WO2010018559A3 - Formulations for a two-phase management of wound healing and dressings incorporating such formulations. - Google Patents

Formulations for a two-phase management of wound healing and dressings incorporating such formulations. Download PDF

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Publication number
WO2010018559A3
WO2010018559A3 PCT/IE2009/000052 IE2009000052W WO2010018559A3 WO 2010018559 A3 WO2010018559 A3 WO 2010018559A3 IE 2009000052 W IE2009000052 W IE 2009000052W WO 2010018559 A3 WO2010018559 A3 WO 2010018559A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound
formulations
formulation
wound healing
active agent
Prior art date
Application number
PCT/IE2009/000052
Other languages
French (fr)
Other versions
WO2010018559A2 (en
Inventor
James Joseph Brennan
Original Assignee
Bk Pharma Systems Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bk Pharma Systems Ltd. filed Critical Bk Pharma Systems Ltd.
Priority to EP09787408A priority Critical patent/EP2315606A2/en
Publication of WO2010018559A2 publication Critical patent/WO2010018559A2/en
Publication of WO2010018559A3 publication Critical patent/WO2010018559A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A formulation for a two-phase management of wound healing comprises a substrate containing a rapid release form of a first active agent in the form of an inclusion complex with a cyclic molecule, such as a cyclodextrin, the first active agent being accommodated in a cavity of the cyclic molecule, for rapid release of the first active agent on application of the formulation to a wound and at least one sustained release form of a second active agent which is released to the wound in response to a trigger by a wound constituent The formulation can be applied directly to a wound or formulated into a dressing for application to a wound. The formulation can be used in the treatment of both acute and chronic wounds and can be applied to all areas of the body. When the first and second active agents are each a pain relieving agent the formulation has particular application in a two-phase management of wound healing.
PCT/IE2009/000052 2008-08-11 2009-07-27 Formulations for a two-phase management of wound healing and dressings incorporating such formulations. WO2010018559A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09787408A EP2315606A2 (en) 2008-08-11 2009-07-27 Formulations for a two-phase management of wound healing and dressings incorporating such formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20080661A IE20080661A1 (en) 2008-08-11 2008-08-11 Formulations for a two-phase management of wound healing and dressings incorporating such formulations.
IE2008/0661 2008-08-11

Publications (2)

Publication Number Publication Date
WO2010018559A2 WO2010018559A2 (en) 2010-02-18
WO2010018559A3 true WO2010018559A3 (en) 2010-06-17

Family

ID=39951883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE2009/000052 WO2010018559A2 (en) 2008-08-11 2009-07-27 Formulations for a two-phase management of wound healing and dressings incorporating such formulations.

Country Status (4)

Country Link
EP (1) EP2315606A2 (en)
GB (1) GB2462664A (en)
IE (1) IE20080661A1 (en)
WO (1) WO2010018559A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103239753A (en) * 2013-04-28 2013-08-14 华南理工大学 Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917238A (en) * 2011-11-08 2014-07-09 3M创新有限公司 Hydrocolloid composition and article containing same
EP2968652B1 (en) 2013-03-13 2020-07-22 Avery Dennison Corporation Improving adhesive properties
CN103536957B (en) * 2013-10-31 2015-01-07 四川大学 Novel collagen-beta-cyclodextrin controlled-release dressing and preparation method thereof
CN110101899A (en) * 2019-04-10 2019-08-09 湖北中部医疗科技有限公司 A kind of medical use hydrocolloid dressing and preparation method thereof
CN112057670A (en) * 2020-09-30 2020-12-11 贯皓医疗科技(惠州市)有限公司 Liquid dressing for wound
CN113679874B (en) * 2021-09-03 2022-07-22 明基材料有限公司 Multi-segment release dressing
CN117959481B (en) * 2024-02-06 2024-07-05 广州乐添生物科技有限公司 Medical functional dressing for repairing scars and manufacturing process thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009592A1 (en) * 1989-12-21 1991-07-11 Kabi Pharmacia Ab Transdermal system
EP0575976A1 (en) * 1992-06-25 1993-12-29 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Inclusion complexes of polymerized cyclodextrins with pharmaceutical drugs
US5690955A (en) * 1992-06-29 1997-11-25 E. R. Squibb & Sons, Inc. Sustained release alginate fibre and process for the preparation thereof
RU2124355C1 (en) * 1996-04-01 1999-01-10 Государственный научно-исследовательский институт экспериментальной медицины полевой фармации и медицинской техники Министерства обороны Российской Федерации Method of an agent devising for wound treatment
WO2002026272A1 (en) * 2000-09-29 2002-04-04 Salvona L.L.C. Multi component controlled release system for sanitary paper products

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953593B2 (en) * 2000-02-01 2005-10-11 Lipoprotein Technologies, Inc. Sustained-release microencapsulated delivery system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009592A1 (en) * 1989-12-21 1991-07-11 Kabi Pharmacia Ab Transdermal system
EP0575976A1 (en) * 1992-06-25 1993-12-29 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Inclusion complexes of polymerized cyclodextrins with pharmaceutical drugs
US5690955A (en) * 1992-06-29 1997-11-25 E. R. Squibb & Sons, Inc. Sustained release alginate fibre and process for the preparation thereof
RU2124355C1 (en) * 1996-04-01 1999-01-10 Государственный научно-исследовательский институт экспериментальной медицины полевой фармации и медицинской техники Министерства обороны Российской Федерации Method of an agent devising for wound treatment
WO2002026272A1 (en) * 2000-09-29 2002-04-04 Salvona L.L.C. Multi component controlled release system for sanitary paper products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200021, Derwent World Patents Index; AN 2000-245410, XP002579004 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103239753A (en) * 2013-04-28 2013-08-14 华南理工大学 Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof

Also Published As

Publication number Publication date
WO2010018559A2 (en) 2010-02-18
GB2462664A (en) 2010-02-17
EP2315606A2 (en) 2011-05-04
GB0817194D0 (en) 2008-10-29
IE20080661A1 (en) 2010-03-03

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