WO2008136378A1 - Novel sulfonamide derivative and salt thereof - Google Patents
Novel sulfonamide derivative and salt thereof Download PDFInfo
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- WO2008136378A1 WO2008136378A1 PCT/JP2008/058015 JP2008058015W WO2008136378A1 WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1 JP 2008058015 W JP2008058015 W JP 2008058015W WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1
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- salt
- bonding hand
- sulfonamide derivative
- hydrogen atom
- aryl group
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D209/04—Indoles; Hydrogenated indoles
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
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- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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Abstract
Disclosed is a compound represented by the following general formula: (wherein R1 represents a hydrogen atom or the like; R2 represents an optionally substituted alkyl or aryl group or the like; R3 and R4 may be the same or different and each represents an aryl group or the like; R5 represents a hydrogen atom or the like; X1 represents an alkylene group, a bonding hand or the like; X2 represents a bonding hand or the like; Y1 represents a bonding hand or the like; and Z1 and Z2 each represents CH or the like) or a salt thereof. Since the compound or a salt thereof has a strong PGE2 production inhibitory activity, it is useful for treatment or prevention of diseases and conditions associated with PGE2.
Priority Applications (1)
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JP2009512960A JP5443975B2 (en) | 2007-04-27 | 2008-04-25 | Novel sulfonamide derivative or salt thereof |
Applications Claiming Priority (2)
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JP2007118061 | 2007-04-27 | ||
JP2007-118061 | 2007-04-27 |
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WO2008136378A1 true WO2008136378A1 (en) | 2008-11-13 |
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PCT/JP2008/058015 WO2008136378A1 (en) | 2007-04-27 | 2008-04-25 | Novel sulfonamide derivative and salt thereof |
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JP (1) | JP5443975B2 (en) |
WO (1) | WO2008136378A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012015723A1 (en) | 2010-07-26 | 2012-02-02 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as cyp17 inhibitors |
US8748615B2 (en) | 2010-03-05 | 2014-06-10 | Sanofi | Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide |
US20160168144A1 (en) * | 2011-05-24 | 2016-06-16 | The Wistar Institute | Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1 |
JP2016523974A (en) * | 2013-07-11 | 2016-08-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | IDO inhibitor |
WO2019219689A1 (en) | 2018-05-18 | 2019-11-21 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulfoximine containing substituents |
WO2022050385A1 (en) * | 2020-09-07 | 2022-03-10 | 大日本住友製薬株式会社 | Phenol derivative |
CN114262293A (en) * | 2022-01-10 | 2022-04-01 | 安徽有吉医药科技有限公司 | Preparation method of 2-amino-3-bromopyridine |
CN114957132A (en) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | S-configuration-containing aminobenzamide pyridazinone compound, preparation method thereof, pharmaceutical composition and application |
Citations (1)
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JPH11510485A (en) * | 1995-07-21 | 1999-09-14 | ニィコメド・オーストリア・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Derivatives of benzenesulfonamide as inhibitors of the enzyme cyclooxygenase II |
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JPH06135934A (en) * | 1991-12-27 | 1994-05-17 | Ishihara Sangyo Kaisha Ltd | Phospholipase a2 inhibitor, anti-inflammatory agent of anti-pancreatitic agent containing pyridine derivative or its salt |
JPH06122669A (en) * | 1991-12-28 | 1994-05-06 | Ishihara Sangyo Kaisha Ltd | Phopholipase a2 inhibitor containing diaminobenzene derivative |
JPH10298076A (en) * | 1997-02-28 | 1998-11-10 | Ishihara Sangyo Kaisha Ltd | Anticancer medicine |
JP4848091B2 (en) * | 2000-01-31 | 2011-12-28 | 石原産業株式会社 | Gastrointestinal disease therapeutic agent or prophylactic agent containing diaminotrifluoromethylpyridine derivative |
JP4848092B2 (en) * | 2000-02-01 | 2011-12-28 | 石原産業株式会社 | Therapeutic or preventive agent for lung failure containing a diaminotrifluoromethylpyridine derivative |
JP2001288089A (en) * | 2000-02-01 | 2001-10-16 | Ishihara Sangyo Kaisha Ltd | Therapeutic agent or prophylactic agent for hepatic disease comprising diaminotrifluoromethylpyridine derivative |
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JPH11510485A (en) * | 1995-07-21 | 1999-09-14 | ニィコメド・オーストリア・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Derivatives of benzenesulfonamide as inhibitors of the enzyme cyclooxygenase II |
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US8748615B2 (en) | 2010-03-05 | 2014-06-10 | Sanofi | Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide |
WO2012015723A1 (en) | 2010-07-26 | 2012-02-02 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as cyp17 inhibitors |
US8916553B2 (en) | 2010-07-26 | 2014-12-23 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as CYP17 inhibitors |
US20160168144A1 (en) * | 2011-05-24 | 2016-06-16 | The Wistar Institute | Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1 |
JP2016523974A (en) * | 2013-07-11 | 2016-08-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | IDO inhibitor |
WO2019219689A1 (en) | 2018-05-18 | 2019-11-21 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulfoximine containing substituents |
WO2022050385A1 (en) * | 2020-09-07 | 2022-03-10 | 大日本住友製薬株式会社 | Phenol derivative |
CN114957132A (en) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | S-configuration-containing aminobenzamide pyridazinone compound, preparation method thereof, pharmaceutical composition and application |
CN114262293A (en) * | 2022-01-10 | 2022-04-01 | 安徽有吉医药科技有限公司 | Preparation method of 2-amino-3-bromopyridine |
CN114262293B (en) * | 2022-01-10 | 2023-09-22 | 上海有吉医药化工有限公司 | Preparation method of 2-amino-3-bromopyridine |
Also Published As
Publication number | Publication date |
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JP5443975B2 (en) | 2014-03-19 |
JPWO2008136378A1 (en) | 2010-07-29 |
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