WO2009018502A3 - Process for the synthesis of diaminopyridine and related compounds - Google Patents

Process for the synthesis of diaminopyridine and related compounds Download PDF

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Publication number
WO2009018502A3
WO2009018502A3 PCT/US2008/071864 US2008071864W WO2009018502A3 WO 2009018502 A3 WO2009018502 A3 WO 2009018502A3 US 2008071864 W US2008071864 W US 2008071864W WO 2009018502 A3 WO2009018502 A3 WO 2009018502A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
diaminopyridine
related compounds
compounds
chlorine
Prior art date
Application number
PCT/US2008/071864
Other languages
French (fr)
Other versions
WO2009018502A2 (en
Inventor
Joachim C Ritter
Original Assignee
Du Pont
Joachim C Ritter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Joachim C Ritter filed Critical Du Pont
Priority to JP2010520209A priority Critical patent/JP2010535249A/en
Priority to CN200880101378A priority patent/CN101784525A/en
Priority to EP08797020A priority patent/EP2176224A2/en
Publication of WO2009018502A2 publication Critical patent/WO2009018502A2/en
Publication of WO2009018502A3 publication Critical patent/WO2009018502A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

A process is provided for the synthesis of a diaminopyridine, such as 2, 6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.
PCT/US2008/071864 2007-08-01 2008-08-01 Process for the synthesis of diaminopyridine and related compounds WO2009018502A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2010520209A JP2010535249A (en) 2007-08-01 2008-08-01 Method for the synthesis of diaminopyridine and related compounds
CN200880101378A CN101784525A (en) 2007-08-01 2008-08-01 Process for the synthesis of diaminopyridine and related compounds
EP08797020A EP2176224A2 (en) 2007-08-01 2008-08-01 Process for the synthesis of diaminopyridine and related compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95326107P 2007-08-01 2007-08-01
US60/953,261 2007-08-01

Publications (2)

Publication Number Publication Date
WO2009018502A2 WO2009018502A2 (en) 2009-02-05
WO2009018502A3 true WO2009018502A3 (en) 2009-03-19

Family

ID=40193549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/071864 WO2009018502A2 (en) 2007-08-01 2008-08-01 Process for the synthesis of diaminopyridine and related compounds

Country Status (5)

Country Link
EP (1) EP2176224A2 (en)
JP (1) JP2010535249A (en)
KR (1) KR20100051689A (en)
CN (1) CN101784525A (en)
WO (1) WO2009018502A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013003708A1 (en) 2011-06-30 2013-01-03 Biomarin Pharmaceuticals, Inc. Methods of administering 3,4-diaminopyridine
CN103288720B (en) * 2013-06-09 2015-05-27 南通市华峰化工有限责任公司 High-pressure synthetic method of 2,6-diaminopyridine
CN109225293A (en) * 2018-10-15 2019-01-18 安徽绩溪县徽煌化工有限公司 A kind of processing method improving 2,3- dichloropyridine output capacity catalyst
CN113149896A (en) * 2021-03-09 2021-07-23 利尔化学股份有限公司 Preparation method of 3-aminopyridine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE510432C (en) * 1927-03-08 1930-10-18 Schering Kahlbaum Ag Process for the preparation of aminopyridine compounds
JPS5353662A (en) * 1976-10-25 1978-05-16 Sumitomo Chem Co Ltd Preparation of aminopyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE510432C (en) * 1927-03-08 1930-10-18 Schering Kahlbaum Ag Process for the preparation of aminopyridine compounds
JPS5353662A (en) * 1976-10-25 1978-05-16 Sumitomo Chem Co Ltd Preparation of aminopyridines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHASE B H ET AL: "Synthesis of 2:6-Diamino-3-arylpyridines", JOURNAL OF THE CHEMICAL SOCIETY, 1953, pages 3548 - 3555, XP009106086, ISSN: 0368-1769 *

Also Published As

Publication number Publication date
KR20100051689A (en) 2010-05-17
WO2009018502A2 (en) 2009-02-05
JP2010535249A (en) 2010-11-18
EP2176224A2 (en) 2010-04-21
CN101784525A (en) 2010-07-21

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