WO2009095646A3 - Peptides from factor viii - Google Patents

Peptides from factor viii Download PDF

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Publication number
WO2009095646A3
WO2009095646A3 PCT/GB2009/000187 GB2009000187W WO2009095646A3 WO 2009095646 A3 WO2009095646 A3 WO 2009095646A3 GB 2009000187 W GB2009000187 W GB 2009000187W WO 2009095646 A3 WO2009095646 A3 WO 2009095646A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
factor viii
haemophilia
inhibitors
patients
Prior art date
Application number
PCT/GB2009/000187
Other languages
French (fr)
Other versions
WO2009095646A2 (en
Inventor
Roderick Peter Hafner
Original Assignee
Circassia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Circassia Limited filed Critical Circassia Limited
Publication of WO2009095646A2 publication Critical patent/WO2009095646A2/en
Publication of WO2009095646A3 publication Critical patent/WO2009095646A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to compositions comprising peptides for preventing or treating the development of inhibitors in patients with haemophilia, in particular certain peptides and / or peptide fragments derived from factor VIII.
PCT/GB2009/000187 2008-01-28 2009-01-23 Peptides from factor viii WO2009095646A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0801513.3A GB0801513D0 (en) 2008-01-28 2008-01-28 Peptides from factor VIII
GB0801513.3 2008-01-28

Publications (2)

Publication Number Publication Date
WO2009095646A2 WO2009095646A2 (en) 2009-08-06
WO2009095646A3 true WO2009095646A3 (en) 2010-03-11

Family

ID=39186435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000187 WO2009095646A2 (en) 2008-01-28 2009-01-23 Peptides from factor viii

Country Status (2)

Country Link
GB (1) GB0801513D0 (en)
WO (1) WO2009095646A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458445A (en) * 2009-05-18 2012-05-16 艾匹托普技术(布里斯托尔)有限公司 Peptide
CN103298482A (en) * 2010-10-27 2013-09-11 巴克斯特国际公司 FVIII peptides for immune tolerance induction and immunodiagnostics

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2917232T (en) * 2012-11-12 2017-06-09 Apitope Int Nv Factor viii-derived peptides for use in the treatment of haemophilia a
MX2016005333A (en) 2013-10-22 2017-02-15 Dbv Tech Method of treating haemophilia by inducing tolerance to blood factors.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
WO2002090542A2 (en) * 2001-05-09 2002-11-14 Departement Central De Fractionnement De La Croix-Rouge S.C.R.L. Antigenic epitopes of factor viii, inhibitors directed against said epitopes and use thereof
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
WO2009071886A1 (en) * 2007-12-04 2009-06-11 Apitope Technology (Bristol) Limited Fviii peptides and their use in tolerising haemophiliacs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
WO2002090542A2 (en) * 2001-05-09 2002-11-14 Departement Central De Fractionnement De La Croix-Rouge S.C.R.L. Antigenic epitopes of factor viii, inhibitors directed against said epitopes and use thereof
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
WO2009071886A1 (en) * 2007-12-04 2009-06-11 Apitope Technology (Bristol) Limited Fviii peptides and their use in tolerising haemophiliacs

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458445A (en) * 2009-05-18 2012-05-16 艾匹托普技术(布里斯托尔)有限公司 Peptide
CN102458445B (en) * 2009-05-18 2014-06-11 艾匹托普国际股份有限公司 Peptide
CN103298482A (en) * 2010-10-27 2013-09-11 巴克斯特国际公司 FVIII peptides for immune tolerance induction and immunodiagnostics
CN103298482B (en) * 2010-10-27 2015-08-19 巴克斯特国际公司 For immunologic tolerance induction and the FVIII peptide of immunologic diagnosis

Also Published As

Publication number Publication date
WO2009095646A2 (en) 2009-08-06
GB0801513D0 (en) 2008-03-05

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