WO2009054004A3 - Process for the preparation of sorafenib - Google Patents
Process for the preparation of sorafenib Download PDFInfo
- Publication number
- WO2009054004A3 WO2009054004A3 PCT/IN2008/000698 IN2008000698W WO2009054004A3 WO 2009054004 A3 WO2009054004 A3 WO 2009054004A3 IN 2008000698 W IN2008000698 W IN 2008000698W WO 2009054004 A3 WO2009054004 A3 WO 2009054004A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sorafenib
- preparation
- formula
- novel
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Abstract
A novel and improved process for the preparation of sorafenib (4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide) of formula (I) involving a novel intermediate of formula (II) as key intermediate is disclosed. Sorafenib tosylate, available in the market as Nexavar is a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinase that promote angiogenesis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2372CH2007 | 2007-10-22 | ||
IN2372/CHE/2007 | 2007-10-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009054004A2 WO2009054004A2 (en) | 2009-04-30 |
WO2009054004A3 true WO2009054004A3 (en) | 2009-07-02 |
Family
ID=40527499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2008/000698 WO2009054004A2 (en) | 2007-10-22 | 2008-10-22 | Process for the preparation of sorafenib |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009054004A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
JP2002534468A (en) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | ω-Carboxyaryl-substituted diphenylureas as p38 kinase inhibitors |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
DE602004011340T2 (en) | 2003-05-20 | 2008-11-06 | Bayer Healthcare Llc | DIARYL-UREA SUBSTANCES WITH CHINESE-INHIBITING EFFECT |
WO2011036647A1 (en) | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
AU2010299484A1 (en) | 2009-09-24 | 2012-05-03 | Ranbaxy Laboratories Limited | Polymorphs of sorafenib acid addition salts |
US8552197B2 (en) | 2009-11-12 | 2013-10-08 | Ranbaxy Laboratories Limited | Sorafenib ethylsulfonate salt, process for preparation and use |
US8618305B2 (en) | 2010-01-29 | 2013-12-31 | Ranbaxy Laboratories Limited | Sorafenib dimethyl sulphoxide solvate |
CN102190616B (en) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | A kind of deuterated synthesis of ω-diphenyl urea and the Method and process of production |
CN103408488A (en) * | 2013-08-13 | 2013-11-27 | 张家港威胜生物医药有限公司 | Optimal synthetic method of sorafenib |
DK3039424T3 (en) | 2013-08-28 | 2020-08-31 | Crown Bioscience Inc Taicang | Gene expression signatures predictive of an individual's response to a multikinase inhibitor and methods of using them |
CN104761492A (en) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | Crystal form of sorafenib tosylate, and preparation method thereof |
CN104177292A (en) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | Method for industrial production of sorafenib tosylate polymorphic form I |
CN105481764A (en) * | 2014-09-16 | 2016-04-13 | 重庆圣华曦药业股份有限公司 | Preparation method of sorafenib p-toluenesulfonate |
CN105399668B (en) * | 2015-12-29 | 2018-11-16 | 开封制药(集团)有限公司 | A kind of method that " one kettle way " prepares Sorafenib |
CN105801475B (en) * | 2016-04-25 | 2018-01-12 | 华润双鹤利民药业(济南)有限公司 | A kind of preparation method of Sorafenib Tosylate |
CN109796400B (en) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | Sorafenib tosylate crystal form and preparation method thereof |
CN113395971A (en) | 2019-01-31 | 2021-09-14 | Ionis制药公司 | Modulators of YAP1 expression |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0848078A (en) * | 1994-08-05 | 1996-02-20 | Nippon Paper Ind Co Ltd | Heat-sensitive recorder |
WO2000041698A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
WO2003068228A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
WO2006034796A1 (en) * | 2004-09-29 | 2006-04-06 | Bayer Healthcare Ag | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
EP1683785A1 (en) * | 2003-11-11 | 2006-07-26 | Eisai Co., Ltd. | Urea derivative and process for producing the same |
-
2008
- 2008-10-22 WO PCT/IN2008/000698 patent/WO2009054004A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0848078A (en) * | 1994-08-05 | 1996-02-20 | Nippon Paper Ind Co Ltd | Heat-sensitive recorder |
WO2000041698A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
WO2003068228A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
EP1683785A1 (en) * | 2003-11-11 | 2006-07-26 | Eisai Co., Ltd. | Urea derivative and process for producing the same |
WO2006034796A1 (en) * | 2004-09-29 | 2006-04-06 | Bayer Healthcare Ag | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
Non-Patent Citations (2)
Title |
---|
D. BANKSTON ET AL.: "A Scalable Synthesis of BAY 43-9006: A Potent Raf Kinase Inhibitor for the Treatment of Cancer", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 6, no. 6, 2002, pages 777 - 781, XP002523918 * |
PAN W ET AL: "Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 24, 15 December 2005 (2005-12-15), pages 5474 - 5477, XP025314229, ISSN: 0960-894X, [retrieved on 20051215] * |
Also Published As
Publication number | Publication date |
---|---|
WO2009054004A2 (en) | 2009-04-30 |
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