic crystal sensors using band edge and/or defect mode modulation
US20080043242A1 (en) * 2004-07-15 2008-02-21 Emmerson Gregory D Optical Sensors
US20080204747A1 (en) * 2004-07-15 2008-08-28 University Of Southampton Multiwavelength Optical Sensors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186567B1 (en) * 2002-08-29 2007-03-06 Science Applications International Corporation Device and method for detection and identification of biological agents
US20080043242A1 (en) * 2004-07-15 2008-02-21 Emmerson Gregory D Optical Sensors
US20080204747A1 (en) * 2004-07-15 2008-08-28 University Of Southampton Multiwavelength Optical Sensors
US7285420B2 (en) * 2004-11-18 2007-10-23 Corning Incorporated System and method for self-referencing a sensor in a micron-sized deep flow chamber
US20080043248A1 (en) * 2006-08-18 2008-02-21 Meric Ozcan Photonic crystal sensors using band edge and/or defect mode modulation

Also Published As

Publication number Publication date
WO2010030251A2 (en) 2010-03-18

Similar Documents

Publication Publication Date Title
WO2010030251A3 (en) Integrated optical sensors operating in the frequency domain
Muellner et al. CMOS-compatible Si3N4 waveguides for optical biosensing
IL180258A0 (en) Optical sensors
AU2018221428B2 (en) Integrated plasmo-photonic biosensor and method of use
EP2101167A3 (en) Optical chemical detector and method
JP2006234693A5 (en)
US20100165351A1 (en) Silicon photonic waveguide biosensor configurations
WO2010096702A3 (en) Optical sensor of bio-molecules using thin-film interferometer
US20130142477A1 (en) Integrated optical waveguide evanscent field sensor
WO2010136809A3 (en) Optical sensor and method of use
JP4511857B2 (en) Sensor using photonic crystal and detection method of target substance
Barshilia et al. Low-cost planar waveguide-based optofluidic sensor for real-time refractive index sensing
ATE450790T1 (en) MULTIPLE WAVELENGTH OPTICAL SENSORS
CN101696934A (en) Cursor effect-based cascading annular cavity waveguide sensor
Purr et al. Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing
Cennamo et al. Biosensors exploiting unconventional platforms: The case of plasmonic light-diffusing fibers
KR101798942B1 (en) Optical sensor with combined type
Bremer et al. Optical Waveguide Based Surface Plasmon Resonance Sensor System for Smartphones
Yadav et al. Highly sensitive lab-on-a-chip biosensor utilizing phase-modulated Mach-Zehnder interferometer
Le Quang et al. Enhanced sensitivity of absorption-based surface plasmon interference sensors in silicon-on-insulator by adsorbed layer
WO2006088976A8 (en) Fiber-optic biosensor and biosensing methods
WO2012070853A3 (en) Sensor for continuously measuring blood sugar
Alam et al. A hybrid waveguide sensor for highly sensitive biosensing
Jung A Study on the Optimization of Silicon Antiresonant Reflecting Optical Waveguides (ARROW) for Integrated Optical Sensor Applications
Yang et al. Linear response and enhanced sensitivity of Mach–Zehnder interferometer with optimized sensing length

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09813330

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09813330

Country of ref document: EP

Kind code of ref document: A2