WO2009118754A3 - A process for preparing a stable lyophilized composition - Google Patents

A process for preparing a stable lyophilized composition Download PDF

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Publication number
WO2009118754A3
WO2009118754A3 PCT/IN2009/000171 IN2009000171W WO2009118754A3 WO 2009118754 A3 WO2009118754 A3 WO 2009118754A3 IN 2009000171 W IN2009000171 W IN 2009000171W WO 2009118754 A3 WO2009118754 A3 WO 2009118754A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
lyophilized composition
stable lyophilized
composition
stable
Prior art date
Application number
PCT/IN2009/000171
Other languages
French (fr)
Other versions
WO2009118754A2 (en
Inventor
Ashish Sehgal
Bhavesh Vallabhbhai Patel
Aditya Patel
Jayanta Kumar Mandal
Original Assignee
Astron Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astron Research Limited filed Critical Astron Research Limited
Publication of WO2009118754A2 publication Critical patent/WO2009118754A2/en
Publication of WO2009118754A3 publication Critical patent/WO2009118754A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin

Abstract

This invention relates to process to obtain stable lyophilized composition by lowering the pH during solution phase before lyophilization without addition of an acid or buffer during preparation of composition.
PCT/IN2009/000171 2008-03-28 2009-03-13 A process for preparing a stable lyophilized composition WO2009118754A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN667/MUM/2008 2008-03-28
IN667MU2008 2008-03-28

Publications (2)

Publication Number Publication Date
WO2009118754A2 WO2009118754A2 (en) 2009-10-01
WO2009118754A3 true WO2009118754A3 (en) 2009-12-10

Family

ID=41114414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000171 WO2009118754A2 (en) 2008-03-28 2009-03-13 A process for preparing a stable lyophilized composition

Country Status (1)

Country Link
WO (1) WO2009118754A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10350364B2 (en) 2009-11-11 2019-07-16 Windgap Medical, Inc. Portable Drug Mixing and Delivery Device and Associated Methods
US9907910B2 (en) 2013-03-15 2018-03-06 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
US10569017B2 (en) 2013-03-15 2020-02-25 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
AU2014232211B2 (en) 2013-03-15 2017-05-25 Windgap Medical, Inc. Portable drug mixing and delivery system and method
US9925335B2 (en) 2014-08-18 2018-03-27 Windgap Medical, Inc Portable drug mixing and delivery device and associated methods
US11116903B2 (en) 2014-08-18 2021-09-14 Windgap Medical, Inc Compression seal for use with a liquid component storage vial of an auto-injector
WO2016190980A1 (en) 2015-04-15 2016-12-01 Windgap Medical, Llc Removable actuating cap for use with an auto-injector assembly
JP6580777B2 (en) 2015-08-13 2019-09-25 ウィンドギャップ メディカル， インコーポレイテッド Mixing and infusion device with aseptic characteristics
WO2017122114A1 (en) * 2016-01-12 2017-07-20 Intron Biotechnology, Inc. Freeze-dried formulations of antibacterial protein
CN115192721B (en) * 2021-12-09 2023-11-07 苏州百迈生物医药有限公司 Bladder perfusion medicine compound preparation and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2034707A (en) * 1978-10-25 1980-06-11 Erba Farmitalia Anthracycline glycosides
WO1993013804A1 (en) * 1992-01-07 1993-07-22 Farmitalia Carlo Erba Srl Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
US20070116729A1 (en) * 2005-11-18 2007-05-24 Palepu Nageswara R Lyophilization process and products obtained thereby

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2034707A (en) * 1978-10-25 1980-06-11 Erba Farmitalia Anthracycline glycosides
WO1993013804A1 (en) * 1992-01-07 1993-07-22 Farmitalia Carlo Erba Srl Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
US20070116729A1 (en) * 2005-11-18 2007-05-24 Palepu Nageswara R Lyophilization process and products obtained thereby

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PERLOVICH G L ET AL: "Thermodynamics of solubility, sublimation and solvation processes of parabens", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, 1 January 2005 (2005-01-01), pages 25 - 33, XP025316207, ISSN: 0928-0987, [retrieved on 20050101] *

Also Published As

Publication number Publication date
WO2009118754A2 (en) 2009-10-01

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