WO2009138847A3 - An improved process for the preparation of cefozopran - Google Patents

An improved process for the preparation of cefozopran Download PDF

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Publication number
WO2009138847A3
WO2009138847A3 PCT/IB2009/005564 IB2009005564W WO2009138847A3 WO 2009138847 A3 WO2009138847 A3 WO 2009138847A3 IB 2009005564 W IB2009005564 W IB 2009005564W WO 2009138847 A3 WO2009138847 A3 WO 2009138847A3
Authority
WO
WIPO (PCT)
Prior art keywords
cefozopran
preparation
improved process
formula
solution
Prior art date
Application number
PCT/IB2009/005564
Other languages
French (fr)
Other versions
WO2009138847A2 (en
Inventor
Ramar Padmanabhan
Konda Athmaram Ramesh
Sivakumaran Sundaravadivelan
Raja Mohamed Anish Raja
Udayampalayam Palanisamy Senthilkumar
Original Assignee
Orchid Chemicals And Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals And Pharmaceuticals Ltd. filed Critical Orchid Chemicals And Pharmaceuticals Ltd.
Priority to JP2011509028A priority Critical patent/JP2011520866A/en
Publication of WO2009138847A2 publication Critical patent/WO2009138847A2/en
Publication of WO2009138847A3 publication Critical patent/WO2009138847A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of Cefozopran of formula (I), as well as pharmaceutical composition of Cefozopran.(Formula 1) (I) Said process comprises the steps of a) addition of sodium chloride and sodium carbonate to a solution of Cefozopran and b) washing said solution using (a) water immiscible organic solvent(s).
PCT/IB2009/005564 2008-05-14 2009-05-12 An improved process for the preparation of cefozopran WO2009138847A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011509028A JP2011520866A (en) 2008-05-14 2009-05-12 Improved production method of cefozopran

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1176CHE2008 2008-05-14
IN1176CH2008 2008-05-14

Publications (2)

Publication Number Publication Date
WO2009138847A2 WO2009138847A2 (en) 2009-11-19
WO2009138847A3 true WO2009138847A3 (en) 2010-04-22

Family

ID=41319110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/005564 WO2009138847A2 (en) 2008-05-14 2009-05-12 An improved process for the preparation of cefozopran

Country Status (2)

Country Link
JP (1) JP2011520866A (en)
WO (1) WO2009138847A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
CN101921276B (en) * 2010-09-07 2012-07-18 江苏天禾迪赛诺制药有限公司 Crystallization refining method of Meropenem
CN102443017B (en) * 2010-10-13 2014-10-29 石药集团中奇制药技术（石家庄）有限公司 Preparation method of cefozopran hydrochloride
CN102443016B (en) * 2010-10-13 2015-01-07 石药集团中奇制药技术（石家庄）有限公司 Method for preparing cefozopran hydrochloride intermediate
CN102920666B (en) * 2011-08-09 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 Cefozopran hydrochloride freeze-dried powder
CN102898445B (en) * 2012-10-11 2015-03-25 南通康鑫药业有限公司 Preparation method for cefozopran
EP2777705A1 (en) * 2013-03-15 2014-09-17 Cubist Pharmaceuticals, Inc. Ceftolozane antibiotic compositions
CN105153201B (en) * 2015-08-29 2017-08-22 济南康和医药科技有限公司 A kind of preparation method of cefozopran hydrochloride
CN113552250A (en) * 2021-06-30 2021-10-26 海南海灵化学制药有限公司 Impurity detection method of cefozopran hydrochloride

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04338332A (en) * 1991-05-13 1992-11-25 Takeda Chem Ind Ltd Cephalosporin injection and its preparation
JPH06128268A (en) * 1992-10-16 1994-05-10 Takeda Chem Ind Ltd Cephem compound, its production and antibacterial composition
JPH11255653A (en) * 1999-01-18 1999-09-21 Takeda Chem Ind Ltd Cephalosporin injection and its production
JP2004161729A (en) * 2002-02-08 2004-06-10 Takeda Chem Ind Ltd Medicinal composition
EP1618894A1 (en) * 2003-04-28 2006-01-25 Takeda Pharmaceutical Company Limited Composition for injection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA791653B (en) * 1978-04-07 1980-05-28 Glaxo Group Ltd Cephalosporin compounds
JPH0662639B2 (en) * 1987-12-04 1994-08-17 武田薬品工業株式会社 Cefem hydrochloride crystals
JP3012986B2 (en) * 1989-06-12 2000-02-28 武田薬品工業株式会社 Cephem compound and method for producing the same
JPH10291993A (en) * 1997-02-19 1998-11-04 Takeda Chem Ind Ltd Crystal of cephalosporin derivative and its production
HUP0202283A3 (en) * 1999-07-30 2003-10-28 Eisai Co Ltd Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04338332A (en) * 1991-05-13 1992-11-25 Takeda Chem Ind Ltd Cephalosporin injection and its preparation
JPH06128268A (en) * 1992-10-16 1994-05-10 Takeda Chem Ind Ltd Cephem compound, its production and antibacterial composition
JPH11255653A (en) * 1999-01-18 1999-09-21 Takeda Chem Ind Ltd Cephalosporin injection and its production
JP2004161729A (en) * 2002-02-08 2004-06-10 Takeda Chem Ind Ltd Medicinal composition
EP1618894A1 (en) * 2003-04-28 2006-01-25 Takeda Pharmaceutical Company Limited Composition for injection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199302, Derwent World Patents Index; AN 1993-012142, XP002197985 *
DATABASE WPI Week 199423, Derwent World Patents Index; AN 1994-188975, XP003026366 *
DATABASE WPI Week 200441, Derwent World Patents Index; AN 2004-435519, XP003026365 *

Also Published As

Publication number Publication date
WO2009138847A2 (en) 2009-11-19
JP2011520866A (en) 2011-07-21

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