WO2009156445A3 - Use of cobalt ferrites as contrast agents for magnetic resonance - Google Patents

Use of cobalt ferrites as contrast agents for magnetic resonance Download PDF

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Publication number
WO2009156445A3
WO2009156445A3 PCT/EP2009/057908 EP2009057908W WO2009156445A3 WO 2009156445 A3 WO2009156445 A3 WO 2009156445A3 EP 2009057908 W EP2009057908 W EP 2009057908W WO 2009156445 A3 WO2009156445 A3 WO 2009156445A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic resonance
contrast agents
cobalt ferrites
ferrites
cobalt
Prior art date
Application number
PCT/EP2009/057908
Other languages
French (fr)
Other versions
WO2009156445A2 (en
Inventor
Giovanni Baldi
Daniele Bonacchi
Marco Bitossi
Alessandro Lascialfari
Original Assignee
Colorobbia Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colorobbia Italia S.P.A. filed Critical Colorobbia Italia S.P.A.
Publication of WO2009156445A2 publication Critical patent/WO2009156445A2/en
Publication of WO2009156445A3 publication Critical patent/WO2009156445A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Compounds Of Iron (AREA)
  • Soft Magnetic Materials (AREA)
  • Hard Magnetic Materials (AREA)

Abstract

There are described contrast media for magnetic resonance comprising nanometer-sized cobalt ferrites, their preparation and use.
PCT/EP2009/057908 2008-06-26 2009-06-24 Use of cobalt ferrites as contrast agents for magnetic resonance WO2009156445A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI2008A000117 2008-06-26
ITFI20080117 ITFI20080117A1 (en) 2008-06-26 2008-06-26 USE OF COBALTO FERRITI AS A CONTRAST AGENT FOR MAGNETIC RESONANCE.

Publications (2)

Publication Number Publication Date
WO2009156445A2 WO2009156445A2 (en) 2009-12-30
WO2009156445A3 true WO2009156445A3 (en) 2010-02-18

Family

ID=40301681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/057908 WO2009156445A2 (en) 2008-06-26 2009-06-24 Use of cobalt ferrites as contrast agents for magnetic resonance

Country Status (2)

Country Link
IT (1) ITFI20080117A1 (en)
WO (1) WO2009156445A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6174603B2 (en) 2012-01-27 2017-08-02 ソルシオネス ナノテクノロジカス，エス．エル．Ｓｏｌｕｃｉｏｎｅｓ Ｎａｎｏｔｅｃｎｏｌｏｇｉｃａｓ，Ｓ．Ｌ． Contrast agent for T2 * -weighted magnetic resonance imaging (MRI)
RU2655303C2 (en) * 2016-07-04 2018-05-24 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Means and method for early experimental contrast magnetic-resonance tomographic detection of malignant glial tumors with feeding vessels

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074406A2 (en) * 2000-03-31 2001-10-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Dendrimer composition for magnetic resonance analysis
DE10205332A1 (en) * 2002-02-06 2003-08-28 Berlin Heart Ag Production of magnetic core nanoparticles or dispersion, used e.g. for magnetic fluid seal, acoustic or oscillation damping, biological or clinical purpose comprises coprecipitation of a solution of an iron(III) and a metal(II) salt
WO2007029980A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
WO2007077240A2 (en) * 2006-01-04 2007-07-12 Colorobbia Italia S.P.A. Functionalised nanoparticles, their production and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074406A2 (en) * 2000-03-31 2001-10-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Dendrimer composition for magnetic resonance analysis
DE10205332A1 (en) * 2002-02-06 2003-08-28 Berlin Heart Ag Production of magnetic core nanoparticles or dispersion, used e.g. for magnetic fluid seal, acoustic or oscillation damping, biological or clinical purpose comprises coprecipitation of a solution of an iron(III) and a metal(II) salt
WO2007029980A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
WO2007077240A2 (en) * 2006-01-04 2007-07-12 Colorobbia Italia S.P.A. Functionalised nanoparticles, their production and use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOYA G F ET AL: "Magnetic nanoparticles for cancer therapy", CURRENT NANOSCIENCE 200802 NL, vol. 4, no. 1, February 2008 (2008-02-01), pages 1 - 16, XP008115822, ISSN: 1573-4137 *
ITTRICH H ET AL: "LABELING OF MESENCHYMAL STEM CELLS WITH DIFFERENT SUPERPARAMAGNETIC PARTICLES OF IRON OXIDE AND DETECTABILITY WITH MRI AT 3T", ROFO - FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, THIEME VERLAG, STUTTGART, DE, vol. 177, no. 8, 1 August 2005 (2005-08-01), pages 1151 - 1163, XP009082851, ISSN: 1438-9029 *
LEE J -H ET AL: "Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging", NATURE MEDICINE 200701 GB, vol. 13, no. 1, January 2007 (2007-01-01), pages 95 - 99, XP002559282 *
SEO WON SEOK ET AL: "FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents.", NATURE MATERIALS DEC 2006, vol. 5, no. 12, December 2006 (2006-12-01), pages 971 - 976, XP002559283, ISSN: 1476-1122 *
SILKE BEHRENS ET AL: "Surface engineering of Co and FeCo nanoparticles for biomedical application", JOURNAL OF PHYSICS: CONDENSED MATTER, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 18, no. 38, 27 September 2006 (2006-09-27), pages S2543 - S2561, XP020102486, ISSN: 0953-8984 *

Also Published As

Publication number Publication date
WO2009156445A2 (en) 2009-12-30
ITFI20080117A1 (en) 2009-12-27

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