WO2009057021A3 - Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission - Google Patents

Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission Download PDF

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Publication number
WO2009057021A3
WO2009057021A3 PCT/IB2008/054392 IB2008054392W WO2009057021A3 WO 2009057021 A3 WO2009057021 A3 WO 2009057021A3 IB 2008054392 W IB2008054392 W IB 2008054392W WO 2009057021 A3 WO2009057021 A3 WO 2009057021A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical energy
contrast agent
nano
phase change
substance
Prior art date
Application number
PCT/IB2008/054392
Other languages
French (fr)
Other versions
WO2009057021A2 (en
Inventor
Yao Wang
William T Shi
Original Assignee
Koninkl Philips Electronics Nv
Yao Wang
William T Shi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Yao Wang, William T Shi filed Critical Koninkl Philips Electronics Nv
Publication of WO2009057021A2 publication Critical patent/WO2009057021A2/en
Publication of WO2009057021A3 publication Critical patent/WO2009057021A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Acoustics & Sound (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

The present disclosure provides systems and methods related to contrast agents for photoacoustic and ultrasound imaging. A contrast agent includes a nanoparticle -based contrast medium that is adapted to absorb optical energy and to undergo a phase change upon absorption of a requisite level of optical energy, such phase change being effective to generate nano-bubbles and/or micro-bubbles that resonate at a frequency or in a frequency range. Various constructions of the PA contrast agent are provided including one substance droplets with both absorbing and evaporating capabilities, and multiple-component complexes of one substance with both absorbing and evaporating materials. Highly absorbing nano-particles (such as gold nano-rods) may be coated with an evaporating material. In addition, disclosed agents (including either one substance or multi-component complex) may be encapsulated or coated with an optically transparent and mechanically elastic shell that allows the droplet to expand and form stabilized nano- and/or microbubbles during phase change.
PCT/IB2008/054392 2007-10-31 2008-10-24 Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission WO2009057021A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98399407P 2007-10-31 2007-10-31
US60/983,994 2007-10-31

Publications (2)

Publication Number Publication Date
WO2009057021A2 WO2009057021A2 (en) 2009-05-07
WO2009057021A3 true WO2009057021A3 (en) 2009-08-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/054392 WO2009057021A2 (en) 2007-10-31 2008-10-24 Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission

Country Status (1)

Country Link
WO (1) WO2009057021A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102724911B (en) * 2009-10-16 2016-06-22 皇家飞利浦电子股份有限公司 Active ultrasonic imaging based on photoacoustic contrast agent
WO2012085751A1 (en) 2010-12-22 2012-06-28 Koninklijke Philips Electronics N.V. Photo-acoustic signal enhancement with microbubble-based contrast agents
KR101654675B1 (en) 2014-02-03 2016-09-06 삼성메디슨 주식회사 Method, apparatus and system for generating diagnostic image using photoacoustic material
KR101665633B1 (en) * 2015-04-15 2016-10-12 서강대학교 산학협력단 System and method for diagnosing using photoacoustic/ultrasound contrast agent
CN109998484B (en) * 2019-02-27 2022-02-25 广东工业大学 Multifunctional arthritis detection and treatment system and method
KR102269497B1 (en) * 2019-06-04 2021-06-25 서강대학교 산학협력단 Size-variation bubble complex and Method for preparing the same
EP3932295A1 (en) * 2020-06-30 2022-01-05 Universität Zürich Optoacoustic tomography method of a living organism, 2d- or 3d opotacoustic images, 2d- or 3d blood flow and light fluence images and a photoabsorbing agent for the use in an optoacoustic method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CONJUSTEAU A ET AL: "Metallic nanoparticles as optoacoustic contrast agents for medical imaging", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING USA, vol. 6086, no. 1, 9 February 2006 (2006-02-09), pages 60860K - 1, XP002516820, ISSN: 0277-786X *
COPLAND J A ET AL: "Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography", MOLECULAR IMAGING & BIOLOGY, ELSEVIER, vol. 6, no. 5, 1 September 2004 (2004-09-01), pages 341 - 349, XP004570390, ISSN: 1536-1632 *
EGHTEDARI MOHAMMAD ET AL: "High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system.", NANO LETTERS JUL 2007, vol. 7, no. 7, July 2007 (2007-07-01), pages 1914 - 1918, XP002516822, ISSN: 1530-6984 *
KRAFFT M P ET AL: "Perfluorocarbons: life sciences and biomedical uses", JOURNAL OF POLYMER SCIENCE, PART A (POLYMER CHEMISTRY) WILEY USA, vol. 45, no. 7, 1 April 2007 (2007-04-01), pages 1185 - 1198, XP002516823, ISSN: 0887-624X *
ORAEVSKY A A ET AL: "Enhancement of optoacoustic tissue contrast with absorbing nanoparticles", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE-INT. SOC. OPT. ENG USA, vol. 4434, 2001, pages 60 - 69, XP002516821, ISSN: 0277-786X *

Also Published As

Publication number Publication date
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