WO2009069291A1 - Prophylactic and/or therapeutic composition for disease caused by inhalation of tobacco smoke - Google Patents

Prophylactic and/or therapeutic composition for disease caused by inhalation of tobacco smoke Download PDF

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Publication number
WO2009069291A1
WO2009069291A1 PCT/JP2008/003480 JP2008003480W WO2009069291A1 WO 2009069291 A1 WO2009069291 A1 WO 2009069291A1 JP 2008003480 W JP2008003480 W JP 2008003480W WO 2009069291 A1 WO2009069291 A1 WO 2009069291A1
Authority
WO
WIPO (PCT)
Prior art keywords
prophylactic
inhalation
therapeutic composition
tobacco smoke
disease caused
Prior art date
Application number
PCT/JP2008/003480
Other languages
French (fr)
Japanese (ja)
Inventor
Satoru Furukawa
Original Assignee
Satoru Furukawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Satoru Furukawa filed Critical Satoru Furukawa
Publication of WO2009069291A1 publication Critical patent/WO2009069291A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is a prophylactic and/or therapeutic composition for chronic obstructive pulmonary disease (COPD) which is a disease caused by the inhalation of tobacco smoke. A composition is prepared, which comprises, as an active ingredient, at least one substance selected from the group consisting of orotic acid, orotidylic acid (a derivative of orotic acid), orotidine and uridine monophosphate (UMP), and inorganic salts and organic salts thereof. In the preparation, it is preferred that the composition be further added with an antioxidative agent, such as glutathione, N-acetylcysteine, coenzyme Q10, α-lipoic acid, vitamin C, vitamin E, polyphenol and carotenoid. The prophylactic and/or therapeutic composition can be administered orally or through inhalation.
PCT/JP2008/003480 2007-11-26 2008-11-26 Prophylactic and/or therapeutic composition for disease caused by inhalation of tobacco smoke WO2009069291A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007305017A JP2011026204A (en) 2007-11-26 2007-11-26 Prophylactic and/or therapeutic composition for disease caused by inhalation of tobacco smoke
JP2007-305017 2007-11-26

Publications (1)

Publication Number Publication Date
WO2009069291A1 true WO2009069291A1 (en) 2009-06-04

Family

ID=40678202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/003480 WO2009069291A1 (en) 2007-11-26 2008-11-26 Prophylactic and/or therapeutic composition for disease caused by inhalation of tobacco smoke

Country Status (2)

Country Link
JP (1) JP2011026204A (en)
WO (1) WO2009069291A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012081604A1 (en) * 2010-12-15 2012-06-21 キリンホールディングス株式会社 Composition containing orotic acid, and process for production thereof
WO2016065419A1 (en) * 2014-10-28 2016-05-06 Medlab Ip Pty Ltd Treatment for depression and depressive disorders
WO2018207929A1 (en) * 2017-05-12 2018-11-15 株式会社古川リサーチオフィス Arterial oxygen saturation degree improver
CN115814090A (en) * 2022-11-22 2023-03-21 广州医科大学附属第一医院 Novel medicine target spot for tobacco-induced inflammation
US11890315B2 (en) 2017-11-17 2024-02-06 Renovion, Inc. Stable ascorbic acid compositions and methods of using same
CN115814090B (en) * 2022-11-22 2024-05-24 广州医科大学附属第一医院 Drug target for tobacco induced inflammation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2556832B1 (en) * 2011-08-12 2017-07-19 Universitätsklinikum Freiburg Uridine and uridine analogues for use in the treatment of chronic obstructive pulmonary disease
GB2524831A (en) * 2014-04-04 2015-10-07 Ermes Medical Company Ltd New pharmaceutical use
JP6811983B2 (en) * 2016-08-18 2021-01-13 株式会社古川リサーチオフィス Oral composition having retinal ganglion cell death inhibitory activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001505553A (en) * 1996-11-07 2001-04-24 インスパイアー ファーマシューティカルズ，インコーポレイティド Method of treating bronchitis with uridine triphosphate and related compounds
WO2002100409A1 (en) * 2001-06-11 2002-12-19 Kyowa Hakko Kogyo Co., Ltd. Antiinflammatoric and antitussive compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001505553A (en) * 1996-11-07 2001-04-24 インスパイアー ファーマシューティカルズ，インコーポレイティド Method of treating bronchitis with uridine triphosphate and related compounds
WO2002100409A1 (en) * 2001-06-11 2002-12-19 Kyowa Hakko Kogyo Co., Ltd. Antiinflammatoric and antitussive compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Encyclopedic Reference of Molecular Pharmacology", 2004, SPRINGER-VERLAG, pages: 784 - 790 *
ANDERSON C.M. ET AL.: "Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotides", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 18, 1997, pages 387 - 392 *
LAZAROWSKI E.R. ET AL.: "Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 39, 1997, pages 24348 - 24354 *
PELS RIJCKEN W.R. ET AL.: "Pyrimidine metabolism and sugar nucleotide synthesis in rat liver", BIOCHEMICAL JOURNAL, vol. 266, 1990, pages 777 - 783 *
SAIAG B. ET AL.: "Lack of uptake, release and action of UTP at sympathetic perivascular nerve terminals in rabbit ear artery", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 358, 1998, pages 139 - 145 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012081604A1 (en) * 2010-12-15 2012-06-21 キリンホールディングス株式会社 Composition containing orotic acid, and process for production thereof
WO2016065419A1 (en) * 2014-10-28 2016-05-06 Medlab Ip Pty Ltd Treatment for depression and depressive disorders
AU2015337800B2 (en) * 2014-10-28 2021-05-27 Medlab Ip Pty Ltd Treatment for depression and depressive disorders
US11135181B2 (en) 2014-10-28 2021-10-05 Medlab Ip Pty Ltd Treatment for depression and depressive disorders
WO2018207929A1 (en) * 2017-05-12 2018-11-15 株式会社古川リサーチオフィス Arterial oxygen saturation degree improver
JPWO2018207929A1 (en) * 2017-05-12 2020-01-23 株式会社古川リサーチオフィス Arterial blood oxygen saturation enhancer
US11331318B2 (en) 2017-05-12 2022-05-17 Furukawa Research Office Co., Ltd. Arterial oxygen saturation degree improver
US11890315B2 (en) 2017-11-17 2024-02-06 Renovion, Inc. Stable ascorbic acid compositions and methods of using same
CN115814090A (en) * 2022-11-22 2023-03-21 广州医科大学附属第一医院 Novel medicine target spot for tobacco-induced inflammation
CN115814090B (en) * 2022-11-22 2024-05-24 广州医科大学附属第一医院 Drug target for tobacco induced inflammation

Also Published As

Publication number Publication date
JP2011026204A (en) 2011-02-10

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