WO2009028867A3 - Bacteria lysates prepared by bacteriolytic lysin enzyme, and vaccine composition for preventing animal disease comprising the same - Google Patents

Bacteria lysates prepared by bacteriolytic lysin enzyme, and vaccine composition for preventing animal disease comprising the same Download PDF

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Publication number
WO2009028867A3
WO2009028867A3 PCT/KR2008/005020 KR2008005020W WO2009028867A3 WO 2009028867 A3 WO2009028867 A3 WO 2009028867A3 KR 2008005020 W KR2008005020 W KR 2008005020W WO 2009028867 A3 WO2009028867 A3 WO 2009028867A3
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WO
WIPO (PCT)
Prior art keywords
vaccine
bacteriolytic
vaccine composition
bacteria
lysin
Prior art date
Application number
PCT/KR2008/005020
Other languages
French (fr)
Other versions
WO2009028867A2 (en
Inventor
Seongjun Yoon
Yun Jaie Choi
Jeesoo Son
Sooyoun Jun
Sanghyeon Kang
Original Assignee
Intron Biotechnology Inc
Seongjun Yoon
Yun Jaie Choi
Jeesoo Son
Sooyoun Jun
Sanghyeon Kang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intron Biotechnology Inc, Seongjun Yoon, Yun Jaie Choi, Jeesoo Son, Sooyoun Jun, Sanghyeon Kang filed Critical Intron Biotechnology Inc
Publication of WO2009028867A2 publication Critical patent/WO2009028867A2/en
Publication of WO2009028867A3 publication Critical patent/WO2009028867A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14—Pretreatment of feeding-stuffs with enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Birds (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)

Abstract

The present invention relates to a vaccine composition for preventing infectious animal diseases caused by bacteria, more precisely a vaccine composition for preventing infectious animal diseases containing the bacterial lysate prepared by lysin, the bacteriophage-originated bacteriolytic protein, capable of destroying specifically peptidoglycan structure of bacterial cell wall. The bacterial lysate prepared by lysin, the bacteriophage-originated bacteriolytic protein, is not converted into a toxic strain, so that it is safer than the conventional live vaccine or attenuated live vaccine and has live vaccine like immunogenicity inducing immune response. Thus, the bacterial lysate of the present invention can be used as a composition having excellent protect ivity against bacterial infection and thereby further applied in a vaccine or a feed additive for preventing infectious animal diseases caused by bacteria.
PCT/KR2008/005020 2007-08-27 2008-08-27 Bacteria lysates prepared by bacteriolytic lysin enzyme, and vaccine composition for preventing animal disease comprising the same WO2009028867A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070086020A KR100974185B1 (en) 2007-08-27 2007-08-27 Bacteria lysates prepared by bacteriolytic lysin enzyme, and vaccine composition for preventing animal disease comprising the same
KR10-2007-0086020 2007-08-27

Publications (2)

Publication Number Publication Date
WO2009028867A2 WO2009028867A2 (en) 2009-03-05
WO2009028867A3 true WO2009028867A3 (en) 2009-04-23

Family

ID=40388012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/005020 WO2009028867A2 (en) 2007-08-27 2008-08-27 Bacteria lysates prepared by bacteriolytic lysin enzyme, and vaccine composition for preventing animal disease comprising the same

Country Status (2)

Country Link
KR (1) KR100974185B1 (en)
WO (1) WO2009028867A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101381795B1 (en) 2013-02-27 2014-04-07 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same
KR101381797B1 (en) 2013-02-27 2014-04-07 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same
KR101381793B1 (en) 2013-02-27 2014-04-07 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same
KR101381798B1 (en) 2013-02-27 2014-04-07 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same
KR101381796B1 (en) 2013-02-27 2014-04-25 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same
KR101590108B1 (en) 2014-04-10 2016-01-29 씨제이제일제당(주) Novel bacteriophage and composition comprising the same
KR101980146B1 (en) * 2016-08-31 2019-05-20 대한민국(관리청: 특허청장, 승계청: 환경부 국립생물자원관장) Mastoparan Peptide for Manufacturing Inactivated Non Living Vaccine and Non Living Vaccine Using the Same
CN114028550A (en) * 2021-11-15 2022-02-11 苏州大学 Vaccine system for preventing or treating diseases based on one or more bacterial whole cell components and preparation method and application thereof
CZ309947B6 (en) * 2022-07-01 2024-02-21 FAGOFARMA s.r.o. Carbomer hydrogel for maintaining natural skin microbiota and reducing pathogenic bacteria

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510907A2 (en) * 1991-04-20 1992-10-28 Agricultural And Food Research Council Bacteriophage lysins and their applications in destroying and testing for bacteria
WO1996007756A1 (en) * 1994-09-09 1996-03-14 Jsd Technologies, Ltd. Decomposition of bacteria cells by phage lysins
KR20020043585A (en) * 1999-09-14 2002-06-10 뉴 호라이즌스 다이아그노스틱스, 인코포레이티드 The use of bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of various illnesses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510907A2 (en) * 1991-04-20 1992-10-28 Agricultural And Food Research Council Bacteriophage lysins and their applications in destroying and testing for bacteria
WO1996007756A1 (en) * 1994-09-09 1996-03-14 Jsd Technologies, Ltd. Decomposition of bacteria cells by phage lysins
KR20020043585A (en) * 1999-09-14 2002-06-10 뉴 호라이즌스 다이아그노스틱스, 인코포레이티드 The use of bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of various illnesses

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 24 December 2006 (2006-12-24), "endolysin [Staphylococcus phage K]", retrieved from http://www.ncbi.nlm.nih.gov/entrezJviewer.fcgi?dbrotein&id=119658102 Database accession no. ABL87139 *
DATABASE GENBANK 30 March 2006 (2006-03-30), "putative lysin [Staphylococcus phage K]", retrieved from http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?48696421:NCBI:13132968 Database accession no. YP 024461 *
DATABASE GENBANK 6 May 2004 (2004-05-06), "ORF30/ORF32 [Staphylococcus phage K]", retrieved from http://www.ncbi.nlm.nih.gov/entrezJviewer.fcgi?dbrotein&id=47060310 Database accession no. AA047477 *
MARTIN J. LOESSNER ET AL.: "A new procedure for efficient recovery of DNA, RNA, and proteins from Listeria cells by rapid lysis with a recombinant Bacteriophage endolysin.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 61, no. 3, March 1995 (1995-03-01), pages 1150 - 1152 *
MARTIN J. LOESSNER.: "'Bacteriophage endolysins-current state of research and applications.' In", CURRENT OPINION IN MICROBIOLOGY., vol. 8, no. 4, August 2005 (2005-08-01), pages 480 - 487 *
S. O'FLAHERTY ET AL.: "Genome of Staphylococcal phage K: a new lineage of Myoviridae infecting gram-positive bacteria with a low G+C content.", JOURNAL OF BACTERIOLOGY., vol. 186, no. 9, May 2004 (2004-05-01), pages 2862 - 2871 *
VIVEK JAIN ET AL.: "Use of lambda phage S and R gene products in an inducible lysis system for Vibrio cholerae and Salmonella enterica serovar Typhimurium-based DNA vaccine delivery system.", INFECTION AND IMMUNITY., vol. 68, no. 2, February 2000 (2000-02-01), pages 986 - 989 *

Also Published As

Publication number Publication date
KR100974185B1 (en) 2010-08-05
WO2009028867A2 (en) 2009-03-05
KR20090021475A (en) 2009-03-04

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