WO2009028387A1 - プロテアーゼ阻害剤耐性を有する癌の治療薬 - Google Patents

プロテアーゼ阻害剤耐性を有する癌の治療薬 Download PDF

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WO2009028387A1
WO2009028387A1 PCT/JP2008/064887 JP2008064887W WO2009028387A1 WO 2009028387 A1 WO2009028387 A1 WO 2009028387A1 JP 2008064887 W JP2008064887 W JP 2008064887W WO 2009028387 A1 WO2009028387 A1 WO 2009028387A1
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lower alkyl
resistance
therapeutic agent
substituted lower
represents hydrogen
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PCT/JP2008/064887
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English (en)
French (fr)
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Takayuki Nakashima
Yukimasa Shiotsu
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Kyowa Hakko Kirin Co., Ltd.
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Priority to EP08792608A priority Critical patent/EP2184073A4/en
Priority to JP2009530067A priority patent/JPWO2009028387A1/ja
Priority to US12/674,230 priority patent/US20110112099A1/en
Publication of WO2009028387A1 publication Critical patent/WO2009028387A1/ja

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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract

　ヒートショック蛋白質90（Hsp90）ファミリー蛋白質阻害剤として、式（I） ［式中、nは1～5の整数を表し、 R1は置換もしくは非置換の低級アルキル、CONR7R8（式中、R7及びR8は同一または異なって、水素原子、置換もしくは非置換の低級アルキル等を表す）等を表し、 R2は置換もしくは非置換のアリール等を表し、 R3及びR5は同一または異なって、水素原子、置換もしくは非置換の低級アルキル等を表し、 R4は水素原子等を表し、 R6は水素原子、ハロゲン、置換もしくは非置換の低級アルキル等を表す］で表されるベンゾイル化合物またはその薬学的に許容される塩を含有する、プロテアーゼ阻害剤耐性を有する癌の治療薬等を提供する。
PCT/JP2008/064887 2007-08-24 2008-08-21 プロテアーゼ阻害剤耐性を有する癌の治療薬 WO2009028387A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08792608A EP2184073A4 (en) 2007-08-24 2008-08-21 AGAINST PROTEASE HEMMER RESISTANT CANCER THERAPEUTICS
JP2009530067A JPWO2009028387A1 (ja) 2007-08-24 2008-08-21 プロテアーゼ阻害剤耐性を有する癌の治療薬
US12/674,230 US20110112099A1 (en) 2007-08-24 2008-08-21 Therapeutic agent for cancer resistant to protease inhibitor

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JP2007217880 2007-08-24
JP2007-217880 2007-08-24

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US11684679B2 (en) 2016-03-07 2023-06-27 University Of Iowa Research Foundation AAV-mediated expression using a synthetic promoter and enhancer
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
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WO2005000778A1 (ja) * 2003-06-27 2005-01-06 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
WO2005063222A1 (ja) * 2003-12-26 2005-07-14 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤

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Cited By (4)

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US8846030B2 (en) * 1999-06-08 2014-09-30 University Of Iowa Research Foundation Compounds and methods to enhance rAAV transduction
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
US11684679B2 (en) 2016-03-07 2023-06-27 University Of Iowa Research Foundation AAV-mediated expression using a synthetic promoter and enhancer
US11999965B2 (en) 2021-09-09 2024-06-04 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof

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US20110112099A1 (en) 2011-05-12
EP2184073A4 (en) 2010-10-20
JPWO2009028387A1 (ja) 2010-12-02

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