WO2009047902A1 - Method for producing pteridine compound and method for producing l-biopterin - Google Patents

Method for producing pteridine compound and method for producing l-biopterin Download PDF

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Publication number
WO2009047902A1
WO2009047902A1 PCT/JP2008/002856 JP2008002856W WO2009047902A1 WO 2009047902 A1 WO2009047902 A1 WO 2009047902A1 JP 2008002856 W JP2008002856 W JP 2008002856W WO 2009047902 A1 WO2009047902 A1 WO 2009047902A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
general formula
compound represented
pteridine
biopterin
Prior art date
Application number
PCT/JP2008/002856
Other languages
French (fr)
Japanese (ja)
Inventor
Yuichi Shiro
Shizuaki Murata
Fumi Iwamatsu
Original Assignee
Shiratori Pharmaceutical Co., Ltd.
Asubio Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd. filed Critical Shiratori Pharmaceutical Co., Ltd.
Publication of WO2009047902A1 publication Critical patent/WO2009047902A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Disclosed is a method which enables to commercially advantageously produce a pteridine compound with high yield. Specifically disclosed is a method for producing a pteridine compound represented by the general formula (3) below, which is characterized in that an optically active epoxy aldehyde compound represented by the general formula (1) below and a pyrimidine compound represented by the general formula (2) below are condensed in a polar solvent in the presence of an acid having a pKa of not more than 4.5, and then the resulting is subjected to oxidation. (In the formulae below, R1 represents a protecting group of a hydroxy group, and R2 represents a hydrogen atom or a protecting group of a hydroxy group.)
PCT/JP2008/002856 2007-10-10 2008-10-09 Method for producing pteridine compound and method for producing l-biopterin WO2009047902A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007264599A JP2011011976A (en) 2007-10-10 2007-10-10 Method for producing pteridine compound and l-biopterin
JP2007-264599 2007-10-10

Publications (1)

Publication Number Publication Date
WO2009047902A1 true WO2009047902A1 (en) 2009-04-16

Family

ID=40549054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002856 WO2009047902A1 (en) 2007-10-10 2008-10-09 Method for producing pteridine compound and method for producing l-biopterin

Country Status (2)

Country Link
JP (1) JP2011011976A (en)
WO (1) WO2009047902A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2837629A4 (en) * 2012-04-10 2015-11-25 Asymchem Lab Tianjin Co Ltd Method for synthesizing sapropterin dihydrochloride

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN09053A (en) 2012-05-07 2015-05-22 Shiratori Pharm

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"The Chemical Society of Japan, Kagaku Binran Kisohen", 2004, MARUZEN CO., LTD. *
ISHIKAWA, T.: "Product class 21: pteridines and related structures", SCIENCE OF SYNTHESIS, vol. 16, 2004, pages 1291 - 1335 *
MURATA, S. ET AL.: "Novel regio- and stereoselective synthesis of 6-substituted pteridines and naturally occurring L-erythro biopterin", SYNTHESIS, vol. 3, 1992, pages 303 - 8 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2837629A4 (en) * 2012-04-10 2015-11-25 Asymchem Lab Tianjin Co Ltd Method for synthesizing sapropterin dihydrochloride

Also Published As

Publication number Publication date
JP2011011976A (en) 2011-01-20

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