WO2009138780A3 - Combination of an egfr inhibitor with an endocrine agent and treatment of breast cancer - Google Patents

Combination of an egfr inhibitor with an endocrine agent and treatment of breast cancer Download PDF

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Publication number
WO2009138780A3
WO2009138780A3 PCT/GB2009/050495 GB2009050495W WO2009138780A3 WO 2009138780 A3 WO2009138780 A3 WO 2009138780A3 GB 2009050495 W GB2009050495 W GB 2009050495W WO 2009138780 A3 WO2009138780 A3 WO 2009138780A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
breast cancer
combination
egfr inhibitor
endocrine agent
Prior art date
Application number
PCT/GB2009/050495
Other languages
French (fr)
Other versions
WO2009138780A2 (en
Inventor
Lisa Renee Bailey Iacona
Ian Smith
Mary Stuart
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Limited filed Critical Astrazeneca Ab
Publication of WO2009138780A2 publication Critical patent/WO2009138780A2/en
Publication of WO2009138780A3 publication Critical patent/WO2009138780A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of treating hormone sensitive breast cancer, in a warm-blooded animal, such as man, that has not received prior endocrine therapy, in need of such treatment which comprises administering to said animal an effective amount of an EGFR inhibitor in combination with an effective amount of an endocrine agent suitable for use in the treatment of breast cancer. Also described are combinations and uses thereof in the method according to the invention.
PCT/GB2009/050495 2008-05-13 2009-05-11 Therapeutic treatment - 355 WO2009138780A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5272108P 2008-05-13 2008-05-13
US61/052,721 2008-05-13
US12058608P 2008-12-08 2008-12-08
US61/120,586 2008-12-08

Publications (2)

Publication Number Publication Date
WO2009138780A2 WO2009138780A2 (en) 2009-11-19
WO2009138780A3 true WO2009138780A3 (en) 2010-03-04

Family

ID=40942791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/050495 WO2009138780A2 (en) 2008-05-13 2009-05-11 Therapeutic treatment - 355

Country Status (1)

Country Link
WO (1) WO2009138780A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019211322A1 (en) * 2018-05-02 2019-11-07 Mithra Pharmaceuticals S.A. Treatment of advanced estrogen receptor positive breast cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005791A2 (en) * 2000-07-18 2002-01-24 Pharmacia Italia Spa Antitumor combination comprising an aromatase inhibitor and an egfr antagonist or inhibitor
WO2005028469A1 (en) * 2003-09-19 2005-03-31 Astrazeneca Ab Quinazoline derivatives
WO2007054551A1 (en) * 2005-11-11 2007-05-18 Boehringer Ingelheim International Gmbh Combination treatment of cancer comprising egfr/her2 inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005791A2 (en) * 2000-07-18 2002-01-24 Pharmacia Italia Spa Antitumor combination comprising an aromatase inhibitor and an egfr antagonist or inhibitor
WO2005028469A1 (en) * 2003-09-19 2005-03-31 Astrazeneca Ab Quinazoline derivatives
WO2007054551A1 (en) * 2005-11-11 2007-05-18 Boehringer Ingelheim International Gmbh Combination treatment of cancer comprising egfr/her2 inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUREBAYASHI JUNICHI ET AL: "Inhibition of HER1 signaling pathway enhances antitumor effect of endocrine therapy in breast cancer.", BREAST CANCER (TOKYO, JAPAN) 2004, vol. 11, no. 1, 2004, pages 38 - 41, XP002542607, ISSN: 1340-6868 *
OKUBO S ET AL: "Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD 1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells.", BRITISH JOURNAL OF CANCER, vol. 90, no. 1, 12 January 2004 (2004-01-12), pages 236 - 244, XP002542606, ISSN: 0007-0920 *
POLYCHRONIS ET AL: "Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial", LANCET ONCOLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 6, no. 6, 1 June 2005 (2005-06-01), pages 383 - 391, XP005008111, ISSN: 1470-2045 *

Also Published As

Publication number Publication date
WO2009138780A2 (en) 2009-11-19

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