WO2009108551A3 - Heteroaryl amide analogues - Google Patents

Heteroaryl amide analogues Download PDF

Info

Publication number
WO2009108551A3
WO2009108551A3 PCT/US2009/034379 US2009034379W WO2009108551A3 WO 2009108551 A3 WO2009108551 A3 WO 2009108551A3 US 2009034379 W US2009034379 W US 2009034379W WO 2009108551 A3 WO2009108551 A3 WO 2009108551A3
Authority
WO
WIPO (PCT)
Prior art keywords
heteroaryl amide
disorder
amide analogues
analogues
heteroaryl
Prior art date
Application number
PCT/US2009/034379
Other languages
French (fr)
Other versions
WO2009108551A2 (en
Inventor
Rajagopal Bakthavatchalam
David C. Ihle
Scott M. Capitosti
David J. Wustrow
Jun Yuan
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of WO2009108551A2 publication Critical patent/WO2009108551A2/en
Publication of WO2009108551A3 publication Critical patent/WO2009108551A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib. In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.
PCT/US2009/034379 2008-02-25 2009-02-18 Heteroaryl amide analogues WO2009108551A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3108208P 2008-02-25 2008-02-25
US61/031,082 2008-02-25

Publications (2)

Publication Number Publication Date
WO2009108551A2 WO2009108551A2 (en) 2009-09-03
WO2009108551A3 true WO2009108551A3 (en) 2009-11-26

Family

ID=41016676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/034379 WO2009108551A2 (en) 2008-02-25 2009-02-18 Heteroaryl amide analogues

Country Status (1)

Country Link
WO (1) WO2009108551A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX336731B (en) 2010-01-28 2016-01-28 Harvard College Compositions and methods for enhancing proteasome activity.
GB201004311D0 (en) * 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
EP3552664A1 (en) 2011-05-12 2019-10-16 Proteostasis Therapeutics, Inc. Proteostasis regulators
AR087274A1 (en) 2011-07-22 2014-03-12 Actelion Pharmaceuticals Ltd DERIVATIVES OF AMETAS HETEROCICLICAS AS ANTAGONISTAS OF RECEPTORS P2X7
GB201115853D0 (en) * 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
EA201490451A1 (en) 2011-09-14 2014-12-30 Проксимаген Лимитед NEW CONNECTIONS - ENZYME INHIBITORS
NZ628910A (en) 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
JOP20130213B1 (en) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co 5-ht3 receptor antagonists
WO2014091415A1 (en) * 2012-12-12 2014-06-19 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
EP2935211B1 (en) * 2012-12-18 2016-11-09 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as p2x7 receptor antagonists
CN104918617B (en) * 2013-01-22 2017-05-10 埃科特莱茵药品有限公司 Heterocyclic amide derivatives as p2x7 receptor antagonists
US9388198B2 (en) 2013-01-22 2016-07-12 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as P2X7 receptor antagonists
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
MD20150071A2 (en) 2013-02-19 2016-02-29 Pfizer Inc. Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of CNS and other disorders
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
EP2905282A1 (en) 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
JP6713982B2 (en) 2014-07-24 2020-06-24 ファイザー・インク Pyrazolopyrimidine compounds
JP6506833B2 (en) 2014-08-06 2019-04-24 ファイザー・インク Imidazopyridazine compounds
JP7055017B2 (en) 2014-09-29 2022-04-15 武田薬品工業株式会社 Crystalline 1- (1-methyl-1H-pyrazole-4-yl) -N-((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] nonane- 7-Il) -1H-Indole-3-Carboxamide
CN107207476B (en) * 2014-12-15 2021-03-19 默克专利有限公司 Indole and azaindole derivatives and their use in neurodegenerative diseases
SI3240785T1 (en) 2014-12-29 2021-11-30 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
MX2018001073A (en) 2015-08-06 2018-06-12 Chimerix Inc Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents.
EP3402780A1 (en) 2016-01-14 2018-11-21 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
EP3290416A1 (en) 2016-08-31 2018-03-07 AXXAM S.p.A. Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist
EP3290417A1 (en) 2016-08-31 2018-03-07 AXXAM S.p.A. 2-chloro-n-[2-(1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)-benzamides and their use as p2x7 receptor antagonists
TW201819361A (en) 2016-09-03 2018-06-01 印度商托仁特生技有限公司 Novel indazole compounds
EP3398941A1 (en) 2017-05-03 2018-11-07 AXXAM S.p.A. Heterocyclic p2x7 antagonists
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
EP4015039A1 (en) 2020-12-18 2022-06-22 AXXAM S.p.A. Heterocyclic derivatives as p2x7 receptor antagonists
IL311165A (en) 2021-09-03 2024-04-01 Breye Therapeutics Aps 2,4-dihydro-3h-1,2,4-triazol-3-one p2x7 antagonists
WO2023030487A1 (en) * 2021-09-03 2023-03-09 深圳零一生命科技有限责任公司 Indole compound, and preparation method therefor and use thereof
WO2023198199A1 (en) * 2022-04-15 2023-10-19 先声再明医药有限公司 Myt1 kinase inhibitor

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018461A2 (en) * 2002-08-23 2004-03-04 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US6927219B2 (en) * 2001-11-12 2005-08-09 Pfizer Inc. N-alkyl-adamantyl triazinyl benzamide derivatives
US20060293337A1 (en) * 2003-06-02 2006-12-28 Richard Evans P2x7 receptor antagonists and their use
WO2007088277A1 (en) * 2006-02-03 2007-08-09 Sanofi-Aventis Tricyclic ν-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and their therapeutic use
US20070203209A1 (en) * 2005-08-18 2007-08-30 Wilmin Bartolini Useful indole compounds
US20080027092A1 (en) * 2003-11-26 2008-01-31 Roger Victor Bonnert 1-Acetic Acid-Indole, -Indazole and -Benzimidazole Derivatives Useful for the Treatment of Respiratory Disorders

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US6927219B2 (en) * 2001-11-12 2005-08-09 Pfizer Inc. N-alkyl-adamantyl triazinyl benzamide derivatives
WO2004018461A2 (en) * 2002-08-23 2004-03-04 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
US20060293337A1 (en) * 2003-06-02 2006-12-28 Richard Evans P2x7 receptor antagonists and their use
US20080027092A1 (en) * 2003-11-26 2008-01-31 Roger Victor Bonnert 1-Acetic Acid-Indole, -Indazole and -Benzimidazole Derivatives Useful for the Treatment of Respiratory Disorders
US20070203209A1 (en) * 2005-08-18 2007-08-30 Wilmin Bartolini Useful indole compounds
WO2007088277A1 (en) * 2006-02-03 2007-08-09 Sanofi-Aventis Tricyclic ν-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and their therapeutic use

Also Published As

Publication number Publication date
WO2009108551A2 (en) 2009-09-03

Similar Documents

Publication Publication Date Title
WO2009108551A3 (en) Heteroaryl amide analogues
UA99729C2 (en) Heteroaryl amide analogues
WO2012021629A3 (en) Novel d3 dopamine receptor agonists to treat dyskinesia in parkinson's disease
EP2119476A3 (en) Amide derivatives as positive allosteric modulators and methods of use thereof
WO2010037059A3 (en) Heteroaryl antagonists of prostaglandin d2 receptors
WO2010057118A3 (en) Heterocyclic antagonists of prostaglandin d2 receptors
UA104869C2 (en) Normal;heading 1;heading 2;heading 3;PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS
WO2010039977A3 (en) Heteroaryl antagonists of prostaglandin d2 receptors
WO2007067616A3 (en) Uses of myostatin antagonists
WO2008152099A3 (en) Aryl/hetarylamides as modulators of the ep2 receptor
EP4268814A3 (en) Pharmaceutical composition for the treatment of dry eye
WO2010148007A3 (en) Nanoparticle and polymer formulations for thyroid hormone, analogs, antagonists, and formulations and uses thereof
WO2010077883A3 (en) Antagonists of lysophosphatidic acid receptors
WO2008140507A8 (en) Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof
WO2007148208A3 (en) Carbonylated (aza) cyclohexanes as dopamine d3 receptor ligands
WO2008121348A8 (en) Peripheral opioid receptor antagonists and uses thereof
WO2010141768A3 (en) Polycyclic antagonists of lysophosphatidic acid receptors
MX2009005462A (en) 7,8-saturated-4,5-epoxy-morphinanium analogs.
WO2008021851A3 (en) Novel compounds as antagonists or inverse agonists for opioid receptors
WO2011103202A3 (en) Androgen receptor modulators and uses thereof
IL207001A0 (en) Parenteral formulations for the administration of dopamine agonists
WO2010003127A3 (en) Antagonists of prostaglandin d2 receptors
WO2008132600A3 (en) Trpv1 antagonists and uses thereof
MX2011008450A (en) Agonists and antagonists of the s1p5 receptor, and methods of uses thereof.
WO2010068775A3 (en) Alkyne antagonists of lysophosphatidic acid receptors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09715672

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09715672

Country of ref document: EP

Kind code of ref document: A2