WO2009152392A3 - Muscarinic agonists for neurological disorders and methods of making the same - Google Patents

Muscarinic agonists for neurological disorders and methods of making the same Download PDF

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Publication number
WO2009152392A3
WO2009152392A3 PCT/US2009/047124 US2009047124W WO2009152392A3 WO 2009152392 A3 WO2009152392 A3 WO 2009152392A3 US 2009047124 W US2009047124 W US 2009047124W WO 2009152392 A3 WO2009152392 A3 WO 2009152392A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
ring
neurological disorders
Prior art date
Application number
PCT/US2009/047124
Other languages
French (fr)
Other versions
WO2009152392A2 (en
Inventor
William S. Messer, Jr.
Aditya Maheshwari
Original Assignee
University Of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Toledo filed Critical University Of Toledo
Publication of WO2009152392A2 publication Critical patent/WO2009152392A2/en
Publication of WO2009152392A3 publication Critical patent/WO2009152392A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Muscarinic receptors with agonist activity and methods of making the same are disclosed. The compound have a thiadiazole compound having a having a quinuclidine ring, a tetrahydropyridine ring, an azobicyclo-heptane ring; or, an azobicyclo-octane ring, wherein a linking group replaces an alkyl sulfonate moiety of the thiadiazole compound.
PCT/US2009/047124 2008-06-11 2009-06-11 Muscarinic agonists for neurological disorders and methods of making the same WO2009152392A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6079408P 2008-06-11 2008-06-11
US61/060,794 2008-06-11

Publications (2)

Publication Number Publication Date
WO2009152392A2 WO2009152392A2 (en) 2009-12-17
WO2009152392A3 true WO2009152392A3 (en) 2010-02-04

Family

ID=41417403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/047124 WO2009152392A2 (en) 2008-06-11 2009-06-11 Muscarinic agonists for neurological disorders and methods of making the same

Country Status (1)

Country Link
WO (1) WO2009152392A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101440529B1 (en) 2011-03-18 2014-09-17 주식회사 엘지화학 Method of preparing dinitrile compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414009A (en) * 1992-01-13 1995-05-09 Novo Nordisk A/S Azabicyclo substituted oxa- or thia-diazole compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US6211204B1 (en) * 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US20010036953A1 (en) * 1999-01-22 2001-11-01 Messer William S. Muscarinic receptor agonists
US20030069290A1 (en) * 2001-08-24 2003-04-10 Wishka Donn G. Substituted-heteroaryl-7-aza[2.2.1] bycycloheptanes for the treatment of desease
US7361668B2 (en) * 2001-10-17 2008-04-22 Ucb, S.A. Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
US20080108618A1 (en) * 1998-03-31 2008-05-08 Mark Brann Compounds with activity on muscarinic receptors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414009A (en) * 1992-01-13 1995-05-09 Novo Nordisk A/S Azabicyclo substituted oxa- or thia-diazole compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US20080108618A1 (en) * 1998-03-31 2008-05-08 Mark Brann Compounds with activity on muscarinic receptors
US6211204B1 (en) * 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US20010036953A1 (en) * 1999-01-22 2001-11-01 Messer William S. Muscarinic receptor agonists
US20030069290A1 (en) * 2001-08-24 2003-04-10 Wishka Donn G. Substituted-heteroaryl-7-aza[2.2.1] bycycloheptanes for the treatment of desease
US7361668B2 (en) * 2001-10-17 2008-04-22 Ucb, S.A. Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTOPOULOS ET AL.: "Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 298, no. 3, September 2001 (2001-09-01), pages 1260 - 1268 *

Also Published As

Publication number Publication date
WO2009152392A2 (en) 2009-12-17

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