WO2010011134A3 - Ozonolysis of aromatics and/or olefins - Google Patents

Ozonolysis of aromatics and/or olefins Download PDF

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Publication number
WO2010011134A3
WO2010011134A3 PCT/NL2009/050429 NL2009050429W WO2010011134A3 WO 2010011134 A3 WO2010011134 A3 WO 2010011134A3 NL 2009050429 W NL2009050429 W NL 2009050429W WO 2010011134 A3 WO2010011134 A3 WO 2010011134A3
Authority
WO
WIPO (PCT)
Prior art keywords
gas
ozone
ozonide
ozonolysis
liquid
Prior art date
Application number
PCT/NL2009/050429
Other languages
French (fr)
Other versions
WO2010011134A2 (en
Inventor
Bruno Heiniger
Original Assignee
Dishman Pharmaceuticals And Chemicals Ltd.
Pluim, Henk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dishman Pharmaceuticals And Chemicals Ltd., Pluim, Henk filed Critical Dishman Pharmaceuticals And Chemicals Ltd.
Publication of WO2010011134A2 publication Critical patent/WO2010011134A2/en
Publication of WO2010011134A3 publication Critical patent/WO2010011134A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Abstract

The invention pertains to a process for oxidizing unsaturated starting materials, comprising: (i) providing a liquid composition containing an olefin and/or aromatic starting compound, (ii) compressing an ozone-containing gas to a pressure of at least 5 bar absolute, (iii) introducing the compressed ozone-containing gas in one or more microreactors, bringing said gas into contact with said liquid composition (i), to obtain an ozonide, (iv) and optionally subjecting said ozonide to oxidative or reductive degradation. The use of compressed ozone makes it possible to mix large gas volumes with small liquid volumes, and achieve satisfactory contact between the gas and liquid reactants. This dramatically improves yields over conventional micro-reactor-driven ozonolysis.
PCT/NL2009/050429 2008-07-21 2009-07-14 Ozonolysis of aromatics and/or olefins WO2010011134A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08160817.6 2008-07-21
EP08160817 2008-07-21

Publications (2)

Publication Number Publication Date
WO2010011134A2 WO2010011134A2 (en) 2010-01-28
WO2010011134A3 true WO2010011134A3 (en) 2010-03-11

Family

ID=40039825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2009/050429 WO2010011134A2 (en) 2008-07-21 2009-07-14 Ozonolysis of aromatics and/or olefins

Country Status (1)

Country Link
WO (1) WO2010011134A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5611013B2 (en) * 2010-12-03 2014-10-22 キヤノン株式会社 Method for producing oxidized self-dispersion pigment and method for producing ink jet ink
JP6204469B2 (en) 2012-07-19 2017-09-27 ピー２ サイエンス，インコーポレイティド Ozonation operation to generate reduced and / or oxidized product stream
JP6772290B2 (en) * 2015-12-10 2020-10-21 ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュラル アンド メカニカル カレッジ Reaction sequence for the synthesis of nootkatone, dihydronootkatone, and tetrahydronootkatone
CN106117027B (en) * 2016-06-20 2019-04-05 聊城大学 The method for preparing cyclocitral using micro-structured reactor
CN108997205A (en) * 2018-09-13 2018-12-14 江苏师范大学 A kind of synthetic method of 2,3- pyridinedicarboxylic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072518A2 (en) * 2001-03-09 2002-09-19 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Method for producing monocarbonyl compounds or biscarbonyl compounds or hydroxyl compounds
WO2007134847A2 (en) * 2006-05-23 2007-11-29 Dsm Ip Assets B.V. Process for the production of compounds via hazardous intermediates in a series of microreactors
WO2008077769A1 (en) * 2006-12-20 2008-07-03 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for the safe ozonolysis of organic compounds in flammable solvents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072518A2 (en) * 2001-03-09 2002-09-19 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Method for producing monocarbonyl compounds or biscarbonyl compounds or hydroxyl compounds
WO2007134847A2 (en) * 2006-05-23 2007-11-29 Dsm Ip Assets B.V. Process for the production of compounds via hazardous intermediates in a series of microreactors
WO2008077769A1 (en) * 2006-12-20 2008-07-03 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for the safe ozonolysis of organic compounds in flammable solvents

Also Published As

Publication number Publication date
WO2010011134A2 (en) 2010-01-28

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