WO2009051460A3 - Peptide coupled ascorbic acid derivatives - Google Patents

Peptide coupled ascorbic acid derivatives Download PDF

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Publication number
WO2009051460A3
WO2009051460A3 PCT/KR2008/006204 KR2008006204W WO2009051460A3 WO 2009051460 A3 WO2009051460 A3 WO 2009051460A3 KR 2008006204 W KR2008006204 W KR 2008006204W WO 2009051460 A3 WO2009051460 A3 WO 2009051460A3
Authority
WO
WIPO (PCT)
Prior art keywords
ascorbic acid
acid derivatives
peptide coupled
peptide
coupled
Prior art date
Application number
PCT/KR2008/006204
Other languages
French (fr)
Other versions
WO2009051460A2 (en
Inventor
Yoon-Sik Lee
Han-Young Kim
Jin-Mi Noh
Original Assignee
Seoul National University Industry Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seoul National University Industry Foundation filed Critical Seoul National University Industry Foundation
Publication of WO2009051460A2 publication Critical patent/WO2009051460A2/en
Publication of WO2009051460A3 publication Critical patent/WO2009051460A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a peptide linked ascorbic acid derivative and preparation method thereof, which has a whitening effect.
PCT/KR2008/006204 2007-10-20 2008-10-20 Peptide coupled ascorbic acid derivatives WO2009051460A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070105843A KR101413939B1 (en) 2007-10-20 2007-10-20 Peptide coupled ascorbic acid derivatives
KR10-2007-0105843 2007-10-20

Publications (2)

Publication Number Publication Date
WO2009051460A2 WO2009051460A2 (en) 2009-04-23
WO2009051460A3 true WO2009051460A3 (en) 2010-07-15

Family

ID=40567994

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/006204 WO2009051460A2 (en) 2007-10-20 2008-10-20 Peptide coupled ascorbic acid derivatives

Country Status (2)

Country Link
KR (1) KR101413939B1 (en)
WO (1) WO2009051460A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5475787B2 (en) * 2008-09-25 2014-04-16 コーニンクレッカ フィリップス エヌ ヴェ Directivity discovery protocol with coordinated channel selection
KR101154233B1 (en) * 2010-02-11 2012-06-18 성민규 Cosmetic whitening composition containing tyrosine derivatives
US9550744B2 (en) * 2013-09-25 2017-01-24 University Of Florida Research Foundation, Inc. Vitamin C prodrugs and uses thereof
SG11201704321TA (en) * 2014-11-27 2017-06-29 Celltrion Inc Stable peptide-conjugated ascorbic acid derivative, method for preparing same, and cosmetic composition comprising same
KR101724409B1 (en) * 2015-06-04 2017-04-11 주식회사 크릴랜드 Hybrid ascorbic acid derivative and method of fabricating the same
KR101969345B1 (en) * 2016-05-26 2019-04-16 (주)셀트리온 Composition Comprising Stabilized Ascorbic Acid Derivatives with Peptide for Alleviating Inflammation
KR102101329B1 (en) * 2018-01-18 2020-04-17 주식회사 라모수 Manufacturing method of ascorbic acid derivatives with ability of heavy metals removal
KR102130701B1 (en) * 2018-09-27 2020-07-06 주식회사 차메디텍 Vitamin c derivatives with a peptidemolecule and composition containing the same
CN110183432B (en) * 2019-06-28 2021-08-31 珠海市柏瑞医药科技有限公司 Preparation process of 5, 6-O-isopropylidene-L-ascorbic acid
KR20220017695A (en) * 2020-08-05 2022-02-14 주식회사 레미바이오 Ascorbic acid derivative and composition including thereof
CN113087899B (en) * 2021-03-30 2023-03-07 山东丰金生物工程有限公司 L-ascorbic acid derivative and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56161314A (en) * 1980-05-15 1981-12-11 Pola Chem Ind Inc Cosmetic for lightening the color of facial skin
WO1996040647A1 (en) * 1995-06-07 1996-12-19 Prototek, Inc. α-(1,3-DICARBONYLENOL ETHER) METHYL KETONES AS CYSTEINE PROTEASE INHIBITORS
US20050075316A1 (en) * 2002-07-29 2005-04-07 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56161314A (en) * 1980-05-15 1981-12-11 Pola Chem Ind Inc Cosmetic for lightening the color of facial skin
WO1996040647A1 (en) * 1995-06-07 1996-12-19 Prototek, Inc. α-(1,3-DICARBONYLENOL ETHER) METHYL KETONES AS CYSTEINE PROTEASE INHIBITORS
US20050075316A1 (en) * 2002-07-29 2005-04-07 Lockwood Samuel Fournier Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease

Also Published As

Publication number Publication date
KR20090040187A (en) 2009-04-23
KR101413939B1 (en) 2014-06-30
WO2009051460A2 (en) 2009-04-23

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