WO2009022897A3 - Composición farmacéutica sinergica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal y de otros órganos en un humano o animal - Google Patents

Composición farmacéutica sinergica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal y de otros órganos en un humano o animal Download PDF

Info

Publication number
WO2009022897A3
WO2009022897A3 PCT/MX2008/000104 MX2008000104W WO2009022897A3 WO 2009022897 A3 WO2009022897 A3 WO 2009022897A3 MX 2008000104 W MX2008000104 W MX 2008000104W WO 2009022897 A3 WO2009022897 A3 WO 2009022897A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
organs
animal
human
angiogenesis
Prior art date
Application number
PCT/MX2008/000104
Other languages
English (en)
French (fr)
Other versions
WO2009022897A2 (es
Inventor
Barraco Juan Eduardo Maria Gallo
Original Assignee
Civil De Estudios Superiores A
Rivas Cuevas Claudio Manuel
Gallo Barraco Juan Eduardo Mar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Civil De Estudios Superiores A, Rivas Cuevas Claudio Manuel, Gallo Barraco Juan Eduardo Mar filed Critical Civil De Estudios Superiores A
Priority to EP08793787A priority Critical patent/EP2186529B1/en
Priority to ES08793787T priority patent/ES2385121T3/es
Priority to DK08793787.6T priority patent/DK2186529T3/da
Priority to CA2736382A priority patent/CA2736382A1/en
Priority to AT08793787T priority patent/ATE551072T1/de
Priority to US12/735,659 priority patent/US9023350B2/en
Publication of WO2009022897A2 publication Critical patent/WO2009022897A2/es
Publication of WO2009022897A3 publication Critical patent/WO2009022897A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/47—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composición farmacéutica sinérgica, útil para inhibir Ia neovascularización (angiogénesis) corneal y retinal, y de otros órganos, en un humano o animal, caracterizada porque comprende, en un vehículo o portador farmacéuticamente aceptable: 60 a 90 % en peso de Suramina, o el equivalente de una de sus sales farmacéuticamente aceptables; y 40 a 10 % en peso de Bevacizumab; en donde dichos porcentajes son con respecto a Ia suma de los pesos de ambos principios activos. Dicha composición farmacéutica sinérgica se presenta bajo Ia forma de una composición inyectable por vía endovenosa, intravítrea o subconjuntival, o bajo Ia forma para Ia administración tópica.
PCT/MX2008/000104 2007-08-07 2008-08-07 Composición farmacéutica sinergica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal y de otros órganos en un humano o animal WO2009022897A2 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08793787A EP2186529B1 (en) 2007-08-07 2008-08-07 Synergic pharmaceutical composition, useful for inhibiting corneal and retinal neovascularization (angiogenesis), and in other organs, in a human being or animal
ES08793787T ES2385121T3 (es) 2007-08-07 2008-08-07 Composición farmacéutica sinérgica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal, y de otros órganos, en un humano o animal
DK08793787.6T DK2186529T3 (da) 2007-08-07 2008-08-07 Anvendelig synergisk og farmaceutisk sammensætning til hæmning af corneal og retinal neovaskularisering (angiogenese), og i andre organer, hos et menneske eller dyr
CA2736382A CA2736382A1 (en) 2007-08-07 2008-08-07 Synergistic pharmaceutical composition useful for inhibiting corneal and retinal neovascularization (angiogenesis), and in other organs, in a human being or animal
AT08793787T ATE551072T1 (de) 2007-08-07 2008-08-07 Synerge pharmazeutische zusammensetzung zur hemmung von hornhaut- und netzhaut- neovaskularisation (angiogenese) und in anderen organen eines menschen oder tieres
US12/735,659 US9023350B2 (en) 2007-08-07 2008-08-07 Synergistic pharmaceutical composition useful for inhibiting corneal and retinal neovascularization (angiogenesis), and in other organs, in a human being or animals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ARP20070103482 2007-08-07
ARP070103482A AR062239A1 (es) 2007-08-07 2007-08-07 Composicion farmaceutica sinergica util para inhibir la neovascularizacion (angiogenesis) corneal y retinal, y de otros organos, en un humano o animal

Publications (2)

Publication Number Publication Date
WO2009022897A2 WO2009022897A2 (es) 2009-02-19
WO2009022897A3 true WO2009022897A3 (es) 2009-03-26

Family

ID=39929413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2008/000104 WO2009022897A2 (es) 2007-08-07 2008-08-07 Composición farmacéutica sinergica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal y de otros órganos en un humano o animal

Country Status (8)

Country Link
US (1) US9023350B2 (es)
EP (1) EP2186529B1 (es)
AR (1) AR062239A1 (es)
AT (1) ATE551072T1 (es)
CA (1) CA2736382A1 (es)
DK (1) DK2186529T3 (es)
ES (1) ES2385121T3 (es)
WO (1) WO2009022897A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2796312C (en) * 2010-05-28 2020-11-03 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-cd160 specific antibodies for the treatment of eye disorders based on neoangiogenesis
US10296814B1 (en) 2013-06-27 2019-05-21 Amazon Technologies, Inc. Automated and periodic updating of item images data store
US10366306B1 (en) 2013-09-19 2019-07-30 Amazon Technologies, Inc. Item identification among item variations
WO2015185977A1 (en) * 2014-06-03 2015-12-10 Arturo Solis Herrera Animal models of corneal angiogenesis and corneal ectatic diseases, methods of producing, and methods of use thereof
CA3037116A1 (en) * 2016-10-14 2018-04-19 Novartis Ag Methods for treating ocular disease using inhibitors of csf-1r
EP3979985A4 (en) * 2019-06-07 2023-05-03 Paxmedica, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES
JP2023541141A (ja) * 2020-09-04 2023-09-28 ザ ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュラル アンド メカニカル カレッジ がんを治療するための組み合わせ組成物及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125815A2 (en) * 2005-05-25 2006-11-30 Nycomed Gmbh Tetrahydropyridothiophenes for use in the treatment of cancer
US20070071756A1 (en) * 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121320A (en) * 1997-02-26 2000-09-19 The University Of Kentucky Research Foundation Combination anti-leukemic therapy by utilizing suramin and biologic response modifiers
FR2953411B1 (fr) * 2009-12-03 2012-02-03 Biocodex Combinaison synergique de composes analgesiques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125815A2 (en) * 2005-05-25 2006-11-30 Nycomed Gmbh Tetrahydropyridothiophenes for use in the treatment of cancer
US20070071756A1 (en) * 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUTSON THOMAS E ET AL: "Targeting growth factor and antiangiogenic pathways in clear-cell renal cellcarcinoma: rationale and ongoing trials", CLINICAL GENITOURINARY CANCER, CANCER INFORMATION GROUP, US, vol. 5, no. 1, 1 December 2006 (2006-12-01), pages s31 - s39, XP008080368, ISSN: 1558-7673 *

Also Published As

Publication number Publication date
ES2385121T3 (es) 2012-07-18
US20110076266A1 (en) 2011-03-31
CA2736382A1 (en) 2009-02-19
EP2186529B1 (en) 2012-03-28
EP2186529A2 (en) 2010-05-19
WO2009022897A2 (es) 2009-02-19
AR062239A1 (es) 2008-10-22
US9023350B2 (en) 2015-05-05
DK2186529T3 (da) 2012-07-16
ATE551072T1 (de) 2012-04-15

Similar Documents

Publication Publication Date Title
WO2009022897A3 (es) Composición farmacéutica sinergica, útil para inhibir la neovascularización (angiogénesis) corneal y retinal y de otros órganos en un humano o animal
WO2005105067A3 (en) Aqueous solutions comprising prednisolone and a cyclodextrin derivative
WO2007106381A3 (en) Ophthalmic compositions comprising povidone-iodine
JP2010222367A5 (es)
WO2005072745A3 (en) Aqueous solutions comprising prednisolone and a cyclodextrin derivative
WO2006133941A3 (en) Cannabinoid active pharmaceutical ingredient for improved dosage forms
NZ594557A (en) Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
WO2005094799A3 (en) Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity
WO2010123569A3 (en) Immunonanotherapeutics providing a th1-biased response
WO2007048219A3 (en) Sustained drug release composition
WO2007044668A3 (en) Compstatin and analogs thereof for eye disorders
WO2008020032A8 (en) Use of 2,5-dihydroxybenzene derivatives for the treatment of ocular diseases
EP4306523A3 (en) Imidazoquinoline compounds and uses thereof
WO2009109613A3 (en) 1-BENZYL-3-HYDROXYMETHYLINDAZOIιE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1
WO2008140052A1 (ja) ロピニロール又はその塩を有効成分として含有する後眼部疾患の予防又は治療剤
RU2012131251A (ru) Композиции и способы для лечения связанных с ангиогенезом заболеваний глаз
MX2009003750A (es) Suministro eficiente de antagonistas del receptor de adenosina a3 de especies cruzadas, para reducir la presion intraocular.
WO2009109616A3 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cxrl and p40
WO2007075720A8 (en) Topical mecamylamine formulations for ocular administration and uses thereof
AR055591A1 (es) Una composicion topica protectora de la piel y su uso
WO2006039252A3 (en) Compositions and methods for treating ophthalmic diseases
JP2009519962A5 (es)
WO2011159100A2 (ko) 항암 활성을 나타내는 약제학적 조성물
EP4344743A3 (en) Heterocyclic flavone derivatives, compositions, and methods related thereto
MX2009007040A (es) Derivados de mononitrato de isosorbida para el tratamiento de hipertension ocular.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08793787

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008793787

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12735659

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2736382

Country of ref document: CA