WO2008105919A3 - Nanomechanical characterization of cellular activity - Google Patents
Nanomechanical characterization of cellular activity Download PDFInfo
- Publication number
- WO2008105919A3 WO2008105919A3 PCT/US2007/076283 US2007076283W WO2008105919A3 WO 2008105919 A3 WO2008105919 A3 WO 2008105919A3 US 2007076283 W US2007076283 W US 2007076283W WO 2008105919 A3 WO2008105919 A3 WO 2008105919A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cellular activity
- nanomechanical
- characterization
- nanomechanical characterization
- cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/32—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
- G01N3/38—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
- G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
- G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
- G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
- G01Q60/42—Functionalisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0016—Tensile or compressive
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0023—Bending
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0069—Fatigue, creep, strain-stress relations or elastic constants
- G01N2203/0075—Strain-stress relations or elastic constants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0076—Hardness, compressibility or resistance to crushing
- G01N2203/0085—Compressibility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0089—Biorheological properties
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0092—Visco-elasticity, solidification, curing, cross-linking degree, vulcanisation or strength properties of semi-solid materials
- G01N2203/0094—Visco-elasticity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/026—Specifications of the specimen
- G01N2203/0286—Miniature specimen; Testing on microregions of a specimen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Electromagnetism (AREA)
- Radiology & Medical Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Methods for the characterization of the nanomechanical properties of cells to determine their differentiation state and methods for influencing the differentiation states of cells by nanomechanical processes are disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82333406P | 2006-08-23 | 2006-08-23 | |
US60/823,334 | 2006-08-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008105919A2 WO2008105919A2 (en) | 2008-09-04 |
WO2008105919A3 true WO2008105919A3 (en) | 2008-11-20 |
Family
ID=39721755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/076283 WO2008105919A2 (en) | 2006-08-23 | 2007-08-20 | Nanomechanical characterization of cellular activity |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008105919A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3064359B1 (en) | 2017-03-21 | 2021-04-16 | Centre Nat Rech Scient | DEVICE FOR THE MECHANICAL CHARACTERIZATION OF AN ELEMENT OF INTEREST, FOR EXAMPLE AN OVOCYTE |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006248A1 (en) * | 1993-08-25 | 1995-03-02 | Children's Medical Center Corporation | Method and system for measurement of mechanical properties of molecules and cells |
US5620854A (en) * | 1993-08-25 | 1997-04-15 | Regents Of The University Of California | Method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification |
-
2007
- 2007-08-20 WO PCT/US2007/076283 patent/WO2008105919A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006248A1 (en) * | 1993-08-25 | 1995-03-02 | Children's Medical Center Corporation | Method and system for measurement of mechanical properties of molecules and cells |
US5620854A (en) * | 1993-08-25 | 1997-04-15 | Regents Of The University Of California | Method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification |
Non-Patent Citations (6)
Title |
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BONFIGLIO ANNALISA ET AL: "Subcellular details of early events of differentiation induced by retinoic acid in human neuroblastoma cells detected by atomic force microscope", EXPERIMENTAL CELL RESEARCH, vol. 216, no. 1, 1995, pages 73 - 79, XP002497361, ISSN: 0014-4827 * |
CAVALCANTI-ADAM E A ET AL: "RGD peptides immobilized on a mechanically deformable surface promote osteoblast differentiation.", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 17, no. 12, December 2002 (2002-12-01), pages 2130 - 2140, XP002497362, ISSN: 0884-0431 * |
CHEN Y ET AL: "Atomic force microscopy imaging and 3-D reconstructions of serial thin sections of a single cell and its interior structures", ULTRAMICROSCOPY, AMSTERDAM, NL, vol. 103, no. 3, 1 June 2005 (2005-06-01), pages 173 - 182, XP004861608, ISSN: 0304-3991 * |
LAL RATNESHWAR ET AL: "Imaging real-time neurite outgrowth and cytoskeletal reorganization with an atomic force microscope", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 269, no. 1 PART 1, 1995, pages C275 - C285, XP008096852, ISSN: 0002-9513 * |
RADMACHER M: "Measuring the elastic properties of biological samples with the AFM", IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE MARCH/APRIL 1997 IEEE US, vol. 16, no. 2, March 1997 (1997-03-01), pages 47 - 57, XP002497363 * |
ZHANG J ET AL: "The effects of the actin cytoskeleton on the transverse mechanical properties of skeletal muscle cells", SECOND JOINT EMBS-BMES CONFERENCE 2002. CONFERENCE PROCEEDINGS. 24TH. ANNUAL INTERNATIONAL CONFERENCE OF THE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL FALL MEETING OF THE BIOMEDICAL ENGINEERING SOCIETY. HOUSTON, TX, OCT. 23 - 26, 2002; [ANN, vol. 1, 23 October 2002 (2002-10-23), pages 400 - 401, XP010621375, ISBN: 978-0-7803-7612-0 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008105919A2 (en) | 2008-09-04 |
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