WO2009001545A1 - 移植片対宿主疾患の検査および治療方法 - Google Patents

移植片対宿主疾患の検査および治療方法 Download PDF

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Publication number
WO2009001545A1
WO2009001545A1 PCT/JP2008/001625 JP2008001625W WO2009001545A1 WO 2009001545 A1 WO2009001545 A1 WO 2009001545A1 JP 2008001625 W JP2008001625 W JP 2008001625W WO 2009001545 A1 WO2009001545 A1 WO 2009001545A1
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Prior art keywords
versus host
graft versus
host disease
detection
treatment
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PCT/JP2008/001625
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English (en)
French (fr)
Inventor
Tsukasa Hori
Yasuo Kokai
Yasuyoshi Naishiro
Hiroyuki Tsutsumi
Kohzoh Imai
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Sapporo Medical University
Immuno-Biological Laboratories Co., Ltd.
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Publication date
Application filed by Sapporo Medical University, Immuno-Biological Laboratories Co., Ltd. filed Critical Sapporo Medical University
Priority to CN200880021422.XA priority Critical patent/CN101743473B/zh
Priority to US12/666,209 priority patent/US20100183586A1/en
Priority to RU2010101909/15A priority patent/RU2479846C2/ru
Priority to EP08764208.8A priority patent/EP2163896B1/en
Priority to JP2009520345A priority patent/JP5403752B2/ja
Priority to CA2692332A priority patent/CA2692332C/en
Priority to KR1020107001343A priority patent/KR101432191B1/ko
Priority to AU2008268842A priority patent/AU2008268842B2/en
Publication of WO2009001545A1 publication Critical patent/WO2009001545A1/ja
Priority to US13/523,791 priority patent/US20130267430A2/en
Priority to US14/244,166 priority patent/US9631014B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　被験者から得た試料中のＣＣＬ８蛋白質の量を測定し，得られた測定値を移植片対宿主疾患の診断または経過の指標とすることを特徴とする，移植片対宿主疾患を検査するための方法が開示される。また，抗ＣＣＬ８抗体を含む移植片対宿主疾患の検査薬も開示される。本発明の方法により，移植片対宿主疾患の発症の診断および経過のモニタリング，特に感染症との鑑別診断が可能である。さらに，抗ＣＣＬ８抗体を用いる移植片対宿主疾患の治療方法も提供される。
PCT/JP2008/001625 2007-06-22 2008-06-23 移植片対宿主疾患の検査および治療方法 WO2009001545A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN200880021422.XA CN101743473B (zh) 2007-06-22 2008-06-23 移植物抗宿主疾病的检查及治疗方法
US12/666,209 US20100183586A1 (en) 2007-06-22 2008-06-23 Method for detection or treatment of graft versus host disease
RU2010101909/15A RU2479846C2 (ru) 2007-06-22 2008-06-23 Способ выявления или лечения реакции "трансплантат против хозяина"
EP08764208.8A EP2163896B1 (en) 2007-06-22 2008-06-23 Method for detection or treatment of graft versus host disease
JP2009520345A JP5403752B2 (ja) 2007-06-22 2008-06-23 移植片対宿主疾患の検査および治療方法
CA2692332A CA2692332C (en) 2007-06-22 2008-06-23 Method for detection or treatment of graft versus host disease
KR1020107001343A KR101432191B1 (ko) 2007-06-22 2008-06-23 이식편대숙주 질환의 검출 또는 치료 방법
AU2008268842A AU2008268842B2 (en) 2007-06-22 2008-06-23 Method for detection or treatment of graft versus host disease
US13/523,791 US20130267430A2 (en) 2007-06-22 2012-06-14 Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease
US14/244,166 US9631014B2 (en) 2007-06-22 2014-04-03 Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007165547 2007-06-22
JP2007-165547 2007-06-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/666,209 A-371-Of-International US20100183586A1 (en) 2007-06-22 2008-06-23 Method for detection or treatment of graft versus host disease
US13/523,791 Continuation US20130267430A2 (en) 2007-06-22 2012-06-14 Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease

Publications (1)

Publication Number Publication Date
WO2009001545A1 true WO2009001545A1 (ja) 2008-12-31

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Application Number Title Priority Date Filing Date
PCT/JP2008/001625 WO2009001545A1 (ja) 2007-06-22 2008-06-23 移植片対宿主疾患の検査および治療方法

Country Status (8)

Country Link
US (3) US20100183586A1 (ja)
EP (1) EP2163896B1 (ja)
JP (1) JP5403752B2 (ja)
KR (1) KR101432191B1 (ja)
CN (1) CN101743473B (ja)
CA (1) CA2692332C (ja)
RU (2) RU2479846C2 (ja)
WO (1) WO2009001545A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011024458A1 (ja) * 2009-08-26 2011-03-03 北海道公立大学法人 札幌医科大学 宿主対移植片疾患の検査方法
JP2016501526A (ja) * 2012-12-06 2016-01-21 エンリヴェックス セラピューティクス リミテッド 治療用アポトーシス細胞調製物、その製造方法及びその使用
RU2603461C1 (ru) * 2015-11-27 2016-11-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ подбора режима иммуносупрессии после трансплантации печени детям раннего возраста
US9528998B2 (en) 2010-04-16 2016-12-27 Abbott Laboratories Methods and reagents for diagnosing rheumatoid arthrtis

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012018260A1 (en) * 2010-08-05 2012-02-09 Universiteit Utrecht Holding B.V. Epidermal growth factor receptor targeted immune therapy
EP2614372B1 (en) * 2010-09-07 2018-07-25 Stephen G. Marx Kit for monitoring, detecting and staging gvhd
GB201021149D0 (en) * 2010-12-14 2011-01-26 Georg August Uni Gottingen Stiftung Offentlichen Rechts Use of a skin explant assay for mRNA expression analysis for the identification of new genes and drug targets associated with graft versus host disease
CN102550486B (zh) * 2012-01-10 2013-07-10 浙江大学 一种nod/scid小鼠异种移植物抗宿主病模型的建立方法
EP2825886A4 (en) * 2012-03-14 2015-11-18 Stephen Marx MEANS AND METHODS FOR THE DIAGNOSIS AND THERAPEUTICS OF DISEASES
WO2013168876A1 (ko) * 2012-05-11 2013-11-14 가톨릭대학교 산학협력단 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법
WO2017031341A1 (en) * 2015-08-19 2017-02-23 Children's Research Institute, Children's National Medical Center Compositions and methods for treating graft versus host disease
CN115327118A (zh) * 2022-09-05 2022-11-11 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Cd38+hla-dr+cd8+t细胞在gvhd早期诊断中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521927A (ja) * 2000-02-03 2003-07-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ヒト化抗ｃｃｒ−２抗体およびその使用方法
JP2007051980A (ja) 2005-08-19 2007-03-01 Okayama Univ 移植片対宿主病の検査方法、検査用試薬ならびに予防薬および／または治療薬のスクリーニング方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
ITMI991299A1 (it) * 1999-06-11 2000-12-11 Consiglio Nazionale Ricerche Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite
CA2428721A1 (en) * 2000-11-14 2002-05-23 The General Hospital Corporation Blockade of t cell migration into epithelial gvhd target tissues
US7304040B2 (en) * 2001-11-02 2007-12-04 Kensuke Egashira Suppression of post-transplant arteriosclerosis
ATE517855T1 (de) * 2001-11-30 2011-08-15 Biogen Idec Inc Antikörper gegen chemotaktische monozytenproteine
EP1567555A4 (en) * 2002-11-27 2006-06-21 Biogen Idec Inc HUMANIZED ANTIBODIES AGAINST CHEMOTOXIC MONOCYTE PROTEINS
WO2005032589A1 (ja) 2003-10-02 2005-04-14 Japan Science And Technology Agency Ｇｖｈｄの予防及び治療
RU2251974C1 (ru) * 2003-10-30 2005-05-20 Московский научно-исследовательский онкологический институт им. П.А. Герцена МЗ России Способ диагностики жизнеспособности костного трансплантата при реконструктивно-пластических операциях
US20060105367A1 (en) 2004-10-14 2006-05-18 Harald Mischak Method and markers for the diagnosis of Graft versus Host Disease (GvHD)
GB0427827D0 (en) * 2004-12-20 2005-01-19 Randox Lab Ltd Method of diagnosis
BRPI0615026A8 (pt) * 2005-08-19 2018-03-06 Abbott Lab imunoglobulina de domínio variável duplo e seus usos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521927A (ja) * 2000-02-03 2003-07-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ヒト化抗ｃｃｒ−２抗体およびその使用方法
JP2007051980A (ja) 2005-08-19 2007-03-01 Okayama Univ 移植片対宿主病の検査方法、検査用試薬ならびに予防薬および／または治療薬のスクリーニング方法

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
ABDI REZA ET AL.: "Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo", JOURNAL OF IMMUNOLOGY, vol. 172, no. 2, 2004, pages 767 - 775, XP008128051 *
FERRARA JL; REDDY P: "Pathophysiology of graft-versus-host disease", SEMIN HEMATOL., vol. 43, 2006, pages 3 - 10
HORI TSUKASA ET AL.: "CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease", BLOOD, vol. 111, no. 8, 15 April 2008 (2008-04-15), pages 4403 - 4412, XP002586771 *
KAISER T; KAMAL H; RANK A ET AL.: "Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation", BLOOD, vol. 104, 2004, pages 340 - 349
MASAYOSHI M. ET AL.: "Non-invasive diagnosis of acute rejection by measuring chemokinegene expression in urine of kidney transplant recipients", JOURNAL OF UROLOGY, vol. 171, no. 4, SUPPL., 2004, pages 490, XP008128136 *
MURAI M. ET AL.: "Kyusei GVHD ni yoru Kan Shinjun CD8 Saibo ni Okeru Chemokine no Kan'yo", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 28, 1998, pages 152 + ABSTR. NO. 3-A4-111 *
NOMURA SHOSAKU ET AL.: "Role of platelet-derived chemokines (RANTES and ENA-78) after stem cell transplantation", TRANSPLANT. IMMUNOLOGY, vol. 15, no. 4, 2006, pages 247 - 253, XP025013517 *
PANOSKALTSIS-MORTARI A. ET AL.: "Amelioration of idiopathic pneumonia syndrome (IPS) and GVHD by KGF-pretreatment is partly mediated via a STAT-6-dependent pathway in the host", BLOOD, vol. 108, no. 11, PART 1, 2006, pages 910A, XP008128134 *
PETRICOIN EF; ARDEKANI AM; HITT BA ET AL.: "Use of proteomic patterns in serum to identify ovarian cancer", LANCET, vol. 359, 2002, pages 572 - 577
REDDY P.: "Pathophysiology of acute graft-versus-host disease", HEMATOL ONCOL., vol. 21, 2003, pages 149 - 161
See also references of EP2163896A4 *
SUGERMAN P. ET AL.: "Kinetics of gene expression in murine cutaneous graft-versus-host disease", AM.J.PATH., June 2004 (2004-06-01)
SULLIVAN KM.: "Hematopoietic Cell Transplantation", 2004, BLACKWELL PUBLISHING, article "Graft vs. host disease", pages: 635 - 664
SULLIVAN KM: "Hematopoietic Cell Transplantation", 2004, BLACKWELL PUBLISHING, pages: 635 - 664
WYSOCKI CA; PANOSKALTSIS-MORTARI A; BLAZAR BR; SERODY JS: "Leukocyte migration and graft-versus-host disease", BLOOD, vol. 105, 2005, pages 4191 - 4199
ZIEGLER J.A. ET AL.: "Chemokine profiling in patients with graft versus host disease (GVHD) following allogeneic blood stem cell transplantation", BLOOD, vol. 108, no. 11, PART 1, 2006, pages 814A - 815A, XP008128135 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011024458A1 (ja) * 2009-08-26 2011-03-03 北海道公立大学法人 札幌医科大学 宿主対移植片疾患の検査方法
US9528998B2 (en) 2010-04-16 2016-12-27 Abbott Laboratories Methods and reagents for diagnosing rheumatoid arthrtis
JP2016501526A (ja) * 2012-12-06 2016-01-21 エンリヴェックス セラピューティクス リミテッド 治療用アポトーシス細胞調製物、その製造方法及びその使用
JP2019047813A (ja) * 2012-12-06 2019-03-28 エンリヴェックス セラピューティクス リミテッド 治療用アポトーシス細胞調製物、その製造方法及びその使用
RU2603461C1 (ru) * 2015-11-27 2016-11-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ подбора режима иммуносупрессии после трансплантации печени детям раннего возраста

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Publication number Publication date
US20130267430A2 (en) 2013-10-10
CN101743473A (zh) 2010-06-16
EP2163896A1 (en) 2010-03-17
US20100183586A1 (en) 2010-07-22
EP2163896A4 (en) 2010-08-04
RU2479846C2 (ru) 2013-04-20
US20130065779A1 (en) 2013-03-14
US9631014B2 (en) 2017-04-25
US20140234335A1 (en) 2014-08-21
EP2163896B1 (en) 2013-09-25
JPWO2009001545A1 (ja) 2010-08-26
CA2692332C (en) 2019-09-24
KR101432191B1 (ko) 2014-08-20
KR20100055390A (ko) 2010-05-26
RU2632434C2 (ru) 2017-10-04
CN101743473B (zh) 2014-03-19
CA2692332A1 (en) 2008-12-31
AU2008268842A1 (en) 2008-12-31
RU2010101909A (ru) 2011-07-27
RU2012157473A (ru) 2014-07-10
JP5403752B2 (ja) 2014-01-29

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