WO2008105178A1 - リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム - Google Patents

リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム Download PDF

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Publication number
WO2008105178A1
WO2008105178A1 PCT/JP2008/000372 JP2008000372W WO2008105178A1 WO 2008105178 A1 WO2008105178 A1 WO 2008105178A1 JP 2008000372 W JP2008000372 W JP 2008000372W WO 2008105178 A1 WO2008105178 A1 WO 2008105178A1
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WO
WIPO (PCT)
Prior art keywords
liposome
agent
resistance
biological component
blood
Prior art date
Application number
PCT/JP2008/000372
Other languages
English (en)
French (fr)
Inventor
Hideyoshi Harashima
Kentaro Kogure
Hidetaka Akita
Akitada Iwasa
Yoshio Nakamura
Shiroh Futaki
Original Assignee
National University Corporation Hokkaido University
Kyoto University
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Hokkaido University, Kyoto University, Shionogi & Co., Ltd. filed Critical National University Corporation Hokkaido University
Priority to JP2009501138A priority Critical patent/JPWO2008105178A1/ja
Priority to US12/449,817 priority patent/US20100104623A1/en
Priority to EP08720286A priority patent/EP2138192A4/en
Publication of WO2008105178A1 publication Critical patent/WO2008105178A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　正の電荷、特にポリアルギニンペプチドを表面に有するリポソームに対し、血液中の蛋白質などのような負の荷電を有する生体成分に対する抵抗性を増強させ、血液中にリポソームが投入された場合でも高い封入物輸送能を維持することのできるリポソームを提供することを目的とし、（ａ）配列番号１又は２に記載のアミノ酸配列からなるペプチド、及び／又は（ｂ）該アミノ酸配列において１又は数個のアミノ酸が欠失又は付加されたアミノ酸配列からなり、酸性条件下において脂質膜融合を促進する活性を有するペプチド、を有効成分とする、リポソーム用生体成分抵抗性増強剤を提供する。当該リポソーム用生体成分抵抗性増強剤は、リポソームに含ませることで、血液中の蛋白質などのような負の荷電を有する生体成分に対する抵抗性を増強させ、血液中にリポソームが投入された場合でも高い封入物輸送能を維持させることができる。
PCT/JP2008/000372 2007-02-28 2008-02-27 リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム WO2008105178A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009501138A JPWO2008105178A1 (ja) 2007-02-28 2008-02-27 リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム
US12/449,817 US20100104623A1 (en) 2007-02-28 2008-02-27 Agent for enhancing the resistance of liposome against biological component, and liposome modified with the agent
EP08720286A EP2138192A4 (en) 2007-02-28 2008-02-27 AGENT USED TO IMPROVE THE RESISTANCE OF A LIPOSOME AGAINST A BIOLOGICAL CONSTITUENT AND A MODIFIED LIPOSOME WITH THAT AGENT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-085628 2007-02-28
JP2007085628 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105178A1 true WO2008105178A1 (ja) 2008-09-04

Family

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PCT/JP2008/000372 WO2008105178A1 (ja) 2007-02-28 2008-02-27 リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム

Country Status (4)

Country Link
US (1) US20100104623A1 (ja)
EP (1) EP2138192A4 (ja)
JP (1) JPWO2008105178A1 (ja)
WO (1) WO2008105178A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010067617A1 (ja) * 2008-12-12 2010-06-17 国立大学法人 北海道大学 脂質膜構造体
WO2011132713A1 (ja) * 2010-04-21 2011-10-27 国立大学法人北海道大学 核内移行性を有する脂質膜構造体
WO2012124688A1 (ja) * 2011-03-14 2012-09-20 国立大学法人北海道大学 肺送達のためのベクター、導入剤及び使用
WO2013073480A1 (ja) 2011-11-18 2013-05-23 日油株式会社 細胞内動態を改善したカチオン性脂質
WO2013140643A1 (ja) * 2012-03-21 2013-09-26 国立大学法人北海道大学 機能性タンパク質を細胞内に送達するためのキャリア
CN114081963A (zh) * 2021-11-16 2022-02-25 上海理工大学 一种提高活性肽生物利用度的纳米载体及其制备与应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0921791B1 (pt) 2008-11-03 2018-10-30 Univ Cornell uso de um material que compreende copolímero de poli(etilenoglicol)/polidiidroxiacetona (peg-pdha) na fabricação de medicamentos
MX2011010045A (es) * 2009-03-25 2011-10-11 Novartis Ag Composicion farmaceutica que contiene un farmaco y siarn.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032593A1 (ja) 2003-10-01 2005-04-14 Japan Science And Technology Agency 核移行能を有するポリアルギニン修飾リポソーム
JP2006028030A (ja) * 2004-07-12 2006-02-02 Japan Science & Technology Agency リポソーム封入物質がエンドソームから脱出可能なリポソーム

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US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
EP0910576B1 (en) * 1996-04-11 2004-08-11 University Of British Columbia Fusogenic liposomes
JP5067733B2 (ja) * 2005-03-09 2012-11-07 国立大学法人北海道大学 目的物質をミトコンドリア内に送達可能な脂質膜構造体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032593A1 (ja) 2003-10-01 2005-04-14 Japan Science And Technology Agency 核移行能を有するポリアルギニン修飾リポソーム
JP2006028030A (ja) * 2004-07-12 2006-02-02 Japan Science & Technology Agency リポソーム封入物質がエンドソームから脱出可能なリポソーム

Non-Patent Citations (11)

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Title
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E. GOORMAGHTIGH ET AL., EUROPEAN J. BIOCHEMISTRY, vol. 195, 1991, pages 421 - 429
GOORMAGHTIGH E. ET AL.: "Secondary structure and orientation of the amphipathic peptide GALA in lipid structures An infrared-spectroscopic approach", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 195, no. 2, 1991, pages 421 - 429, XP008122572 *
HARASHIMA H.: "Saibonai Dotai Seigyo no Tameno Intelligent Soshi no Kaihatsu GALA to NLS ni yoru Endosome-maku. Kakumaku Barrier no Toppa", DRUG DELIVERY SYSTEM, vol. 16, no. 4, 10 July 2001 (2001-07-10), pages 286, XP008122789 *
KAKUDO T. ET AL.: "Transferrin-Modified Liposomes Equipped with a pH-Sensitive Fusogenic Peptide: AN Artificial Viral-like Delivery System", BIOCHEMISTRY, vol. 43, no. 19, 18 May 2004 (2004-05-18), pages 5618 - 5628, XP003000487 *
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PARENTE R.A. ET AL.: "pH-dependent Fusion of Phosphatidylcholine Small Vesicles. Induction by a synthetic amphipathic peptide", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 10, 5 April 1988 (1988-04-05), pages 4724 - 4730, XP008122573 *
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010067617A1 (ja) * 2008-12-12 2010-06-17 国立大学法人 北海道大学 脂質膜構造体
WO2011132713A1 (ja) * 2010-04-21 2011-10-27 国立大学法人北海道大学 核内移行性を有する脂質膜構造体
US8981044B2 (en) 2010-04-21 2015-03-17 National University Corporation Hokkaido University Lipid membrane structure having intranuclear migrating property
JP5794541B2 (ja) * 2010-04-21 2015-10-14 国立大学法人北海道大学 核内移行性を有する脂質膜構造体
WO2012124688A1 (ja) * 2011-03-14 2012-09-20 国立大学法人北海道大学 肺送達のためのベクター、導入剤及び使用
JP5850915B2 (ja) * 2011-03-14 2016-02-03 国立大学法人北海道大学 肺送達のためのベクター、導入剤及び使用
US9532950B2 (en) 2011-03-14 2017-01-03 National University Corporation Hokkaido University Vector for pulmonary delivery, inducing agent, and uses
WO2013073480A1 (ja) 2011-11-18 2013-05-23 日油株式会社 細胞内動態を改善したカチオン性脂質
WO2013140643A1 (ja) * 2012-03-21 2013-09-26 国立大学法人北海道大学 機能性タンパク質を細胞内に送達するためのキャリア
CN114081963A (zh) * 2021-11-16 2022-02-25 上海理工大学 一种提高活性肽生物利用度的纳米载体及其制备与应用
CN114081963B (zh) * 2021-11-16 2023-09-26 上海理工大学 一种提高活性肽生物利用度的纳米载体及其制备与应用

Also Published As

Publication number Publication date
JPWO2008105178A1 (ja) 2010-06-03
EP2138192A4 (en) 2010-07-14
US20100104623A1 (en) 2010-04-29
EP2138192A1 (en) 2009-12-30

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