WO2008105454A1 - ラクリチン高発現細胞 - Google Patents
ラクリチン高発現細胞 Download PDFInfo
- Publication number
- WO2008105454A1 WO2008105454A1 PCT/JP2008/053396 JP2008053396W WO2008105454A1 WO 2008105454 A1 WO2008105454 A1 WO 2008105454A1 JP 2008053396 W JP2008053396 W JP 2008053396W WO 2008105454 A1 WO2008105454 A1 WO 2008105454A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lacritin
- expressing
- expressing cell
- high level
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/449,833 US20100183572A1 (en) | 2007-02-28 | 2008-02-27 | Cell capable of expressing lacritin at high level |
JP2009501270A JPWO2008105454A1 (ja) | 2007-02-28 | 2008-02-27 | ラクリチン高発現細胞 |
EP08720944A EP2130915A4 (en) | 2007-02-28 | 2008-02-27 | CELL THAT CAN EXPRESS A LARGE QUANTITY OF LACRITIN |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-049936 | 2007-02-28 | ||
JP2007049936 | 2007-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008105454A1 true WO2008105454A1 (ja) | 2008-09-04 |
Family
ID=39721279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/053396 WO2008105454A1 (ja) | 2007-02-28 | 2008-02-27 | ラクリチン高発現細胞 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100183572A1 (ja) |
EP (1) | EP2130915A4 (ja) |
JP (1) | JPWO2008105454A1 (ja) |
WO (1) | WO2008105454A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011007337A2 (en) | 2009-07-16 | 2011-01-20 | L'oreal | Cosmetic use of lacritin-type polypeptides |
WO2011037196A1 (ja) * | 2009-09-25 | 2011-03-31 | 千寿製薬株式会社 | ラクリチン遺伝子の転写調節因子のスクリーニング方法 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013974A1 (en) | 1994-11-08 | 1996-05-17 | Organogenesis Inc. | In vitro tissue and organ equivalent models |
WO2000029553A1 (en) | 1998-11-19 | 2000-05-25 | Organogenesis Inc. | Bioengineered tissue constructs and methods for producing and using them |
JP2001161353A (ja) | 1999-12-09 | 2001-06-19 | Japan Ophthalmic Consultants:Kk | 移植用細胞片及びその作成方法 |
US20020039788A1 (en) | 2000-02-29 | 2002-04-04 | Isseroff Roslyn R. | Corneal epithelial graft composites |
WO2002065943A2 (en) | 2001-02-20 | 2002-08-29 | University Of Virginia Patent Foundation | Ocular tear growth factor-like protein |
WO2003009783A1 (fr) | 2001-07-25 | 2003-02-06 | Japan Tissue Engineering Co., Ltd. | Lamines pour traitement de la cornee et leur procede de production |
JP2003038170A (ja) | 2001-07-26 | 2003-02-12 | Mitsuo Okano | 前眼部関連細胞シート、3次元構造体、及びそれらの製造法 |
WO2003026712A1 (fr) | 2001-09-25 | 2003-04-03 | Japan Science And Technology Agency | Procede de formation de membrane basale, procede d'elaboration d'echantillon de membrane basale, tissu artificiel reconstitue utilisant cet echantillon, et procede d'elaboration de ce tissu |
WO2003084431A2 (en) | 2002-03-29 | 2003-10-16 | Singapore Eye Research Institute | Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering |
WO2005119899A2 (en) * | 2004-05-13 | 2005-12-15 | University Of Virginia Patent Foundation | Use of lacritin in promoting ocular cell survival |
JP2006129724A (ja) * | 2004-11-02 | 2006-05-25 | Senju Pharmaceut Co Ltd | ラクリチン活性を有する化合物のスクリーニング方法 |
WO2006129867A2 (en) * | 2005-06-01 | 2006-12-07 | Senju Pharmaceutical Co., Ltd. | ENHANCED EXPRESSION OF LACTOFERRIN mRNA BY LACRITIN |
JP2007049936A (ja) | 2005-08-18 | 2007-03-01 | Wakayama Univ | 変異検出方法、変異検出プログラム及び記憶媒体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585265A (en) * | 1992-11-30 | 1996-12-17 | Gillette Company | Human corneal epithelial cell lines with extended lifespan |
US5827702A (en) * | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
US20030087850A1 (en) * | 2001-07-10 | 2003-05-08 | Philip Dehazya | Gene therapy for dry eye syndrome |
US20050013806A1 (en) * | 2003-04-04 | 2005-01-20 | Chang Min S. | Use of contact lens for corneal cell transplant |
US8101169B2 (en) * | 2005-02-23 | 2012-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Ocular gene therapy using avalanche-mediated transfection |
-
2008
- 2008-02-27 EP EP08720944A patent/EP2130915A4/en not_active Ceased
- 2008-02-27 US US12/449,833 patent/US20100183572A1/en not_active Abandoned
- 2008-02-27 JP JP2009501270A patent/JPWO2008105454A1/ja not_active Abandoned
- 2008-02-27 WO PCT/JP2008/053396 patent/WO2008105454A1/ja active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013974A1 (en) | 1994-11-08 | 1996-05-17 | Organogenesis Inc. | In vitro tissue and organ equivalent models |
WO2000029553A1 (en) | 1998-11-19 | 2000-05-25 | Organogenesis Inc. | Bioengineered tissue constructs and methods for producing and using them |
JP2001161353A (ja) | 1999-12-09 | 2001-06-19 | Japan Ophthalmic Consultants:Kk | 移植用細胞片及びその作成方法 |
US20020039788A1 (en) | 2000-02-29 | 2002-04-04 | Isseroff Roslyn R. | Corneal epithelial graft composites |
WO2002065943A2 (en) | 2001-02-20 | 2002-08-29 | University Of Virginia Patent Foundation | Ocular tear growth factor-like protein |
WO2003009783A1 (fr) | 2001-07-25 | 2003-02-06 | Japan Tissue Engineering Co., Ltd. | Lamines pour traitement de la cornee et leur procede de production |
JP2003038170A (ja) | 2001-07-26 | 2003-02-12 | Mitsuo Okano | 前眼部関連細胞シート、3次元構造体、及びそれらの製造法 |
WO2003026712A1 (fr) | 2001-09-25 | 2003-04-03 | Japan Science And Technology Agency | Procede de formation de membrane basale, procede d'elaboration d'echantillon de membrane basale, tissu artificiel reconstitue utilisant cet echantillon, et procede d'elaboration de ce tissu |
WO2003084431A2 (en) | 2002-03-29 | 2003-10-16 | Singapore Eye Research Institute | Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering |
WO2005119899A2 (en) * | 2004-05-13 | 2005-12-15 | University Of Virginia Patent Foundation | Use of lacritin in promoting ocular cell survival |
JP2006129724A (ja) * | 2004-11-02 | 2006-05-25 | Senju Pharmaceut Co Ltd | ラクリチン活性を有する化合物のスクリーニング方法 |
WO2006129867A2 (en) * | 2005-06-01 | 2006-12-07 | Senju Pharmaceutical Co., Ltd. | ENHANCED EXPRESSION OF LACTOFERRIN mRNA BY LACRITIN |
JP2007049936A (ja) | 2005-08-18 | 2007-03-01 | Wakayama Univ | 変異検出方法、変異検出プログラム及び記憶媒体 |
Non-Patent Citations (5)
Title |
---|
BRONDYK B. ET AL.: "pCI and pSI mammalian expression vectors", PROMEGA NOTES MAGAZINE, no. 49, 1994, pages 7 - 12, XP008117162 * |
INVEST OPHTHALMOL VIS SCI., vol. 36, 1995, pages 614 - 621 |
SANGHI S. ET AL.: "cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland", J. MOL. BIOL., vol. 310, no. 1, 2001, pages 127 - 139, XP004464186 * |
SANGHI, S. ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 310, 2001, pages 127 - 139 |
See also references of EP2130915A4 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011007337A2 (en) | 2009-07-16 | 2011-01-20 | L'oreal | Cosmetic use of lacritin-type polypeptides |
WO2011007337A3 (en) * | 2009-07-16 | 2012-08-16 | L'oreal | Cosmetic use of lacritin-type polypeptides |
US9168215B2 (en) | 2009-07-16 | 2015-10-27 | L'oreal | Cosmetic use of lacritin-type polypeptides |
WO2011037196A1 (ja) * | 2009-09-25 | 2011-03-31 | 千寿製薬株式会社 | ラクリチン遺伝子の転写調節因子のスクリーニング方法 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008105454A1 (ja) | 2010-06-03 |
EP2130915A4 (en) | 2010-04-21 |
EP2130915A1 (en) | 2009-12-09 |
US20100183572A1 (en) | 2010-07-22 |
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