WO2009148600A8 - Deuterated lysine-based compounds - Google Patents
Deuterated lysine-based compounds Download PDFInfo
- Publication number
- WO2009148600A8 WO2009148600A8 PCT/US2009/003391 US2009003391W WO2009148600A8 WO 2009148600 A8 WO2009148600 A8 WO 2009148600A8 US 2009003391 W US2009003391 W US 2009003391W WO 2009148600 A8 WO2009148600 A8 WO 2009148600A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- based compounds
- lysine
- deuterated
- deuterated lysine
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to novel lysine-based compounds, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an HIV protease inhibitor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5955608P | 2008-06-06 | 2008-06-06 | |
US61/059,556 | 2008-06-06 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009148600A2 WO2009148600A2 (en) | 2009-12-10 |
WO2009148600A8 true WO2009148600A8 (en) | 2010-02-25 |
WO2009148600A3 WO2009148600A3 (en) | 2010-04-15 |
Family
ID=41258656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/003391 WO2009148600A2 (en) | 2008-06-06 | 2009-06-04 | Deuterated lysine-based compounds |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009148600A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5401652B2 (en) | 2006-09-21 | 2014-01-29 | タイメッド バイオロジクス インコーポレイテッド | Protease inhibitor |
US20120295898A1 (en) | 2010-01-27 | 2012-11-22 | Mark Richard Underwood | Antiviral Therapy |
US9187415B2 (en) | 2010-10-29 | 2015-11-17 | Merck Canada Inc. | Sulfonamides as HIV protease inhibitors |
WO2012151361A1 (en) * | 2011-05-03 | 2012-11-08 | Concert Pharmaceuticals Inc. | Carbamoylpyridone derivatives |
CN105315178B (en) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | Prezista related substances and preparation method thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69535592T2 (en) * | 1994-03-25 | 2008-06-12 | Isotechnika, Inc., Edmonton | IMPROVING THE EFFECTIVENESS OF MEDICINES BY DEUTERIZATION |
US6334997B1 (en) * | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
US6632816B1 (en) * | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
ATE417823T1 (en) * | 2004-08-02 | 2009-01-15 | Ambrilia Biopharma Inc | LYSINE-BASED COMPOUNDS |
EP1877091B1 (en) * | 2005-04-27 | 2015-03-25 | TaiMed Biologics, Inc. | Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors |
CN101405293B (en) * | 2005-11-30 | 2013-03-13 | 中裕新药股份有限公司 | Lysme-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
JP2010502569A (en) * | 2006-07-17 | 2010-01-28 | アンブリリア バイオファーマ インコーポレイテッド | How to improve pharmacokinetics |
-
2009
- 2009-06-04 WO PCT/US2009/003391 patent/WO2009148600A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2009148600A3 (en) | 2010-04-15 |
WO2009148600A2 (en) | 2009-12-10 |
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