WO2009089121A3 - Hemagglutinin polypeptides, and reagents and methods relating thereto - Google Patents

Hemagglutinin polypeptides, and reagents and methods relating thereto Download PDF

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Publication number
WO2009089121A3
WO2009089121A3 PCT/US2009/030058 US2009030058W WO2009089121A3 WO 2009089121 A3 WO2009089121 A3 WO 2009089121A3 US 2009030058 W US2009030058 W US 2009030058W WO 2009089121 A3 WO2009089121 A3 WO 2009089121A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
methods relating
hemagglutinin polypeptides
polypeptides
bind
Prior art date
Application number
PCT/US2009/030058
Other languages
French (fr)
Other versions
WO2009089121A2 (en
Inventor
Ram Sasisekharan
Karthik Viswanathan
Aarthi Chandrasekaran
Rahul Raman
Aravind Srinivasan
S. Raguram
Viswanathan Sasisekharan
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/969,040 external-priority patent/US20090081193A1/en
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Priority to EP09701014A priority Critical patent/EP2238146A4/en
Priority to CA2711334A priority patent/CA2711334A1/en
Publication of WO2009089121A2 publication Critical patent/WO2009089121A2/en
Publication of WO2009089121A3 publication Critical patent/WO2009089121A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
PCT/US2009/030058 2008-01-03 2009-01-02 Hemagglutinin polypeptides, and reagents and methods relating thereto WO2009089121A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP09701014A EP2238146A4 (en) 2008-01-03 2009-01-02 Hemagglutinin polypeptides, and reagents and methods relating thereto
CA2711334A CA2711334A1 (en) 2008-01-03 2009-01-02 Hemagglutinin polypeptides, and reagents and methods relating thereto

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US1878308P 2008-01-03 2008-01-03
US11/969,040 2008-01-03
US11/969,040 US20090081193A1 (en) 2006-08-14 2008-01-03 Hemagglutinin polypeptides, and reagents and methods relating thereto
US61/018,783 2008-01-03
US30112608A 2008-11-17 2008-11-17
US12/301,126 2008-11-17

Publications (2)

Publication Number Publication Date
WO2009089121A2 WO2009089121A2 (en) 2009-07-16
WO2009089121A3 true WO2009089121A3 (en) 2009-10-08

Family

ID=40853716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/030058 WO2009089121A2 (en) 2008-01-03 2009-01-02 Hemagglutinin polypeptides, and reagents and methods relating thereto

Country Status (3)

Country Link
EP (1) EP2238146A4 (en)
CA (1) CA2711334A1 (en)
WO (1) WO2009089121A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328002B (en) * 2010-10-04 2020-01-14 麻省理工学院 Hemagglutinin polypeptides and reagents and methods related thereto

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0817682A2 (en) 2007-10-16 2015-04-07 Peptimmune Inc Methods for designing and preparing vaccines comprising sequence-directed polymer compositions via direct epitope expansion
AU2011305371B2 (en) 2010-09-21 2015-05-21 Massachusetts Institute Of Technology Human-adapted HA polypeptides, vaccines, and influenza treatment
CA2871160C (en) 2012-05-10 2023-03-14 Massachusetts Institute Of Technology Agents for influenza neutralization

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2660038A1 (en) * 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GAMBLIN ET AL.: "The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin.", SCIENCE, vol. 303, 2004, pages 1838 - 1842, XP002445848 *
See also references of EP2238146A4 *
STEVENS ET AL.: "Glycan Microarray Analysis of the Hemagglutinins from Modem and Pandemic Influenza Viruses Reveals Different Receptor Specificities.", J. MOL. BIOL., vol. 355, 2006, pages 1143 - 155, XP024950637 *
TUMPEY ET AL.: "A Two Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission.", SCIENCE, vol. 315, 2007, pages 655 - 659, XP008129180 *
YANG ET AL.: "Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity.", SCIENCE, vol. 317, 2007, pages 825 - 828, XP002503152 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328002B (en) * 2010-10-04 2020-01-14 麻省理工学院 Hemagglutinin polypeptides and reagents and methods related thereto

Also Published As

Publication number Publication date
CA2711334A1 (en) 2009-07-16
EP2238146A2 (en) 2010-10-13
WO2009089121A2 (en) 2009-07-16
EP2238146A4 (en) 2012-03-21

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