WO2009022346A3 - Phenyl carbamates for treating gastrointestinal inflammation - Google Patents

Phenyl carbamates for treating gastrointestinal inflammation Download PDF

Info

Publication number
WO2009022346A3
WO2009022346A3 PCT/IL2008/001127 IL2008001127W WO2009022346A3 WO 2009022346 A3 WO2009022346 A3 WO 2009022346A3 IL 2008001127 W IL2008001127 W IL 2008001127W WO 2009022346 A3 WO2009022346 A3 WO 2009022346A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl carbamates
diseases
treating gastrointestinal
gastrointestinal inflammation
pharmaceutical compositions
Prior art date
Application number
PCT/IL2008/001127
Other languages
French (fr)
Other versions
WO2009022346A2 (en
Inventor
Marta Weinstock-Rosin
Avraham Rubinstein
Tareq Taha Jubeh
Original Assignee
Yissum Res Dev Co
Marta Weinstock-Rosin
Avraham Rubinstein
Tareq Taha Jubeh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Marta Weinstock-Rosin, Avraham Rubinstein, Tareq Taha Jubeh filed Critical Yissum Res Dev Co
Publication of WO2009022346A2 publication Critical patent/WO2009022346A2/en
Publication of WO2009022346A3 publication Critical patent/WO2009022346A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is directed to pharmaceutical compositions comprising inhibitors of acetylcholine esterase useful in methods for treating inflammatory diseases and autoimmune diseases of the gastrointestinal tract. In particular, the present invention provides pharmaceutical compositions comprising phenyl carbamates including rivastigmine that are known acetylcholine esterase inhibitors, now disclosed to be useful for treating inflammatory bowel disease and other autoimmune and chronic inflammatory gastrointestinal diseases and conditions.
PCT/IL2008/001127 2007-08-14 2008-08-14 Phenyl carbamates for treating gastrointestinal inflammation WO2009022346A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95566407P 2007-08-14 2007-08-14
US60/955,664 2007-08-14

Publications (2)

Publication Number Publication Date
WO2009022346A2 WO2009022346A2 (en) 2009-02-19
WO2009022346A3 true WO2009022346A3 (en) 2009-06-04

Family

ID=39926563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2008/001127 WO2009022346A2 (en) 2007-08-14 2008-08-14 Phenyl carbamates for treating gastrointestinal inflammation

Country Status (1)

Country Link
WO (1) WO2009022346A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118126A1 (en) 2012-02-12 2013-08-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Ladostigil therapy for immunomodulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222123A1 (en) * 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
WO2007071394A2 (en) * 2005-12-22 2007-06-28 Novartis Ag Combination of a 5-ht4 agonist with a cholinesterase inhibitor
WO2007147883A1 (en) * 2006-06-23 2007-12-27 Laboratorios Del Dr. Esteve, S.A. Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222123A1 (en) * 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
WO2007071394A2 (en) * 2005-12-22 2007-06-28 Novartis Ag Combination of a 5-ht4 agonist with a cholinesterase inhibitor
WO2007147883A1 (en) * 2006-06-23 2007-12-27 Laboratorios Del Dr. Esteve, S.A. Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity

Also Published As

Publication number Publication date
WO2009022346A2 (en) 2009-02-19

Similar Documents

Publication Publication Date Title
WO2009064457A3 (en) Corticosteroid compositions
WO2008019124A8 (en) Heteroaryl compounds useful as inhibitors of e1 activating enzymes
IL210916A (en) Clonidine and pharmaceutical composition comprising it for the prevention or treatment of an inflammatory disease in the mucosa
WO2008085794A3 (en) Methods and compositions related to clot binding compounds
EP2369017B8 (en) Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases
HK1132302A1 (en) Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers rna
IL176960A0 (en) Compositions and methods of treatment for inflammatory diseases
WO2010088518A3 (en) Heterocyclic modulators of gpr119 for treatment of disease
WO2008067219A3 (en) Quinazolinone modulators of tgr5
WO2010074588A8 (en) Pharmaceutical compounds
ZA200800448B (en) Methods and compositions for the prevention and treatment of inflammatory disease
WO2007093183A3 (en) Use of a compound that enhances gabaa-ergic neurotransmission for the treatment of inflammatory diseases
EP2203057A4 (en) Method and compositions for treatment or prevention of inflammatory conditions
AU2007243282A8 (en) Compositions and methods for the treatment of cardiovascular disease
WO2007101161A8 (en) Methods and compositions for the treatment of gastrointestinal disorders
EP2040726A4 (en) Trachelospermi caulis extract composition for the treatment and prevention of inflammatory diseases
WO2007109088A3 (en) Combinationtherapies of thiazolidinedione analogues and glucocorticoid agonists
ZA201001055B (en) Compositions and methods for treating immunological and inflammatory diseases and disorders
WO2010051320A3 (en) Methods for assembling panels of cancer cell lines for use in testing the efficacy of one or more pharmaceutical compositions
WO2011088160A3 (en) Novel cyp17 inhibitors
WO2010062506A3 (en) Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors
IL195771A0 (en) Methods and immune modulatory nucleic acid compositions for preventing and treating disease
EP2004164A4 (en) Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases
HK1150971A1 (en) Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome phy906
EP1843781A4 (en) Composition for prevention, treatment and diagnosis of chronic inflammatory airway diseases

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08789800

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08789800

Country of ref document: EP

Kind code of ref document: A2