WO2009062128A3 - Combination drug therapy for the treatment of cancer - Google Patents

Combination drug therapy for the treatment of cancer Download PDF

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Publication number
WO2009062128A3
WO2009062128A3 PCT/US2008/082924 US2008082924W WO2009062128A3 WO 2009062128 A3 WO2009062128 A3 WO 2009062128A3 US 2008082924 W US2008082924 W US 2008082924W WO 2009062128 A3 WO2009062128 A3 WO 2009062128A3
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WO
WIPO (PCT)
Prior art keywords
drug therapy
cancer
combination drug
combination
inhibits
Prior art date
Application number
PCT/US2008/082924
Other languages
French (fr)
Other versions
WO2009062128A2 (en
Inventor
Karen E. Pollok
Lindsey D. Mayo
Original Assignee
Indiana University Research And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research And Technology Corporation filed Critical Indiana University Research And Technology Corporation
Publication of WO2009062128A2 publication Critical patent/WO2009062128A2/en
Publication of WO2009062128A3 publication Critical patent/WO2009062128A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A combination of drugs was used to kill or inhibit the growth of cancer cells. The combination drug therapy includes administering to a human or animal patient diagnosed with cancer at least one drug that inhibits the activity of an intracellular protein that repairs alkylated DNA and a drug that inhibits the interaction between Hdm2 and p53. The combination drug therapy is useful in the treatment of tumors including some tumors that have become drug resistant. In some instances the combination drug therapy allows the drugs to be administered to a patient at therapeutically effective submyeloablative levels. Still another aspect provides a combination drug therapy that includes administering to a cancer patient a therapeutically effective dose of at least one compound that alkylates DNA, at least one compound that inhibits at least one DNA repair protein and at least one compound that prolongs the half-life of p53 by inhibiting the interaction of p53 with HDM2.
PCT/US2008/082924 2007-11-08 2008-11-08 Combination drug therapy for the treatment of cancer WO2009062128A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98652507P 2007-11-08 2007-11-08
US60/986,525 2007-11-08

Publications (2)

Publication Number Publication Date
WO2009062128A2 WO2009062128A2 (en) 2009-05-14
WO2009062128A3 true WO2009062128A3 (en) 2009-09-17

Family

ID=40626463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/082924 WO2009062128A2 (en) 2007-11-08 2008-11-08 Combination drug therapy for the treatment of cancer

Country Status (1)

Country Link
WO (1) WO2009062128A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2981279T3 (en) 2013-04-05 2019-09-30 Biomarck Pharmaceuticals Ltd. Marcks inhibitor peptides for inhibiting metastasis
CN104174020A (en) * 2013-05-21 2014-12-03 北京大学 Application of human derived protein hCINAP and its gene in development of anticancer drugs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211757A1 (en) * 2005-02-22 2006-09-21 Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211757A1 (en) * 2005-02-22 2006-09-21 Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAI ET AL.: "Mitochondrial Targeting of Human o6-Methylguanine DNA Methyltransferase Protects Against Cell Killing by Chemotherapeutic Alkylating Agent.", CANCER RESEARCH, vol. 65, no. 8, 2005, pages 3319 - 3327 *
CAIMCROSS ET AL.: "Myeloablative Chemotherapy for Recurrent Aggressive Oligodendroglioma.", NEURO-ONCOLOGY, vol. 2, April 2000 (2000-04-01), pages 114 - 119 *
CHANG ET AL.: "Differential Mechanisms in the Regulation of Endogenous Levels of Thrombopoletln and Interleukin-11 Durlng Thrombocytopenla: Insight Into the Regulation of Platelet Production.", BLOOD, vol. 88, 1996, pages 3354 - 3362 *
DATABASE GENBANK 1 October 2007 (2007-10-01), "Chain A, Human O6-Alkylguanine-Dna Alkyltransferase Covalently Crosslinked To DNA", XP003025507, retrieved from http:llwww.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?51247521:PROT:5241323 Database accession no. 1T39_A *
MCKEOWN ET AL.: "DNA Repair: Therapeutic Implications.", BRIT. J. RADIOL., vol. 79, 2006, pages 91 - 93 *
UENO ET AL.: "Modulation of Chemotherapy Resistance in Regional Therapy: A Novel Therapeutic Approach to Advanced Extremity Melanoma.", MOLECULAR CANCER THERAPEUTICS, vol. 5, no. 3, 2006, pages 731 - 738 *

Also Published As

Publication number Publication date
WO2009062128A2 (en) 2009-05-14

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