WO2008105088A1 - 脊髄損傷治療薬剤 - Google Patents

脊髄損傷治療薬剤 Download PDF

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Publication number
WO2008105088A1
WO2008105088A1 PCT/JP2007/053804 JP2007053804W WO2008105088A1 WO 2008105088 A1 WO2008105088 A1 WO 2008105088A1 JP 2007053804 W JP2007053804 W JP 2007053804W WO 2008105088 A1 WO2008105088 A1 WO 2008105088A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
spinal cord
cord injury
treating spinal
treating
Prior art date
Application number
PCT/JP2007/053804
Other languages
English (en)
French (fr)
Inventor
Hideyuki Okano
Yoshiaki Toyama
Masaya Nakamura
Akio Iwanami
Kazuya Kitamura
Toshikazu Nakamura
Hiroshi Funakoshi
Original Assignee
Keio University
Osaka University
Kringle Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keio University, Osaka University, Kringle Pharma Inc. filed Critical Keio University
Priority to PCT/JP2007/053804 priority Critical patent/WO2008105088A1/ja
Priority to PCT/JP2008/053557 priority patent/WO2008105507A1/ja
Priority to CA2675953A priority patent/CA2675953C/en
Priority to PT87210068T priority patent/PT2116255E/pt
Priority to CN200880004651.0A priority patent/CN101610783B/zh
Priority to ES08721006T priority patent/ES2412388T3/es
Priority to JP2009501304A priority patent/JP5419045B2/ja
Priority to KR1020157033326A priority patent/KR20150138413A/ko
Priority to KR1020097019957A priority patent/KR101670677B1/ko
Priority to DK08721006.8T priority patent/DK2116255T3/da
Priority to CN201510716455.8A priority patent/CN105311620A/zh
Priority to EP08721006.8A priority patent/EP2116255B1/en
Publication of WO2008105088A1 publication Critical patent/WO2008105088A1/ja
Priority to US12/548,881 priority patent/US8518880B2/en
Priority to HK10101945.2A priority patent/HK1134445A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明は、脊髄損傷および脱髄性疾患を根本的に治療するのに有効な薬剤を提供することを目的とする。本発明の薬剤は、ＨＧＦ蛋白質を有効成分とする脊髄損傷治療剤および脱髄性疾患治療剤である。
PCT/JP2007/053804 2007-02-28 2007-02-28 脊髄損傷治療薬剤 WO2008105088A1 (ja)

Priority Applications (14)

Application Number Priority Date Filing Date Title
PCT/JP2007/053804 WO2008105088A1 (ja) 2007-02-28 2007-02-28 脊髄損傷治療薬剤
KR1020157033326A KR20150138413A (ko) 2007-02-28 2008-02-28 척수 손상 치료제
KR1020097019957A KR101670677B1 (ko) 2007-02-28 2008-02-28 척수 손상 치료제
PT87210068T PT2116255E (pt) 2007-02-28 2008-02-28 Administração intratecal de hgf após lesão da medula espinal
CN200880004651.0A CN101610783B (zh) 2007-02-28 2008-02-28 脊髓损伤治疗剂
ES08721006T ES2412388T3 (es) 2007-02-28 2008-02-28 Administración intratecal de FCH después de una lesión en la médula espinal
JP2009501304A JP5419045B2 (ja) 2007-02-28 2008-02-28 脊髄損傷治療薬剤
PCT/JP2008/053557 WO2008105507A1 (ja) 2007-02-28 2008-02-28 脊髄損傷治療薬剤
CA2675953A CA2675953C (en) 2007-02-28 2008-02-28 Therapeutic agent for spinal cord injuries
DK08721006.8T DK2116255T3 (da) 2007-02-28 2008-02-28 Intratekal indgivelse af hgf efter rygmarvsskade
CN201510716455.8A CN105311620A (zh) 2007-02-28 2008-02-28 脊髓损伤治疗剂
EP08721006.8A EP2116255B1 (en) 2007-02-28 2008-02-28 Intrathecal administration of hgf after spinal cord injury
US12/548,881 US8518880B2 (en) 2007-02-28 2009-08-27 Therapeutic agent for spinal cord injuries
HK10101945.2A HK1134445A1 (en) 2007-02-28 2010-02-24 Intrathecal administration of hgf after spinal cord injury

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/053804 WO2008105088A1 (ja) 2007-02-28 2007-02-28 脊髄損傷治療薬剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053557 Continuation-In-Part WO2008105507A1 (ja) 2007-02-28 2008-02-28 脊髄損傷治療薬剤

Publications (1)

Publication Number Publication Date
WO2008105088A1 true WO2008105088A1 (ja) 2008-09-04

Family

ID=39720932

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2007/053804 WO2008105088A1 (ja) 2007-02-28 2007-02-28 脊髄損傷治療薬剤
PCT/JP2008/053557 WO2008105507A1 (ja) 2007-02-28 2008-02-28 脊髄損傷治療薬剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053557 WO2008105507A1 (ja) 2007-02-28 2008-02-28 脊髄損傷治療薬剤

Country Status (10)

Country Link
US (1) US8518880B2 (ja)
EP (1) EP2116255B1 (ja)
KR (2) KR101670677B1 (ja)
CN (2) CN105311620A (ja)
CA (1) CA2675953C (ja)
DK (1) DK2116255T3 (ja)
ES (1) ES2412388T3 (ja)
HK (1) HK1134445A1 (ja)
PT (1) PT2116255E (ja)
WO (2) WO2008105088A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012018069A1 (ja) * 2010-08-06 2012-02-09 大日本住友製薬株式会社 脊髄損傷治療用製剤
CN106714823A (zh) * 2014-09-10 2017-05-24 克霖固鲁制药股份有限公司 适合神经***疾病的治疗的hgf制剂

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2351574B1 (en) * 2008-10-10 2016-08-24 Kringle Pharma, Inc. Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue
KR101446711B1 (ko) * 2011-05-23 2014-10-06 아주대학교산학협력단 간세포 성장인자 유전자 및 염기성 나선-고리-나선 계열의 신경형성 전사인자 유전자가 도입된 성체 줄기세포주 및 그의 용도
US10478280B2 (en) * 2017-02-17 2019-11-19 Ethicon Llc Methods and devices for delivering and securing adjunct materials to a treatment site
US10716564B2 (en) 2017-02-17 2020-07-21 Ethicon Llc Stapling adjunct attachment
CN109535243B (zh) * 2019-01-07 2019-09-24 北京诺思兰德生物技术股份有限公司 人肝细胞生长因子突变体及其应用
CN113433324B (zh) * 2021-05-28 2022-11-18 南通大学 Nck1蛋白作为标志物在诊断脊髓损伤中的应用
WO2023171808A1 (ja) * 2022-03-11 2023-09-14 慶應義塾 脊髄損傷治療剤

Citations (2)

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WO2003045439A1 (fr) * 2001-11-28 2003-06-05 Anges Mg, Inc. Preparations medicinales contenant du materiel genetique destinees au traitement de maladies neurodegeneratives
JP2005035945A (ja) * 2003-07-16 2005-02-10 Cardio Corp 組織再生複合療法

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WO2003045439A1 (fr) * 2001-11-28 2003-06-05 Anges Mg, Inc. Preparations medicinales contenant du materiel genetique destinees au traitement de maladies neurodegeneratives
JP2005035945A (ja) * 2003-07-16 2005-02-10 Cardio Corp 組織再生複合療法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012018069A1 (ja) * 2010-08-06 2012-02-09 大日本住友製薬株式会社 脊髄損傷治療用製剤
JPWO2012018069A1 (ja) * 2010-08-06 2013-10-03 大日本住友製薬株式会社 脊髄損傷治療用製剤
US9040062B2 (en) 2010-08-06 2015-05-26 Sumitomo Dainippon Pharma Co., Ltd. Preparation for treatment of spinal cord injury
JP5881606B2 (ja) * 2010-08-06 2016-03-09 大日本住友製薬株式会社 脊髄損傷治療用製剤
CN106714823A (zh) * 2014-09-10 2017-05-24 克霖固鲁制药股份有限公司 适合神经***疾病的治疗的hgf制剂

Also Published As

Publication number Publication date
DK2116255T3 (da) 2013-05-13
EP2116255A1 (en) 2009-11-11
CN101610783B (zh) 2016-11-16
ES2412388T3 (es) 2013-07-11
US20100081617A1 (en) 2010-04-01
CN105311620A (zh) 2016-02-10
EP2116255A4 (en) 2011-05-04
KR101670677B1 (ko) 2016-11-01
CA2675953A1 (en) 2008-09-04
US8518880B2 (en) 2013-08-27
PT2116255E (pt) 2013-06-21
US20120021040A9 (en) 2012-01-26
HK1134445A1 (en) 2010-04-30
CN101610783A (zh) 2009-12-23
KR20090118078A (ko) 2009-11-17
EP2116255B1 (en) 2013-04-10
CA2675953C (en) 2016-05-10
KR20150138413A (ko) 2015-12-09
WO2008105507A1 (ja) 2008-09-04

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