WO2008105473A1 - Anti-malignant-tumor agent - Google Patents

Anti-malignant-tumor agent Download PDF

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Publication number
WO2008105473A1
WO2008105473A1 PCT/JP2008/053442 JP2008053442W WO2008105473A1 WO 2008105473 A1 WO2008105473 A1 WO 2008105473A1 JP 2008053442 W JP2008053442 W JP 2008053442W WO 2008105473 A1 WO2008105473 A1 WO 2008105473A1
Authority
WO
WIPO (PCT)
Prior art keywords
tumor agent
tumor
malignant
agent
ability
Prior art date
Application number
PCT/JP2008/053442
Other languages
French (fr)
Japanese (ja)
Inventor
Yasushi Arano
Hiromichi Akizawa
Masahiro Kurokawa
Satoshi Matsushima
Kiyonori Hatsushiba
Original Assignee
National University Corporation Chiba University
Fujifilm Ri Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Chiba University, Fujifilm Ri Pharma Co., Ltd. filed Critical National University Corporation Chiba University
Priority to JP2009501284A priority Critical patent/JP5156733B2/en
Publication of WO2008105473A1 publication Critical patent/WO2008105473A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

[PROBLEMS] To provide an anti-tumor agent which is excellent in the tumor accumulation property and the ability of reducing a tumor size. [MEANS FOR SOLVING PROBLEMS] Disclosed is an anti-tumor agent comprising a compound represented by the formula (1) as an active ingredient. (1) wherein R1, R2 and R3 independently represent a hydrogen atom, an alkyl group or a benzyl group and may be the same as or different from one another; and X* represents a radioactive halogen atom.
PCT/JP2008/053442 2007-02-28 2008-02-27 Anti-malignant-tumor agent WO2008105473A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009501284A JP5156733B2 (en) 2007-02-28 2008-02-27 Antineoplastic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-050776 2007-02-28
JP2007050776 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105473A1 true WO2008105473A1 (en) 2008-09-04

Family

ID=39721297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053442 WO2008105473A1 (en) 2007-02-28 2008-02-27 Anti-malignant-tumor agent

Country Status (2)

Country Link
JP (1) JP5156733B2 (en)
WO (1) WO2008105473A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6426586A (en) * 1987-06-24 1989-01-27 Dow Chemical Co Functionalized polyamine chelating agent and its rhodium complex and production thereof
JPH04504247A (en) * 1988-06-24 1992-07-30 ザ　ダウ　ケミカル　カンパニー Macrocyclic bifunctional chelating agents, complexes thereof and antibody conjugates thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6426586A (en) * 1987-06-24 1989-01-27 Dow Chemical Co Functionalized polyamine chelating agent and its rhodium complex and production thereof
JPH04504247A (en) * 1988-06-24 1992-07-30 ザ　ダウ　ケミカル　カンパニー Macrocyclic bifunctional chelating agents, complexes thereof and antibody conjugates thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BONGARD J.E. ET AL.: "Monofunctionalized tetraazacrowns for use in bioconjugation and catalysis", SYNTHESIS AND REACTIVITY IN INORGANIC, METAL-ORGANIC, AND NANO-METAL CHEMISTRY, vol. 35, no. 9, 2005, pages 727 - 731 *

Also Published As

Publication number Publication date
JP5156733B2 (en) 2013-03-06
JPWO2008105473A1 (en) 2010-06-03

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