WO2008099920A1 - 抗hmgb-1抗体を含む間質性肺疾患治療剤 - Google Patents

抗hmgb-1抗体を含む間質性肺疾患治療剤 Download PDF

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Publication number
WO2008099920A1
WO2008099920A1 PCT/JP2008/052526 JP2008052526W WO2008099920A1 WO 2008099920 A1 WO2008099920 A1 WO 2008099920A1 JP 2008052526 W JP2008052526 W JP 2008052526W WO 2008099920 A1 WO2008099920 A1 WO 2008099920A1
Authority
WO
WIPO (PCT)
Prior art keywords
hmgb
pulmonary disease
antibody
interstitial pulmonary
therapeutic agent
Prior art date
Application number
PCT/JP2008/052526
Other languages
English (en)
French (fr)
Inventor
Kazuyoshi Kuwano
Naoki Hamada
Ikuro Maruyama
Shingo Yamada
Original Assignee
Kyushu University, National University Corporation
Kagoshima University
Shino-Test Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyushu University, National University Corporation, Kagoshima University, Shino-Test Corporation filed Critical Kyushu University, National University Corporation
Priority to EP08711356A priority Critical patent/EP2123299A4/en
Priority to JP2008558149A priority patent/JP5241518B2/ja
Priority to US12/449,562 priority patent/US20100216977A1/en
Publication of WO2008099920A1 publication Critical patent/WO2008099920A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

　本発明は、IPF等の間質性肺炎を含む間質性肺疾患を治療するのに有効な手段を提供することを目的とする。本発明により、HMGB-1に対する抗体が肺線維症の治療に効果的であることが示唆された。そこで本発明は、抗HMGB-1抗体を含む間質性肺疾患を治療するための製剤を提供するものである。
PCT/JP2008/052526 2007-02-15 2008-02-15 抗hmgb-1抗体を含む間質性肺疾患治療剤 WO2008099920A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08711356A EP2123299A4 (en) 2007-02-15 2008-02-15 THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY
JP2008558149A JP5241518B2 (ja) 2007-02-15 2008-02-15 抗ｈｍｇｂ−１抗体を含む間質性肺疾患治療剤
US12/449,562 US20100216977A1 (en) 2007-02-15 2008-02-15 Therapeutic agent for interstitial pulmonary disease comprising anti-hmgb-1 antibody

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-034293 2007-02-15
JP2007034293 2007-02-15

Publications (1)

Publication Number Publication Date
WO2008099920A1 true WO2008099920A1 (ja) 2008-08-21

Family

ID=39690145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052526 WO2008099920A1 (ja) 2007-02-15 2008-02-15 抗hmgb-1抗体を含む間質性肺疾患治療剤

Country Status (5)

Country Link
US (1) US20100216977A1 (ja)
EP (1) EP2123299A4 (ja)
JP (1) JP5241518B2 (ja)
TW (1) TW200900077A (ja)
WO (1) WO2008099920A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023037562A1 (ja) * 2021-09-07 2023-03-16 国立大学法人大阪大学 肺炎の治療薬

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123297A4 (en) * 2007-02-15 2011-10-12 Univ Kumamoto THERAPEUTIC AGENT COMPRISING AN ANTIBODY CAPABLE OF BINDING SPECIFICALLY TO HMGB-1 AS ACTIVE INGREDIENT
WO2008099917A1 (ja) * 2007-02-15 2008-08-21 Fukuoka University 抗hmgb-1抗体を含む臓器移植拒絶抑制剤
FI20105715A0 (fi) 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023037562A1 (ja) * 2021-09-07 2023-03-16 国立大学法人大阪大学 肺炎の治療薬

Also Published As

Publication number Publication date
US20100216977A1 (en) 2010-08-26
JPWO2008099920A1 (ja) 2010-05-27
JP5241518B2 (ja) 2013-07-17
EP2123299A1 (en) 2009-11-25
TW200900077A (en) 2009-01-01
EP2123299A4 (en) 2011-10-05

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