WO2009000447A3 - In vivo device, system and usage thereof - Google Patents

In vivo device, system and usage thereof Download PDF

Info

Publication number
WO2009000447A3
WO2009000447A3 PCT/EP2008/004870 EP2008004870W WO2009000447A3 WO 2009000447 A3 WO2009000447 A3 WO 2009000447A3 EP 2008004870 W EP2008004870 W EP 2008004870W WO 2009000447 A3 WO2009000447 A3 WO 2009000447A3
Authority
WO
WIPO (PCT)
Prior art keywords
vivo
exterior
human
pathological condition
usage
Prior art date
Application number
PCT/EP2008/004870
Other languages
French (fr)
Other versions
WO2009000447A2 (en
Inventor
Michael Herbert
Klaus Schilling
Original Assignee
Univ Wuerzburg J Maximilians
Michael Herbert
Klaus Schilling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wuerzburg J Maximilians, Michael Herbert, Klaus Schilling filed Critical Univ Wuerzburg J Maximilians
Priority to EP08759267A priority Critical patent/EP2170164A2/en
Priority to US12/666,095 priority patent/US8425492B2/en
Publication of WO2009000447A2 publication Critical patent/WO2009000447A2/en
Publication of WO2009000447A3 publication Critical patent/WO2009000447A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

An in vivo device (1) for an at least temporary placement in a human or animal body (17), comprising an actuator (2) adapted to be actively triggered from the exterior in order to induce a local impact on the adjacent body area for in vivo treatment of a patient in need, and/or comprising a sensor adapted to be actively triggered from the exterior for sensing a pathological condition in the body (17). An in vivo system comprises at least two and/or a plurality of the in vivo devices (1), wherein the in vivo devices (1) are adapted to communicate with each other and/or with an external controller (24). The use of the in vivo device/s (1) for treating and/or diagnosing a pathological condition in a human or animal body (17) comprises: administering the device/s (1); monitoring the movement of the device/s (1) through the body (17); triggering the device/s (1) from the outside once the device/s (1) reach/es a defined position in the body (17).
PCT/EP2008/004870 2007-06-26 2008-06-17 In vivo device, system and usage thereof WO2009000447A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08759267A EP2170164A2 (en) 2007-06-26 2008-06-17 In vivo device, system and usage thereof
US12/666,095 US8425492B2 (en) 2007-06-26 2008-06-17 In vivo device, system and usage thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07012495.3 2007-06-26
EP07012495A EP2008584A1 (en) 2007-06-26 2007-06-26 In vivo device, system and usage thereof

Publications (2)

Publication Number Publication Date
WO2009000447A2 WO2009000447A2 (en) 2008-12-31
WO2009000447A3 true WO2009000447A3 (en) 2009-07-09

Family

ID=38707229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/004870 WO2009000447A2 (en) 2007-06-26 2008-06-17 In vivo device, system and usage thereof

Country Status (3)

Country Link
US (1) US8425492B2 (en)
EP (3) EP2008584A1 (en)
WO (1) WO2009000447A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107806B2 (en) 2010-11-22 2015-08-18 Proteus Digital Health, Inc. Ingestible device with pharmaceutical product

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8912908B2 (en) * 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
WO2008112578A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a deployable antenna
MY154217A (en) 2008-08-13 2015-05-15 Proteus Digital Health Inc Ingestible circuitry
AU2009329868A1 (en) * 2008-12-23 2011-06-30 Mario W. Cardullo Method and apparatus for chemical detection and release
US8540664B2 (en) 2009-03-25 2013-09-24 Proteus Digital Health, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
NZ596292A (en) 2009-04-28 2014-04-30 Proteus Digital Health Inc Highly reliable ingestible event markers and methods for using the same
EP2432458A4 (en) 2009-05-12 2014-02-12 Proteus Digital Health Inc Ingestible event markers comprising an ingestible component
US20110077718A1 (en) * 2009-09-30 2011-03-31 Broadcom Corporation Electromagnetic power booster for bio-medical units
CN102905672B (en) 2010-04-07 2016-08-17 普罗秋斯数字健康公司 Miniature ingestible device
WO2012046166A1 (en) * 2010-10-06 2012-04-12 Koninklijke Philips Electronics N.V. Electronic pill for delivery of powder medication
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
JP2015534539A (en) 2012-07-23 2015-12-03 プロテウス デジタル ヘルス， インコーポレイテッド Technique for producing an ingestible event marker with an ingestible component
ES2683709T3 (en) 2012-10-18 2018-09-27 Proteus Digital Health, Inc. Apparatus, system, and procedure for adaptively optimizing energy dissipation and diffusion energy in a power source for a communication device
JP2016508529A (en) 2013-01-29 2016-03-22 プロテウス デジタル ヘルス， インコーポレイテッド Highly expandable polymer film and composition containing the same
EP2972333B1 (en) 2013-03-11 2018-09-19 The University of Toledo A biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
WO2015187289A1 (en) 2014-06-03 2015-12-10 Pop Test Abuse Deterrent Technology Llc Drug device configured for wireless communication
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
MX2019000888A (en) 2016-07-22 2019-06-03 Proteus Digital Health Inc Electromagnetic sensing and detection of ingestible event markers.
IL265827B2 (en) 2016-10-26 2023-03-01 Proteus Digital Health Inc Methods for manufacturing capsules with ingestible event markers
WO2019195389A1 (en) * 2018-04-04 2019-10-10 Cylerus, Inc. Dual-lumen drug reservoir fill and withdrawal devices and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193020A1 (en) * 2001-08-29 2004-09-30 Reametaru Co., Ltd. In-vivo information extracting system, tag device used for the same, and relay device
WO2006077528A2 (en) * 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. Electronically controlled capsule

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US193020A (en) * 1877-07-10 Improvement in box-fasteners
US6285897B1 (en) * 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6929636B1 (en) * 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US7083578B2 (en) * 2001-07-12 2006-08-01 Given Imaging Ltd. Device and method for examining a body lumen
EP1536731A2 (en) * 2002-08-01 2005-06-08 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
ATE399501T1 (en) 2004-12-30 2008-07-15 Given Imaging Ltd SYSTEM FOR LOCALIZING AN IN-VIVO SIGNAL SOURCE
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193020A1 (en) * 2001-08-29 2004-09-30 Reametaru Co., Ltd. In-vivo information extracting system, tag device used for the same, and relay device
WO2006077528A2 (en) * 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. Electronically controlled capsule

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107806B2 (en) 2010-11-22 2015-08-18 Proteus Digital Health, Inc. Ingestible device with pharmaceutical product

Also Published As

Publication number Publication date
EP2623030A2 (en) 2013-08-07
WO2009000447A2 (en) 2008-12-31
EP2170164A2 (en) 2010-04-07
US8425492B2 (en) 2013-04-23
EP2623030A3 (en) 2018-03-07
US20100189779A1 (en) 2010-07-29
EP2008584A1 (en) 2008-12-31

Similar Documents

Publication Publication Date Title
WO2009000447A3 (en) In vivo device, system and usage thereof
AU2003220065A8 (en) Detection, diagnosis, and monitoring of a medical condition or disease with artificial olfactometry
EP1815787A4 (en) Heartbeat/respiration sensor and body monitor employing same
WO2007081679A3 (en) Medical imaging reference devices
EP1602318A4 (en) Capsule medical treatment device and capsule medical treatment device collecting system
PL2134259T3 (en) Patient's skin puncturing device
BRPI0815175A2 (en) A device and procedure for the diagnosis or preparation of the diagnosis and / or monitoring of therapy for inflammatory diseases such as rheumatoid arthritis.
WO2007101141A3 (en) A medical signal processing system with distributed wireless sensors
ATE441456T1 (en) ACTIVE MEDICAL IMPLANTABLE DEVICE HAVING AT LEAST TWO DIAGNOSTIC AND/OR THERAPEUTIC FUNCTIONS
EP1613214A4 (en) Respiratory monitoring, diagnostic and therapeutic system
EP1774910A4 (en) Medical image diagnosis assisting system, device and image processing program
WO2007083288A3 (en) Heart anchor device
WO2008134569A3 (en) Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
BR112012003078A2 (en) interrogable external sensor system for obtaining one or more biological characteristics of a patient's body internal tissue surface or region, method for obtaining one or more biological characteristics of a patient's internal tissue surface or region, transdermal sensor system for obtaining one or more biological characteristics of a patient's internal tissue region, method for obtaining one or more biological characteristics of a patient's internal tissue region, and interrogable sensor system for obtaining one or more biological characteristics of an internal tissue region of a patient
WO2007124128A3 (en) Biological vessel flow control devices and methods
WO2007092390A3 (en) Devices and methods for gastrointestinal stimulation
BRPI0909352A2 (en) therapeutic device and which may be contacted with a patient to therapeutically cool the patient, system to therapeutically regulate a patient's body temperature, therapeutic method to regulate a patient's body temperature method to therapeutically cool the body temperature of a A patient wrapper and wrapper.
WO2011060275A3 (en) Systems and methods for diagnostics, control and treatment of neurological functions and disorders by exposure to electromagnetic waves
EP1968648A4 (en) Diagnostic system for the detection and diagnosis of skin cancer
PL2104452T3 (en) Patient's skin puncturing device
WO2004047907A3 (en) Minimally-invasive smart devices
WO2012104513A3 (en) Device for measuring compliance with oxygen therapy using a three-dimensional accelerometer
FR2907665B1 (en) IMPLANTABLE MEDICAL DEVICE WITH PRESSURE LIMITER
EP2074661A4 (en) Use of quantum system identification and quantum control techniques for medical diagnostic and therapeutic purposes
BRPI0918398A2 (en) Method for diagnosing a physiological abnormality in a patient, System for diagnosing a physiological abnormality in a patient, Catheter and Device for diagnosing a physiological abnormality in a patient

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08759267

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12666095

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008759267

Country of ref document: EP