WO2009141833A3 - An improved process for synthesizing highly pure atomoxetine - Google Patents

An improved process for synthesizing highly pure atomoxetine Download PDF

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Publication number
WO2009141833A3
WO2009141833A3 PCT/IN2009/000236 IN2009000236W WO2009141833A3 WO 2009141833 A3 WO2009141833 A3 WO 2009141833A3 IN 2009000236 W IN2009000236 W IN 2009000236W WO 2009141833 A3 WO2009141833 A3 WO 2009141833A3
Authority
WO
WIPO (PCT)
Prior art keywords
highly pure
improved process
synthesizing highly
atomoxetine
pure atomoxetine
Prior art date
Application number
PCT/IN2009/000236
Other languages
French (fr)
Other versions
WO2009141833A2 (en
Inventor
Chidambaram Venkateswaran Srinivasan
Perminder Singh Johar
Lalit Wadhwa
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2009141833A2 publication Critical patent/WO2009141833A2/en
Publication of WO2009141833A3 publication Critical patent/WO2009141833A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.
PCT/IN2009/000236 2008-04-17 2009-04-17 An improved process for synthesizing highly pure atomoxetine WO2009141833A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1002/DEL/2008 2008-04-17
IN1002DE2008 2008-04-17

Publications (2)

Publication Number Publication Date
WO2009141833A2 WO2009141833A2 (en) 2009-11-26
WO2009141833A3 true WO2009141833A3 (en) 2010-11-25

Family

ID=41340644

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000236 WO2009141833A2 (en) 2008-04-17 2009-04-17 An improved process for synthesizing highly pure atomoxetine

Country Status (1)

Country Link
WO (1) WO2009141833A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9604906B2 (en) * 2013-07-02 2017-03-28 Zcl Chemicals Limited Process for the preparation of 3-aryloxy-3-phenylpropylamine and salt thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
EP0052492A1 (en) * 1980-11-14 1982-05-26 Eli Lilly And Company 3-Aryloxy-3-phenylpropylamines
EP1171417B1 (en) * 1999-04-09 2005-11-09 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
WO2006037055A1 (en) * 2004-09-27 2006-04-06 Dr. Reddy's Laboratories Ltd. Synthesis of atomoxetine hydrochloride
WO2007009405A1 (en) * 2005-07-21 2007-01-25 Zentiva, A.S. A method for the preparation of (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride (atomoxetine)
WO2008062473A1 (en) * 2006-10-31 2008-05-29 Cadila Healthcare Limited Process for preparing atomoxetine hydrochloride

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
EP0052492A1 (en) * 1980-11-14 1982-05-26 Eli Lilly And Company 3-Aryloxy-3-phenylpropylamines
EP1171417B1 (en) * 1999-04-09 2005-11-09 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
WO2006037055A1 (en) * 2004-09-27 2006-04-06 Dr. Reddy's Laboratories Ltd. Synthesis of atomoxetine hydrochloride
WO2007009405A1 (en) * 2005-07-21 2007-01-25 Zentiva, A.S. A method for the preparation of (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride (atomoxetine)
WO2008062473A1 (en) * 2006-10-31 2008-05-29 Cadila Healthcare Limited Process for preparing atomoxetine hydrochloride

Also Published As

Publication number Publication date
WO2009141833A2 (en) 2009-11-26

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