WO2009075863A3 - Method for diagnosing stroke - Google Patents

Method for diagnosing stroke Download PDF

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Publication number
WO2009075863A3
WO2009075863A3 PCT/US2008/013603 US2008013603W WO2009075863A3 WO 2009075863 A3 WO2009075863 A3 WO 2009075863A3 US 2008013603 W US2008013603 W US 2008013603W WO 2009075863 A3 WO2009075863 A3 WO 2009075863A3
Authority
WO
WIPO (PCT)
Prior art keywords
stroke
alpha
tubulin
associated markers
protein
Prior art date
Application number
PCT/US2008/013603
Other languages
French (fr)
Other versions
WO2009075863A2 (en
Inventor
Paul H Pevsner
Frederick Naftolin
Original Assignee
Univ New York School Medicine
Paul H Pevsner
Frederick Naftolin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York School Medicine, Paul H Pevsner, Frederick Naftolin filed Critical Univ New York School Medicine
Publication of WO2009075863A2 publication Critical patent/WO2009075863A2/en
Publication of WO2009075863A3 publication Critical patent/WO2009075863A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides methods for diagnosing stroke or providing a prognosis for a stroke by identifying the presence or absence of or determining the amount of one or more stroke associated markers. The stroke associated markers may be selected from the group consisting of alpha-tubulin, neurof ilament-L, alpha-globin, tubulin beta 2, Ulip2 protein, myelin basic protein isofortn 1, alpha-1-globin, similar to glyceraldehyde-3-phosphate dehydrogenase, brain abundant, membrane attached signal protein 1 and tubulin alpha-like 3. The present invention also provides a diagnostic kit for diagnosing stroke or for providing a prognosis for a stroke by identifying the presence of or determining the amount of one or more stroke associated markers.
PCT/US2008/013603 2007-12-11 2008-12-11 Method for diagnosing stroke WO2009075863A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US711907P 2007-12-11 2007-12-11
US61/007,119 2007-12-11

Publications (2)

Publication Number Publication Date
WO2009075863A2 WO2009075863A2 (en) 2009-06-18
WO2009075863A3 true WO2009075863A3 (en) 2009-08-13

Family

ID=40503148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013603 WO2009075863A2 (en) 2007-12-11 2008-12-11 Method for diagnosing stroke

Country Status (1)

Country Link
WO (1) WO2009075863A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2415579B1 (en) 2011-09-28 2014-11-17 Instituto Tecnológico De Castilla Y León PROCEDURE AND MULTIAGENT ELECTRONIC DEVICE WITH DIFFUSIVE CONTROL FOR THE DETECTION OF THE SIDE CEREBRAL ICTUS.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119064A1 (en) * 2001-08-20 2003-06-26 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
WO2006036220A2 (en) * 2004-09-22 2006-04-06 Prediction Sciences Llc Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US20070281326A1 (en) * 2006-05-11 2007-12-06 Roni Wechsler Screening systems utilizing RTP801

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119064A1 (en) * 2001-08-20 2003-06-26 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
WO2006036220A2 (en) * 2004-09-22 2006-04-06 Prediction Sciences Llc Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US20070281326A1 (en) * 2006-05-11 2007-12-06 Roni Wechsler Screening systems utilizing RTP801

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PEVSNER P.H. ET AL.: "Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation", RAPID COMMUN. MASS SPECTROM., vol. 21, no. 3, 2007, pages 429 - 436, XP002522866 *

Also Published As

Publication number Publication date
WO2009075863A2 (en) 2009-06-18

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