WO2009004491A3 - Preparation of oxycodone - Google Patents

Preparation of oxycodone Download PDF

Info

Publication number
WO2009004491A3
WO2009004491A3 PCT/IB2008/002610 IB2008002610W WO2009004491A3 WO 2009004491 A3 WO2009004491 A3 WO 2009004491A3 IB 2008002610 W IB2008002610 W IB 2008002610W WO 2009004491 A3 WO2009004491 A3 WO 2009004491A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxycodone
preparation
thebaine
specifically
relates
Prior art date
Application number
PCT/IB2008/002610
Other languages
French (fr)
Other versions
WO2009004491A2 (en
Inventor
Harald Halvorsen
Trond Lovli
Original Assignee
Alpharma Aps
Harald Halvorsen
Trond Lovli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma Aps, Harald Halvorsen, Trond Lovli filed Critical Alpharma Aps
Publication of WO2009004491A2 publication Critical patent/WO2009004491A2/en
Publication of WO2009004491A3 publication Critical patent/WO2009004491A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Abstract

This invention relates to a pharmaceutical process, specifically for the preparation of oxycodone (II) from thebaine.
PCT/IB2008/002610 2007-07-02 2008-06-25 Preparation of oxycodone WO2009004491A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0712783A GB2450691A (en) 2007-07-02 2007-07-02 One-pot preparation of oxycodone from thebaine
GB0712783.0 2007-07-02

Publications (2)

Publication Number Publication Date
WO2009004491A2 WO2009004491A2 (en) 2009-01-08
WO2009004491A3 true WO2009004491A3 (en) 2009-04-02

Family

ID=38421057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002610 WO2009004491A2 (en) 2007-07-02 2008-06-25 Preparation of oxycodone

Country Status (2)

Country Link
GB (1) GB2450691A (en)
WO (1) WO2009004491A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SA07280459B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
EP2377866B1 (en) 2010-03-23 2014-02-26 Siegfried AG Preparation of low impurity opiates in a continuous flow reactor
TW201639855A (en) 2012-07-16 2016-11-16 羅德科技公司 Process for improved opioid synthesis
BR112015002024A2 (en) 2012-08-03 2017-07-04 Johnson Matthey Plc process for preparing an oxycodone adduct, aqueous oxycodone adduct aqueous solution, solid oxycodone acid adduct, and solid oxycodone alkaloid
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
AU2015207733A1 (en) * 2014-01-15 2016-07-14 Rhodes Technologies Process for improved oxycodone synthesis
EP3642207B1 (en) * 2017-06-20 2022-08-31 Johnson Matthey Public Limited Company Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004109090A1 (en) * 2003-06-05 2004-12-16 Audi Ag Method for operating an internal combustion engine of a vehicle, especially a motor vehicle, and device for implementing said method
US20050038251A1 (en) * 2003-06-05 2005-02-17 Francis Charles Auxilium Process for manufacturing opioid analgesics
WO2006019364A1 (en) * 2004-08-18 2006-02-23 Zentiva, A.S. A method of preparation of oxycodone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
CN101198612A (en) * 2005-06-16 2008-06-11 马林克罗特公司 A new synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004109090A1 (en) * 2003-06-05 2004-12-16 Audi Ag Method for operating an internal combustion engine of a vehicle, especially a motor vehicle, and device for implementing said method
US20050038251A1 (en) * 2003-06-05 2005-02-17 Francis Charles Auxilium Process for manufacturing opioid analgesics
WO2006019364A1 (en) * 2004-08-18 2006-02-23 Zentiva, A.S. A method of preparation of oxycodone

Also Published As

Publication number Publication date
GB2450691A (en) 2009-01-07
WO2009004491A2 (en) 2009-01-08
GB0712783D0 (en) 2007-08-08

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